Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T10670 | Target Info | |||
| Target Name | Neuropeptide Y receptor type 2 (NPY2R) | ||||
| Synonyms |
Y2 receptor; NPY2R; NPY2-R; NPY-Y2 receptor
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| Target Type | Clinical trial Target | ||||
| Gene Name | NPY2R | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[[2-(4-Chlorophenyl)-2-phenylacetyl]amino]-5-(diaminomethylideneamino)-N-[(1S)-2,3-dihydro-1H-inden-1-yl]pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41686; BDBM50090271; 2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-guanidino-pentanoic acid (S)-indan-1-ylamide
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| Activity |
IC50 = 59000 nM
|
[1] | |||
| Compound Name |
N-[1-(7-Hydroxy-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-1-oxo-5-[[N'-(3-phenylpropyl)carbamimidoyl]amino]pentan-2-yl]-2-(4-phenylphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL290175; BDBM50090282
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| Activity |
IC50 = 78000 nM
|
[1] | |||
| Compound Name |
2-[2-(4-Chloro-phenyl)-2-phenyl-acetylamino]-5-guanidino-pentanoic acid benzylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41457; BDBM50090274
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| Activity |
IC50 = 97000 nM
|
[1] | |||
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid 4-hydroxy-benzylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL44246; BDBM84996; BDBM50065469; NSC_5311023; L000127; 2-(2,2-Diphenylacetamido)-5-guanidino-N-(4-hydroxybenzyl)pentanamide; 5-carbamimidamido-2-(2,2-diphenylacetamido)-N-[(4-hydroxyphenyl)methyl]pentanamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((R)-1-phenyl-ethyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41673; BDBM50090288
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|
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| Activity |
IC50 = 177000 nM
|
[1] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[4-Guanidino-1-(7-hydroxy-1,3,4,5-tetrahydro-benzo[c]azepine-2-carbonyl)-butyl]-2,2-diphenyl-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42747; BDBM50090277
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| Activity |
IC50 = 247000 nM
|
[1] | |||
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((R)-carbamoyl-phenyl-methyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42686; BDBM50090272
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|
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| Activity |
IC50 > 400000 nM
|
[1] | |||
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid ((S)-2-hydroxy-1-phenyl-ethyl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41981; BDBM50090276
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|
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| Activity |
IC50 = 540000 nM
|
[1] | |||
| Compound Name |
2-Diphenylacetylamino-5-guanidino-pentanoic acid [1-(4-hydroxy-phenyl)-ethyl]-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288355; BDBM50090281
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| Activity |
IC50 = 575000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1597-600. | ||||
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