| Patent(s) and the Corresponding Patented Drug(s) |
Top |
| World Intellectual Property Organization (WIPO) |
| Patent ID |
WO2014207069 |
| Title |
Multitarget Hedgehog Pathway Inhibitors and Uses Thereof. |
| Abstract |
The present invention concerns compounds that selectively inhibit the activity of the Hedgehog (Hh) pathway, their preparation and uses thereof. The compounds of the present invention are useful in treating Hh-dependent tumors, such as medulloblastoma (MB). |
| Applicant(s) |
Universita 'Degli Studi Di Siena |
| Representative Drug(s) |
D00RRB |
Drug Info
|
N.A. |
Click to Show More |
[1] |
|
2
|
D01BGG
|
Drug Info
|
N.A.
|
[1] |
|
3
|
D04IFL
|
Drug Info
|
N.A.
|
[1] |
|
4
|
D05NRG
|
Drug Info
|
N.A.
|
[1] |
|
5
|
D09VIE
|
Drug Info
|
N.A.
|
[1] |
|
6
|
D0J1RB
|
Drug Info
|
N.A.
|
[1] |
|
7
|
D0TP0S
|
Drug Info
|
N.A.
|
[1] |
| Patent ID |
WO2013192301 |
| Title |
Imidazo Bicyclic Imminium Compounds As Antitumor Agents. |
| Abstract |
Imidazobicycles having a quaternary nitrogen, i.e. imminium salts, are disclosed. Examples include derivatives of 6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepinium and 2,3-dihydroimidazo[2,1-b]thiazolium salts. The compounds are inhibitors of the Hedgehog pathway and therefore useful as antitumor agents and as probes of the function of Hedgehog-dependent systems. |
| Applicant(s) |
The Board of Trustes of the Leland Stanford Junior University |
| Representative Drug(s) |
D0FL0T |
Drug Info
|
N.A. |
Click to Show More |
[2] |
|
2
|
D0II7X
|
Drug Info
|
N.A.
|
[2] |
| Patent ID |
WO2014116651 |
| Title |
Targeting Gli Proteins In Human Cancer By Small Molecules. |
| Abstract |
The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide. The disclosed compositions and pharmaceutical preparations may comprise one or more pyrazolyl-containing compounds, or an analog or derivative thereof. |
| Applicant(s) |
The Regents of the University of California |
| Representative Drug(s) |
D00KXJ |
Drug Info
|
N.A. |
[1] |
| Patent ID |
WO2007067814 |
| Title |
Targeting Gli Proteins In Human Cancer By Small Molecules. |
| Abstract |
This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3. |
| Applicant(s) |
The Regents of the University of California |
| Representative Drug(s) |
D00KXJ |
Drug Info
|
N.A. |
[1] |
| United States Patent and Trademark Office (USPTO) |
| Patent ID |
US2015191489 |
| Title |
Imidazo Bicyclic Imminium Compounds As Antitumor Agents. |
| Applicant(s) |
The Board of Trustes of the Leland Stanford Junior University |
| Representative Drug(s) |
D0FL0T |
Drug Info
|
N.A. |
Click to Show More |
[1] |
|
2
|
D0II7X
|
Drug Info
|
N.A.
|
[1] |
