Target's General Information
Target ID T94479
Target Name Ribosomal protein S6 kinase beta-1 (S6K1)
Synonyms p70-S6K 1; p70 ribosomal S6 kinase alpha; p70 S6KA; p70 S6K-alpha; p70 S6 kinase alpha; Serine/threonine-protein kinase 14A; STK14A; S6K-beta-1; S6K; Ribosomal protein S6 kinase I; P70S6K1; P70-S6K; 70 kDa ribosomal protein S6 kinase 1
Target Type Clinical trial
Gene Name RPS6KB1
Biochemical Class Kinase
UniProt ID KS6A1_HUMAN||KS6A2_HUMAN||KS6A3_HUMAN||KS6A4_HUMAN||KS6A5_HUMAN||KS6A6_HUMAN||KS6B1_HUMAN||KS6B2_HUMAN||KS6C1_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Ulcerative colitis
Example drug PF-4708671 Clinical trial [1], [2], [3]
Tissue Colon mucosal tissue
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: 0.03
Z-score: 0.07
P-value: 4.83E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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