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| Protein General Information |
Top |
| Full Name |
Ski oncogene (SKI)
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| UniProt ID |
SKI_HUMAN
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| Gene Name |
SKI
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| Gene ID |
6497
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| Interacting TTD Target Information |
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| Interacting Successful Target(s) |
Mothers against decapentaplegic homolog 3 (SMAD3) |
Target Info
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PPI Info
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[1] |
| Interacting Clinical trial Target(s) |
Retinoic acid receptor alpha (RARA) |
Target Info
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PPI Info
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[2] |
| References |
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| REF 1 |
Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling. J Biol Chem. 2003 Aug 29;278(35):32489-92.
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| REF 2 |
The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway. Biochem Biophys Res Commun. 2009 May 22;383(1):119-24.
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