Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T89529 | ||||
| Target Name | PTPN1 messenger RNA (PTPN1 mRNA) | ||||
| Synonyms | Tyrosine-protein phosphatase non-receptor type 1 (mRNA); PTP-1B (mRNA) | ||||
| Target Type | Successful | ||||
| Gene Name | PTPN1 | ||||
| Biochemical Class | mRNA target | ||||
| UniProt ID | PTN1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Type 2 diabetes | ||||
| Example drug | ISIS-PTP1Brx | Phase 2 | [1], [2], [3] | ||
| Tissue | Liver tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 7.21E-03 Z-score: 0.08 P-value: 9.44E-01 |
||||
|
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
|
|||||
| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
|
|||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01918865) Safety, Tolerability, and Efficacy of ISIS-PTP1BRx in Type 2 Diabetes. U.S. National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.