Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08123 | Target Info | |||
| Target Name | Leucine-rich repeat kinase 2 (LRRK2) | ||||
| Synonyms |
PARK8; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | LRRK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(1-Methylimidazol-4-yl)-5-(4-methylphenyl)pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064894; BDBM50470162
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[1] | |||
| Compound Name |
3-(4,5-Dihydro-1H-imidazol-2-yl)-7-(4-methylsulfonylphenyl)-N-propan-2-ylquinolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2347821; BDBM50431894
Click to Show/Hide
|
||||
| Activity |
IC50 = 88597 nM
|
[2] | |||
| Compound Name |
Ethyl 2-[(3,7-diphenyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)sulfanyl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348981; BDBM50432027
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8-Methyl-3-thiophen-2-yl-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348980; BDBM50432028
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Ethyl 3-thiophen-2-yl-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine-8-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348982; BDBM50432026
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Phenyl-N-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348984; BDBM50432024
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1H-Pyrrolo[2,3-B]pyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Azaindole-3-carbonitrile; 3-CYANO-1H-PYRROLO[2,3-B]PYRIDINE; 3-Cyano-7-azaindole; CHEMBL4075970; PubChem19342; 3-cyano-7 -azaindole; ACMC-20a4vp; SCHEMBL586268; CTK1D5175; DTXSID70437960; ACT06863; CS-B0514; 3-Cyano-1H-pyrrolo[2,3b]pyridine; ANW-57251; BDBM50250337; GEO-03547; MFCD07778359; ZINC14984912; 7-Azaindole-3-carbonitrile, >=95%; AKOS006349268; PB29451; QC-2799; AK-45335; DS-13511; AB0038085; DB-003188; AM20051182; FT-0660072; Y5434; KS-00000376; C-8871; 414P895; A826501; J-504761; Q27454346
Click to Show/Hide
|
||||
| Activity |
IC50 = 101080 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4500-4505. | ||||
| REF 2 | Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1974-7. | ||||
| REF 3 | Triazolopyridazine LRRK2 kinase inhibitors. Bioorg Med Chem Lett. 2013 Apr 1;23(7):1967-73. | ||||
| REF 4 | Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1). J Med Chem. 2017 Nov 9;60(21):8945-8962. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.