Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07663 | Target Info | |||
| Target Name | Phosphodiesterase 5A (PDE5A) | ||||
| Synonyms |
cGMP-specific 3',5'-cyclic phosphodiesterase; PDE5A; CGMP-binding cGMP-specific phosphodiesterase; CGB-PDE
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| Target Type | Successful Target | ||||
| Gene Name | PDE5A | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 90 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Milrinone
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|
Approved | Compound Info | ||
| Synonyms |
Corotrop; Corotrope; Milrila; Milrinona; Milrinonum; Primacor; Milrinona [Spanish]; Milrinonum [Latin]; M 4659; M1663; YM 018; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; Milrila (TN); PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; Primacor (TN); WIN 47203-2; Win-47203; Milrinone [USAN:BAN:INN]; Win-47203-2; Milrinone (JAN/USAN/INN); 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; 111GE027; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile; 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone; 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Ibudilast
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Approved | Compound Info | ||
| Synonyms |
Eyevinal; Ibudilastum; Ketas; Ibudilastum [Latin]; Ke Tas; AV 411; I 0157; KC 404; AV-411; Ibudilast [INN:JAN]; KC-404; Ketas (TN); MN-166; Ibudilast (JAN/INN); 1-(2-Isopropylpyrazolo(1,5-a)pyridin-3-yl)-2-methyl-1-propanone; 2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine; 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone; 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one; 3-Isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine; 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
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| Activity |
IC50 = 103000 nM
|
[2] | |||
| Compound Name |
AC1MOZOL
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Patented | Compound Info | ||
| Synonyms |
686770-82-1; AC1MOZOL; CHEMBL3919432; SCHEMBL16200742; BDBM86644; AKOS024584761; MCULE-1812319467; BC11-38-2; EU-0022203; SR-01000120183; SR-01000120183-1; F0579-0063; 2-(sec-butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one; 2-butan-2-ylsulfanyl-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
BC11-28
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Patented | Compound Info | ||
| Synonyms |
BDBM86641; 7-(4-fluorophenyl)-N-(2-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; AC1MM8WN; Oprea1_524381; CHEMBL2132713; SCHEMBL14998917; BDBM60812; HMS1911I05; ZINC2713985; STK859438; AKOS002104616; MCULE-7713625102; BC11-28; NCGC00138975-01; ST50069829; EU-0095146; US9173884, BC11-28; SR-01000567887; SR-01000567887-1; K405-0344; 7-(4-fluorophenyl)-N-(2-methylphenyl)-5-phenylpyrrolo[2,3-d]pyrimidin-4-amine; [7-(4-fluorophenyl)-5-phenylpyrrolo[3,2-e]pyrimidin-4-yl](2-methylphenyl)amine
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
AC1M1SP5
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Patented | Compound Info | ||
| Synonyms |
3-(2-methoxyphenyl)-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one; 850915-31-0; AC1M1SP5; SCHEMBL16200721; CHEMBL3913943; BDBM86646; ZINC2719834; AKOS024584906; MCULE-4663000139; BC11-38-4; SR-01000120201; SR-01000120201-1; F0579-0260; 3-(2-methoxyphenyl)-2-propylsulfanyl-6,7-dihydrothieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Isomazole
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Terminated | Compound Info | ||
| Synonyms |
Isosulmazole; Isomazole fumarate; Isomazole hydrochloride; EMD-41064; EMD-47200; EMD-50250; EMD-52750; LY-175326
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| Activity |
IC50 = 58000 nM
|
[4] | |||
| Compound Name |
Moracin C
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Investigative | Compound Info | ||
| Synonyms |
MORACIN-C; CHEMBL2018876; 5-(6-hydroxy-1-benzofuran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol; 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)-; CTK5C9095; DTXSID70219182; ZINC5158948; BDBM50381284; 5-(6-hydroxy-1-benzofuran-2-yl)-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol; AKOS032948816; W2020; 2-(3,5-Dihydroxy-4-prenylphenyl)-6-hydroxybenzofuran; 5-(6-Hydroxy-benzofuran-2-yl)-2-(3-methyl-but-2-enyl)-benzene-1,3-diol; 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol; 5-(6-hydroxybenzofuran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol; 5-(6-Hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)-1,3-benzenediol, 9CI
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[4-Methoxy-3-(tetrahydropyran-4-yloxy)phenyl]butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456368; BDBM50273333
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
6-(3,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
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|
Investigative | Compound Info | ||
| Synonyms |
triazolothiadiazine, 21; MLS000040393; BMCL181297 Compound 5A; CHEMBL251785; cid_662965; SCHEMBL1773326; REGID_for_CID_662965; BDBM30027; HMS2427C11; ZINC4312962; STK877959; AKOS002046530; CCG-193287; MCULE-2949109211; NCGC00071837-02; NCGC00071837-03; NCGC00071837-05; SMR000043645; ST081704; SR-01000612138; SR-01000612138-3; BRD-K77507773-001-10-1
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL457216; BDBM50273601
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
1-Benzoyl-5-(piperidin-1-ylmethyl)indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085450; BDBM50269742
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
1-[4-(Difluoromethoxy)-3-(oxolan-3-yloxy)phenyl]-3-methylbutan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL458298; 1-(4-(difluoromethoxy)-3-((tetrahydrofuran-3-yl)oxy)phenyl)-3-methylbutan-1-one; Roflupram; Zl-n-91; Roflupram, >=98% (HPLC); GTPL10691; BDBM50273512; 1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)phenyl]-3-methylbutan-1-one
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[3-(dimethylamino)propyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL427513; BDBM50151592
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|
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| Activity |
IC50 ~ 50700 nM
|
[9] | |||
| Compound Name |
8-Chloro-6-[3-(4-methylpiperazine-1-carbonyl)phenyl]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185370; BDBM50151604
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| Activity |
IC50 = 52400 nM
|
[9] | |||
| Compound Name |
[3-Hydroxymethyl-1-(3-methanesulfonyl-4,5-dimethoxy-phenyl)-6,7-dimethoxy-naphthalen-2-yl]-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL91064; BDBM50052081; 1-[3-(Methylsulfonyl)-4,5-dimethoxyphenyl]-6,7-dimethoxynaphthalene-2,3-dimethanol
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| Activity |
IC50 = 53000 nM
|
[10] | |||
| Compound Name |
1,3-Bis(cyclopropylmethyl)-7-methyl-8-[(phenylsulfonyl)amino]xanthine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL344720; SCHEMBL7446384; BDBM50040373; N-[1,3-bis(cyclopropylmethyl)-7-methyl-2,6-dioxopurin-8-yl]benzenesulfonamide
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| Activity |
IC50 = 53000 nM
|
[11] | |||
| Compound Name |
1,3-Bis(cyclopropylmethyl)-7-methyl-8-[[(4-methoxyphenyl)sulfonyl]amino]xanthine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL144978; SCHEMBL7400585; BDBM50040378; N-[1,3-bis(cyclopropylmethyl)-7-methyl-2,6-dioxopurin-8-yl]-4-methoxybenzenesulfonamide
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| Activity |
IC50 = 54000 nM
|
[11] | |||
| Compound Name |
N'-[1,3-Bis(cyclopropylmethyl)-2,6-dioxo-7H-purin-8-yl]-N,N-dimethylmethanimidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL145515; BDBM50040370; N''-(1,3-Bis-cyclopropylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-N,N-dimethyl-formamidine
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| Activity |
IC50 = 56000 nM
|
[11] | |||
| Compound Name |
2,3-Dichloro-8-phenyl-6H-imidazo[1,2-d][1,2,4]triazin-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL368322; BDBM50289352
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| Activity |
IC50 = 56100 nM
|
[12] | |||
| Compound Name |
4-[(3-Chloro-4-methoxyphenyl)methylamino]-1-(4-hydroxypiperidin-1-yl)-N,N-dimethylphthalazine-6-carboxamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL553934
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxypropane-1-sulfonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL360627; BDBM50151636
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| Activity |
IC50 = 60000 nM
|
[13] | |||
| Compound Name |
3-[5-[(Diethylamino)methyl]-2-furyl]-1-benzyl-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL121831; SCHEMBL7492367; BDBM50105996; [5-(1-Benzyl-1H-indazol-3-yl)-furan-2-ylmethyl]-diethyl-amine
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| Activity |
IC50 = 63000 nM
|
[14] | |||
| Compound Name |
2-[2-(2-Hydroxyethoxy)phenyl]-1H-imidazo[4,5-b]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL31964; BDBM50045022; ZINC13827111; 2-[2-(3H-Imidazo[4,5-b]pyridin-2-yl)-phenoxy]-ethanol
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| Activity |
IC50 = 64000 nM
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[4] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-(2-nitrophenyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45687; SCHEMBL7337371; BDBM50041851; 3-Cyclopentyloxy-4-methoxy-N-(2-nitro-phenyl)-benzamide; N-(2-Nitrophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
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| Activity |
IC50 = 65000 nM
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[15] | |||
| Compound Name |
2-Isopropyl-3-(6-chloropyridazine-3-yl)pyrazolo[1,5-a]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779440; BDBM50344322; 3-(6-chloropyridazin-3-yl)-2-isopropylpyrazolo[1,5-a]pyridine
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| Activity |
IC50 = 65000 nM
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[2] | |||
| Compound Name |
2-Bromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triazin-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL369431; BDBM50289370
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| Activity |
IC50 = 66700 nM
|
[12] | |||
| Compound Name |
4-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[2-(dimethylamino)ethyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL366149; BDBM50151598
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| Activity |
IC50 ~ 67300 nM
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[9] | |||
| Compound Name |
1,3-Di(cyclopropylmethyl)-8-(4-methoxybenzenesulphonylamino)xanthine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL146165; SCHEMBL7395897; BDBM50040345; 1,3-Bis(cyclopropylmethyl)-8-[[(4-methoxyphenyl)sulfonyl]amino]xanthine; 1,3-di(cyclopropylmethyl)-8-(4-methoxybenzenesulphonylamino )xanthine; N-[1,3-bis(cyclopropylmethyl)-2,6-dioxo-7H-purin-8-yl]-4-methoxybenzenesulfonamide
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| Activity |
IC50 = 68000 nM
|
[11] | |||
| Compound Name |
8-Chloro-6-pyridin-2-ylspiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL361469; BDBM50151599
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| Activity |
IC50 = 68400 nM
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[9] | |||
| Compound Name |
6-Phenyl-8-chlorospiro[quinazoline-4(3H),1'-cyclohexane]-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL182703; SCHEMBL7003950; BDBM50151593
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| Activity |
IC50 = 69800 nM
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[9] | |||
| Compound Name |
5-(2-Aminoethoxy)-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185275; BDBM50151639
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| Activity |
IC50 = 73200 nM
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[13] | |||
| Compound Name |
8-Chloro-5-[2-(dimethylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184903; BDBM50151648
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| Activity |
IC50 = 74000 nM
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[13] | |||
| Compound Name |
6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779427; BDBM50344308
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| Activity |
IC50 = 78000 nM
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[2] | |||
| Compound Name |
6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1777830; BDBM50344309
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| Activity |
IC50 = 79000 nM
|
[2] | |||
| Compound Name |
Ethyl 5-[(8-chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]furan-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL359890; BDBM50151644
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| Activity |
IC50 = 80000 nM
|
[13] | |||
| Compound Name |
3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[3-(dimethylamino)propyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL182617; BDBM50151603
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| Activity |
IC50 ~ 84900 nM
|
[9] | |||
| Compound Name |
Lorneic acid B
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079948; BDBM50312004
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| Activity |
IC50 = 87100 nM
|
[16] | |||
| Compound Name |
(2S,8R)-2-(2-Bromophenyl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097585; BDBM50316430
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| Activity |
IC50 = 88000 nM
|
[17] | |||
| Compound Name |
8-Chloro-5-(2H-tetrazol-5-ylmethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184861; BDBM50151635
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| Activity |
IC50 ~ 88000 nM
|
[13] | |||
| Compound Name |
6-Methoxy-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-12-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL113368; SCHEMBL6441960; BDBM50147632; 4-Methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-benzo[cd]azulen-9-one
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| Activity |
IC50 = 91000 nM
|
[18] | |||
| Compound Name |
8-Chloro-5-(2-hydroxyethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183965; SCHEMBL5115877; BDBM50151647; OM-995
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| Activity |
IC50 ~ 91000 nM
|
[13] | |||
| Compound Name |
1-Benzoyl-5-methyl-3H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094543; BDBM50269736
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| Activity |
IC50 = 91200 nM
|
[8] | |||
| Compound Name |
N-(6-Methoxy-12-oxo-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-11-yl)pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL112996; SCHEMBL6440075; BDBM50147630; N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9-tetrahydro-5,7,9a-triaza-benzo[cd]azulen-8-yl)-nicotinamide; N-(4-methoxy-9-oxo-6-phenyl-1,2,8,9-tetrahydro-5,7,9a-triazabenzo[cd]azulen-8-yl)nicotinamide
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| Activity |
IC50 = 95000 nM
|
[18] | |||
| Compound Name |
8-Chloro-5-[3-(dimethylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185108; BDBM50151637
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| Activity |
IC50 = 98000 nM
|
[13] | |||
| Compound Name |
N-(4-Methoxybenzyl)-3-(cyclopentyloxy)-4-(difluoromethoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628685; BDBM50129817
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| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883753; BDBM50208310
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[(11R)-6-Methoxy-12-oxo-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-11-yl]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2111730; BDBM50451952
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
Chembl4206423
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455384
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Chembl4215772
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
1-Benzoyl-5-[(4-methoxyanilino)methyl]indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062800; BDBM50269743
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[8] | |||
| Compound Name |
3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884224; BDBM50208315
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-2-yl)-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90974; BDBM50052089; ZINC13756799; 6,7-Dimethoxynaphthalene-2,3-dimethanol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-Bromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triazin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL369172; BDBM50289369
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
PDE4 inhibitor intermediate 1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344944; methyl (3S,4S)-3-acetyl-4-(3-cyclopentyloxy-4-methoxyphenyl)-3-methylpyrrolidine-1-carboxylate; SCHEMBL5357822; BDBM50048241; HY-U00410; CS-7357; GW-3600
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[22] | |||
| Compound Name |
(2,4,6-Trimethoxy-benzyl)-(6,7,8-trimethoxy-quinazolin-4-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL125373; SCHEMBL7498249; BDBM50042788; N-(2,4,6-Trimethoxybenzyl)-6,7,8-trimethoxyquinazolin-4-amine; 6,7,8-trimethoxy-N-[(2,4,6-trimethoxyphenyl)methyl]quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955950; SCHEMBL16200699; BDBM86643; ZINC2719706; AKOS024584760; MCULE-1273250191; BC11-38-1; EU-0022193; SR-01000120181; SR-01000120181-1; F0579-0062
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-Methoxy-3,8-Dimethyl-4-(Piperazin-1-Yl)-1h-Pyrazolo[3,4-B]quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939782; BDBM50362709; Q27451015; 0CV
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[24] | |||
| Compound Name |
N-[5-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthalen-1-yl)-2,3-dimethoxy-phenyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL92043; BDBM50052084; 1-[3-(Acetylamino)-4,5-dimethoxyphenyl]-6,7-dimethoxynaphthalene-2,3-dimethanol
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[10] | |||
| Compound Name |
2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950652; SCHEMBL16200731; BDBM86645; ZINC2459466; AKOS024584842; MCULE-6274932978; BC11-38-3; EU-0088907; SR-01000120189; SR-01000120189-1; F0579-0160
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM86640; Maybridge4_000373; Oprea1_392751; CHEMBL3974407; SCHEMBL14998934; BDBM60808; HMS1522A21; ZINC134330; CCG-51916; BC11-19; MCULE-1137806289; IDI1_030955; NCGC00177650-01; US9173884, BC11-19; SR-01000641186-1; BRD-K04557143-001-01-6
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885161; BDBM50208311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
6,7,8-Trimethoxy-n-[(4-nitrophenyl)methyl]-4-quinazolinamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL125163; SCHEMBL7495560; BDBM50042778; ZINC13834085; N-(4-Nitrobenzyl)-6,7,8-trimethoxyquinazolin-4-amine; (4-Nitro-benzyl)-(6,7,8-trimethoxy-quinazolin-4-yl)-amine; 6,7,8-trimethoxy-N-[(4-nitrophenyl)methyl]quinazolin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-(2-Chlorophenyl)-3(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884788; BDBM50208314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N,N,5-Trimethyl-2,3-dioxoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100407; BDBM50269744
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[8] | |||
| Compound Name |
6-(2-Isopropyl-7-methoxypyrazolo[1,5-a]pyridin-4-yl)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779444; SCHEMBL2957010; BDBM50344326; 3-(7-methoxy-2-propan-2-ylpyrazolo[1,5-a]pyridin-4-yl)-1H-pyridazin-6-one; 6-(7-methoxy-2-isopropyl-pyrazolo[1,5-a]pyridine-4-yl)-3-(2h)pyridazinone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-[2-(2-Aminoethoxy)ethoxy]-8-chlorospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184701; BDBM50151643
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
4-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361512; SCHEMBL4247887; SCHEMBL4247888; BDBM50151544; 4-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[25] | |||
| Compound Name |
2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyacetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184279; BDBM50151631
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
8-Chloro-5-(2-morpholin-4-ylethoxy)spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185523; BDBM50151645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
2-[2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyethylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363658; BDBM50151630
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
8-Chloro-5-[2-(methylamino)ethoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184979; BDBM50151642
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
2-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185531; SCHEMBL4249533; SCHEMBL4249536; BDBM50151525; 2-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[25] | |||
| Compound Name |
3-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184960; SCHEMBL4249085; SCHEMBL4249087; BDBM50151555; 3-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[25] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-(3-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365206; SCHEMBL4246678; SCHEMBL4246681; BDBM50151529; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-(3-fluoro-phenyl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[25] | |||
| Compound Name |
5-(4-Chlorophenyl)-N-(4-fluorophenyl)-3-methyl-1,3,4-thiadiazol-2-imine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362719; SCHEMBL4250388; SCHEMBL4250390; BDBM50151559; [5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylidene]-(4-fluoro-phenyl)-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 101000 nM
|
[25] | |||
| Compound Name |
3-[[5-(4-Chlorophenyl)-3-methyl-1,3,4-thiadiazol-2-ylidene]amino]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363709; SCHEMBL4251363; SCHEMBL4251364; BDBM50151567; 3-[5-(4-Chloro-phenyl)-3-methyl-3H-[1,3,4]thiadiazol-(2Z)-ylideneamino]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[25] | |||
| Compound Name |
8-Chloro-6-[2-(4-methylpiperazine-1-carbonyl)phenyl]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185588; BDBM50151595
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[9] | |||
| Compound Name |
3-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-6-yl)-N-[2-(dimethylamino)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363084; BDBM50151602
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[9] | |||
| Compound Name |
8-Chloro-5-[2-hydroxy-3-(methylamino)propoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364200; BDBM50151633
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
8-Chloro-5-[3-(dimethylamino)-2-hydroxypropoxy]spiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184013; BDBM50151632
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
2-(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxyacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183280; BDBM50151641
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
5-[(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]furan-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365447; SCHEMBL3021551; BDBM50151634
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
3-[(8-Chloro-2-oxospiro[1,3-dihydroquinazoline-4,1'-cyclohexane]-5-yl)oxymethyl]-4H-1,2,4-oxadiazol-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL182536; BDBM50151638
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 101000 nM
|
[13] | |||
| Compound Name |
5-Bromo-1-[(4-bromophenyl)methyl]indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100935; 5-bromo-1-(4-bromobenzyl)-1H-indole-2,3-dione; ZINC4554847; BDBM50269741; STK215596; AKOS005418178; MCULE-2937643029; ST50868073; 5-bromo-1-[(4-bromophenyl)methyl]benzo[d]azolidine-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 130620 nM
|
[8] | |||
| Compound Name |
3,4,11,12-Tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779429; BDBM50344311; rac-4,4a,5,6-Tetrahydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 145000 nM
|
[2] | |||
| Compound Name |
5,6-Dihydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779433; BDBM50344315
Click to Show/Hide
|
||||
| Activity |
IC50 = 156000 nM
|
[2] | |||
| Compound Name |
N-[4-(Diethylaminomethyl)-2-[2-(diethylamino)-2-oxoacetyl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068888; BDBM50269734
Click to Show/Hide
|
||||
| Activity |
IC50 = 157510 nM
|
[8] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2-hydroxy-phenyl)-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416466; SCHEMBL7335104; BDBM50041868; 3-cyclopentyloxy-N-(2-hydroxyphenyl)-4-methoxybenzamide; N-(2-Hydroxyphenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 175000 nM
|
[15] | |||
| Compound Name |
5-Methyl-1-[(2-nitrophenyl)methyl]indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074655; BDBM50269740; AKOS000246214
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[8] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 69 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Benzamide,n-(2-chlorophenyl)-3-(cyclopentyloxy)-4-methoxy-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289190; SCHEMBL7334642; BDBM50041828; ZINC13736941; n-(2-chlorophenyl)-3-cyclopentyloxy-4-methoxybenzamide; N-(2-Chloro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide; N-(2-Chlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2,5-dichloro-phenyl)-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL44673; SCHEMBL7340498; BDBM50041823; 3-cyclopentyloxy-N-(2,5-dichlorophenyl)-4-methoxybenzamide; N-(2,5-Dichlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2,3-dichloro-phenyl)-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL44967; BDBM50041852; N-(2,3-Dichlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL50378; (2R,3S)-EHNA; (2R,3S)-3-(6-aminopurin-9-yl)nonan-2-ol; (2R,3S)-3-(adenin-9-yl)-2-nonanol; (2R,3S)-9-(2-hydroxy-3-nonyl)adenine; erythro-9-(2-hydroxy-3-nonyl)adenine; (R,S)-6-amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol; EHNA.HCl; HWC 52; eh-na; Tocris-1261; (-)-erythro-9-(2-hydroxy-3-nonyl)adenine; Lopac0_000504; BSPBio_001061; KBioGR_000401; KBioSS_000401; SCHEMBL1742893; DTXSID6043880; BCBcMAP01_000066; CTK2H9386; KBio2_000401; KBio2_002969; KBio2_005537; KBio3_000761; KBio3_000762; Bio1_000430; Bio1_000919; Bio1_001408; Bio2_000361; Bio2_000841; HMS1792E03; HMS1990E03; HMS3403E03; ZINC1614354; (R-(R*,S*))-6-Amino-beta-hexyl-alpha-methyl-9H-purine-9-ethanol; BDBM50034908; CCG-36414; 9H-Purine-9-ethanol, 6-amino-beta-hexyl-alpha-methyl-, (R*,S*)-(+-)-; 9H-Purine-9-ethanol, 6-amino-beta-hexyl-alpha-methyl-, (R-(R*,S*))-; SDCCGSBI-0050488.P002; 3-(6-Amino-purin-9-yl)-nonan-2-ol; IDI1_002116; SMP2_000310; NCGC00025087-01; NCGC00025087-02; NCGC00025087-03; NCGC00025087-04; NCGC00025087-05; NCGC00025087-06; NCGC00025087-08; (EHNA)3-(6-Amino-purin-9-yl)-nonan-2-ol; 3-(6-Amino-purin-9-yl)-nonan-2-ol(EHNA); (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol; (2R,3S)-3-(6-Amino-9H-purine-9-yl)2-nonanol; (2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol; BRD-K27450477-001-03-9; (2R,3S)-rel-3-(6-Amino-9H-purin-9-yl)nonan-2-ol
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[26] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-(2-methylsulfanylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47957; Benzamide, 3-(cyclopentyloxy)-4-methoxy-N-[2-(methylthio)phenyl]-; ACMC-20n3iw; SCHEMBL73091; CTK0E9814; DTXSID10438390; BDBM50041841; N-[2-(Methylthio)phenyl]-3-(cyclopentyloxy)-4-methoxybenzamide; 3-Cyclopentyloxy-4-methoxy-N-(2-methylsulfanyl-phenyl)-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295669; SCHEMBL7334292; BDBM50041826; 3-cyclopentyloxy-N-(2,6-dimethylphenyl)-4-methoxybenzamide; N-(2,6-Dimethylphenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-p-tolyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47954; BDBM50041860; N-(4-Methylphenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
6-(2-Isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779438; BDBM50344320
Click to Show/Hide
|
||||
| Activity |
IC50 = 225000 nM
|
[2] | |||
| Compound Name |
15-Propan-2-yl-3,4,13,14-tetrazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(16),2,9,11,14-pentaen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779435; BDBM50344317; rac-1-Isopropyl-6a,9-dihydro-6H,7H-2,2a,9,10-tetraaza-aceanthrylen-8-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[2] | |||
| Compound Name |
2-Isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,5-a]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779442; BDBM50344324
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
3-(6-Chloro-4-methylpyridazin-3-yl)-2-isopropylpyrazolo[1,5-a]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779441; BDBM50344323
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
2-Benzyl-6-(2-isopropyl-7-methoxypyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779439; BDBM50344321
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
2-Benzyl-6-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779437; BDBM50344319; 2-Benzyl-6-(2-isopropylpyrazolo[1,5-a]pyridine-3-yl)-4,5-dihydropyridazine-3(2H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
7-Methyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779431; BDBM50344313; rac-4a-Methyl-4,4a,5,6-tetrahydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
(S)-6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779426; BDBM50344307; 4,5-Dihydro-5alpha-methyl-6-(2-isopropylpyrazolo[1,5-a]pyridine-3-yl)pyridazine-3(2H)-one; (4S)-4-methyl-3-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)-4,5-dihydro-1H-pyridazin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
4-Benzyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779430; BDBM50344312; rac-2-Benzyl-4,4a,5,6-tetrahydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
4-Benzyl-7-methyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779432; BDBM50344314; rac-2-Benzyl-4a-methyl-4,4a,5,6-tetrahydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-methylpyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779428; BDBM50344310
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
4-Benzyl-3,4,11,12-tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,6,10,13,15-hexaen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779434; BDBM50344316; 2-Benzyl-5,6-dihydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
4-Benzyl-15-propan-2-yl-3,4,13,14-tetrazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(16),2,9,11,14-pentaen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779436; BDBM50344318; rac-9-Benzyl-1-isopropyl-6a,9,10b,10c-tetrahydro-6H,7H-2,2a,9,10-tetraaza-aceanthrylen-8-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
Proxyphylline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Proxiphylline; Purophyllin; Monophylline; Spasmolysin; Brontyl; Sanwaphyllin; Sigophyl; Theoden; Thean; Theon; Oxypropyltheophylline; 7-(2-Hydroxypropyl)theophylline; Proxy-Retardoral; Hydroxypropyltheophylline; 7-(beta-Hydroxypropyl)theophylline; 2-Hydroxypropyl-7-theophylline; Theophylline, 7-(2-hydroxypropyl)-; Proxylphylline; 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine; NSC 163343; CHEMBL37390; MLS000069521; .beta.-Hydroxypropyltheophylline; 7-(.beta.-Hydroxypropyl)theophylline; Proxiphyllinum; SMR000058629; DSSTox_CID_3536; 7-(.beta.-Hydroxypropyl)-1,3-dimethylxanthine; DSSTox_RID_77068; DSSTox_GSID_23536; Proxifilina; Proxyphyllinum; beta-Oxypropyltheophyllin; UNII-13G1DMN4P0; Proxifilina [INN-Spanish]; Proxyphyllinum [INN-Latin]; Proxyphylline [INN:BAN:JAN]; EINECS 210-028-7; Proxyfylline; Proxyphyllin; Spantin; 7-(-Hydroxypropyl)theophylline; 7-(beta-Hydroxypropyl)-1,3-dimethylxanthine; 13G1DMN4P0; Monophyllin (TN); NCGC00016521-01; Opera_ID_1170; Prestwick0_000890; Prestwick1_000890; Prestwick2_000890; Prestwick3_000890; Proxyphylline (JAN/INN); SCHEMBL35569; BSPBio_000680; 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione; SPBio_002899; BPBio1_000748; 7-(b-Hydroxypropyl)theophylline; DTXSID5023536; HMS1570B22; HMS2097B22; HMS2233E08; HMS3371A07; HMS3886C07; Pharmakon1600-01505915; HY-B1742; KS-000017UY; Tox21_110471; BDBM50028190; KM0393; MFCD00022833; NSC163343; NSC759279; PDSP1_001132; PDSP2_001116; s4932; SBB058155; 3,3-dimethyl-1H-purine-2,6-dione; AKOS015967318; Tox21_110471_1; CCG-213993; CS-7727; DB13449; MCULE-2304226036; NSC-163343; NSC-759279; Proxyphylline; Monophylline, Spasmolysin; NCGC00018121-02; NCGC00018121-03; NCGC00018121-07; NCGC00179479-01; AS-11774; 7-(2-hydroxypropyl)-1,3-dimethylxanthine; SBI-0207057.P001; DB-053586; AB00513948; FT-0603485; ST50409303; D01771; AB00384297_13; SR-01000003009; Q7252904; SR-01000003009-2; W-105265; BRD-A28887267-001-03-7; 1,3-DIMETHYL-7-(2-HYDROXYPROPYL)-2,6-DIOXOPURINE
Click to Show/Hide
|
||||
| Activity |
Ki = 600000 nM
|
[27] | |||
| Compound Name |
1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-S0ELR18QO5; S0ELR18QO5; CHEMBL37019; Proxyphylline, (R)-; (R)-PROXYPHYLLINE; 7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; ZINC57348; DTXSID60235654; BDBM50028191; (R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
Click to Show/Hide
|
||||
| Activity |
Ki = 600000 nM
|
[27] | |||
| Compound Name |
1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-, (S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-YV88341QW3; CHEMBL290644; YV88341QW3; NCGC00016521-01; Proxyphylline, (S)-; (S)-PROXYPHYLLINE; SCHEMBL35570; 7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; ZINC57347; DTXSID00235653; BDBM50028192; NCGC00018121-01; NCGC00018121-04; A16821; UNII-13G1DMN4P0 component KYHQZNGJUGFTGR-LURJTMIESA-N; UNII-13G1DMN4P0 component KYHQZNGJUGFTGR-ZCFIWIBFSA-N; (S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
Click to Show/Hide
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||||
| Activity |
Ki = 600000 nM
|
[27] | |||
| Compound Name |
1-Benzoyl-5-methylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073582; BDBM50269739; AKOS002684929
Click to Show/Hide
|
||||
| Activity |
IC50 = 746450 nM
|
[8] | |||
| Compound Name |
3-(Cyclopentyloxy)-N-(2-fluorophenyl)-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47683; SCHEMBL7336803; BDBM50041862; 3-cyclopentyloxy-N-(2-fluorophenyl)-4-methoxybenzamide; 3-Cyclopentyloxy-N-(2-fluoro-phenyl)-4-methoxy-benzamide; N-(2-Fluorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
3-(Cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45834; Benzamide, 3-(cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methoxy-; ACMC-20n3iv; SCHEMBL7338641; CTK0E9815; DTXSID10437343; BDBM50041838; 3-cyclopentyloxy-N-(2,6-dichlorophenyl)-4-methoxybenzamide; 3-Cyclopentyloxy-N-(2,6-dichloro-phenyl)-4-methoxy-benzamide; N-(2,6-Dichlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-N-(2,6-dibromo-phenyl)-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46044; SCHEMBL7332380; BDBM50041833; 3-cyclopentyloxy-N-(2,6-dibromophenyl)-4-methoxybenzamide; N-(2,6-Dibromophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
N-(2-Chloro-6-methyl-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294949; benzamide,n-(2-chloro-6-methylphenyl)-3-(cyclopentyloxy)-4-methoxy-; SCHEMBL7334555; ZINC605606; BDBM50041854; n-(2-chloro-6-methylphenyl)-3-cyclopentyloxy-4-methoxybenzamide; N-(2-Methyl-6-chlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
N-(4-Chloro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45822; BDBM50041857; N-(4-Chlorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
3-(Cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47113; Benzamide, 3-(cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methoxy-; ACMC-20n3iu; SCHEMBL7335862; CTK0E9816; DTXSID20430906; BDBM50041844; 3-cyclopentyloxy-N-(2,6-difluorophenyl)-4-methoxybenzamide; N-(2,6-difiuorophenyl)-3-cyclopentyloxy-4-methoxybenzamide; N-(2,6-difluorophenyl)-3-cyclopentyloxy-4-methoxybenzamide; 3-Cyclopentyloxy-N-(2,6-difluoro-phenyl)-4-methoxy-benzamide; N-(2,6-Difluorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-N-(4-fluoro-phenyl)-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL296646; BDBM50041871; N-(4-Fluorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
1-Benzoyl-5-[(4-methylpiperazin-1-yl)methyl]indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063877; BDBM50269737
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[8] | |||
| Compound Name |
Benzamide,n-(2-bromophenyl)-3-(cyclopentyloxy)-4-methoxy-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL296700; SCHEMBL7334985; BDBM50041845; ZINC13736951; n-(2-bromophenyl)-3-cyclopentyloxy-4-methoxybenzamide; N-(2-Bromo-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide; N-(2-Bromophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-phenyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46321; SCHEMBL7340175; BDBM50041829; 3-cyclopentyloxy-4-methoxy-N-phenylbenzamide; N-Phenyl-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-(2-trifluoromethyl-phenyl)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL44109; SCHEMBL7335856; 3-cyclopentyloxy-4-methoxy-N-[2-(trifluoromethyl)phenyl]benzamide; BDBM50041863; 3-(cyclopentyloxy)-4-methoxy-N-(2-(trifluoromethyl)phenyl)benzamide; N-[2-(Trifluoromethyl)phenyl]-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
N-(2-Chloro-6-fluoro-phenyl)-3-cyclopentyloxy-4-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45128; benzamide,n-(2-chloro-6-fluorophenyl)-3-(cyclopentyloxy)-4-methoxy-; SCHEMBL7334330; ZINC605604; BDBM50041855; N-(2-Chloro-6-fluorophenyl)-3-(cyclopentyloxy)-4-methoxybenzamide; n-(2-chloro-6-fluorophenyl)-3-cyclopentyloxy-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
3-Cyclopentyloxy-4-methoxy-N-o-tolyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431146; BDBM50041858; N-(2-Methylphenyl)-3-(cyclopentyloxy)-4-methoxybenzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
1-Methyl-5-[6-(4-methylpiperazin-1-yl)sulfonyl-1,3-benzodioxol-4-yl]-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL247190; BDBM50411585
Click to Show/Hide
|
||||
| Activity |
IC50 = 2344228815 nM
|
[28] | |||
| Compound Name |
5-[6-[4-(2-Hydroxyethyl)piperazin-1-yl]sulfonyl-1,3-benzodioxol-4-yl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245789; BDBM50411583
Click to Show/Hide
|
||||
| Activity |
IC50 = 3019951720 nM
|
[28] | |||
| Compound Name |
5-[2,3-Dihydro-5-(4-methylpiperazin-1-ylsulfonyl)-7-benzofuryl]-1-methyl-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245389; Biagra; SCHEMBL7334441; BDBM50411584
Click to Show/Hide
|
||||
| Activity |
IC50 = 4168693835 nM
|
[28] | |||
| Compound Name |
5-[5-[4-(2-Hydroxyethyl)piperazin-1-yl]sulfonyl-2,3-dihydro-1-benzofuran-7-yl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245595; BDBM50411586
Click to Show/Hide
|
||||
| Activity |
IC50 = 4897788194 nM
|
[28] | |||
| Compound Name |
5-[6-[4-(2-Hydroxyethyl)piperazin-1-yl]sulfonyl-3,4-dihydro-2H-chromen-8-yl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397076; BDBM50411587
Click to Show/Hide
|
||||
| Activity |
IC50 = 79432823472 nM
|
[28] | |||
| Compound Name |
1-Methyl-5-[7-(4-methylpiperazin-1-yl)sulfonyl-2,3-dihydro-1,4-benzodioxin-5-yl]-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245391; BDBM50027775
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.26E+11 nM
|
[28] | |||
| Compound Name |
5-[7-[4-(2-Hydroxyethyl)piperazin-1-yl]sulfonyl-2,3-dihydro-1,4-benzodioxin-5-yl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245790; BDBM50027726
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.58E+11 nM
|
[28] | |||
| Compound Name |
5-[5-[4-(2-Diethoxyphosphorylethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246536; BDBM50241305
Click to Show/Hide
|
||||
| Activity |
IC50 = 9.55E+11 nM
|
[28] | |||
| Compound Name |
2-(4-(3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenylsulfonyl)piperazin-1-yl)ethylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245721; BDBM50241308
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.07E+12 nM
|
[28] | |||
| Compound Name |
N-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248165; BDBM50027733
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.23E+12 nM
|
[28] | |||
| Compound Name |
1-(3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenylsulfonyl)piperidin-4-ylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245922; BDBM50241309
Click to Show/Hide
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| Activity |
IC50 = 1.41E+12 nM
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[28] | |||
| Compound Name |
5-[5-[4-(Diethoxyphosphorylmethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL63686; BDBM50027772; BDBM50144220
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| Activity |
IC50 = 1.74E+12 nM
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[28] | |||
| Compound Name |
1-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246135; BDBM50027738
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| Activity |
IC50 = 1.95E+12 nM
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[28] | |||
| Compound Name |
4-[1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395660; BDBM50027769
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| Activity |
IC50 = 2.00E+12 nM
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[28] | |||
| Compound Name |
N-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]cyclohexanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396610; BDBM50027730
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| Activity |
IC50 = 2.40E+12 nM
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[28] | |||
| Compound Name |
3-[4-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperazin-1-yl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246337; SCHEMBL17390175; BDBM50027774
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| Activity |
IC50 = 2.45E+12 nM
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[28] | |||
| Compound Name |
5-[5-(4-Diethoxyphosphorylpiperidin-1-yl)sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245522; BDBM50241306
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| Activity |
IC50 = 2.45E+12 nM
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[28] | |||
| Compound Name |
N-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392182; BDBM50027768
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| Activity |
IC50 = 2.63E+12 nM
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[28] | |||
| Compound Name |
2-Methyl-N-[3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246743; BDBM50027727
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| Activity |
IC50 = 2.88E+12 nM
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[28] | |||
| Compound Name |
5-[5-[4-(Diethoxyphosphorylmethyl)piperidin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL394040; BDBM50241307
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| Activity |
IC50 = 2.95E+12 nM
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[28] | |||
| Compound Name |
2-[1-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidin-4-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246136; BDBM50027734
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| Activity |
IC50 = 3.02E+12 nM
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[28] | |||
| Compound Name |
(1-(3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenylsulfonyl)piperidin-4-yl)methylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245323; BDBM50241310
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| Activity |
IC50 = 3.09E+12 nM
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[28] | |||
| Compound Name |
{1-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperidin-4-yl}-phosphonic acid monoethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245315; BDBM50241302
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| Activity |
IC50 = 3.31E+12 nM
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[28] | |||
| Compound Name |
(2-{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperazin-1-yl}-ethyl)-phosphonic acid monoethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL541468; BDBM50241301
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| Activity |
IC50 = 3.55E+12 nM
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[28] | |||
| Compound Name |
N-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246329; BDBM50027771
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| Activity |
IC50 = 3.72E+12 nM
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[28] | |||
| Compound Name |
4-[1-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidin-4-yl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL264319; BDBM50027773
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| Activity |
IC50 = 4.57E+12 nM
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[28] | |||
| Compound Name |
{4-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperazin-1-ylmethyl}-phosphonic acid monoethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245517; BDBM50241300
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| Activity |
IC50 = 5.50E+12 nM
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[28] | |||
| Compound Name |
{1-[3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxy-benzenesulfonyl]-piperidin-4-ylmethyl}-phosphonic acid monoethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245317; BDBM50241303
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| Activity |
IC50 = 5.89E+12 nM
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[28] | |||
| Compound Name |
3-[1-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidin-4-yl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL391333; BDBM50027766
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| Activity |
IC50 = 6.61E+12 nM
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[28] | |||
| Compound Name |
1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidine-4-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL394886; BDBM50027728
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| Activity |
IC50 = 6.61E+12 nM
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[28] | |||
| Compound Name |
2-[1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246988; BDBM50027767
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| Activity |
IC50 = 9.12E+12 nM
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[28] | |||
| Compound Name |
3-[1-[3-(1-Methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245388; BDBM50027770
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| Activity |
IC50 = 2.00E+13 nM
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[28] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. J Med Chem. 2000 Jun 29;43(13):2523-9. | ||||
| REF 2 | Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3307-12. | ||||
| REF 3 | US patent application no. 9173884B2, Inhibitors of phosphodiesterase 11 (PDE11) | ||||
| REF 4 | Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. J Med Chem. 1993 May 14;36(10):1387-92. | ||||
| REF 5 | Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4. | ||||
| REF 6 | Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. J Med Chem. 2008 Dec 25;51(24):7673-88. | ||||
| REF 7 | Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1297-303. | ||||
| REF 8 | Design, synthesis and biological evaluation of dual acetylcholinesterase and phosphodiesterase 5A inhibitors in treatment for Alzheimer's disease. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4180-4184. | ||||
| REF 9 | Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4623-6. | ||||
| REF 10 | Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans. J Med Chem. 1996 Jul 5;39(14):2696-704. | ||||
| REF 11 | Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. J Med Chem. 1994 Feb 18;37(4):476-85. | ||||
| REF 12 | Imidazotriazinone inhibitors of the Ca2+-calmodulin sensitive phosphodiesterase (PDE I). Bioorg Med Chem Lett. 1997 Jan 7;7(1):89-94. | ||||
| REF 13 | Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4627-31. | ||||
| REF 14 | Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents. J Med Chem. 2001 Oct 25;44(22):3746-9. | ||||
| REF 15 | Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues. J Med Chem. 1994 May 27;37(11):1696-703. | ||||
| REF 16 | Lorneic acids, trialkyl-substituted aromatic acids from a marine-derived actinomycete. J Nat Prod. 2009 Nov;72(11):2046-8. | ||||
| REF 17 | Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective. Eur J Med Chem. 2010 Apr;45(4):1278-86. | ||||
| REF 18 | New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3303-6. | ||||
| REF 19 | Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships. Bioorg Med Chem. 2015 Nov 15;23(22):7332-9. | ||||
| REF 20 | Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings. Eur J Med Chem. 2016 Nov 29;124:372-379. | ||||
| REF 21 | Structure-based design and structure-activity relationships of 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1188-1193. | ||||
| REF 22 | Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase. J Med Chem. 1995 Dec 22;38(26):4972-5. | ||||
| REF 23 | Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline. J Med Chem. 1993 Nov 26;36(24):3765-70. | ||||
| REF 24 | The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1019-22. | ||||
| REF 25 | Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4607-13. | ||||
| REF 26 | 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors. J Med Chem. 1997 Jun 6;40(12):1768-70. | ||||
| REF 27 | Optical resolution, absolute configuration, and activity of the enantiomers of proxyphylline. J Med Chem. 1983 Oct;26(10):1514-8. | ||||
| REF 28 | 3D-QSAR studies on sildenafil analogues, selective phosphodiesterase 5 inhibitors. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4271-4. | ||||
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