Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15851 | Target Info | |||
| Target Name | Orotidine 5'-monophosphate decarboxylase (UMPS) | ||||
| Synonyms |
Uridine 5'-monophosphate synthase; UMP synthase
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| Target Type | Literature-reported Target | ||||
| Gene Name | UMPS | ||||
| Biochemical Class | Pentosyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Fluorouridine monophosphate
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Investigative | Compound Info | ||
| Synonyms |
Fosfluoridine; 5-Fluorouridylic acid; Fump-5'; UNII-BMW6RNK254; 5-fluorouridine 5'-monophosphate; BMW6RNK254; 5-Fluoro-Uridine-5'-Monophosphate; 5-Fluorouridine 5'-phosphate; 5-fluorouridine 5'-(dihydrogen phosphate); 5-Fluorouridylate; 5-F-UMP; 5-fluoro-UMP; uridine derivative, 39; 5F-UMP; SCHEMBL465109; 5'-Uridylic acid, 5-fluoro-; CHEMBL474163; BDBM27943; DTXSID601000617; C16634; Q27120389; 5-Fluoro-4-hydroxy-1-(5-O-phosphonopentofuranosyl)pyrimidin-2(1H)-one
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| Activity |
Ki = 98000 nM
|
[1] | |||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Uridine-5'-Monophosphate
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Investigative | Compound Info | ||
| Synonyms |
5'-URIDYLIC ACID; Uridine 5'-monophosphate; Uridylic acid; Uridine monophosphate; 58-97-9; uridine-5'-monophosphate; Uridine phosphate; Uridine 5'-phosphate; Uridine 5'-phosphoric acid; 5'-UMP; UMP; UMP (nucleic acid); Uridine 5'-(dihydrogen phosphate); 5'Uridylic acid; uridylate; UNII-E2OU15WN0N; BRN 0047486; CHEBI:16695; Uridine 5-monophosphate; EINECS 200-408-0; E2OU15WN0N; CHEMBL214393; U 5'-P; AK113761; 27416-86-0; 2,4(1H,3H)-pyrimidinedione, 1-(5-O-phosphono-beta-D-ribofuranosyl)-; Polyuridylic acids
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| Activity |
Ki = 220000 nM
|
[2] | |||
| Compound Name |
Azane;[(2S,3R,4R,5R)-5-(5-cyano-2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1765122
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| Activity |
Ki = 759000 nM
|
[3] | |||
| Compound Name |
Cytidine-5'-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
5'-CYTIDYLIC ACID; Cytidine 5'-monophosphate; cytidylic acid; Cytidine monophosphate; 5'-CMP; cytidylate; Cytidine 5'-phosphate; CMP (nucleotide); Polyribocytidylic acid; Cytidine 5'-phosphoric acid; Cytidine 5'-monophosphoric acid; Cytidine 5'-(dihydrogenphosphate); C-5'-P; cytidine-P; cytidine-phosphate; Cytidine 3'-(dihydrogen phosphate); Poly(rC); Polyribonucleotide complex C; 1beta-Ribofuranosylcytosine 5'-phosphate, d-; Poly(cytidylic acid); POLY C; UNII-F469818O25; MFCD00006544; Cytidine 5 -monophosphate; Cytidine 5'-monophosphate, free acid; CHEMBL307679; 5'-Cytidylic acid(homopolymer); 5'-Cytidylic acid (8CI,9CI); 5'-Cytidylic acid, polymers (8CI); 5'-Cytidylic acid, homopolymer (9CI); CMP group; Cytidine, mono(dihydrogen phosphate) (ester); F469818O25; Cytidine-5' Monophosphate; cytidine-monophosphate; 5'-Cytidylate monophosphate; Cytidine 5'-monophosphate hydrate, 99%; Cytidine 5'-monophosphate, 97%, from yeast; cytidine-5-monophosphate; EINECS 200-556-6; NSC 120953; BRN 0046982; C9H14N3O8P; 5-cytidylate; 5-Cytidylic acid; cytidine mono phosphate; CytidylsA currencyure a; PubChem14183; cytidine 5''-phosphate; Cytidine 5'-phosphorate; bmse000311; Epitope ID:196257; Cytidine 5'-monophosphorate; 3H-Cytidin-5'-monophosphat; SCHEMBL16189; 4-25-00-03673 (Beilstein Handbook Reference); CTK7F2756; DTXSID50889322; Cytidine mono(dihydrogen phosphate); CYTIDINE-5''-MONOPHOSPHATE; ZINC3861744; ANW-34625; BDBM50310540; Cytidine 5' Monophosphate Free Acid; s5374; AKOS015854843; AKOS015888565; CCG-267735; CS-W009878; DB03403; HY-W009162; MP-0568; AC-32139; AS-56853; BR-73065; SY030157; 5,(S); C1675; C00055; 006C544; A820633; Q412622; Q-101433; B755C4F3-3D29-45E0-9432-16F902ABCFE1
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| Activity |
Ki = 1400000 nM
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[2] | |||
| Compound Name |
Azane;[(2S,3R,4R,5R)-5-(6-cyano-2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1765124
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| Activity |
Ki > 2000000 nM
|
[3] | |||
| Compound Name |
Azane;[(2S,3R,4R,5R)-5-(6-carbamoyl-2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1765121
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| Activity |
Ki > 4000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. | ||||
| REF 2 | Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. J Med Chem. 2012 Nov 26;55(22):9988-97. | ||||
| REF 3 | Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J Med Chem. 2011 Apr 28;54(8):2891-901. | ||||
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