miRNA General Information
miRNA Mature ID hsa-miR-145-3p
miRNA Stemloop AC MI0000461
miRNA Stemloop ID hsa-mir-145
Sequence ggauuccuggaaauacuguucu
TTD Target(s) Regulated by This miRNA Mothers against decapentaplegic homolog 3 (SMAD3) Successful Target Target Info [1]
Matrix metalloproteinase-16 (MMP-16) Literature-reported Target Target Info [2]
Metastasis adhesion protein (MTDH) Literature-reported Target Target Info [3]
Protein(s) Regulated by This miRNA 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Regulated Protein [4]
References
REF 1 Peroxisome proliferator-activated receptor- (PPAR-) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145. Biochem Biophys Res Commun. 2015 Mar 27;459(1):49-53.
REF 2 MicroRNA-145 Suppresses Osteosarcoma Metastasis via Targeting MMP16. Cell Physiol Biochem. 2015;37(6):2183-93.
REF 3 Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma. Oncotarget. 2016 Nov 1;7(44):72084-72098.
REF 4 Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma.Oncotarget. 2016 Jan 12;7(2):1777-95.

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