Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08133 | Target Info | |||
| Target Name | Transient receptor potential cation channel V6 (TRPV6) | ||||
| Synonyms |
Transient receptor potential cation channel subfamily V, member 6; TRPV6; HTRP8; ECaC2; Calcium transport protein CaT1; Calcium channel CAT1
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| Target Type | Clinical trial Target | ||||
| Gene Name | TRPV6 | ||||
| Biochemical Class | Transient receptor potential catioin channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Phenyl-2-(4-phenylphenyl)-1-oxa-3-azonia-2-boranuidacyclopentane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386181; BDBM50434540
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| Activity |
IC50 = 51300 nM
|
[1] | |||
| Compound Name |
Bis(4-fluorophenyl)borinic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386173; Borinic acid, B,B-bis(4-fluorophenyl)-; SCHEMBL1003006; BDBM50434548
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| Activity |
IC50 = 61600 nM
|
[1] | |||
| Compound Name |
3,3-Dimethyl-2,2-diphenyl-1-oxa-3-azonia-2-boranuidacyclopentane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385996; BDBM50434564
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| Activity |
IC50 = 63600 nM
|
[1] | |||
| Compound Name |
2-(2-Methylphenyl)-2-phenyl-1-oxa-3-azonia-2-boranuidacyclopentane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386178; BDBM50434543
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| Activity |
IC50 = 67900 nM
|
[1] | |||
| Compound Name |
2,2-Bis(4-methoxyphenyl)-1-oxa-3-azonia-2-boranuidacyclopentane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386175; BDBM50434546
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| Activity |
IC50 = 89800 nM
|
[1] | |||
| Compound Name |
2,2-Diphenyl-1-thia-3-azonia-2-boranuidacyclopentane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386006; BDBM50434556
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| Activity |
IC50 = 93500 nM
|
[1] | |||
| Compound Name |
2-Benzhydryloxyethanamine
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Investigative | Compound Info | ||
| Synonyms |
UNII-YCO6ZP0WF3; YCO6ZP0WF3; CHEMBL2386007; FAR-9058D; NSC-55993; Didesmethyldiphenhydramine; Dinordiphenhydramine; NSC55993; N,N-Didemethyldiphenhydramine; 2-(Diphenylmethoxy)ethylamine; 2-(Benzhydryloxy)ethanamine #; SCHEMBL7288351; 2-[Di(phenyl)methoxy]ethanamine; CTK0H9061; DTXSID90275381; 2-(Diphenylmethoxy)-N-ethylamine; Ethylamine, 2-(diphenylmethoxy)-; BDBM50434555; AKOS026729138; 2-(Diphenyl)methoxy-N,N-demethylethanamin
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| Activity |
IC50 = 159100 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2,2-Bis(2-methoxyphenyl)-1-oxa-3-azonia-2-boranuidacyclopentane
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386011; BDBM50434551
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| Activity |
IC50 = 412300 nM
|
[1] | |||
| Compound Name |
11-Hydroxy-5,6-dihydrobenzo[b][1]benzoborepine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386176; NSC404896; BDBM50434545; ZINC170186657; NSC-404896
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
Bis(2-methoxyphenyl)borinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386010; BDBM50434552
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. Bioorg Med Chem. 2013 Jun 1;21(11):3202-13. | ||||
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