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| Interaction between the Drug and Microbe |
Top |
| The Metabolism of Drug Affected by Studied Microbe(s) |
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota |
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Studied Microbe: Gut microbiota unspecific
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[3] |
| Metabolic Reaction |
Nitroreduction |
| Experimental Method |
High-throughput screening |
| Description |
Flutamide can be metabolized by gut microbiota through nitroreduction. |
| Target and Pathway |
Top |
| Target(s) |
Androgen receptor (AR) |
Target Info
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Antagonist |
[4] |
| References |
Top |
| REF 1 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6943).
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| REF 2 |
FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075298.
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| REF 3 |
Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22.
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| REF 4 |
Androgen receptor as a target in androgen-independent prostate cancer. Urology. 2002 Sep;60(3 Suppl 1):132-8; discussion 138-9.
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