Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T63484 | ||||
| Target Name | Glucose-6-phosphate dehydrogenase (G6PD) | ||||
| Synonyms | Glucose-6-phosphate 1-dehydrogenase | ||||
| Target Type | Successful | ||||
| Gene Name | G6PD | ||||
| Biochemical Class | CH-OH donor oxidoreductase | ||||
| UniProt ID | G6PD_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Rheumatoid arthritis | ||||
| Example drug | CBF-BS2 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 2.13 Z-score: 4.86 P-value: 7.05E-07 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | Prasterone | Phase 3 | [2], [3], [4] | ||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.18 Z-score: -0.3 P-value: 4.01E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
|
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| Disease | Chronic obstructive pulmonary disease | ||||
| Example drug | Prasterone | Phase 3 | [2], [3], [4] | ||
| Tissue | Small airway epithelium | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.44 Z-score: 0.6 P-value: 2.39E-03 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007279) | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | Direct agonist/antagonist functions of dehydroepiandrosterone. Endocrinology. 2005 Nov;146(11):4568-76. | ||||
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