Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T04507 | Target Info | |||
| Target Name | Presynaptic density protein 95 (DLG4) | ||||
| Synonyms |
Synapse-associated protein 90; SAP90; SAP-90; Postsynaptic density-95; Postsynaptic density protein 95; PSD95; PSD-95; Disks large homolog 4; Discs, large homolog 4
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | DLG4 | ||||
| Biochemical Class | Ezrin/radixin/moesin-binding phosphoprotein 50 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 23 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-(2-pyren-1-ylethylamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688625; BDBM50339561
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|
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| Activity |
Ki = 51000 nM
|
[1] | |||
| Compound Name |
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(3-naphthalen-2-ylpropylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688622; BDBM50339558
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| Activity |
Ki = 53000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S,3R)-3-Hydroxy-2-[[(2S)-2-(2-naphthalen-2-ylethylamino)propanoyl]amino]butanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688613; BDBM50339549
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| Activity |
Ki = 56000 nM
|
[1] | |||
| Compound Name |
(4S)-4-Amino-5-[[(2S)-1-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494306; ESDV; SCHEMBL12436724; BDBM50253146
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|
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| Activity |
Ki = 56000 nM
|
[2] | |||
| Compound Name |
(S)-4-Amino-5-((S)-1-((S)-5-amino-1-((S)-1-carboxy-2-methylpropylamino)-1,5-dioxopentan-2-ylamino)-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492284; BDBM50253261
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|
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| Activity |
Ki = 57000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S,3R)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688603; QTDV; BDBM50339542
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|
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| Activity |
Ki = 60000 nM
|
[1] | |||
| Compound Name |
(4S)-4-(Benzylamino)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372216
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| Activity |
Ki = 63000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[2-(3,4-Dichlorophenyl)ethylamino]propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688614; BDBM50339550
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|
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| Activity |
Ki = 64000 nM
|
[1] | |||
| Compound Name |
(S)-4-Amino-5-((S)-1-((S)-4-amino-1-((S)-1-carboxy-2-methylpropylamino)-1,4-dioxobutan-2-ylamino)-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493105; BDBM50253297
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|
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| Activity |
Ki = 67000 nM
|
[2] | |||
| Compound Name |
(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-carboxy-butyrylamino)-3-hydroxy-propionylamino]-4-carboxy-butyrylamino}-3-methyl-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522656; BDBM50253262
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|
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| Activity |
Ki = 67000 nM
|
[2] | |||
| Compound Name |
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(ethylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372218
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|
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| Activity |
Ki = 69000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-Aminopropanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688604; BDBM50339543
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|
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| Activity |
Ki = 73000 nM
|
[1] | |||
| Compound Name |
Thr-Ala-Val
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|
Investigative | Compound Info | ||
| Synonyms |
Threonyl-alanyl-valine; L-Threonyl-L-alanyl-L-valine; CHEMBL3798463; (2S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
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| Activity |
Ki = 74000 nM
|
[3] | |||
| Compound Name |
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxo-4-(4-pyren-1-ylbutylamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688626; BDBM50339562
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|
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| Activity |
Ki = 76000 nM
|
[1] | |||
| Compound Name |
(S)-4-Amino-5-((S)-1-((S)-3-carboxy-1-((S)-1-carboxy-2,2-dimethylpropylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493722; BDBM50253260
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|
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| Activity |
Ki = 76000 nM
|
[2] | |||
| Compound Name |
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(methylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688627; BDBM50339563
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|
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| Activity |
Ki = 78000 nM
|
[2] | |||
| Compound Name |
(S)-4-Amino-5-((S)-1-(((S)-3-carboxy-1-((S)-1-carboxy-2-methylpropylamino)-1-oxopropan-2-yl)(methyl)amino)-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492272; BDBM50253222
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|
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| Activity |
Ki = 78000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-(2-Cyclohexylethylamino)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688609; BDBM50339538
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|
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| Activity |
Ki = 89000 nM
|
[1] | |||
| Compound Name |
(4S)-4-(3-Anthracen-9-ylpropylamino)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688624; BDBM50339560
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|
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| Activity |
Ki = 95000 nM
|
[1] | |||
| Compound Name |
(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-carbamoyl-butyrylamino)-3-hydroxy-propionylamino]-3-carboxy-propionylamino}-3-methyl-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493257; BDBM50252700
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|
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| Activity |
Ki = 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2,5-Diamino-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688602; QTAV; BDBM50339541
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|
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| Activity |
Ki = 110000 nM
|
[1] | |||
| Compound Name |
(4S)-5-[[(2S,3R)-1-[[(2S)-3-Carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[2-(3,4-dichlorophenyl)ethylamino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688612; BDBM50339548
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|
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| Activity |
Ki = 130000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-Amino-2-(2-cyclohexylethylamino)-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688607; BDBM50339537
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|
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| Activity |
Ki = 141000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(4S)-5-[[(2S,3R)-1-[[(2S)-3-Carboxy-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-(2-naphthalen-2-ylethylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688611; BDBM50339547
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|
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| Activity |
Ki = 210000 nM
|
[1] | |||
| Compound Name |
(4S)-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-Carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-sulfanylidenebutan-2-yl]amino]-4-(methylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688629; BDBM50339565
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|
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| Activity |
Ki = 220000 nM
|
[1] | |||
| Compound Name |
Ser-Ala-Val
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|
Investigative | Compound Info | ||
| Synonyms |
Seryl-alanyl-valine; L-Seryl-L-alanyl-L-valine; CHEMBL3798169; (2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
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| Activity |
Ki = 229000 nM
|
[3] | |||
| Compound Name |
(S)-4-Amino-5-((S)-1-((S)-3-carboxy-1-((S)-1-carboxypropylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-ylamino)-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522862; BDBM50253224
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|
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| Activity |
Ki = 230000 nM
|
[2] | |||
| Compound Name |
(4S)-4-Amino-5-[[(2S,3R)-1-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688636
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|
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| Activity |
Ki = 260000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[4-[(1R,2R)-1-Amino-2-hydroxypropyl]triazol-1-yl]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3797401
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|
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| Activity |
Ki = 289000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[[(2S)-3-Carboxy-2-[[(2S,3R)-2-[[(2S)-2-(2-cyclohexylethylamino)propanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688610; BDBM50339539
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|
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| Activity |
Ki > 400000 nM
|
[1] | |||
| Compound Name |
1-(3-Carboxypropyl)-3-methyl-5-phenylmethoxyindole-2,6-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800619
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|
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| Activity |
Ki > 500000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[[1-[(1S)-1-Carboxy-2-methylpropyl]triazole-4-carbonyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799743
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|
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| Activity |
Ki > 500000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[4-[(1S)-1-[[(2S,3R)-2-Amino-3-hydroxybutanoyl]amino]ethyl]triazol-1-yl]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3797716
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| Activity |
Ki > 500000 nM
|
[3] | |||
| Compound Name |
5-Hydroxy-3-methyl-1H-indole-2,6-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798607
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|
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| Activity |
Ki = 530000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2011 Mar 10;54(5):1333-46. | ||||
| REF 2 | Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. | ||||
| REF 3 | Design and synthesis of triazole-based peptidomimetics of a PSD-95 PDZ domain inhibitor. Medchemcomm. 2016;7:531-6. | ||||
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