Drug Information
Drug General Information | Top | |||
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Drug ID |
D0T5SG
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Former ID |
DIB003611
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Drug Name |
ME-3221
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Synonyms |
EF-2831
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1] | |
Company |
Meiji Seika Kaisha Ltd
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Structure |
Download2D MOL |
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Formula |
C22H21N5O2
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Canonical SMILES |
CC1=CC(=C(C(=N1)C)OC)OCC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4
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InChI |
1S/C22H21N5O2/c1-14-12-20(21(28-3)15(2)23-14)29-13-16-8-10-17(11-9-16)18-6-4-5-7-19(18)22-24-26-27-25-22/h4-12H,13H2,1-3H3,(H,24,25,26,27)
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InChIKey |
FTDRSCZZEUAAIP-UHFFFAOYSA-N
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CAS Number |
CAS 139958-16-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Angiotensin II receptor (AGTR) | Target Info | Modulator | [2] |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Vascular smooth muscle contraction | ||||
Renin-angiotensin system | ||||
Renin secretion | ||||
Pathways in cancer |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002995) | |||
REF 2 | Protective effects of ME3221 on hypertensive complications and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1996 Mar;23(3):229-35. |
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