Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00663 | Target Info | |||
| Target Name | Stress-activated protein kinase JNK3 (JNK3) | ||||
| Synonyms |
Stress-activated protein kinase 1b; SAPK1b; PRKM10; Mitogen-activated protein kinase 10; MAPK 10; MAP kinase p49 3F12; MAP kinase 10; JNK3A; C-Jun N-terminal kinase 3
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| Target Type | Patented-recorded Target | ||||
| Gene Name | MAPK10 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(5-(Naphthalen-2-yl)-1H-tetrazol-1-yl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784662; BDBM50345603
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl 5-(2-(naphthalen-1-yl)acetamido)-1,2,3-thiadiazole-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288271; BDBM50332057
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(4-Methylpyridin-3-yl)-2-(naphthalen-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288299; BDBM50332062
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-(2-Methylpyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784645; BDBM50345612
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl 4-(2-(naphthalen-1-yl)acetamido)thiazole-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288297; BDBM50332060
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Ethyl 3-methyl-5-(2-(naphthalen-1-yl)acetamido)isothiazole-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288273; BDBM50332059
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-(Pyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784643; BDBM50345610
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Methylpyrazin-2-yl)-2-(naphthalen-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1287857; BDBM50332093
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-(4-(Naphthalen-2-yl)-5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784652; BDBM50345619
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl 2-(2-(naphthalen-1-yl)acetamido)nicotinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288298; BDBM50332061
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(2-(Hydroxymethyl)thiophen-3-yl)-2-phenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288933; BDBM50332094
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Methyl 4-(2-(naphthalen-1-yl)acetamido)-1,2,5-oxadiazole-3-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288272; BDBM50332058
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Phenyl-N-(2-(prop-1-en-2-yl)thiophen-3-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288965; BDBM50332096
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(2-Methoxyethyl)-N-methyl-3-(2-phenylacetamido)thiophene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288245; BDBM50332092
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-(2-Bromopyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784647; BDBM50345614
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[6-[(3-Chlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222992; BDBM50325368; (S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide
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| Activity |
IC50 = 78000 nM
|
[3] | |||
| Compound Name |
4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-(2-pyrrolidin-1-ylethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222474; BDBM50325373; 4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide
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| Activity |
IC50 = 90000 nM
|
[3] | |||
| Compound Name |
4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223203; BDBM50325369; 4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(2-(dimethylamino)ethyl)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(S)-4-(6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222990; BDBM50325375
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222565; BDBM50325374; (S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3726-9. | ||||
| REF 2 | Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7303-7. | ||||
| REF 3 | Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5113-8 | ||||
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