Target's General Information
Target ID T08133
Target Name Transient receptor potential cation channel V6 (TRPV6)
Synonyms Transient receptor potential cation channel subfamily V, member 6; TRPV6; HTRP8; ECaC2; Calcium transport protein CaT1; Calcium channel CAT1
Target Type Clinical trial
Gene Name TRPV6
Biochemical Class Transient receptor potential catioin channel
UniProt ID TRPV6_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Ovarian cancer
Example drug SOR-C13 Phase 1 [1], [2], [3]
Tissue Ovarian tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 3.02E-03
Z-score: 1.04E-02
P-value: 2.52E-01
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: 0.15
Z-score: 0.41
P-value: 3.21E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 ClinicalTrials.gov (NCT01578564) Safety and Tolerability Study of SOR-C13 in Subjects With Advanced Cancers Commonly Known to Express the TRPV6 Channel. U.S. National Institutes of Health.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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