Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
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Full Name | E3 ubiquitin protein ligase CBLB (CBLB) | Literature-reported | Target Info | ||
UniProt ID | CBLB_HUMAN | ||||
Gene Name | CBLB | ||||
Gene ID | 868 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Tyrosine-protein kinase SYK (SYK) | Target Info | PPI Info | [2] | ||
Interacting Patented-recorded Target(s) | Polyubiquitin-C (UBC) | Target Info | PPI Info | [3] | |
Interacting Literature-reported Target(s) | Proto-oncogene c-Crk (c-Crk) | Target Info | PPI Info | [4] | |
Signal transduction protein CBL (CBL) | Target Info | PPI Info | [5] |
References | Top | ||||
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REF 1 | EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. Oncogene. 2006 Oct 19;25(49):6497-509. | ||||
REF 2 | Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene. 1999 Feb 4;18(5):1147-56. | ||||
REF 3 | Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene. 2004 Mar 4;23(9):1645-55. | ||||
REF 4 | Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9. | ||||
REF 5 | The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor (PDGFR) Internalization and Signaling. J Biol Chem. 2016 May 27;291(22):11608-18. |
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