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| Protein General Information (TTD Target) |
Top |
| Full Name |
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2)
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Literature-reported
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Target Info
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| UniProt ID |
WWP2_HUMAN
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| Gene Name |
WWP2
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| Gene ID |
11060
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| Interacting TTD Target Information |
Top |
| Interacting Successful Target(s) |
Mothers against decapentaplegic homolog 3 (SMAD3) |
Target Info
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PPI Info
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[1] |
| Interacting Clinical trial Target(s) |
Mothers against decapentaplegic homolog 7 (SMAD7) |
Target Info
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PPI Info
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[2] |
| Interacting Literature-reported Target(s) |
Phosphatase and tensin homolog (PTEN) |
Target Info
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PPI Info
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[3] |
| NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) |
Target Info
|
PPI Info
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[4] |
| References |
Top |
| REF 1 |
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGF signalling and EMT. Oncogene. 2011 May 26;30(21):2451-62.
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| REF 2 |
USP11 augments TGF signalling by deubiquitylating ALK5. Open Biol. 2012 Jun;2(6):120063.
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| REF 3 |
Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. Proteomics. 2005 Apr;5(5):1250-62.
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| REF 4 |
Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer. Biochim Biophys Acta. 2013 Dec;1832(12):2127-35.
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