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| Interaction between the Drug and Microbe |
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| The Abundace of Studied Microbe(s) Regulated by Drug |
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales |
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Studied Microbe: Blautia obeum
Show/Hide Hierarchy
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[3] |
| Hierarchy |
Kingdom: Bacteria
Phylum: Bacillota
Class: Clostridia
Order: Eubacteriales
Family: Lachnospiraceae
Genus: Blautia
Species: Blautia obeum
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Abundance Change
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Decrease
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| Experiment Method |
High-throughput screening |
| Description |
The abundance of Blautia obeum was decreased by Bosentan (adjusted p-values: 2.36E-05). |
| Target and Pathway |
Top |
| Target(s) |
Endothelin A receptor (EDNRA) |
Target Info
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Modulator |
[4] |
| Endothelin B receptor (EDNRB) |
Target Info
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Modulator |
[4] |
| References |
Top |
| REF 1 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3494).
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| REF 2 |
Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension. Vasc Health Risk Manag. 2008;4(5):943-52.
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| REF 3 |
Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628.
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| REF 4 |
Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
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