miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-129-5p | ||||
miRNA Stemloop AC | MI0000252 | MI0000473 | ||||
miRNA Stemloop ID | hsa-mir-129-1 | hsa-mir-129-2 | ||||
Sequence | cuuuuugcggucugggcuugc | ||||
TTD Target(s) Regulated by This miRNA | Cyclin-dependent kinase 6 (CDK6) | Successful Target | Target Info | [1] | |
Protein(s) Regulated by This miRNA | Adenomatous polyposis coli protein | Regulated Protein | [2] | ||
Calmodulin-binding transcription activator 1 | Regulated Protein | [3] | |||
Collagen alpha-1(I) chain | Regulated Protein | [4] | |||
Fibronectin type-III domain-containing protein 3A | Regulated Protein | [5] | |||
Insulin-like growth factor 2 mRNA-binding protein 3 | Regulated Protein | [6] | |||
Microspherule protein 1 | Regulated Protein | [7] | |||
Multidrug resistance-associated protein 5 | Regulated Protein | [8] | |||
NEDD8-conjugating enzyme UBE2F | Regulated Protein | [9] | |||
Polypeptide N-acetylgalactosaminyltransferase 1 | Regulated Protein | [10] | |||
Protein argonaute-3 | Regulated Protein | [3] | |||
Protein Wnt-4 | Regulated Protein | [11] | |||
Synaptic functional regulator FMR1 | Regulated Protein | [12] | |||
Transcription factor ETV6 | Regulated Protein | [10] | |||
Transcription factor SOX-4 | Regulated Protein | [10] | |||
Twist-related protein 1 | Regulated Protein | [13] | |||
Vimentin | Regulated Protein | [7] | |||
References | |||||
REF 1 | Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet. 2005 Dec 15;14(24):3813-21. | ||||
REF 2 | Down-regulation of miR-129-5p inhibits growth and induces apoptosis in laryngeal squamous cell carcinoma by targeting APC.PLoS One. 2013 Oct 23;8(10):e77829. | ||||
REF 3 | MicroRNAs play a role in the development of human hematopoietic stem cells. J Cell Biochem. 2008 Jun 1;104(3):805-17. | ||||
REF 4 | MiR-129-5p suppresses gastric cancer cell invasion and proliferation by inhibiting COL1A1.Biochem Cell Biol. 2018 Feb;96(1):19-25. | ||||
REF 5 | Potential mechanisms of microRNA-129-5p in inhibiting cell processes including viability, proliferation, migration and invasiveness of glioblastoma cells U87 through targeting FNDC3B.Biomed Pharmacother. 2017 Mar;87:405-411. | ||||
REF 6 | MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1.J Med Genet. 2016 Jan;53(1):24-33. | ||||
REF 7 | miRNA-129-5p suppresses cell proliferation and invasion in lung cancer by targeting microspherule protein 1, E-cadherin and vimentin.Oncol Lett. 2016 Dec;12(6):5163-5169. | ||||
REF 8 | Methylation of miR-129-5p CpG island modulates multi-drug resistance in gastric cancer by targeting ABC transporters.Oncotarget. 2014 Nov 30;5(22):11552-63. | ||||
REF 9 | Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer.Cancer Res. 2009 Dec 1;69(23):9038-46. | ||||
REF 10 | Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro.Cancer Res. 2009 Jun 1;69(11):4851-60. | ||||
REF 11 | Dysregulation of the BRCA1/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesis.Oncotarget. 2016 Oct 4;7(40):65067-65089. | ||||
REF 12 | The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse.Hum Mol Genet. 2013 May 15;22(10):1971-82. | ||||
REF 13 | Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer.Oncotarget. 2015 Oct 27;6(33):34423-36. |
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