Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0TK7R
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| Former ID |
DNCL002417
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| Drug Name |
LGX818
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| Synonyms |
Encorafenib; 1269440-17-6; LGX-818; Encorafenib (LGX818); UNII-8L7891MRB6; LGX 818; 8L7891MRB6; Encorafenib [USAN:INN]; LGX-818(Encorafenib)
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| Drug Type |
Small molecular drug
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| Indication | Melanoma [ICD-11: 2C30; ICD-9: 172] | Approved | [1] | |
| Company |
Array BioPharma
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| Structure |
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Download2D MOL
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| Formula |
C22H27ClFN7O4S
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| Canonical SMILES |
CC(C)N1C=C(C(=N1)C2=C(C(=CC(=C2)Cl)NS(=O)(=O)C)F)C3=NC(=NC=C3)NCC(C)NC(=O)OC
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| InChI |
1S/C22H27ClFN7O4S/c1-12(2)31-11-16(17-6-7-25-21(28-17)26-10-13(3)27-22(32)35-4)20(29-31)15-8-14(23)9-18(19(15)24)30-36(5,33)34/h6-9,11-13,30H,10H2,1-5H3,(H,27,32)(H,25,26,28)/t13-/m0/s1
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| InChIKey |
CMJCXYNUCSMDBY-ZDUSSCGKSA-N
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| CAS Number |
CAS 1269440-17-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. | |||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | |||
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