Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T31204 Target Info
Target Name 5-HT 2B receptor (HTR2B)
Synonyms Serotonin receptor 2B; 5-hydroxytryptamine receptor 2B; 5-HT2B; 5-HT-2B; 5-HT 2B
Target Type Successful Target
Gene Name HTR2B
Biochemical Class GPCR rhodopsin
UniProt ID
5HT2B_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2007019083
Title Pyrimidine Compounds As Serotonin Receptor Modulators.
Abstract Certain pyrimidine-containing compounds are serotonin receptor modulators useful in the treatment of serotonin-mediated diseases.
Applicant(s) Janssen Pharmaceutica Nv
Representative Drug(s) D00YGY Drug Info Ki = 30 nM Click to Show More [1]
2 D0B7NS Drug Info Ki = 70 nM [1]
3 D0P9VX Drug Info Ki = 250 nM [1]
4 D0N2VA Drug Info Ki = 900 nM [1]
5 D0SE9K Drug Info Ki = 1185 nM [1]
6 D08DJY Drug Info Ki = 2200 nM [1]
Patent ID WO2010058858
Title Novel Pyrazole-3-Carboxamide Derivative Having 5-Ht2B Receptor Antagonist Activity.
Abstract Disclosed is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, which is useful as a selective antagonist of a 5-HT2B receptor.The compound and salt are useful for treatment or prevention of various diseases and conditions associated with a 5-HT2B receptor.
Applicant(s) Raqualia Pharma Inc
Representative Drug(s) D0D3BL Drug Info N.A. [1]
Patent ID WO2003091250
Title [1,4]Diazepino[6,7,1-Ij]Quinoline Derivatives As Anti Psychotic and Antiobesity Agents.
Abstract Compounds of formula 1 or a pharmaceutically acceptable salt thereof are provided: I where R1 through R7 are defined herein. The compounds of formula I are 5HT2c agonists or partial agonists, and are useful for treating a variety of disorders.
Applicant(s) RAMAMOORTHY, Sivaramakrishnan, P et al
Representative Drug(s) D01LVT Drug Info N.A. [1]
United States Patent and Trademark Office (USPTO)
Patent ID US8618288
Title Pyrimidine Compounds As Serotonin Receptor Modulators.
Applicant(s) Janssen Pharmaceutica Nv
Representative Drug(s) D00YGY Drug Info Ki = 30 nM Click to Show More [1]
2 D0B7NS Drug Info Ki = 70 nM [1]
3 D0P9VX Drug Info Ki = 250 nM [1]
4 D0N2VA Drug Info Ki = 900 nM [1]
5 D0SE9K Drug Info Ki = 1185 nM [1]
6 D08DJY Drug Info Ki = 2200 nM [1]
References  Top
REF 1 Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106.

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