Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T69375 Target Info
Target Name Stress-activated protein kinase JNK2 (JNK2)
Synonyms Stress-activated protein kinase 1a; SAPK1a; PRKM9; Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 8-interacting protein 2; MAPK 9; MAP kinase 9; Jun-N-terminal kinase 2; JNK-interacting protein 2; JNK-55; JNK MAP kinase scaffold protein 2; JIP-2; Islet-brain-2; IB-2; C-jun-amino-terminal kinase interacting protein 2; C-Jun N-terminal kinase 2
Target Type Preclinical Target
Gene Name MAPK9
Biochemical Class Kinase
UniProt ID
MK09_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2013074986
Title Inhibitors of C-Jun-N-Terminal Kinase (Jnk).
Abstract The present invention provides novel compounds according to Formula (I): where Ring A, Ring B, X, L1, L2, RA, RC, RD, RE, m, n, and p are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of human diseases associated with kinase activity, for example, proliferative diseases, neurodegenerative diseases, metabolic disorders, inflammatory diseases, and cardiovascular diseases.
Applicant(s) Dana-Farber Cancer Institute, Inc
Representative Drug(s) D08JOC Drug Info IC50 = 2 nM Click to Show More [1]
2 D0RQ8Q Drug Info IC50 = 18 nM [1]
Patent ID WO2010097335
Title Imidazo [1, 2 -A] Pyridines As Jnk Modulators.
Abstract Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH-R2 Or N-SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals; R2 is (II), where R3 is H, lower acyl, or an amino acid, or a pharmaceutically acceptable salt thereof.
Applicant(s) F. Hoffmann-La Roche Ag
Representative Drug(s) D04JUD Drug Info IC50 = 53 nM Click to Show More [1]
2 D0S1OV Drug Info IC50 = 104 nM [1]
Patent ID WO2010091310
Title Inhibitors of Jun N-Terminal Kinase.
Abstract The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula (I): or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
Applicant(s) Elan Pharmaceuticals, Inc
Representative Drug(s) D08DNZ Drug Info IC50 = 43 nM Click to Show More [1]
2 D0L2MS Drug Info IC50 = 23000 nM [1]
Patent ID WO2010069833
Title Pyrimidin- 2 -Ylamino Derivatives and Their Use To Treat Inflammation.
Abstract Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH-R2 or N-SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals; R2 is formula (II), where R3 is H, lower acyl, or an amino acid, or a pharmaceutically acceptable salt thereof.
Applicant(s) F. Hoffmann-La Roche Ag
Representative Drug(s) D0RV2Z Drug Info IC50 = 14 nM Click to Show More [1]
2 D0H4HD Drug Info IC50 = 97 nM [1]
Patent ID WO2010046273
Title Pyrimidinyl Pyridone Inhibitors of Jnk.
Abstract This application discloses novel pyrimidinyl pyridone derivatives according to Formulae I and II, wherein R1 and R2 are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of Formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of Formula I to a subject in need thereof.
Applicant(s) F. Hoffmann-La Roche Ag
Representative Drug(s) D0B4IH Drug Info IC50 = 154 nM Click to Show More [1]
2 D07JQX Drug Info IC50 = 409 nM [1]
Patent ID WO2010015803
Title Diazaindole Derivatives and Their Use In The Inhibition of C-Jun N-Terminal Kinase.
Abstract The invention relates to diazaindole derivatives represented by the general formula (I): where A, E, G, R1, R2, R3 and R4 are defined herein, or pharmaceutically acceptable salts thereof, their use in the inhibition of c-Jun N-terminal kinase (JNK) activity, their use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases, autoimmune diseases and/or organ failure. The invention also provides processes for the manufacture of said diazaindole derivatives and compositions containing them.
Applicant(s) Eisai R & D Management Co. Ltd
Representative Drug(s) D05SJB Drug Info IC50 = 59 nM Click to Show More [1]
2 D07KMK Drug Info IC50 = 135 nM [1]
3 D0T6IZ Drug Info IC50 = 339 nM [1]
Patent ID WO2008095944
Title 7-Azaindole Derivatives and Their Use In The Inhibition of C-Jun N-Terminal Kinase.
Abstract The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
Applicant(s) Eisai R & D Management Co. Ltd
Representative Drug(s) D05SJB Drug Info IC50 = 59 nM Click to Show More [1]
2 D07KMK Drug Info IC50 = 135 nM [1]
3 D0T6IZ Drug Info IC50 = 339 nM [1]
Patent ID WO2013091670
Title Novel Jnk Inhibitor Molecules for Treatment of Various Diseases.
Abstract The present invention relates to the use of novel JNK inhibitor molecules and their use in a method of treatment of the human or animal body by therapy.
Applicant(s) COMBETTE, Jean-Marc et al
Representative Drug(s) D0Q4WA Drug Info IC50 = 55 nM [1]
Patent ID WO2011151357
Title Inhibitors of Jnk.
Abstract Compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein: wherein m, n, p, q, X Y, Z, A, R1, R2, R3, R4, R5 and Y6 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity.
Applicant(s) F. Hoffmann-La Roche Ag
Representative Drug(s) D07KVU Drug Info IC50 = 12 nM [1]
Patent ID WO2011071491
Title Isotopologues of 4-[9-(Tetrahydro-Furan-3-Yl)-8-(2, 4, 6- Trifluoro-Phenylamino)-9H-Purin-2-Ylamino]-Cyclohexan-1-Ol.
Abstract Provided herein are isotopologues of Compound 1, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided.
Applicant(s) Signal Pharmaceuticals
Representative Drug(s) D06JRV Drug Info IC50 = 7 nM [1]
Patent ID WO2008028860
Title Benzotriazole Kinase Modulators.
Abstract The invention is concerned with novel benzotriazole derivatives of Formula (I) Wherein R, R1, R2, R3, and m are as defined in the description and the claims, as well as physiologically acceptable salts thereof. These compounds are JNK and CDK modulators.
Applicant(s) F. Hoffmann-La Roche Ag
Representative Drug(s) D0H4HD Drug Info IC50 = 97 nM [1]
United States Patent and Trademark Office (USPTO)
Patent ID US20110034470
Title Pyrimidine Derivatives As Jnk Inhibitors and Their Preparation and Use for The Treatment of Jnk-Mediated Diseases.
Representative Drug(s) D03HEK Drug Info IC50 = 6 nM Click to Show More [1]
2 D0AM2B Drug Info IC50 = 18 nM [1]
3 D09YEH Drug Info IC50 = 19 nM [1]
4 D0S3AP Drug Info IC50 = 55 nM [1]
References  Top
REF 1 c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72.

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