Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16739 | Target Info | |||
| Target Name | Lysine-specific histone demethylase 1 (LSD) | ||||
| Synonyms |
Lysine-specific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; BRAF35-HDAC complex protein BHC110; AOF2
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| Target Type | Clinical trial Target | ||||
| Gene Name | KDM1A | ||||
| Biochemical Class | CH-NH(2) donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 154 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Vorinostat
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|
Approved | Compound Info | ||
| Synonyms |
NHNPODA; SAHA; SHH; Zolinza; Merck brand of Vorinostat; OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE; SAHA cpd; Suberanilohydroxamic acid; Suberoylanilide hydroxamic acid; Vorinostat MSD; Vorinostat [USAN]; M344; MK0683; SKI390; WIN64652; MK-0683; SAHA, Suberoylanilide hydroxamic acid; SW-064652; Zolinza (TN); Vorinostat (JAN/USAN); N1-hydroxy-N8-phenyloctanediamide; Zolinza, MK-0683, SAHA; N'-hydroxy-N-phenyloctanediamide; N-Hydroxy-N'-phenyl octanediamide; N-Hyrdroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide; Vorinostat (HDAC inhibitor)
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-Cyclopropyl-4-[2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3760100; BDBM50142085
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)-3-[4-(piperidin-1-ylmethyl)phenyl]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758241; BDBM50139122
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
[4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]phenyl]-piperazin-1-ylmethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759525; BDBM50142195
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
[4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]phenyl]methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759614; BDBM50140251
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(4-Fluorophenyl)-2-[[(1S,2R)-2-phenylcyclopropyl]amino]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3651568; BDBM101253; US8524717, 8
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(1S,2R)-2-(4-Ethoxyphenyl)-2-fluorocyclopropan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090801; BDBM50256992
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(1S,2R)-2-Fluoro-2-(3-methoxyphenyl)cyclopropan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076750; BDBM50256993
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(1S,2R)-2-Fluoro-2-(3-nitrophenyl)cyclopropan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103002; BDBM50256934
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(1S,2R)-2-Fluoro-2-[3-(pentafluoro-lambda6-sulfanyl)phenyl]cyclopropan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088315; BDBM50256980
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-[5-Hydroxy-2-(4-methylphenyl)pyridin-3-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3760089; BDBM50142073
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(1S,2S)-2-Fluoro-2-(4-nitrophenyl)cyclopropan-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083630; BDBM50256991
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759578; BDBM50140249
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
[4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]phenyl]-piperidin-1-ylmethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759628; BDBM50142244
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
3-(4-Ethynylphenyl)-2-(4-methylphenyl)-5-(piperidin-4-ylmethoxy)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758600; BDBM50142081
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(1S,2S)-2-(4-Ethoxyphenyl)-2-fluorocyclopropan-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074238; BDBM50256984
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
[4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]phenyl]-morpholin-4-ylmethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758296; BDBM50142246
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
2,3-Diphenyl-5-(piperidin-4-ylmethoxy)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759745; BDBM50142247
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Phenyl-5-(piperidin-4-ylmethoxy)pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758505; BDBM50142194
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
4-[2-(4-Methylphenyl)-5-phenylmethoxypyridin-3-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758342; BDBM50142074
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(1S,2R)-2-Fluoro-2-(4-nitrophenyl)cyclopropan-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069807; BDBM50256979
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-4-methyl-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL335326; SCHEMBL8356809; BDBM50061923; ZINC13776369; N-[4-(4-Chlorophenyl)-2-thiazolyl]-4-methylbenzenesulfonamide; N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]-4-METHYLBENZENESULFONAMIDE
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| Activity |
IC50 = 50500 nM
|
[5] | |||
| Compound Name |
3-Chloro-6-nitro-2-(trifluoromethyl)chromone
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Investigative | Compound Info | ||
| Synonyms |
NAMOLINE; Namolin; CHEMBL2426136; CTK5I3531; BDBM50445351; STK806346; AKOS004912844; MCULE-9416381009; 3-chloro-6-nitro-2-trifluoromethylchromone; SR-01000472117; SR-01000472117-1; 3-chloro-6-nitro-2-(trifluoromethyl)-4H-chromen-4-one
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| Activity |
IC50 = 51000 nM
|
[6] | |||
| Compound Name |
Tert-butyl 4-[[1-[(2,6-difluorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440542; BDBM50442014
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| Activity |
IC50 = 51200 nM
|
[7] | |||
| Compound Name |
3-Chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_476644; Oprea1_679181; CHEMBL3134356
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| Activity |
IC50 = 51600 nM
|
[5] | |||
| Compound Name |
1-[Methyl(prop-2-ynyl)amino]-3-naphthalen-2-yloxypropan-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426051; BDBM50440479
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|
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| Activity |
IC50 = 51700 nM
|
[8] | |||
| Compound Name |
Benzyl 4-[[1-[(2-chlorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334486; BDBM50442037
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| Activity |
IC50 = 53200 nM
|
[7] | |||
| Compound Name |
[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl 4-methylsulfonylpiperazine-1-carbodithioate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440570; BDBM50441981
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| Activity |
IC50 = 55100 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334500; BDBM50442049
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|
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| Activity |
IC50 = 56500 nM
|
[7] | |||
| Compound Name |
N-[1-(4-Chlorophenyl)pyrazol-3-yl]-3-(trifluoromethyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134374
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|
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| Activity |
IC50 = 56900 nM
|
[5] | |||
| Compound Name |
1-[2-(4-Hydroxyanilino)-1,3-thiazol-4-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134322
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| Activity |
IC50 = 57000 nM
|
[5] | |||
| Compound Name |
4-Chloro-2-(prop-2-yn-1-ylthio)-6-(p-tolyl)pyrimidine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415541; TQR0480; BDBM50075486
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| Activity |
IC50 = 59160 nM
|
[9] | |||
| Compound Name |
3-Chloro-N-[4-(2-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134359
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| Activity |
IC50 = 61600 nM
|
[5] | |||
| Compound Name |
Chembl4299336
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Investigative | Compound Info | ||
| Activity |
IC50 = 63000 nM
|
[10] | |||
| Compound Name |
Tert-butyl 4-[[1-[(2-hydroxyphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440538; BDBM50442019
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| Activity |
IC50 = 69200 nM
|
[7] | |||
| Compound Name |
[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334187; BDBM50442048
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| Activity |
IC50 = 69300 nM
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[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[(4-hydroxyphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440537; BDBM50442020
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| Activity |
IC50 = 70700 nM
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[7] | |||
| Compound Name |
N-[2-(2-Aminocyclopropyl)phenyl]benzamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416430
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| Activity |
IC50 = 74650 nM
|
[11] | |||
| Compound Name |
Chembl4250459
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463878
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| Activity |
IC50 ~ 75000 nM
|
[12] | |||
| Compound Name |
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-methoxybenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134340; ZINC57690631
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| Activity |
IC50 = 76050 nM
|
[5] | |||
| Compound Name |
Tert-butyl 4-[[1-[(3-hydroxyphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440540; BDBM50442017
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| Activity |
IC50 = 77100 nM
|
[7] | |||
| Compound Name |
(1R,2S)-2-(4-Fluorophenyl)cyclopropanamine Hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
(1R,2S)-2-(4-Fluorophenyl)cyclopropanamine HCl; (1R,2S)-2-(4-fluorophenyl)cyclopropan-1-amine hydrochloride; CHEMBL1795973; MFCD28386682; SCHEMBL16987869; trans-2-(4-Fluoro-phenyl)-cyclopropylamine hydrochloride; AKOS026741978; SB32794; SB36294; CS-12275; DB-102156; CS-0008704; trans-2-(4-Fluorophenyl)cyclopropanamine hydrochloride; trans-[2-(4-Fluorophenyl)cyclopropyl]amine hydrochloride; (1R,2S)-2-(4-Fluoro-phenyl)-cyclopropylamine hydrochloride
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| Activity |
Ki = 79600 nM
|
[13] | |||
| Compound Name |
Parnate
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Investigative | Compound Info | ||
| Synonyms |
tranylcypromine; (1R,2S)-2-phenylcyclopropan-1-amine; (1R,2S)-2-phenylcyclopropanamine; Transamine; d-Tranylcypromine; (1R,2S)-2-phenyl-cyclopropylamine; Cyclopropanamine, 2-phenyl-, trans-; trans-2-phenyl-cyclopropylamine; (1R,2S)-tranylcypromine; (+)-(R)-Tranylcypromine; Cyclopropanamine, 2-phenyl-, (1R,2S)-rel-; Jatrosom; (+)-Tranylcypromine; (1r,2s)-rel-2-phenylcyclopropanamine; trans-2-phenylcyclopropanamine; l-Tranylcypromine; dl-Tranylcypromine; NSC 80664; CHEMBL1179; Racemic Tranylcypromine; SKF 385; trans-DL-2-Phenylcyclopropylamine; (1R,2S)-rel-2-phenylcyclopropan-1-amine; trans-(-)-2-Phenylcyclopropanamine; Cyclopropanamine, 2-phenyl-, trans-(.+/-.)-; Cyclopropylamine, 2-phenyl-, trans-(.+/-.)-; Tranilcipromina; Parnitene; Tranylcyprominum; (1R)-1-Amino-2-phenylcyclopropane; 2-Phenyl-1-aminocyclopropane, trans-; Parnate (Salt/Mix); SKF-trans-385; Cyclopropylamine, 2-phenyl-, (1S-trans)-; (.+/-.)-Tranylcypromine; SKF Trans-385; Tranylcypromine [INN:BAN]; trans-2-phenylcyclopropan-1-amine; Tranylcipromine; Tranylcyprominum [INN-Latin]; trans amine; trans-amine; Tranilcipromina [INN-Spanish]; CCRIS 3344; Cyclopropanamine, 2-phenyl-, trans-(+-)-; (+/-)-trans-2-phenylcyclopropylamine; HSDB 3404; S-Tranylcypromine; (.+/-.)-trans-2-Phenylcyclopropamine; rel-Tranylcypromine; (.+/-.)-trans-2-Phenylcyclopropylamine; EINECS 205-841-9; BRN 2802413; BRN 3195803; Cyclopropylamine, 2-phenyl-, trans-(-)-; Cyclopropylamine, 2-phenyl-, trans-(+-)-; Prestwick0_000173; Prestwick1_000173; Prestwick2_000173; Lopac-P-8511; CBChromo1_000132; SCHEMBL34339; 3-12-00-02797 (Beilstein Handbook Reference); Cyclopropanamine, 2-phenyl-, (1R-trans)- (9CI); SPBio_001986; trans-2-phenyl cyclopropylamine; (1R,2S)-trans-tranylcypromine; DTXSID2023694; (Trans)-2-phenylcyclopropanamine; [trans-2-phenylcyclopropyl]amine; cid_2723716; CTK3G8797; DTXSID201015773; [(trans)-2-phenylcyclopropyl]amine; ZINC1482197; 4694AJ; 8372AH; BDBM50240772; PDSP2_001079; PDSP2_001080; (1R-trans)-2-phenyl-cyclopropanamine; AKOS006282586; (1R,2S)-2-phenyl-1-cyclopropanamine; NE64561; SB33883; SB36881; (1R,2S)-(-)-2-phenylcyclopropylamine; NCGC00015848-01; NCGC00015848-07; NCGC00015848-09; (tranylcypromine)2-Phenyl-cyclopropylamine; AC-15970; CS-0008259; trans-(1R,2S)-2-Phenylcyclopropan-1-amine; BRD-K47029922-003-03-4; UNII-3E3V44J4Z9 component AELCINSCMGFISI-DTWKUNHWSA-N
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| Activity |
IC50 = 80700 nM
|
[14] | |||
| Compound Name |
Tert-butyl 4-[[1-[(2,4-dihydroxyphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440541; BDBM50442016
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| Activity |
IC50 = 81300 nM
|
[7] | |||
| Compound Name |
[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl 4-(2-hydroxyethyl)piperazine-1-carbodithioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440559; BDBM50441992
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| Activity |
IC50 = 83400 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[(7-fluoro-2-oxochromen-4-yl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133848
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| Activity |
IC50 = 84200 nM
|
[15] | |||
| Compound Name |
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134332; ZINC57690622
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| Activity |
IC50 = 85700 nM
|
[5] | |||
| Compound Name |
[1-[[4-(Trifluoromethyl)phenyl]methyl]triazol-4-yl]methyl piperazine-1-carbodithioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440571; BDBM50442043
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| Activity |
IC50 = 87400 nM
|
[7] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-(3,6-dihydro-2H-pyridin-1-yl)hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402051; BDBM50067548
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| Activity |
IC50 = 88000 nM
|
[16] | |||
| Compound Name |
Tert-butyl 4-[[1-[(3,4-dichlorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334503; BDBM50442015
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| Activity |
IC50 = 88900 nM
|
[7] | |||
| Compound Name |
Oc1ccc(Cl)cc1Nc1nc2cc(ccc2[nH]1)S(=O)(=O)N1CCOCC1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3786908; SCHEMBL16535201; BDBM50158877; 4-chloro-2-((5-(morpholinosulfonyl)-1H-benzo[d]imidazol-2-yl)amino)phenol
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| Activity |
IC50 = 90000 nM
|
[17] | |||
| Compound Name |
1-Naphthalen-2-yloxy-3-(prop-2-ynylamino)propan-2-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426052; BDBM50440478
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|
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| Activity |
IC50 = 92200 nM
|
[8] | |||
| Compound Name |
N-[3-[3-[Methyl(prop-2-ynyl)amino]propoxy]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426047; BDBM50440480
Click to Show/Hide
|
||||
| Activity |
IC50 = 93100 nM
|
[8] | |||
| Compound Name |
4-Chloro-2-[[1-[(2-chlorophenyl)methyl]triazol-4-yl]methylsulfanyl]-6-phenylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415549; BDBM50075478
Click to Show/Hide
|
||||
| Activity |
IC50 = 97274.72 nM
|
[9] | |||
| Compound Name |
[[5-Cyano-2-[(3,4-dichlorophenyl)methylsulfanyl]-6-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl]amino]thiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415551; BDBM50075476
Click to Show/Hide
|
||||
| Activity |
IC50 = 98174.79 nM
|
[9] | |||
| Compound Name |
(1R,2S)-2-(2-Phenylphenyl)cyclopropan-1-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795984
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
4'-(Methoxycarbonyl)-[2,2'-bipyridine]-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
bipyridine analogue, 7; SCHEMBL2868531; CHEMBL3108956; BDBM26119; MFCD28291872; ZINC62232986; AS-39281; 2-(4-methoxycarbonylpyridin-2-yl)pyridine-4-carboxylic acid; 2-[4-(methoxycarbonyl)pyridin-2-yl]pyridine-4-carboxylic acid; 4-(METHOXYCARBONYL)-[2,2-BIPYRIDINE]-4-CARBOXYLIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2R)-2-aminopropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-(2,5-dihydropyrrol-1-yl)hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402050; BDBM50067547
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Ethyl (1S,2S)-1-amino-2-phenylcyclopropane-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330343; BDBM50023757; ZINC75422378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-[Benzyl-[(1S,2R)-2-phenylcyclopropyl]amino]-N-tert-butylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3651580; BDBM101266; US8524717, 21
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,2R)-2-Phenylcyclopropan-1-amine;(1R,2S)-2-phenylcyclopropan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3989843
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(1R,2S)-2-(3-Phenylphenyl)cyclopropan-1-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795983
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
1-Amino-2-phenylcyclopropanecarboxylic acid, cis-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-61O01AHZ0M; 61O01AHZ0M; CHEMBL3330344; SCHEMBL4739718; BDBM50023756; ZINC39208804; 1alpha-Amino-2alpha-phenylcyclopropanecarboxylic acid; (1S,2S)-1-Amino-2-phenylcyclopropanecarboxylic acid; (1S-cis)-1-Amino-2-phenyl-cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, cis-; (1S,2S)-1-amino-2-phenylcyclopropane-1-carboxylic acid; 1-Amino-2-phenylcyclopropanecarboxylic acid, (1S-cis)-; Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, (1S,2S)-; Cyclopropanecarboxylic acid, 1-amino-2-phenyl-, (1S-cis)-; UNII-D4NJ2ZUL47 component MRUPFDZGTJQLCH-WPRPVWTQSA-N; UNII-V1780T3AP6 component MRUPFDZGTJQLCH-WPRPVWTQSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-(2-hydroxyethyl)piperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440560; BDBM50441991
Click to Show/Hide
|
||||
| Activity |
IC50 = 100100 nM
|
[7] | |||
| Compound Name |
4-(Tert-Butoxycarbonyl)piperazine-1-dithiocarboxylic acid 1-(7-hydroxycoumarin-3-ylmethyl)-1H-1,2,3-triazole-4-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133845
Click to Show/Hide
|
||||
| Activity |
IC50 = 102560 nM
|
[15] | |||
| Compound Name |
1-(6-Bromonaphthalen-2-yl)oxy-3-(cyclopropylamino)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426134; BDBM50440476
Click to Show/Hide
|
||||
| Activity |
IC50 = 111400 nM
|
[8] | |||
| Compound Name |
1-[2-(4-Chloroanilino)-1,3-thiazol-4-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134310; ZINC122637; CCG-40660; MCULE-3532397608; SR-01000630786-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 121000 nM
|
[5] | |||
| Compound Name |
1-[2-(3-Chloroanilino)-1,3-thiazol-4-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134316
Click to Show/Hide
|
||||
| Activity |
IC50 = 123000 nM
|
[5] | |||
| Compound Name |
4-(4-Nitroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415532; BDBM50075497
Click to Show/Hide
|
||||
| Activity |
IC50 = 123310.48 nM
|
[9] | |||
| Compound Name |
[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl 4-methylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440552; BDBM50441999
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-Phenyl-2-prop-2-ynylsulfanyl-6-[3-(trifluoromethyl)anilino]pyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330502; BDBM50075501
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
[1-[(2-Chlorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334188; BDBM50442047
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl morpholine-4-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440530; BDBM50442053
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-(4-methylphenyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334493; BDBM50442012
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(3,4,5-Trimethoxyphenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334193; BDBM50442040
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl morpholine-4-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440529; BDBM50442054
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-(naphthalen-2-ylmethyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440546; BDBM50442005
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[(2-methylphenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440533; BDBM50442024
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(2,6-Difluorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440572; BDBM50442042
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(3-Chloroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330507; BDBM50075499
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
Tert-butyl 4-[[1-[[2-(trifluoromethyl)phenyl]methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440535; BDBM50442022
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl 4-ethylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440555; BDBM50441996
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(4-Bromophenyl)-6-(4-chloroanilino)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415536; BDBM50075491
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
4-Chloro-6-(4-chlorophenyl)-2-[[1-[(2-chlorophenyl)methyl]triazol-4-yl]methylsulfanyl]pyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415550; BDBM50075477
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[9] | |||
| Compound Name |
[1-[(2-Chlorophenyl)methyl]triazol-4-yl]methyl 4-methylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440554; BDBM50441997
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-(2-oxochromen-4-yl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440550; BDBM50442001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-ethylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440556; BDBM50441995
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-methylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440551; BDBM50442000
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl 4-(2-hydroxyethyl)piperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440561; BDBM50441990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[(5-oxo-2H-furan-3-yl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440549; BDBM50442002
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl morpholine-4-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440528; BDBM50442055
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(Tert-Butoxycarbonyl)piperazine-1-dithiocarboxylic acid 1-(coumarin-3-ylmethyl)-1H-1,2,3-triazole-4-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133844
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[15] | |||
| Compound Name |
4-(4-Chloroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330505; BDBM50075500
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[9] | |||
| Compound Name |
[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl piperidine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440523; BDBM50442060
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
2-Prop-2-ynylsulfanyl-4-[3-(trifluoromethyl)anilino]-6-(3,4,5-trimethoxyphenyl)pyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415538; BDBM50075489
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
Benzyl 4-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334487; BDBM50442036
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
(1-Benzyltriazol-4-yl)methyl piperidine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440525; BDBM50442058
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-(4-methoxyphenyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334495; BDBM50442011
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(Tert-Butoxycarbonyl)piperazine-1-dithiocarboxylic acid 1-(5-methyl-7-hydroxycoumarin-4-ylmethyl)-1H-1,2,3-triazole-4-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133840
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[15] | |||
| Compound Name |
4-Chloro-6-(4-nitrophenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415544; BDBM50075483
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[9] | |||
| Compound Name |
4-(Tert-Butoxycarbonyl)piperazine-1-dithiocarboxylic acid 1-(6-chlorocoumarin-4-ylmethyl)-1H-1,2,3-triazole-4-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133847
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[15] | |||
| Compound Name |
Tert-butyl 4-[[1-[2-(4-methylphenyl)ethyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440543; BDBM50442008
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(2-Chloroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329233; BDBM50075496
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
[[5-Cyano-2-[(4-fluorophenyl)methylsulfanyl]-6-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl]amino]thiourea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415552; BDBM50075475
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[9] | |||
| Compound Name |
Tert-butyl 4-[[1-[(6-methyl-2-oxochromen-4-yl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[15] | |||
| Compound Name |
[1-[(3,4-Dichlorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334192; BDBM50442041
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-(2-fluorophenyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334492; BDBM50442010
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[(4-nitrophenyl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440539; BDBM50442018
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl 4-phenylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440564; BDBM50441987
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[2-(4-fluorophenyl)ethyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440544; BDBM50442007
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(4-Methoxyanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330500; BDBM50075494
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl piperidine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440524; BDBM50442059
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Chlorophenyl)methyl]triazol-4-yl]methyl piperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334189; BDBM50442046
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-phenylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440563; BDBM50441988
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(4-Methoxyanilino)-2-prop-2-ynylsulfanyl-6-(3,4,5-trimethoxyphenyl)pyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415537; BDBM50075490
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl piperidine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440522; BDBM50442061
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Chlorophenyl)methyl]triazol-4-yl]methyl morpholine-4-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440531; BDBM50442052
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Fluorophenyl)methyl]triazol-4-yl]methyl 4-methylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440553; BDBM50441998
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(4-Chlorophenyl)-6-(4-methoxyanilino)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415534; BDBM50075493
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
Tert-butyl 4-[[1-[2-(2-oxochromen-4-yl)oxyethyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440545; BDBM50442006
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[3-(trifluoromethyl)phenyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2334494; BDBM50442009
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-(1H-benzimidazol-2-ylmethyl)triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440548; BDBM50442003
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-(4-Methylanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415533; BDBM50075495
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
[1-[(2-Fluorophenyl)methyl]triazol-4-yl]methyl 4-benzylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440558; BDBM50441993
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[[4-(trifluoromethyl)phenyl]methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440534; BDBM50442023
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
(1-Benzyltriazol-4-yl)methyl morpholine-4-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440527; BDBM50442056
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
Tert-butyl 4-[[1-[(2-oxo-1H-quinolin-4-yl)methyl]triazol-4-yl]methylsulfanylcarbothioyl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440547; BDBM50442004
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Methylphenyl)methyl]triazol-4-yl]methyl 4-benzylpiperazine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440557; BDBM50441994
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
[1-[(4-Chlorophenyl)methyl]triazol-4-yl]methyl piperidine-1-carbodithioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440526; BDBM50442057
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
4-Chloro-6-(3-chlorophenyl)-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415548; BDBM50075479
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
2-[[5-Cyano-6-(4-nitrophenyl)-2-prop-2-ynylsulfanylpyrimidin-4-yl]amino]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415530; BDBM50075502
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
4-(4-Chlorophenyl)-2-prop-2-ynylsulfanyl-6-[3-(trifluoromethyl)anilino]pyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415535; BDBM50075492
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[20] | |||
| Compound Name |
4-(4-Fluoroanilino)-6-phenyl-2-prop-2-ynylsulfanylpyrimidine-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415531; BDBM50075498
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[9] | |||
| Compound Name |
Tert-butyl (2S)-2-benzamido-6-(but-2-ynylamino)hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426041; BDBM50440482
Click to Show/Hide
|
||||
| Activity |
IC50 = 131900 nM
|
[8] | |||
| Compound Name |
Tert-butyl (2S)-2-benzamido-6-(prop-2-ynylamino)hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426040; BDBM50440483
Click to Show/Hide
|
||||
| Activity |
IC50 = 143600 nM
|
[8] | |||
| Compound Name |
2-(4-Cyano-N-(4-methylphenyl)sulfonylanilino)-N-pyridin-3-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093280; BDBM50241518
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[21] | |||
| Compound Name |
2-[5-[(3R)-3-Aminopiperidine-1-carbonyl]-2-(4-cyanophenyl)pyrazol-3-yl]oxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070901; BDBM50242958
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[22] | |||
| Compound Name |
trans-2-Phenylcyclopropylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(1S,2R)-2-phenylcyclopropanamine; (1S,2R)-2-phenylcyclopropan-1-amine; (1S,2R)-2-Phenyl-cyclopropylamine; (-)-Tranylcypromine; (1S,2R)-tranylcypromine; (+)-Tranylcypromine; tranylcypromine; Cyclopropanamine, 2-phenyl-, (1S,2R)-; CHEMBL257990; l-Tranylcypromine; 2-Phenyl-1-aminocyclopropane, trans-; Cyclopropylamine, 2-phenyl-, (1S-trans)-; trans-2-phenylcyclopropan-1-amine; trans-(-)-2-Phenylcyclopropanamine; MFCD01735853; R-Tranylcypromine; MLS001306494; SCHEMBL145650; (1S,2R)-trans-tranylcypromine; BRD9146; HMS2089B04; ZINC896663; (+)-trans-2-Phenylcyclopropylamine; BRD-9146; (1S-trans)-2-Phenylcyclopropanamine; 8412AH; BDBM50236898; STL563237; (+)-trans-2-Phenyl-cyclopropyl-amin; 1s,2r-trans-2-phenylcyclopropylamine; (1S,2R)-2-phenyl-1-cyclopropanamine; MCULE-4252215835; NE64562; SB36882; (1S,2R)-(+)-2-phenylcyclopropylamine; NCGC00179670-01; SMR000039637; Cyclopropanamine, 2-phenyl-, trans-(+)-; CYCLOPROPYLAMINE, 2-PHENYL-, trans-; BRD-K88809146-003-02-1; UNII-3E3V44J4Z9 component AELCINSCMGFISI-BDAKNGLRSA-N
Click to Show/Hide
|
||||
| Activity |
Ki = 168000 nM
|
[13] | |||
| Compound Name |
(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-carbamimidamido-2-[(2-hydroxyacetyl)amino]pentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081282
Click to Show/Hide
|
||||
| Activity |
Ki = 170000 nM
|
[23] | |||
| Compound Name |
N-[3-[3-(Prop-2-ynylamino)propoxy]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426046; BDBM50440481
Click to Show/Hide
|
||||
| Activity |
IC50 = 184200 nM
|
[8] | |||
| Compound Name |
1-(4-Acetyl-1,3-thiazol-2-yl)-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134329; AKOS013870101
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134333
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
N-(4-Acetyl-1,3-thiazol-2-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134328; ZINC22532114; AKOS001395939; MCULE-9828820221; Z245068452
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1-phenylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134336
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
1-[2-(3-Hydroxyanilino)-1,3-thiazol-4-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-N,4-dimethylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134335
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
N-(4-Acetyl-1,3-thiazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134330; AKOS012297576
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
1-[2-(2-Methylanilino)-1,3-thiazol-4-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134317
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
1-{2-[(4-Methoxyphenyl)amino]-1,3-thiazol-4-yl}ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3134324; ZINC71562901; AKOS022554129; Z2158749031
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL)BENZAMIDE; Oprea1_299600; CHEMBL3134331; ZINC46947; STK804781; AKOS000523194; MCULE-3067585607; ST036747; N-(4-(4-chlorophenyl)thiazol-2-yl)benzamide; SR-01000401059; SR-01000401059-1; N-[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]benzamide; F0098-0284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000578538; Oprea1_848524; CHEMBL1609289; HMS2515B22; HMS3375M18; STK447457; STK853370; ZINC13549450; AKOS003268110; AKOS005630363; MCULE-8578217985; SMR000197725; ST50918754; 1-(4-(4-chlorophenyl)thiazol-2-yl)-3-phenylurea; F5772-7667; N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-N'-phenylurea; {[4-(4-chlorophenyl)(1,3-thiazol-2-yl)]amino}-N-benzamide; 1-[(2E)-4-(4-chlorophenyl)-1,3-thiazol-2(3H)-ylidene]-3-phenylurea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
2-(4-Methoxyphenyl)cyclopropan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-Methoxyphenyl)Cyclopropanamine; Cyclopropanamine, 2-(4-methoxyphenyl)-; CHEMBL1938899; 4-Methoxytranylcypromine; SCHEMBL7094099; DTXSID80940551; 2-(4-methoxyphenyl)cyclopropylamine; BDBM50361479; SBB084072; AKOS005217124; 2-(4-Methoxy-phenyl)-cyclopropylamine; MCULE-9424350399; DB-127242; EN300-64560
Click to Show/Hide
|
||||
| Activity |
Ki = 188000 nM
|
[24] | |||
| Compound Name |
1-[2-(2-Chloroanilino)thiazole-4-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000834930; CHEMBL1594810; HMS2810H10; ZINC122641; CCG-254672; MCULE-9547520105; SMR000461446; 1-[2-(2-chloroanilino)-1,3-thiazol-4-yl]ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 188000 nM
|
[5] | |||
| Compound Name |
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-Amino-1-[(2S)-2-[[(2S)-1-amino-6-[(2-hydroxyacetyl)amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-(2-hydroxyacetyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885101; BDBM50210049
Click to Show/Hide
|
||||
| Activity |
Ki = 190000 nM
|
[25] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID25468267-Compound-46
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 620000 nM
|
[26] | |||
| Compound Name |
(2S)-1-[(17S,20S,23S,26S,29S,32S,35S,38S)-29-Benzyl-20,35-bis[3-(diaminomethylideneamino)propyl]-32-(hydroxymethyl)-26-(2-methylpropyl)-2,11,19,22,25,28,31,34,37-nonaoxo-23-propan-2-yl-3,10-dioxa-1,12,18,21,24,27,30,33,36-nonazabicyclo[36.3.0]hentetracontane-17-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884529; BDBM50210050; J3.603.361D
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[25] | |||
| Compound Name |
(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099300
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[23] | |||
| Compound Name |
(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[(2-hydroxyacetyl)amino]propanoyl]amino]pentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104579
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[23] | |||
| Compound Name |
(2S)-2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[(2-hydroxyacetyl)amino]propanoyl]amino]pentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]-6-[(2-hydroxyacetyl)amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081041
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[23] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-Amino-2-[[2-[[2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[(2-hydroxyacetyl)amino]propanoyl]amino]pentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-6-[(2-hydroxyacetyl)amino]hexanoyl]amino]-N-[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]pentanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069633
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| Activity |
Ki > 500000 nM
|
[23] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
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| REF 2 | 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2016 Jan 14;59(1):253-263. | ||||
| REF 3 | US patent application no. 8524717B2, Oxidase inhibitors and their use | ||||
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| REF 8 | Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity. J Med Chem. 2013 Sep 26;56(18):7334-42. | ||||
| REF 9 | 3D-QSAR (CoMFA, CoMSIA), molecular docking and molecular dynamics simulations study of 6-aryl-5-cyano-pyrimidine derivatives to explore the structure requirements of LSD1 inhibitors. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3521-3528. | ||||
| REF 10 | Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators. J Med Chem. 2016 Feb 25;59(4):1531-44. | ||||
| REF 11 | Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts. Eur J Med Chem. 2015 Apr 13;94:163-74. | ||||
| REF 12 | Optimization of 5-arylidene barbiturates as potent, selective, reversible LSD1 inhibitors for the treatment of acute promyelocytic leukemia. Bioorg Med Chem. 2018 Sep 15;26(17):4871-4880. | ||||
| REF 13 | Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3709-16. | ||||
| REF 14 | Design, synthesis and evaluation of -turn mimetics as LSD1-selective inhibitors. Bioorg Med Chem. 2018 Feb 1;26(3):775-785. | ||||
| REF 15 | Synthesis and biological evaluation of coumarin-1,2,3-triazole-dithiocarbamate hybrids as potent LSD1 inhibitors. Medchemcomm. 2014;5:650-4. | ||||
| REF 16 | Histone H3 peptide based LSD1-selective inhibitors. Bioorg Med Chem Lett. 2015 May 1;25(9):1925-8. | ||||
| REF 17 | Recent Progress in Histone Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1308-29. | ||||
| REF 18 | Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem. 2014 Jan 9;57(1):42-55. | ||||
| REF 19 | Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. Eur J Med Chem. 2014 Oct 30;86:352-63. | ||||
| REF 20 | Design, synthesis, and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents. J Med Chem. 2015 Feb 26;58(4):1705-16. | ||||
| REF 21 | Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2017 Oct 12;60(19):7984-7999. | ||||
| REF 22 | Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3190-3195. | ||||
| REF 23 | Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorg Med Chem. 2017 May 1;25(9):2617-2624. | ||||
| REF 24 | Lysine demethylases inhibitors. J Med Chem. 2011 Dec 22;54(24):8236-50. | ||||
| REF 25 | Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker. Bioorg Med Chem. 2017 Feb 1;25(3):1227-1234. | ||||
| REF 26 | Development of second generation epigenetic agents. Medchemcomm. 2012;3:135-61. | ||||
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