Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07930 | Target Info | |||
| Target Name | Histone deacetylase 5 (HDAC5) | ||||
| Synonyms |
KIAA0600; HD5; Antigen NY-CO-9
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|
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| Target Type | Patented-recorded Target | ||||
| Gene Name | HDAC5 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 84 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
SNDX-275
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|
Phase 3 | Compound Info | ||
| Synonyms |
Entinostat; Histone Deacetylase Inhibitor I; IN1470; MS 275; SNDX 275; MS 27-275; Ms-275; Entinostat (USAN/INN); MS-27-275; Pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate; Pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate; Pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate; Pyridin-3-ylmethyl{4-[(2-aminophenyl)carbamoyl]benzyl}carbamate; Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester; Carbamic acid, [[4-[[(2-aminophenyl)carbaonyl]phenyl]methyl]-, 3-pyridinylmethyl ester; Entinostat, SNDX-275, MS-27-275, MS-275; N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]benzamide; N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide; Carbamic acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3-pyridinylmethyl ester; 3-Pyridinylmethyl ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)carbamate
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
RG-2833
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|
Phase 1 | Compound Info | ||
| Synonyms |
RG-FA; HDAC-1 inhibtors (Friedreich ataxia), RepliGen
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N-(2-aminophenyl)nicotinamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-(2-Amino-phenyl)-nicotinamide; 436089-31-5; N-(2-aminophenyl)nicotinamide; N-(2-aminophenyl)pyridine-3-carboxamide; CHEMBL236678; AC1LMN6K; SCHEMBL18086514; CTK4I7538; DTXSID50360661; CHEBI:125506; ZINC873967; BDBM50220259; 3463AE; AKOS000129725; RTR-042156; MCULE-7933541910; N-(2-aminophenyl)-3-pyridylcarboxamide; ZB014940; ACM436089315; ST086607; ASN 01337807; KB-298440; TR-042156; BC4148434; SR-01000329900; SR-01000329900-1; BRD-K20880473-001-04-6
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(4-hydroxybiphenyl-3-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269935; N-(4-hydroxybiphenyl-3-yl)benzamide; SCHEMBL5724398; BDBM50232005
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(4-aminobiphenyl-3-yl)nicotinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255805; N-(4-aminobiphenyl-3-yl)nicotinamide; BDBM50232035
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(4-aminobiphenyl-3-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-(4-aminobiphenyl-3-yl)benzamide; CHEMBL271741; 3max; SCHEMBL16380794; BDBM50232053; N-(4-amino-biphenyl-3-yl)-benzamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256440; N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide; SCHEMBL1066609
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(2-aminophenyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-(2-aminophenyl)benzamide; 2'-AMINOBENZANILIDE; 721-47-1; CHEMBL405072; AC1LFSYX; AC1Q5NOK; ACMC-1AE0C; Oprea1_478192; MLS000084661; SCHEMBL407834; N-(2-amino-phenyl)-benzamide; AC1Q514U; Benzamide, N-(2-aminophenyl)-; CTK2H2825; DTXSID60353948; RFDVMOUXHKTCDO-UHFFFAOYSA-N; MolPort-001-783-352; ZINC225957; HMS2355D18; STL497474; BDBM50232046; AKOS000133162; MCULE-5545982713; NE17312; SMR000019009; TC-170926; KB-298435; ST51030142; EN300-31745; SR-01000389415; AE-641/00785046
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[(2S)-3-(1H-Indol-3-yl)-1-oxo-1-[4-(propylaminocarbamoyl)anilino]propan-2-yl]-4-methoxybenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063938; BDBM50244779
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide pyren-1-ylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934900; BDBM50361258; ZINC82158497; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-pyren-1-yloctanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
Carbamic acid,N-[[4-[[(4-amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]-,methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398420; Carbamic acid, N-[[4-[[(4-amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]-, methyl ester; SCHEMBL4314772; BDBM50229192; ZINC29039034; Methyl {4-[(4-amino-3-biphenylyl)carbamoyl]benzyl}carbamate; [4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid methyl ester; methyl N-[[4-[(2-amino-5-phenylphenyl)carbamoyl]phenyl]methyl]carbamate; N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-3-ylamide hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934904; BDBM50361262; ZINC73224983; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-(3-phenylphenyl)octanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
N-(2-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104197; BDBM50235702
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
CID 57336568
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934905; BDBM50361263; ZINC73224984; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-naphthalen-2-yloctanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide (4-iodo-phenyl)amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934895; BDBM50361253; ZINC82158280; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-(4-iodophenyl)octanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(2-methylphenyl)octanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080874; BDBM50235706
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(4-Chlorophenyl)Amide Hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934892; BDBM50361250; ZINC82158277; 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide; N-(4-chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
Benzyl (2S)-4-[5-[(2-amino-5-phenylphenyl)carbamoyl]pyridin-2-yl]-2-methylpiperazine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437029; SCHEMBL4534462; BDBM50374011
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[4-(Dimethylamino)phenyl]-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066515; BDBM50235703
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-2-ylamide hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934906; BDBM50361264; ZINC73224985; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-(2-phenylphenyl)octanediamide
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
N-(3-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093113; BDBM50235705
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
5-[[6-Oxo-4-(4-phenylphenyl)-1H-pyrimidin-2-yl]sulfanyl]pentanehydroxamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
MC1742; CHEMBL3426803; SCHEMBL18495059; BDBM50087845; AKOS027470271; ZINC140782936; MC 1742; MC-1742
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(4-Cyanophenyl)Amide Hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934894; BDBM50361252; ZINC82158279; 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (4-cyanophenyl)amide hydroxyamide; N-(4-cyanophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
CID 57336565
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934902; BDBM50361260; ZINC82164608; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-[4-(3-phenyltriazol-4-yl)phenyl]octanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic Acid(3-Ethylphenyl)Amide Hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934898; BDBM50361256; ZINC82158495; 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (3-ethylphenyl)amide hydroxyamide; N-(3-ethylphenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(2,2-Dimethylpropanoyl)-N-hydroxy-1,3-dihydroisoindole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431907; SCHEMBL1262950; BDBM50440909
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-[3-(1-phenyltriazol-4-yl)phenyl]octanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066343; BDBM50235704
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-1,3,4,5-tetrahydro-2-benzazepine-7-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431912; SCHEMBL1264164; BDBM50440908
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (4-acetylaminophenyl)-amide hydroxyamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934893; BDBM50361251; ZINC82158278; N-(4-acetamidophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide phenan-thren-9-ylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934908; BDBM50361266; ZINC73224987; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-phenanthren-9-yloctanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-(4-fluorophenyl)-N'-hydroxyoctanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079958; BDBM50235708
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|
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
Ethyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399494; SCHEMBL8101991; BDBM50229197; ethyl N-[[4-[(2-amino-5-thiophen-2-ylphenyl)carbamoyl]phenyl]methyl]carbamate
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide (4-phenylthiazol-2-yl)amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934901; BDBM50361259; ZINC73219822; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-(4-phenyl-1,3-thiazol-2-yl)octanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(4-methoxyphenyl)octanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095542; BDBM50235707
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
CID 57336570
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934907; BDBM50361265; ZINC73224986; N-anthracen-2-yl-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
[4-(4-Amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid pyridin-3-ylmethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253868; SCHEMBL3646556; BDBM50229189; SB19285; pyridin-3-ylmethyl N-[[4-[(2-amino-5-phenylphenyl)carbamoyl]phenyl]methyl]carbamate; pyridin-3-ylmethyl[(4-{[(4-aminobiphenyl-3-yl)amino]carbonyl}phenyl)methyl]carbamate
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid biphenyl-4-ylamide hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934897; BDBM50361255; ZINC82158320; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-(4-phenylphenyl)octanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
N-Hydroxy-2-(1-methylpyrrole-2-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
MPI-5a; MPI_5a; CHEMBL2431901; SCHEMBL722256; SYN1218; BCP29593; EX-A1852; BDBM50440907; ZINC68248700; DB-092801; HY-113957; CS-0064770; MPI 5a;MPI5a;HDAC6 Inhibitor;Histone Deacetylase 6
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-(2-Amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
MRLB-223; CHEMBL3286732; SCHEMBL1639102; BDBM50016941
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|
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
N-Hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]isoindoline-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431906; SCHEMBL1263733; BDBM50440910; N-hydroxy-2-(1-methylpyrrole-2-carbonyl)-1,3-dihydroisoindole-5-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
Diethyl(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)benzylamino)methylphosphonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL470225; SCHEMBL2208777; BDBM50278515; N-(2-amino-5-thiophen-2-ylphenyl)-4-[(diethoxyphosphorylmethylamino)methyl]benzamide; diethyl [({[4-({[2-amino-5-(2-thienyl)phenyl]amino) carbonyl}phenyl]methyl}amino)methyl]phosphonate
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-(2,2-Dimethylpropanoyl)-N-hydroxy-3,4-dihydro-1H-isoquinoline-6-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431902; SCHEMBL1263305; BDBM50440911
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|
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid (3,4-dimethylphenyl)-amide hydroxyamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934896; BDBM50361254; ZINC82158281; N-(3,4-dimethylphenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
N-(2-Amino-5-thiophen-2-ylphenyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL271949; SCHEMBL1067101; BDBM50374007
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide naph-thalen-1-ylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934903; BDBM50361261; ZINC73224745; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-naphthalen-1-yloctanediamide
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N,N'-diphenyloctanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934910; BDBM50361268
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(3-methylphenyl)octanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098910; BDBM50235701
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid hydroxyamide 4-methyl-phenylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934891; BDBM50361249; ZINC73240866; 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-N'-(4-methylphenyl)octanediamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluorooctanedioic acid anthracen-1-ylamide hydroxyamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934909; BDBM50361267; ZINC73220718; N-anthracen-1-yl-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(E)-3-[4-[3-(1-Adamantyl)-4-hydroxyphenyl]phenyl]-N-hydroxyprop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235463; SCHEMBL3295457; SCHEMBL3295460; BDBM50005744; E-3-[3'-(1-adamantyl)-4'-hydroxy-biphenyl-4-yl]-N-hydroxy-acrylamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 78400 nM
|
[12] | |||
| Compound Name |
2-{[2-(4-Tert-butylphenyl)-2-oxoethyl]sulfanyl}-6-methyl-3,4-dihydropyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800374; ZINC9143521; BDBM50348375; AKOS034466005; MCULE-3132766776; Z56923981
Click to Show/Hide
|
||||
| Activity |
IC50 = 94300 nM
|
[13] | |||
| Compound Name |
2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(6-phenylhexyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800385; BDBM50348387
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Pimelic Diphenylamide 106
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TC-H 106; N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide; N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide; RGFA-8;TC-H 106;Histone Deacetylase Inhibitor VII; RGFA-8; SCHEMBL1065609; CHEMBL3940985; DTXSID10581754; EX-A916; TC-H106; BDBM207628; HMS3648I10; BCP16854; US9265734, RGFA8; 1900AH; MFCD17010287; s6738; ZINC34997445; AKOS024458065; CCG-208665; CS-5229; TC-H 106;Pimelic Diphenylamide 106; AK222718; AS-56015; HY-19348; FT-0700415; n1-(2-aminophenyl)-n7-p-tolylheptanediamide; EC-000.2470; Pimelic Diphenylamide 106, >=98% (HPLC); SR-01000946373; SR-01000946373-1; N-(4-Methylphenyl)-N'-(2-aminophenyl)heptanediamide; N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide; Q27165947; N~1~-(2-Aminophenyl)-N~7~-(4-methylphenyl)heptanediamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(2E,4E)-5-[4-[3-(1-Adamantyl)-4-methoxyphenyl]phenyl]-N-hydroxypenta-2,4-dienamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235787; BDBM50005732
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[4-[2-(4-Methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800242; BDBM50348389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800248; SCHEMBL17382802; BDBM50348395
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-[2-[(4-Methyl-6-oxo-1H-pyridin-2-yl)oxy]acetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800247; BDBM50348394
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4-phenylbutyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800384; BDBM50348385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-((4-Hydroxy-6-methylpyrimidin-2-yl)thio)propan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800381; BDBM50348382; STL267143; AKOS008981021; AKOS016354209; MCULE-9373031239; 6-methyl-2-[(2-oxopropyl)sulfanyl]pyrimidin-4(3H)-one; 1-[(4-Oxo-6-methyl-3,4-dihydropyrimidine-2-yl)thio]-2-propanone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-[2-(3-Hydroxyphenyl)sulfanylacetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800245; BDBM50348392
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-[1-Hydroxy-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]ethyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800249; BDBM50348396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
E,E-5-(4''-Methoxybiphenyl-4-yl)-penta-2,4-dienoic acid Nhydroxyamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538364; BDBM50293369
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800377; SCHEMBL17382809; BDBM50348378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-[(4-Methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-phenylethyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000531589; CHEMBL1722433; SMR000136527; 2-[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)thio]-N-(2-phenylethyl)acetamide; Oprea1_304490; cid_892234; BDBM96613; HMS2466G16; STK116346; ZINC18093765; AKOS000716785; AKOS001049225; MCULE-1856560484; SR-01000264561; SR-01000264561-1; Z56847664; 2-[(4-keto-6-methyl-1H-pyrimidin-2-yl)thio]-N-phenethyl-acetamide; 2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(2-phenylethyl)acetamide; 2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]-N-(2-phenylethyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-[2-(4-Hydroxyphenyl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800376; BDBM50348377
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-{4-[2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetyl]-phenyl}-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800244; Oprea1_373990; Oprea1_543124; ZINC841137; BDBM50348391; STK285981; AKOS001628005; MCULE-9514505423; N-(4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}phenyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
6-Methyl-2-phenacylsulfanyl-1H-pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800250; 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)-1-phenylethanone; 6-methyl-2-(2-oxo-2-phenylethylthio)-3-hydropyrimidin-4-one; NSC338484; CBKinase1_000908; CBKinase1_013308; Cambridge id 5509606; IFLab1_000456; CTK0H7748; DTXSID70319010; HMS1413E16; ZINC9446020; BDBM50348397; SBB085164; STK830457; STL281533; 6-methyl-2-[(2-oxo-2-phenylethyl)sulfanyl]-3,4-dihydropyrimidin-4-one; AKOS000565987; AKOS001012387; AKOS003626716; MCULE-4095585670; NSC-338484; IDI1_008675; ST50113123; 2-Benzoylmethylmercapto-4-methyl-6-oxypyrimidin; AB00087040-01; SR-01000416787; SR-01000416787-1; BRD-K22643941-001-01-6; Z56767694; F0176-0059; 6-methyl-2-(2-oxo-2-phenylethyl-thio)pyrimidin-4(3h)-one; 6-methyl-2-[(2-oxo-2-phenylethyl)thio]-4(1H)-pyrimidinone; 2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-phenylethanone; 6-METHYL-2-((2-OXO-2-PHENYLETHYL)THIO)-4(3H)-PYRIMIDINONE; 6-methyl-2-[(2-oxo-2-phenylethyl)sulfanyl]-4(3H)-pyrimidinone; 6-methyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyrimidin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-Methyl-N-[4-[2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800251; BDBM50348372
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(Tert-butylcarbonylmethylthio)-4-hydroxy-6-methylpyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800382; Maybridge1_007088; CTK6C4190; HMS561K04; BDBM50348383; SBB099296; ZINC13468269; AKOS008981059; CCG-244729; MCULE-6331991984; 1-(4-hydroxy-6-methylpyrimidin-2-ylthio)-3,3-dimethylbutan-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(4-Chlorophenacylthio)-4-hydroxy-6-methylpyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800375; 2-[2-(4-chlorophenyl)-2-oxoethylthio]-6-methyl-3-hydropyrimidin-4-one; BAS 00853818; MLS001143876; CTK6G9149; CCG-304; BDBM50348376; SBB085170; STL281529; STL330245; ZINC17750270; AKOS000565394; AKOS001021795; AKOS003625541; MCULE-8980888190; SMR000473315; ST50113505; AE-641/01210025; SR-01000637247-1; 1-(4-Chlorophenyl)-2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)ethan-1-one; 1-(4-chlorophenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-yl)thio]ethanone; 2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-6-methylpyrimidin-4(3H)-one; 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methyl-4(3H)-pyrimidinone; 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methylpyrimidin-4(1H)-one; 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methylpyrimidin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Hdac3-IN-T326
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622375; N-(2-Aminophenyl)-5-(1-(3-nitrophenethyl)-1H-1,2,3-triazol-4-yl)thiophene-2-carboxamide; BDBM50121211; T-326; N-(2-aminophenyl)-5-[1-[2-(3-nitrophenyl)ethyl]triazol-4-yl]thiophene-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-[(4-Hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1307946; SMR000104980; CBMicro_000564; Oprea1_387281; Oprea1_513871; MLS000109033; REGID_for_CID_722456; HMS2167C19; HMS3314O04; SMSF0007972; ZINC8632101; BDBM50348374; STK927199; STL281551; AKOS000566015; AKOS002232718; AKOS008969277; CB01814; MCULE-2661039450; BIM-0000433.P001; ST50112774; AB00097791-01; AB00097791-06; SR-01000417195; SR-01000417195-1; 2-[2-(4-methoxyphenyl)-2-oxoethylthio]-6-methyl-3-hydropyrimidin-4-one; 2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-6-methylpyrimidin-4(3H)-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Chembl4165684
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50283687
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(7R)-N-Hydroxy-7-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3338418; BDBM50027662
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
HDAC3-IN-T247; CHEMBL3622374; SCHEMBL18208054; BDBM50121210; MFCD29089340; T 247; T-247; N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)triazol-4-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Methyl 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800380; methyl 2-(6-methyl-4-oxo-3-hydropyrimidin-2-ylthio)acetate; BDBM50348381; SBB062603; STK641838; STL281936; ZINC13739146; AKOS002262380; AKOS002308199; AKOS008981057; MCULE-6551097558; 2-Methoxycarbonylmethylenethio-6-methyluracil; ST50186106; methyl [(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetate; methyl [(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetate; [(4-Oxo-3,4-dihydro-6-methylpyrimidine-2-yl)thio]acetic acid methyl ester; METHYL ((4-METHYL-6-OXO-1,6-DIHYDRO-2-PYRIMIDINYL)THIO)ACETATE; Methyl [(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetate #
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-YL)thio]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209453; CHEMBRDG-BB 6606317; MLS001212148; SMR000518041; 1-(3,4-Dihydroxy-phenyl)-2-(4-hydroxy-6-methyl-pyrimidin-2-ylsulfanyl)-ethanone; 1-(3,4-Dihydroxyphenyl)-2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)ethanone; Cambridge id 6606317; Oprea1_441814; cid_687937; SCHEMBL17382815; BDBM55151; CTK4I6835; DTXSID20350771; KUC104368N; BDBM50477568; MFCD02366437; STK770887; ZINC18163844; 2-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl-6-methyl-1H-pyrimidin-4-one; AKOS000563316; AKOS001653377; AKOS008967906; KSC-10-146; MCULE-3270859217; W-9419; 2-[[2-(3,4-dihydroxyphenyl)-2-oxoethyl]thio]-6-methyl-1H-pyrimidin-4-one; 2-{[2-(3,4-dihydroxyphenyl)-2-oxoethyl]thio}-6-methylpyrimidin-4(3H)-one; 1-(3,4-dihydroxyphenyl)-2-(4-hydroxy-6-methyl-pyrimidin-2-yl)sulfanyl-ethanone; 1-(3,4-Dihydroxyphenyl)-2-[(4-hydroxy-6-methyl-2-pyrimidinyl)thio]ethanone; 2-[[2-(3,4-dihydroxyphenyl)-2-keto-ethyl]thio]-6-methyl-1H-pyrimidin-4-one; 2-{[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl}-6-methylpyrimidin-4(3H)-one; Ethanone, 1-(3,4-dihydroxyphenyl)-2-[(4-hydroxy-6-methyl-2-pyrimidinyl)thio]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[[(4R,5S)-4,5-diphenyl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605506; BDBM50113971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
6-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]-1,3-dihydroindol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800378; SCHEMBL17382803; BDBM50348379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-[2-(4-Methoxy-6-methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800243; BDBM50348390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
6-Methyl-2-{[2-oxo-2-(thiophen-2-yl)ethyl]sulfanyl}-3,4-dihydropyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800379; ChemDiv3_001859; SCHEMBL13401534; HMS1478E11; BDBM50348380; ZINC18084678; AKOS001038722; AKOS008966863; CCG-107559; MCULE-5001803542; IDI1_020825; Z56864923
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800373; BDBM50348373
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(E)-3-[4-[3-(1-Adamantyl)-4-(cyanomethyl)phenyl]-3-chlorophenyl]-N-hydroxyprop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235790; BDBM50005730
Click to Show/Hide
|
||||
| Activity |
IC50 = 124000 nM
|
[12] | |||
| Compound Name |
N1-(2-Aminophenyl)-N7-phenylheptanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NKL 22; N-(2-AMINOPHENYL)-N'-PHENYLHEPTANEDIAMIDE; Histone Deacetylase Inhibitor IV; HDAC inhibitor IV; CHEMBL277805; VC-4154 (HDAC inhibitor IV); N'-(2-AMINOPHENYL)-N-PHENYLHEPTANEDIAMIDE; Heptanediamide, N-(2-aminophenyl)-N'-phenyl-; NKL22; Probes2_000492; NKL-22; SCHEMBL1063954; CTK1E3681; DTXSID60429495; EX-A923; BCP16847; KS-00001CM1; BDBM50254774; MFCD16293760; s6548; ZINC29054251; AKOS027439961; CS-5542; N-Phenyl-N'-(2-aminophenyl)pimelamide; N1-2-Aminophenyl-N7-phenyl-heptanediamide; HY-100384; FT-0662016; N-(2-Aminophenyl)-N inverted exclamation mark -phenylheptanediamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Valproate
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
99-66-1; Dipropylacetic acid; Depakine; Depakene; 2-Propylvaleric acid; Ergenyl; Di-n-propylacetic acid; Mylproin; Pentanoic acid, 2-propyl-; 4-Heptanecarboxylic acid; Propylvaleric acid; n-Dipropylacetic acid; Myproic Acid; Di-n-propylessigsaure; n-DPA; Dipropylacetate; Convulex; Depakin; Vupral; Acido valproico; Acide valproique; Acidum valproicum; Stavzor; Avugane; Baceca; Kyselina 2-propylvalerova; 2-n-Propyl-n-valeric acid; Acetic acid, dipropyl-; Abbott 44090; Valproinsaeure; Savicol; Convulsofin; Deproic; VPA; Depakin chrono; Dipropyl Acetate; Med Valproic; Valproic acid USP; Valproic acid USP24; Acide valproique [INN-French]; Acido valproico [INN-Spanish]; Acidum valproicum [INN-Latin]; Alti-Valproic; Depakote (TM); Dom-Valproic; G2M-777; Kyselina 2-propylvalerova [Czech]; N-DPA; N-Dipropylacetic acid; Novo-Valproic; Nu-Valproic; PMS-Valproic Acid; Penta-Valproic; Valproic acid (USP); Di-n-propylessigsaeure; Di-n-propylessigsaure [German]; Valproic acid [USAN:INN:BAN]; Valproic Acid, SodiumSalt (2:1); 2 PP (base)
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| Activity |
IC50 > 2000000 nM
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[19] | |||
| Compound Name |
Phenylbutyrate
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Phase 2 | Compound Info | ||
| Synonyms |
Benzenebutyric acid; Phenyl butanoate; Phenyl butyrate; HDInhib_000004; Butanoic acid, phenyl ester; Butyric acid, phenyl ester; FR-2080; Gamma-Phenylbutyric acid; Omega-Phenylbutanoic acid; GAMMA-PHENYL-BUTYRIC ACID; Butyric acid, 4-phenyl-(8CI); 1-Phenylbutyric acid; 4-PHENYL-BUTANOIC ACID; 4-PHENYLBUTYRIC ACID; 4-Phenylbutanoic acid; 4-phenylbutans; 4-phenylbutyrate
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| Activity |
IC50 > 2000000 nM
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[19] | |||
| Compound Name |
Butanoic Acid
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Investigative | Compound Info | ||
| Synonyms |
butyric acid; butanoic acid; n-Butyric acid; 107-92-6; n-Butanoic acid; propylformic acid; ethylacetic acid; 1-propanecarboxylic acid; Butanic acid; butyrate; 1-Butyric acid; Buttersaeure; butanoate; Kyselina maselna; Butyric acid (natural); Propanecarboxylic acid; Buttersaeure [German]; 1-butanoic acid; FEMA Number 2221; Kyselina maselna [Czech]; FEMA No. 2221; CCRIS 6552; HSDB 940; butoic acid; Ethyacetic Acid; 2-butanoate; NSC 8415; UNII-40UIR9Q29H; UN2820; AI3-15306; EINECS 203-532-3; BRN 0906770; CH3-[CH2]2-COOH; 40UIR9Q29H
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| Activity |
IC50 > 2000000 nM
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[19] | |||
| Compound Name |
(E)-N-Hydroxy-3-[3-[6-methoxy-3-(3,4,5-trimethoxybenzoyl)indol-1-yl]sulfonylphenyl]prop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081822; BDBM50259807
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| Activity |
IC50 = 356000 nM
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[20] | |||
| Compound Name |
N-Hydroxybutanamide
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Investigative | Compound Info | ||
| Synonyms |
Butyrylhydroxamic acid; CHEMBL1672332; N-hydroxybutyramide; butyrohydroxamic acid; (n-propyl)hydroxamic acid; SCHEMBL264922; DTXSID10329294; ZINC4809144; BDBM50336883; AKOS000170033; MCULE-8710375368; Butyrylhydroxamic acid, >=98% (HPLC); EN300-72141; Z59181937
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| Activity |
IC50 = 360000 nM
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[19] | |||
| References | Top | ||||
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| REF 1 | Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2). Bioorg Med Chem Lett. 2008 Jan 15;18(2):726-31. | ||||
| REF 2 | Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). J Med Chem. 2018 Mar 8;61(5):1745-1766. | ||||
| REF 3 | Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8. | ||||
| REF 4 | Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). | ||||
| REF 5 | Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status. J Med Chem. 2018 Mar 22;61(6):2589-2603. | ||||
| REF 6 | Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1508-1512. | ||||
| REF 7 | Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J Med Chem. 2015 May 14;58(9):4073-9. | ||||
| REF 8 | Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform. J Med Chem. 2013 Sep 26;56(18):7201-11. | ||||
| REF 9 | Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5450-4. | ||||
| REF 10 | Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. ACS Med Chem Lett. 2014 Jan 2;5(4):340-5. | ||||
| REF 11 | Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2). Bioorg Med Chem Lett. 2009 Apr 1;19(7):2053-8. | ||||
| REF 12 | Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors. Eur J Med Chem. 2014 May 22;79:251-9. | ||||
| REF 13 | A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4164-9. | ||||
| REF 14 | US patent application no. 9265734B2, Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors | ||||
| REF 15 | Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators. J Med Chem. 2015 Oct 8;58(19):7611-33. | ||||
| REF 16 | Discovery of a fluorescent probe with HDAC6 selective inhibition. Eur J Med Chem. 2017 Dec 1;141:596-602. | ||||
| REF 17 | Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors. J Med Chem. 2014 Oct 9;57(19):8026-34. | ||||
| REF 18 | Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit. J Med Chem. 2015 Sep 10;58(17):6803-18. | ||||
| REF 19 | Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. ACS Med Chem Lett. 2010 Oct 8;2(1):39-42. | ||||
| REF 20 | 3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity. Eur J Med Chem. 2017 Jan 5;125:1268-1278. | ||||
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