Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05387 | Target Info | |||
| Target Name | Tissue transglutaminase (TG2) | ||||
| Synonyms |
Transglutaminase-2; Transglutaminase H; Transglutaminase C; Transglutaminase 2; Tranglutaminase 2; TTg; TGase-H; TGase-2; TGase H; TGase C; TGC; TG(C)Protein-glutamine gamma-glutamyltransferase; TG(C); Protein-glutamine gamma-glutamyltransferase 2
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| Target Type | Clinical trial Target | ||||
| Gene Name | TGM2 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 46 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-chloro-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
5-Chloroisatin; 17630-76-1; 5-chloroindoline-2,3-dione; 5-Chloro-1H-indole-2,3-dione; 5-chlorisatin; 1H-Indole-2,3-dione, 5-chloro-; 5-chloro-2,3-dihydro-1H-indole-2,3-dione; 5-CHLORO ISATIN; 5-chlor-2,3-dioxoindolin; NSC 135811; XHDJYQWGFIBCEP-UHFFFAOYSA-N; MFCD00014567; 5-chlor-1h-indol-2,3-dion; 2HQ; EINECS 241-614-0; NSC135811; PubChem13607; ACMC-209zyf; 5-Chloroisatin, 97%; AC1Q3MRO; AC1Q3KL6; Isatin-based compound, 33; AC1Q3KL5; AC1L3D5R; 5-chloro-2,3-dioxoindolin; 5-Chloroindolin-2,3-dione; 1H-Indole-2, 5-chloro-; KSC174O1F
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| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
LDN-91946
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Investigative | Compound Info | ||
| Synonyms |
compound 7
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| Activity |
Ki = 100000 nM
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[2] | |||
| Compound Name |
Quinolin-3-ylmethyl 1-((3-bromo-4,5-dihydroisoxazol-5-yl)methylamino)-3-(5-methoxy-1H-indol-3-yl)-1-oxopropan-2-ylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL216391; SCHEMBL4302162; BDBM50200146
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| Activity |
Ki = 51000 nM
|
[3] | |||
| Compound Name |
Benzyl N-[(2S)-1-(4-acetylpiperazin-1-yl)-1-oxo-6-(prop-2-enoylamino)hexan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078058; BDBM50241240
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| Activity |
Ki = 52100 nM
|
[4] | |||
| Compound Name |
Benzyl N-[4-[(3S)-3-(prop-2-enoylamino)pyrrolidin-1-yl]sulfonylphenyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152095; SCHEMBL14134612; BDBM50392887
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| Activity |
IC50 = 55000 nM
|
[5] | |||
| Compound Name |
N-[2-(4-Phenylphenyl)ethyl]-4-[4-(prop-2-enoylamino)piperidin-1-yl]sulfonylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152206; SCHEMBL14056336; BDBM50392908
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| Activity |
IC50 = 57000 nM
|
[5] | |||
| Compound Name |
N-(4-Methoxyphenyl)acrylamide
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Investigative | Compound Info | ||
| Synonyms |
N-(4-methoxyphenyl)prop-2-enamide; CHEMBL2089383; 2-Propenamide, N-(4-methoxyphenyl)-; N-[4-Methoxyphenyl]Acrylamide; EINECS 231-860-7; N-(p-Anisyl)acrylamide; SCHEMBL782552; CTK5E4755; DTXSID00228303; ZINC3194611; BDBM50420526; n -(4-methoxyphenyl)prop-2-enamide; AKOS003287444; AM87197; MCULE-7368207731; NE46800; VS-0104; Z1270502318
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| Activity |
IC50 = 58000 nM
|
[6] | |||
| Compound Name |
alpha-N-Carbobenzyloxy-epsilon-N-acryloyl-L-lysine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203477; SCHEMBL15619216; BDBM50400618; (S)-6-acrylamido-2-(((benzyloxy)carbonyl)amino)hexanoic acid; (2S)-2-(phenylmethoxycarbonylamino)-6-(prop-2-enoylamino)hexanoic acid; (2S)-2-{[(Benzyloxy)carbonyl]amino}-6-(prop-2-enamido)hexanoic acid
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| Activity |
Ki = 60300 nM
|
[4] | |||
| Compound Name |
(2S)-2-[(4-Nitrophenyl)methoxycarbonylamino]-6-(prop-2-enoylamino)hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203485; SCHEMBL15619325; BDBM50400654
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| Activity |
IC50 = 62000 nM
|
[7] | |||
| Compound Name |
(S)-Quinolin-3-ylmethyl 2-(((3-bromo-4,5-dihydroisoxazol-5-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218647; BDBM50200157
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| Activity |
Ki = 62000 nM
|
[3] | |||
| Compound Name |
Chembl4165391
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Investigative | Compound Info | ||
| Activity |
IC50 = 64100 nM
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[8] | |||
| Compound Name |
Chembl4227629
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461613
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| Activity |
Ki = 64300 nM
|
[9] | |||
| Compound Name |
5-Bromoisatin
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Investigative | Compound Info | ||
| Synonyms |
5-Bromoindoline-2,3-dione; 5-Bromo-1H-indole-2,3-dione; 5-Bromoindole-2,3-dione; Isatin, 5-bromo-; 5-Bromisatin; 1H-Indole-2,3-dione, 5-bromo-; Bromoisatin; INDOLE-2,3-DIONE, 5-BROMO-; 5-bromo-2,3-dihydro-1H-indole-2,3-dione; 5-bromo-2-hydroxy-3H-indol-3-one; MFCD00149345; 5-Bromoisatin, 98%; 5-Bromisatin [Czech]; NSC 4980; EINECS 201-747-7; BRN 0383760; 5-bromo isatin; 5-bromo-isatin; PubChem1666; Indole-2, 5-bromo-; ACMC-209qo2; Isatin-based compound, 34; 1H-Indole-2, 5-bromo-; 5-Bromo-2,3-indolinedione; WLN: T56 BMVVJ GE; 5-21-10-00264 (Beilstein Handbook Reference); 5-bromoindoline-2,3-dione;; ARONIS24976; SCHEMBL136581; 5-bromo-1H-indole-2,3dione; CHEMBL115897; 5-BROMOISATIN MONOHYDRATE; BDBM22814; CTK3J2486; KS-00000DIW; DTXSID30236037; NSC4980; 5-Bromo -1H-indole-2,3-dione; 5-Bromo-1H-indole-2,3-dione #; BCP04280; EBD47956; KS-000046VO; NSC-4980; STR04158; ZINC2041212; ANW-38832; BBL009767; BBL016372; HTS001090; MFCD00005719; SBB038749; STK364356; STL140691; 5-Bromoisatin, technical grade, 90%; AKOS000200674; AKOS002375882; AS04548; CS-W007383; FS-2520; LS20870; MCULE-7183184474; 5-bromo-1H-benzo[d]azoline-2,3-dione; 5-bromo-1H-benzo[d]azolidine-2,3-dione; AC-14581; AK-45956; AM808100; BC002205; BR-45956; SC-07101; 1H-Indole-2,3-dione, 5-bromo- (9CI); AB0014286; DB-026328; BB 0258954; FT-0620163; H4431; ST45053713; EN300-18123; M-1894; SR-01000402436; SR-01000402436-1; W-104018; Z57833927; F0900-5717
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| Activity |
IC50 = 65000 nM
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[1] | |||
| Compound Name |
5,7-Difluoroindoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
5,7-difluoro-1H-indole-2,3-dione; 1H-Indole-2,3-dione, 5,7-difluoro-; 5,7-DIFLUORO ISATIN; CHEMBL1770387; 5,7-Difluoroindole-2,3-dione; 5,7-Difluoroisatin; 5,7-difluoro-2,3-dione; SCHEMBL4586483; CTK4A9862; DTXSID80588619; 2712AA; ANW-63072; BDBM50342572; MFCD09741498; SBB084094; ZINC19257975; AKOS000151030; AB51119; MCULE-2479165871; AK-89850; SC-89500; EN300-40026; 5,7-difluoro-1H-benzo[d]azolidine-2,3-dione; W-1444; AB01000455-01; 5,7-DIFLUORO-2,3-DIHYDRO-1H-INDOLE-2,3-DIONE; Z415636634
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| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
5-Iodoisatin
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Investigative | Compound Info | ||
| Synonyms |
5-Iodo-1H-indole-2,3-dione; 5-iodoindoline-2,3-dione; 1H-Indole-2,3-dione, 5-iodo-; 5-iodo-2,3-dihydro-1H-indole-2,3-dione; 5-IODO ISATIN; 5-Iodoindole-2,3-dione; MFCD00016899; 5-iodo-1H-benzo[d]azolidine-2,3-dione; 5-Iodo-2,3-dioxoindoline; 5-iodo-isatine; 5-iodo-isatin; NSC92515; EINECS 244-035-1; NSC 92515; PubChem15509; 5-Iodoisatin 97%; ACMC-209fe8; 5-Iodo-2,3-indolinedione; Isatin-based compound, 35; NCIOpen2_005933; SCHEMBL75159; 5-iodo-1H-indole-2,3dione; 5-Iodoisatin, technical grade; AMOT0040; CHEMBL325480; BDBM22815; CTK4E5089; DTXSID50174866; 1H-Indole-2,3-dione,5-iodo-; 5-Iodo-1H-indole-2,3-dione #; KS-000007VF; ZINC3909323; ANW-24222; BBL002075; NSC-92515; QC-525; SBB061948; STK391512; AKOS000139160; MCULE-7165182272; VZ30404; AC-29452; AK-45283; DS-13507; SC-20171; ST047848; AB0040572; DB-045362; AM20030318; CS-0041245; EU-0060270; FT-0620515; H2540; I0640; Y8200; SR-01000550633; SR-01000550633-1; W-107594; F0348-1933
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| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
Benzyl (S)-1-(((S)-3-bromo-4,5-dihydroisoxazol-5-yl)methylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-ylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL375595; SCHEMBL13934076; BDBM50200148
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| Activity |
Ki = 68000 nM
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[3] | |||
| Compound Name |
Benzyl 4-[3-[methyl(2-methylpropyl)amino]-4-(prop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086501; SCHEMBL1871666; BDBM50420499
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| Activity |
IC50 = 76000 nM
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[6] | |||
| Compound Name |
Benzyl N-[4-[(3R)-3-(prop-2-enoylamino)piperidin-1-yl]sulfonylphenyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152094; SCHEMBL14055188; BDBM50392886
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| Activity |
IC50 ~ 80000 nM
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[5] | |||
| Compound Name |
N-(2-Bromophenyl)prop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
N-(2-Bromophenyl)Acrylamide; CHEMBL2086471; 2-Propenamide, N-(2-bromophenyl)-; ACMC-20m5rk; SCHEMBL11808631; CTK0D8875; DTXSID80544573; BDBM50420534; GP-0593
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
Tert-butyl 4-[4-(cyanomethylcarbamoyl)phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086493; BDBM50420491
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
Tert-butyl 4-[4-[[(E)-2-methylbut-2-enoyl]amino]phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086486; BDBM50420484
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
(2S)-2-(Methoxycarbonylamino)-6-(prop-2-enoylamino)hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203480; SCHEMBL15619557; BDBM50400659
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| Activity |
IC50 ~ 80000 nM
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[7] | |||
| Compound Name |
Benzyl N-[4-[(3S)-3-(prop-2-enoylamino)piperidin-1-yl]sulfonylphenyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152093; SCHEMBL14057206; BDBM50392885
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| Activity |
IC50 ~ 80000 nM
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[5] | |||
| Compound Name |
(S)-3-(1-Acryloylpiperidin-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203456; SCHEMBL15623265; BDBM50400628; (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(1-prop-2-enoylpiperidin-4-yl)propanoic acid
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| Activity |
IC50 ~ 80000 nM
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[7] | |||
| Compound Name |
Tert-butyl 4-(4-cyanophenyl)sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086496; Cerep_003671; SCHEMBL15232086; HMS537H13; BDBM50420494; 4-(4-Cyano-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
Tert-butyl 4-[4-(cyanomethylcarbamoylamino)phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086491; BDBM50420489
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
Tert-butyl 4-[4-[(2-cyanoacetyl)amino]phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086494; BDBM50420492
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
Tert-butyl 4-[4-[(2-ethoxy-2-oxoethyl)amino]phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086492; BDBM50420490
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
(S)-3-(4-Acrylamidophenyl)-2-(((benzyloxy)methyl)amino)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203458; SCHEMBL15619593; BDBM50400629; (2S)-2-(phenylmethoxymethylamino)-3-[4-(prop-2-enoylamino)phenyl]propanoic acid
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| Activity |
IC50 ~ 80000 nM
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[7] | |||
| Compound Name |
Tert-butyl 4-[4-(2-methylprop-2-enoylamino)phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086483; BDBM50420481
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
Benzyl 4-[4-[(E)-3-ethoxy-3-oxoprop-1-enyl]phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086497; BDBM50420496
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
[4-(4-Aminophenyl)sulfonylpiperazin-1-yl]-cyclopropylmethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086886; BDBM50392880
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| Activity |
IC50 ~ 80000 nM
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[5] | |||
| Compound Name |
Tert-butyl 4-[4-(2-oxopropanoylamino)phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086495; BDBM50420493
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
N-(4-Bromophenyl)propionamide
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Investigative | Compound Info | ||
| Synonyms |
N-(4-bromophenyl)propanamide; CHEMBL2086468; 1-bromo-4-ethylcarbonylaminobenzene; NSC404309; N-propionyl-4-bromoaniline; SCHEMBL969565; CTK4F9953; Propanamide,N-(4-bromophenyl)-; DTXSID20323561; ZINC397763; BDBM50420537; AKOS000171969; MCULE-5379856005; NSC-404309; FT-0629210
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| Activity |
IC50 ~ 80000 nM
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[6] | |||
| Compound Name |
(E)-3-(2-Oxo-2-(pyridin-3-yl)ethylidene)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1770538; SCHEMBL9900052; SCHEMBL9900055; BDBM50342569; STK589701; ZINC32012483; AKOS005512067; (3E)-3-(2-oxo-2-pyridin-3-ylethylidene)-1H-indol-2-one; (3E)-3-[2-oxo-2-(pyridin-3-yl)ethylidene]-1,3-dihydro-2H-indol-2-one
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| Activity |
Ki = 86000 nM
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[10] | |||
| Compound Name |
Benzyl 4-[4-[(E)-4-ethoxy-4-oxobut-2-enyl]phenyl]sulfonylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2086498; BDBM50420497
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| Activity |
IC50 = 91000 nM
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[6] | |||
| Compound Name |
[1-[(3-Bromo-4,5-dihydroisoxazol-5-ylmethyl)carbamoyl]-2-(4-fluoro-1H-indol-3-yl)ethyl]carbamic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL374887; SCHEMBL4297252; BDBM50200158
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| Activity |
Ki = 99000 nM
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[3] | |||
| Compound Name |
Indirubin
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Investigative | Compound Info | ||
| Synonyms |
Indigo Red; Couroupitine B; Indigopurpurin; (Z)-[2,3'-biindolinylidene]-2',3-dione; 3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; UNII-V86L8P74GI; NSC 105327; NSC-105327; C.I. 73200; UNII-1LXW6D3W2Z; 1LXW6D3W2Z; V86L8P74GI; (E)-[2,3'-biindolinylidene]-2',3-dione; MFCD00956441; (3E)-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; [2,3'-Biindolinylidene]-2',3-dione; C.I. 75790; MFCD00221745; SMR000466311; BRN 0088279; Isoindirubin; Isoindirubine; Isoindogotin; Indirubin/; Indirubin [MI]; Indirubin,(S); INDARUBICIN; CPD000466311; Indirubin derivative, 1; BiomolKI_000069; EM-A05-INDIRUBIN; [.DELTA.2,3-dione; Indirubin 3E-form [MI]; BiomolKI2_000073; Indirubin 479-41-4; (3Z)-3-(3-oxoindolin-2-ylidene)indolin-2-one; (delta(sup 2,3')-BIINDOLINE)-2',3-DIONE; SCHEMBL27678; BMK1-G9; BSPBio_001110; KBioGR_000450; KBioSS_000450; 5-24-08-00507 (Beilstein Handbook Reference); MLS000759416; MLS001424211; MLS002473308; MLS006010732; CHEMBL35349; BDBM7392; CHEMBL259664; SCHEMBL9899338; (3Z)-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; CHEMBL1276127; CHEMBL3185783; cid_5318433; KBio2_000450; KBio2_003018; KBio2_005586; KBio3_000839; KBio3_000840; EX-A347; Bio2_000395; Bio2_000875; HMS1362H11; HMS1792H11; HMS1990H11; HMS2051H20; HMS2234G06; HMS3369O15; HMS3393H20; HMS3403H11; HMS3656O13; ACT03264; BCP28869; HY-N0117; KS-000000OC; ABP000850; BDBM50023867; BDBM50349806; NSC105327; s2386; ZINC18825333; AKOS015895136; AKOS028108775; AKOS032455876; ZINC100015416; AC-8003; BCP9000788; CCG-100673; CCG-101058; CCG-267073; CS-3682; DB12379; NC00308; IDI1_002150; (2'Z)-Indirubin, >=98% (HPLC); NCGC00163356-01; NCGC00163356-02; NCGC00163356-03; NCGC00163356-04; NCGC00179302-02; AC-29931; AK128411; CS-12423; SMR004701694; SY058396; 3-(3-oxoindolin-2-ylidene)indolin-2-one; 3-(3-indolinone-2-ylidene)-indolin-2-one; AB0020115; UNM-0000305766; FT-0627199; I0868; SW197688-2; V0881; (delta2,3'-Biindoline)-2',3-dione (8CI); W-2665; (E)-[2,3-BIINDOLINYLIDENE]-2,3-DIONE; AB00639939-06; 2-(2-oxo-1H-indol-3-ylidene)-1H-indol-3-one; 479I414; A827403; SR-01000759396; Q-100514; Q1661452; SR-01000759396-5; BRD-K17894950-001-03-6; BRD-K17894950-001-04-4; Q27164070; Indigo Red; Couroupitine B; (3E)-3-(3-Oxo-1H-indol-2-ylidene)-1H-indol-2-one
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Chembl4167132
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
Chembl4164796
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
Chembl4160319
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
2-[(3-Bromo-4,5-dihydroisoxazol-5-ylmethyl)carbamoyl]-2,3-dihydroindole-1-carboxylic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL387226; SCHEMBL1103746; BDBM50200150; Benzyl 2-[(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methylcarbamoyl]-2,3-dihydroindole-1-carboxylate
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| Activity |
Ki = 138000 nM
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[3] | |||
| Compound Name |
Chembl4165260
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Investigative | Compound Info | ||
| Activity |
IC50 = 145000 nM
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[8] | |||
| Compound Name |
Chembl4168680
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Investigative | Compound Info | ||
| Activity |
IC50 = 147000 nM
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[8] | |||
| Compound Name |
Chembl4174000
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Investigative | Compound Info | ||
| Activity |
IC50 = 151000 nM
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[8] | |||
| Compound Name |
(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-4-Carbamoyl-2-[(2S)-pyrrolidin-2-ylformamido]butanoyl]pyrrolidin-2-yl]formamido}-5-(2-oxoacetamido)pentanamido]-4-methylpentanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397328; BDBM50216777
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| Activity |
Ki = 200000 nM
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[11] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 16 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1H-Indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
Isatin; 91-56-5; Indoline-2,3-dione; 2,3-Indolinedione; INDOLE-2,3-DIONE; 2,3-Dioxoindoline; Isatine; Pseudoisatin; Isatic acid lactam; Tribulin; Isotin; 2,3-Diketoindoline; Isatinic acid anhydride; 2,3-Ketoindoline; o-Aminobenzoylformic anhydride; 2,3-Dioxo-2,3-dihydroindole; 2,3-dihydro-1H-indole-2,3-dione; NSC 9262; UNII-82X95S7M06; EINECS 202-077-8; BRN 0383659; AI3-03111; CHEMBL326294; 2,3-dihydroindole-2,3-dione; CHEBI:27539; JXDYKVIHCLTXOP-UHFFFAOYSA-N; MFCD00005718; 82X95S7M06; 84788-92-1; Isatin, 98%
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| Activity |
IC50 > 250000 nM
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[1] | |||
| Compound Name |
(2S)-5-Oxo-2-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]-6-(1,4,5-trimethyl-3-propylimidazol-1-ium-2-yl)sulfanylhexanoic acid;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413701
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
(2S)-5-Oxo-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]-6-(1,4,5-trimethyl-3-propylimidazol-1-ium-2-yl)sulfanylhexanoic acid;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413707
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
(2S)-6-(1,3-Diethyl-4,5-dimethylimidazol-1-ium-2-yl)sulfanyl-5-oxo-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]hexanoic acid;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413706
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
(2S)-6-(1,3-Diethyl-4,5-dimethylimidazol-1-ium-2-yl)sulfanyl-5-oxo-2-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]hexanoic acid;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413700
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
(2S)-6-(1-Benzyl-3,4,5-trimethylimidazol-3-ium-2-yl)sulfanyl-5-oxo-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]hexanoic acid;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413709
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
(2S)-5-Oxo-2-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]-6-(1,4,5-trimethyl-3-phenylimidazol-1-ium-2-yl)sulfanylhexanoic acid;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413702
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
(2S)-6-(1-Benzyl-3,4,5-trimethylimidazol-3-ium-2-yl)sulfanyl-5-oxo-2-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]hexanoic acid;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413703
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
(2S)-5-Oxo-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]-6-(1,4,5-trimethyl-3-phenylimidazol-1-ium-2-yl)sulfanylhexanoic acid;bromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413708
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
1-{4-[(2,3-Dioxo-2,3-dihydro-1H-indol-1-YL)methyl]-2,5-dimethylbenzyl}-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1770392; ZINC2029645; BDBM50342574; AKOS024421201; MCULE-6154111075; 1,4-bis(2,3-dioxoindol-1-ylmethyl)-2,5-dimethyl-benzene; 1,1''-(2,5-dimethyl-1,4-phenylene)bis(methylene)diindoline-2,3-dione
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| Activity |
IC50 > 250000 nM
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[1] | |||
| Compound Name |
(E)-3-(3-Hydroxyphenyl)-1-pyridin-3-ylprop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1517429; MLS001002818; SCHEMBL3591492; SCHEMBL3591494; HMS2654O05; ZINC5864856; BDBM50237134; AKOS001044987; SMR000370779; SR-01000056912; SR-01000056912-1
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| Activity |
IC50 = 266000 nM
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[13] | |||
| Compound Name |
(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-4-Carbamoyl-2-[(2S)-pyrrolidin-2-ylformamido]butanoyl]pyrrolidin-2-yl]formamido}-3-(2-oxoacetamido)propanamido]-4-methylpentanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397378; BDBM50216772
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| Activity |
Ki = 300000 nM
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[11] | |||
| Compound Name |
Chembl4177374
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Investigative | Compound Info | ||
| Synonyms |
BDBM50277163; AKOS001302411
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| Activity |
IC50 = 484000 nM
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[13] | |||
| Compound Name |
Chembl4169514
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Investigative | Compound Info | ||
| Synonyms |
BDBM50277165
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| Activity |
IC50 = 688000 nM
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[13] | |||
| Compound Name |
Chembl4166095
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Investigative | Compound Info | ||
| Synonyms |
BDBM50277161
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| Activity |
IC50 = 1001000 nM
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[13] | |||
| Compound Name |
Chembl4174015
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1604142; ZINC7739335; BDBM50277162; AKOS001320024
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| Activity |
IC50 > 2000000 nM
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[13] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. Bioorg Med Chem Lett. 2011 May 1;21(9):2692-6. | ||||
| REF 2 | Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol. 2007 Nov;3(11):697-705. | ||||
| REF 3 | Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. J Med Chem. 2006 Dec 14;49(25):7493-501. | ||||
| REF 4 | Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase. J Med Chem. 2017 Sep 28;60(18):7910-7927. | ||||
| REF 5 | Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease. ACS Med Chem Lett. 2012 Aug 9;3(9):731-5. | ||||
| REF 6 | Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease. J Med Chem. 2012 Feb 9;55(3):1021-46. | ||||
| REF 7 | SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease. ACS Med Chem Lett. 2012 Oct 4;3(12):1024-8. | ||||
| REF 8 | Development of new scaffolds as reversible tissue transglutaminase inhibitors, with improved potency or resistance to glutathione addition. Medchemcomm. 2016 Dec 5;8(2):338-345. | ||||
| REF 9 | N -Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure-Activity Relationships, and Pharmacokinetic Profiling. J Med Chem. 2018 May 24;61(10):4528-4560. | ||||
| REF 10 | An unprecedented dual antagonist and agonist of human Transglutaminase 2. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4922-4926. | ||||
| REF 11 | Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2. Bioorg Med Chem. 2007 Sep 15;15(18):6253-61. | ||||
| REF 12 | Imidazolium-based warheads strongly influence activity of water-soluble peptidic transglutaminase inhibitors. Eur J Med Chem. 2013 Aug;66:526-30. | ||||
| REF 13 | Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease. Eur J Med Chem. 2017 Oct 20;139:378-389. | ||||
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