miRNA General Information
miRNA Mature ID hsa-miR-129-5p
miRNA Stemloop AC MI0000252 | MI0000473
miRNA Stemloop ID hsa-mir-129-1 | hsa-mir-129-2
Sequence cuuuuugcggucugggcuugc
TTD Target(s) Regulated by This miRNA Cyclin-dependent kinase 6 (CDK6) Successful Target Target Info [1]
Protein(s) Regulated by This miRNA Adenomatous polyposis coli protein Regulated Protein [2]
Calmodulin-binding transcription activator 1 Regulated Protein [3]
Collagen alpha-1(I) chain Regulated Protein [4]
Fibronectin type-III domain-containing protein 3A Regulated Protein [5]
Insulin-like growth factor 2 mRNA-binding protein 3 Regulated Protein [6]
Microspherule protein 1 Regulated Protein [7]
Multidrug resistance-associated protein 5 Regulated Protein [8]
NEDD8-conjugating enzyme UBE2F Regulated Protein [9]
Polypeptide N-acetylgalactosaminyltransferase 1 Regulated Protein [10]
Protein argonaute-3 Regulated Protein [3]
Protein Wnt-4 Regulated Protein [11]
Synaptic functional regulator FMR1 Regulated Protein [12]
Transcription factor ETV6 Regulated Protein [10]
Transcription factor SOX-4 Regulated Protein [10]
Twist-related protein 1 Regulated Protein [13]
Vimentin Regulated Protein [7]
References
REF 1 Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet. 2005 Dec 15;14(24):3813-21.
REF 2 Down-regulation of miR-129-5p inhibits growth and induces apoptosis in laryngeal squamous cell carcinoma by targeting APC.PLoS One. 2013 Oct 23;8(10):e77829.
REF 3 MicroRNAs play a role in the development of human hematopoietic stem cells. J Cell Biochem. 2008 Jun 1;104(3):805-17.
REF 4 MiR-129-5p suppresses gastric cancer cell invasion and proliferation by inhibiting COL1A1.Biochem Cell Biol. 2018 Feb;96(1):19-25.
REF 5 Potential mechanisms of microRNA-129-5p in inhibiting cell processes including viability, proliferation, migration and invasiveness of glioblastoma cells U87 through targeting FNDC3B.Biomed Pharmacother. 2017 Mar;87:405-411.
REF 6 MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1.J Med Genet. 2016 Jan;53(1):24-33.
REF 7 miRNA-129-5p suppresses cell proliferation and invasion in lung cancer by targeting microspherule protein 1, E-cadherin and vimentin.Oncol Lett. 2016 Dec;12(6):5163-5169.
REF 8 Methylation of miR-129-5p CpG island modulates multi-drug resistance in gastric cancer by targeting ABC transporters.Oncotarget. 2014 Nov 30;5(22):11552-63.
REF 9 Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer.Cancer Res. 2009 Dec 1;69(23):9038-46.
REF 10 Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro.Cancer Res. 2009 Jun 1;69(11):4851-60.
REF 11 Dysregulation of the BRCA1/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesis.Oncotarget. 2016 Oct 4;7(40):65067-65089.
REF 12 The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse.Hum Mol Genet. 2013 May 15;22(10):1971-82.
REF 13 Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer.Oncotarget. 2015 Oct 27;6(33):34423-36.

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