Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T86192 | ||||
| Target Name | Voltage-gated potassium channel Kv7 (KCNQ) | ||||
| Synonyms | Voltage-gated potassium channel subunit Kv7; Potassium voltage-gated channel subfamily KQT; Kv7; KVLQT; KQT-like; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT | ||||
| Target Type | Clinical trial | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | KCNQ1_HUMAN||KCNQ2_HUMAN||KCNQ3_HUMAN||KCNQ4_HUMAN||KCNQ5_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Parkinson's disease | ||||
| Example drug | DMP-543 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Substantia nigra tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.11 Z-score: 0.85 P-value: 6.24E-01 |
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| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009278) | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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