Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15023 | Target Info | |||
| Target Name | Neuropilin-1 (NRP1) | ||||
| Synonyms |
Vascular endothelial cell growth factor 165 receptor; VEGF165R; Platelet-derived endothelial cell growth factor receptor; NRP; Membrane-bound; CD304
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| Target Type | Successful Target | ||||
| Gene Name | NRP1 | ||||
| Biochemical Class | Neuropilin and tolloid-like | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-2-{[3-(4-Nitro-benzenesulfonylamino)-thiophene-2-carbonyl]-amino}-5-guanidinopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079279; SCHEMBL4569808; BDBM50313488; (S)-5-guanidino-2-(3-(4-nitrophenylsulfonamido)thiophene-2-carboxamido)pentanoic acid
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
5-Chloro-3-(2,6-dimethylphenylamino)-2-phenylindolizine-1-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL213321; BDBM50189005
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| Activity |
IC50 = 60000 nM
|
[2] | |||
| Compound Name |
5-Chloro-3-(3-(dimethylamino)propylamino)-2-phenylindolizine-1-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL436932; BDBM50188980
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| Activity |
IC50 = 62000 nM
|
[2] | |||
| Compound Name |
3-(Cyclohexylamino)-5-(3-(dimethylamino)propoxy)-2-phenylindolizine-1-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL212560; BDBM50188995
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| Activity |
IC50 = 79000 nM
|
[2] | |||
| Compound Name |
3-(3-Aminophenylamino)-5-chloro-2-phenylindolizine-1-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL425440; BDBM50188987
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| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
3,6-Anhydro-2-deoxy-4,5-O-isopropylidene-7-[N-(aminoiminomethyl)-N-(2-guanidinoethyl)amino]-N-[2-(1Hindol-3-yl)ethyl]-L-galacto-heptonoamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098234; BDBM50317440; J3.568.825K
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| Activity |
IC50 = 92000 nM
|
[3] | |||
| Compound Name |
5-Chloro-3-(phenethylamino)-2-(piperidin-4-yl)indolizine-1-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214266; BDBM50189002
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| Activity |
IC50 = 95000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26. | ||||
| REF 2 | Discovery of protein-protein binding disruptors using multi-component condensations small molecules. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3998-4001. | ||||
| REF 3 | Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1. Bioorg Med Chem. 2010 May 1;18(9):3285-98. | ||||
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