Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16808 | Target Info | |||
| Target Name | Protein arginine methyltransferase 1 (PRMT1) | ||||
| Synonyms |
Protein arginine N-methyltransferase 1; Interferon receptor 1-bound protein 4; IR1B4; Histone-arginine N-methyltransferase PRMT1; HRMT1L2; HMT2
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PRMT1 | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 40 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Pentamidine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (*Isethionate); Pentacarinat (*Isethionate); Pentam 300 (*Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (*Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[1] | |||
| Compound Name |
GSK343
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
compound 6 [PMID 24900432]; GSK 343
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(3-Bromophenyl)methyl]-1-[2-(methylamino)ethyl]piperidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-[3-[[(1S,2R,3S,4R)-4-(6-Aminopurin-9-yl)-2,3-dihydroxycyclopentyl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3087501; SCHEMBL16424780; BDBM50443020
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
1-[3-[[(1R,2R,3S,4R)-4-(6-Aminopurin-9-yl)-2,3-dihydroxycyclopentyl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3087503; SCHEMBL16424848; BDBM50443018
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
N-Benzyl-1-[2-(methylamino)ethyl]piperidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099850
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-[3-[[(3R,4S,5R)-3-(6-Aminopurin-9-yl)-4,5-dihydroxycyclopenten-1-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3087502; SCHEMBL16424776; BDBM50443019
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
5'-[(3-{[(4-Tert-Butylphenyl)carbamoyl]amino}propyl)(Propan-2-Yl)amino]-5'-Deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171169; SCHEMBL9970132; BDBM50396980; ZINC95557720; Q27458098
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
7-Hydroxy-8-((2-methoxy-5-(vinylsulfonyl)phenyl)diazenyl)naphthalene-1,3-disulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271164; CBDivE_002781; SCHEMBL13880753; BDBM50328744
Click to Show/Hide
|
||||
| Activity |
IC50 = 50500 nM
|
[5] | |||
| Compound Name |
Hexamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hexamidina; Hexamidinum; UNII-3483C2H13H; CHEMBL25105; 4,4'-(1,6-Hexanediylbis(oxy))bis-benzenecarboximidamide; 3483C2H13H; 4,4'-[hexane-1,6-diylbis(oxy)]dibenzenecarboximidamide; Hexamidinum [INN-Latin]; Hexamidina [INN-Spanish]; CHEMBL494852; Hexamidine [INN:BAN:DCF]; 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide; Hexamidine[antipeptic]; Hexamidine (INN/BAN); 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzamidine; SCHEMBL144738; 1,6-Di(4-amidinophenoxy)hexane; DTXSID60191524; 4,4'[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE; Benzenecarboximidamide, 4,4'-(1,6-hexanediylbis(oxy))bis-; ZINC1705403; BDBM50015234; STL483397; 1,6-Di (4-amidinophenoxy)-n-hexane; DB03808; FT-0700701; FT-0700706; D07206; Q250360; 4-[6-(4-Carbamimidoyl-phenoxy)-hexyloxy]-benzamidine; 4,4'-[hexane-1,6-diylbis(oxy)]di(benzene-1-carboximidamide); 4,4''''[1,6-HEXANEDIYLBIS(OXY)]BISBENZENECARBOXIMIDAMIDE; 4-{6-[4-amino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanamine; 4-{6-[4-ammino(imino)methylphenoxy]hexyloxy}phenyl-iminomethanammine
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
Stilbamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Diamidino stilbene; 4,4'-Diamidinostilbene; Benzamidine, 4,4'-vinylenedi-; UNII-ST31IIO5EW; 4,4'-Stilbenedicarboxamidine; BA 2652; ST31IIO5EW; CHEMBL142304; Stilbamidinum; NSC-35605; Stilbamidine [BAN]; EINECS 204-519-5; BRN 3206434; Stilbamidin; 4-09-00-03639 (Beilstein Handbook Reference); SCHEMBL208655; ZINC2079; NCI35605; BDBM50210461; CCG-36712; HY-U00007; CS-6597; 4,4''-(ethene-1,2-diyl)dibenzimidamide; 4,4'-(1,2-Ethanediyl)bisbenzenecarboximidamide; Benzenecarboximidamide, 4,4'-(1,2-ethenediyl)bis-; Q27289385; 4-((E)-2-{4-[(Z)-amino(imino)methyl]phenyl}vinyl)benzenecarboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
N-(3-(1H-Imidazol-4-yl)propyl)-9H-purin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390383; BDBM50210466
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[6] | |||
| Compound Name |
2-Benzylsulfanyl-2-methylpropan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227298; NSC-154983; 2-benzylthio 2-methyl propylamine; 2-(benzylthio)-2-methyl-1-propanamine; 2-(benzylthio)-2-methylpropan-1-amine; NSC154983; 2-Methyl-2-(benzylthio)propylamine; NCIStruc1_000860; NCIStruc2_000934; SCHEMBL1654642; SCHEMBL11188983; 2-Benzylthio-2-methylpropylamine; CTK2F5353; DTXSID00329763; 2-(benzylthio)-2-methylpropylamine; ZINC1873109; BDBM50210462; CCG-37527; NCGC00014423; NCI154983; NCGC00014423-02; NCGC00097528-01; NCI60_001101
Click to Show/Hide
|
||||
| Activity |
IC50 = 56500 nM
|
[6] | |||
| Compound Name |
4'-Sulfanilylbenzanilide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797441; BRN 3426549; Benzanilide, 4'-sulfanilyl-; Benzanilide, 4'-((p-aminophenyl)sulfonyl)-; DTXSID20954339; BDBM50346722; 3-13-00-01300 (Beilstein Handbook Reference); N-[4-(4-Aminobenzene-1-sulfonyl)phenyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 65600 nM
|
[7] | |||
| Compound Name |
4-Iodo-N-[4-(2-phenylethylsulfamoyl)phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797551; BDBM50346717
Click to Show/Hide
|
||||
| Activity |
IC50 = 68100 nM
|
[7] | |||
| Compound Name |
4,5-Dihydroxy-3-((8-hydroxy-3,6-disulfonatonaphthalen-1-yl)diazenyl)naphthalene-2,7-disulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL409290; CBDivE_013166; SCHEMBL11233580; BDBM50328745; ZINC49794030; AKOS000577547; ZINC261109255
Click to Show/Hide
|
||||
| Activity |
IC50 = 68200 nM
|
[5] | |||
| Compound Name |
4-Amino-N-(pyridin-2-ylmethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797556; Oprea1_709753; MLS001197338; SCHEMBL15822958; CTK7D7940; HMS2854J16; ZINC233866; ALBB-006217; BDBM50346720; MFCD02109647; STK503768; AKOS000142139; MCULE-8617300646; SMR000555310; EU-0039085; Y-9683; SR-01000441229; SR-01000441229-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 70700 nM
|
[7] | |||
| Compound Name |
2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Funduscein-25; 2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid; Fluorescite; 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID; CHEMBL177756; 2-(6-hydroxy-3-oxoxanthen-9-yl)benzoic acid; 2-(6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; flourescein; cid_3383; CBDivE_002901; SCHEMBL107875; ARONIS014456; CTK1G3923; KS-000044VW; ZINC3872582; BBL002034; BDBM50143424; SBB001359; STK391288; AKOS000503167; MCULE-8810198732; TG2-210; NS-05493; ST009474; T7547; C.I.45350:1; 2-(3-hydroxy-6-keto-xanthen-9-yl)benzoic acid; 2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoesaure; 321H075; 2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid; 2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid #; 3H-Xanthen-3-one, 6-hydroxy-10-[2-carboxyphenyl]-; Q27460338; 3',6'-Dihydroxy-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one; (3H)Xanthen-3-one, 10-deshydro-6-hydroxy-10-[2-carboxyphen-1-yl]-; 3'',6''-dihydroxyspiro[1,3-dihydroisobenzofuran-1,9''-(9''H-xanthene)]-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[8] | |||
| Compound Name |
Guanidine, 5-nitro-1H-benzimidazol-2-yl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC126757; NSC-126757; 2-guanidino-5-nitrobenzimidazole; MLS000737577; CHEMBL228132; 2-Guanidine-5-nitrobenzimidazole; NSC 126757; 5-Nitro-1H-benzimidazol-2-ylguanidine; 2-(6-nitro-1H-benzimidazol-2-yl)guanidine; NCIStruc1_000886; NCIStruc2_000775; 1-(6-nitro-1H-1,3-benzodiazol-2-yl)guanidine; SCHEMBL6990673; DTXSID00194690; HMS2885L14; BDBM50210467; CCG-37576; NCGC00014283; NCI126757; ZINC13147221; AKOS024333484; MCULE-5394726598; NCGC00014283-02; NCGC00097392-01; NCI60_000612; SMR000528567; N-(5-nitro-1H-benzoimidazol-2-yl)-guanidine; 1-(5-nitro-1H-benzo[d]imidazol-2-yl)guanidine; N-(5-(hydroxy(oxido)amino)-1H-benzimidazol-2-yl)guanidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 76100 nM
|
[6] | |||
| Compound Name |
N-[(4-Methylphenyl)methyl]-7H-purin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441718; N-(4-methylbenzyl)-N-(9H-purin-6-yl)amine; Oprea1_836830; SCHEMBL723525; IFLab1_002231; CTK2G8676; DTXSID20357341; HMS1418F09; ZINC385656; BDBM50210460; STK944580; AKOS001396664; AKOS008968153; CCG-330032; MCULE-7554472890; N-(4-methylbenzyl)-9H-purin-6-amine; [(4-methylphenyl)methyl]purin-6-ylamine; NCGC00168550-01; (4-methyl-benzyl)-(9H-purin-6-yl)-amine; ST50139385; 1H-Purin-6-amine, N-[(4-methylphenyl)methyl]-; AP-770/42745240; SR-01000007301; SR-01000007301-1; Z372978570
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[6] | |||
| Compound Name |
6-[(6-Carboxy-8-hydroxynaphthalen-2-yl)carbamoylamino]-4-hydroxynaphthalene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179350
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[9] | |||
| Compound Name |
3-Hydroxy-4-(naphthalen-1-yldiazenyl)-7-nitronaphthalene-1-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375405; BDBM50206436
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[8] | |||
| Compound Name |
(2S)-2-Amino-5-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2172427; BDBM50396017
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-(2-Methoxybenzyl)-1-(3-((2-(methylamino)ethylamino)methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080460; SCHEMBL5069659; BDBM50311688
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNC0379; UNC-0379; CHEMBL3318285; UNC 0379; 6,7-Dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine; C23H35N5O2; CS-3345; HY-12335; SCHEMBL22568439; AOB6365; EX-A461; SYN5081; BCP10429; KS-00000T5A; 3362AH; BDBM50051117; MFCD28167817; s7570; ZINC98214604; AKOS025404942; UNC 0379;UNC-0379; CCG-268809; SB19349; NCGC00384189-06; NCGC00384189-10; AK174945; AS-16447; DA-43617; B8009; FT-0699830; A14320; UNC0379 trifluoroacetate salt, >=98% (HPLC)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S)-2-Amino-5-[[(2R,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2169918; BDBM50396016
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GSK926; CHEMBL2204998; SCHEMBL2590353; BDBM50400779
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-(4-Tert-butylphenyl)-3-[3-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(prop-2-enylamino)purin-9-yl]oxolan-2-yl]methyl-propan-2-ylamino]propyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171171; BDBM50396978
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
1-[3-[[(2R,3S,4R,5R)-5-[6-(Benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171172; BDBM50396977
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
Chembl4282866
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50470498; ZINC38895935; AT-096/43397269; 4-[2-(1,3-benzothiazol-2-yl)vinyl]-N,N-diethylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1-(4-Tert-butylphenyl)-3-[3-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methyl-propan-2-ylamino]propyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171170; BDBM50396979
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204997; SCHEMBL12180659; BDBM50400781
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Hydroxy-5-{[4-(4-methoxy-3-methylphenyl)-1,3-thiazol-2-yl]amino}benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4128513; Oprea1_203261; ZINC955929; BDBM50271657; STK024442; AKOS001673438; MCULE-8723917637; SR-01000111406; SR-01000111406-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(S)-1-(5-((2-Aminopropanamido)methyl)thiophen-3-yl)-N-(2-methoxybenzyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazole scaffold, 7a; CHEMBL475503; SCHEMBL5064201; BDBM27642; ZINC40406065
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Methyl 2-[[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PRMT5-IN-C17; ZINC00659298; ChemDiv1_002844; Oprea1_645106; CHEMBL4092336; HMS595B06; ZINC5455374; STK346078; AKOS000421473; AKOS000830714; MCULE-9755352312; AG-690/12869587; SR-01000429953; SR-01000429953-1; Z16078172; methyl 2-({[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoate; methyl 2-({[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoate; methyl 2-{2-[(6-methoxy-1H-1,3-benzodiazol-2-yl)sulfanyl]acetamido}benzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
4-Hydroxy-6-(phenylamino)naphthalene-2-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Anilino-1-naphthol-3-sulfonic Acid; 6-anilino-4-hydroxynaphthalene-2-sulfonic acid; 6-Anilino-4-hydroxynaphthalene-2-sulphonic acid; 7-Anilino-1-naphthol-3-sulfonicAcid; MLS002638059; CHEMBL1271266; 6-anilino-4-hydroxy-2-naphthalenesulfonic acid; Gamma acid, N-phenyl-; 2-Naphthalenesulfonic acid, 6-anilino-4-hydroxy-; 2-Naphthalenesulfonic acid, 4-hydroxy-6-(phenylamino)-; NSC8660; Phenyl gamma-Acid; N-Phenylgamma acid; EINECS 204-305-1; ACMC-1BOVI; CBChromo1_000073; 2-Aniline-8-hydroxy-6-naphthalene sulfonic acid; CBDivE_001845; cid_67062; SCHEMBL590150; CTK0H7058; DTXSID20152277; HMS3084M21; NSC-8660; NSC37154; ZINC1648162; ANW-17290; BBL000678; BDBM50328746; MFCD00021509; NSC-37154; STK366700; 2-Anilino-8-naphthol-6-sulfonic acid; AKOS005443024; MCULE-4917868370; KS-000012K5; AC-14008; SMR000069020; AB0017281; FT-0621354; P0137; ST50545251; T7336; AB00074270-01; 4-hydroxy-6-(phenylamino)naphthalene-2-sulfonate; SR-01000196555; SR-01000196555-1; W-108525; 2-Naphthalenesulfonicacid, 4-hydroxy-6-(phenylamino)-; 4-Hydroxy-6-(phenylamino)-2-naphthalenesulfonic Acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 104200 nM
|
[5] | |||
| Compound Name |
Fluorone black
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Phenylfluorone; 9-Phenyl-2,3,7-trihydroxy-6-fluorone; Fluorone, phenyl-; 2,6,7-Trihydroxy-9-phenylxanthen-3-one; 2,6,7-Trihydroxy-9-phenyl-3H-xanthen-3-one; 3H-Xanthen-3-one, 2,6,7-trihydroxy-9-phenyl-; UNII-73861AE9L7; 2,3,7-Trihydroxy-9-phenyl-6-fluorone; CHEMBL375328; NSC2608; C19H12O5; MFCD00005048; 73861AE9L7; 9-pheny-3-fluorone; 2,7-Trihydroxy-9-phenyl-6-fluorone; 9-Phenyl-2,7-trihydroxy-6-fluorone; 3H-Xanthen-3-one,6,7-trihydroxy-9-phenyl-; 9-Phenyl-3-fluorone; phenylfluoron; NSC 2608; EINECS 213-550-3; NSC 66463; 9-PhFl; 2,6,7-Trihydroxy-9-phenyl-3-isoxanthone; 2,6,7-trihydroxy-9-phenyl-xanthen-3-one; AI3-63041; Chembridge 5108509; 2,6,7-Trihydroxy-9-phenylisoxanthene-3-one; CBChromo1_000049; CBDivE_003845; CBDivE_004001; cid_70420; SCHEMBL2860609; DTXSID2061355; NSC-2608; NSC66463; ZINC3860685; BDBM50206442; NSC-66463; SBB056803; STK003215; AKOS000520600; MCULE-3716942314; NE10373; 9-Phenyl-2,3-7-trihydroxy-6-fluorone; AS-66194; TG2-222-7; FT-0621686; ST50307979; X6793; 2,6,7-Trihydroxy-9-phenyl-3H-xanthen-3-one #; SR-01000404013; SR-01000404013-1; Q27266154
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[8] | |||
| Compound Name |
(2E)-1-Butyl-2-[(E)-3-(1-butyl-3,3-dimethylindol-1-ium-2-yl)prop-2-enylidene]-3,3-dimethylindole;iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2047479
Click to Show/Hide
|
||||
| Activity |
IC50 = 160800 nM
|
[18] | |||
| Compound Name |
1-(2,4,6-Trioxo-tetrahydropyrimidin-5(6H)-ylideneamino)-1,3,5-triazinane-2,4,6-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220162; BDBM50206438
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 164000 nM
|
[8] | |||
| Compound Name |
C.I. Direct Red 23
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092740; NSC-47762; CTK4F5168; DTXSID40892289; EINECS 246-726-3; BDBM50328743; ZINC95101015; ZINC150347502; ZINC150347503; ZINC150347504; ZINC257354982
Click to Show/Hide
|
||||
| Activity |
IC50 = 176500 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 38 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Suramin
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
Antrypol; Belganyl; Farma; Fourneau; Germanin; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride; SVR; Suramine; SURAMIN SODIUM; Sodium suramin; Suramine sodium; Farma 939; Naganol 6 Na; Germanin (TN); SGCTO-001
Click to Show/Hide
|
||||
| Activity |
IC50 = 1011000 nM
|
[5] | |||
| Compound Name |
SACCHARIN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
saccharin; 81-07-2; o-Sulfobenzimide; Saccharine; o-Benzoic sulfimide; Saccharimide; Benzosulfimide; o-Benzosulfimide; Benzoic sulfimide; Benzosulphimide; Saccharinose; Garantose; Saccharinol; Gluside; Saccharin acid; Benzosulfinide; Hermesetas; Saccharol; Sweeta; Saccharin insoluble; Glucid; Benzoic sulphimide; 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide; Saccharina; Zaharina; Sucrette; Sacarina; Kandiset; Sykose; Saxin; o-Benzoyl sulfimide; Benzo-2-sulphimide; Sucre edulcor; o-Benzoic sulphimide; Benzoylsulfonic Imide; o-Sulfobenzoic acid im
Click to Show/Hide
|
||||
| Activity |
IC50 > 510000 nM
|
[8] | |||
| Compound Name |
7-amino-4-hydroxy-2-naphthalenesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
87-02-5; J acid; 7-AMINO-4-HYDROXY-2-NAPHTHALENESULFONIC ACID; 7-amino-4-hydroxynaphthalene-2-sulfonic acid; Isogamma acid; I acid; 2-Naphthalenesulfonic acid, 7-amino-4-hydroxy-; Kyselina I; 2-Amino-5-naphthol-7-sulfonic Acid; Kyselina I [Czech]; Aminonaphthol sulfonic acid J; 6-Amino-1-naphthol-3-sulfonic acid; CCRIS 8989; EINECS 201-718-9; NSC 31510; Kyselina 2-amino-5-naftol-7-sulfonova; BRN 2217192; UNII-9A1IU1C93L; MLS002638012; CHEMBL220259; 9A1IU1C93L; CHEBI:87316; 7-Amino-4-hydroxynaphthalene-2-sulphonic acid; Kyselina 6
Click to Show/Hide
|
||||
| Activity |
IC50 = 928000 nM
|
[8] | |||
| Compound Name |
5-(3,5-Dichloro-2-hydroxybenzylideneamino)naphthalene-1-sulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271373; CBMicro_022403; CCG-9368; BDBM50328750; BIM-0022399.P001
Click to Show/Hide
|
||||
| Activity |
IC50 = 205900 nM
|
[5] | |||
| Compound Name |
(E)-5-(5-Chloro-2-hydroxybenzylideneamino)naphthalene-1-sulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271374; BDBM50328751
Click to Show/Hide
|
||||
| Activity |
IC50 = 234100 nM
|
[5] | |||
| Compound Name |
[4-[(3-Hydroxynaphthalene-2-carbonyl)diazenyl]anilino] benzenesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171190; BDBM50397031
Click to Show/Hide
|
||||
| Activity |
Ki > 257000 nM
|
[19] | |||
| Compound Name |
4-[(4-Aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Fuchsine Base; Rosaniline base; rosanilin free base; MAGENTA BASE; CI Solvent Red 41; C.I. Solvent Red 41; C.I. Basic Violet 14, free base; CI Basic Violet 41, free base; CI 42510B; UNII-I8F3948441; Solvent Red 41; CHEMBL220998; 4-[(4-aminophenyl)-(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]aniline; para-Rosaniline; Fuchsive base; I8F3948441; Fuchsin (basic); Magenta base; Rosaniline Base; Waxoline Red A; Waxoline Red A; Fuchsine HF Base; C.I. 42510 acetate; Brilliant Oil Crimson Base; NSC5006; NSC10466; C.I. Solvent Red 41, monoacetate; HSDB 2955; NCGC00166015-01; EINECS 221-832-2; BRN 2814815; ROSANILINE HCl; C.I. Basic Violet 14- free base (parent); NCIMech_000176; o-Toluidine, 4-((p-aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl)-; Neuro_000040; SCHEMBL238220; CHEMBL4303311; DTXSID0043844; SCHEMBL14948114; ZINC5138592; BBL034707; BDBM50206428; CCG-35316; MFCD00055278; STL280466; 4-((4-Aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl)-o-toluidine; AKOS022127403; ZINC100089805; MCULE-3096256630; VA10376; NCGC00166015-02; NCI60_042092; SC-48548; DB-048226; FT-0634748; A821298; Q27159811; F8880-7574; 2-Methyl-4-[bis(4-aminophenyl)methylene]-2,5-cyclohexadiene-1-imine; 4-((4-aminophenyl)(4-iminocyclohexa-2,5-dienylidene)methyl)-2-methylaniline; 4-[(4-aminophenyl)-(4-imino-3-methyl-1-cyclohexa-2,5-dienylidene)methyl]aniline
Click to Show/Hide
|
||||
| Activity |
IC50 = 280000 nM
|
[8] | |||
| Compound Name |
Gallion
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CBDivE_001968; EINECS 223-205-9; CHEMBL3351046; CTK1C2602; MFCD00021475; ZINC64527371; ZINC261190223; 8-Amino-2-(3-chloro-2-hydroxy-5-nitrophenylazo)-1-naphthol-3,6-disulfonic Acid; G0222
Click to Show/Hide
|
||||
| Activity |
IC50 = 280600 nM
|
[5] | |||
| Compound Name |
1,1'-Diethyl-3,3,3',3'-tetramethylindocarbocyanine iodide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
C3-indocyanine; Astrophloxine; CHEMBL467894; Indocarbocyanine(C3); C3-DI (C3-di-indolenine); MFCD22573598; J-008291; Q27123556
Click to Show/Hide
|
||||
| Activity |
IC50 = 284200 nM
|
[18] | |||
| Compound Name |
3-[(2E)-5-Bromo-2-[(E)-3-[5-bromo-3,3-dimethyl-1-[3-(trimethylazaniumyl)propyl]indol-1-ium-2-yl]prop-2-enylidene]-3,3-dimethylindol-1-yl]propyl-trimethylazanium;tribromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2047482
Click to Show/Hide
|
||||
| Activity |
IC50 = 291700 nM
|
[18] | |||
| Compound Name |
5-Amino-4-hydroxy-3-((4-sulfonatophenyl)diazenyl)naphthalene-2,7-disulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269836; SCHEMBL7065494; BDBM50328753
Click to Show/Hide
|
||||
| Activity |
IC50 = 325000 nM
|
[5] | |||
| Compound Name |
3-[(2E)-2-[(E)-3-[3,3-Dimethyl-1-[3-(trimethylazaniumyl)propyl]indol-1-ium-2-yl]prop-2-enylidene]-3,3-dimethylindol-1-yl]propyl-trimethylazanium;tribromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2047481
Click to Show/Hide
|
||||
| Activity |
IC50 = 368300 nM
|
[18] | |||
| Compound Name |
Methyl red
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
O-METHYL RED; C.I. Acid Red 2; Acid Red 2; 4-Dimethylamino-2'-carboxylazobenzene; 2-Carboxy-4'-(dimethylamino)azobenzene; Cerven methylova; 2-(4-Dimethylaminophenylazo)benzoic acid; Cerven kysela 2; p-(Dimethylamino)azobenzene-o-carboxylic acid; Benzoic acid, 2-[[4-(dimethylamino)phenyl]azo]-; 2-((4-Dimethylamino)phenylazo)benzoic acid; C.I. 13020; o-((p-(Dimethylamino)phenyl)azo)benzoic acid; 4'-Dimethylaminoazobenzene-2-carboxylic acid; NSC 215212; UNII-69083AX1ZX; Methyl Red (C.I. 13020); 4-Dimethylaminoazobenzene-2'-carboxylic acid; Methyl Red, ACS reagent; 4'-(Dimethylamino)azobenzene-2-carboxylic acid; MFCD00002425; Benzoic acid, o-((p-(dimethylamino)phenyl)azo)-; 2-[[4-(dimethylamino)phenyl]diazenyl]benzoic acid; 2-[(p-Dimethylamino)phenyl]azobenzoic acid; CHEMBL375971; 2-(4-Dimethylaminophenyl)diazenylbenzoic Acid; Benzoic acid, 2-((4-dimethylamino)phenylazo)-; 69083AX1ZX; 2-{[4-(dimethylamino)phenyl]diazenyl}benzoic acid; Benzoic acid, 2-((4-(dimethylamino)phenyl)azo)-; Methyl Red, pure, indicator; 2-((4-(dimethylamino)phenyl)diazenyl)benzoic acid; 2-[4-(dimethylamino)phenyl]azobenzoic acid; CI Acid Red 2; WLN: QVR BNUNR DN1&1; Cerven methylova [Czech]; Cerven kysela 2 [Czech]; p-Dimethylaminoazobenzene-o-carboxylic acid; 2-[(4-Dimethylamino)phenylazo]benzoic acid; CCRIS 2250; o-[[p-(Dimethylamino)phenyl]azo]benzoic acid; HSDB 2786; Benzoic acid, 2-[(4-dimethylamino)phenylazo]-; Benzoic acid, o-[[p-(dimethylamino)phenyl]azo]-; 2-[[4-(dimethylamino)phenyl]azo]benzoic acid; EINECS 207-776-1; Dimethylaminoazobenzene-2-carboxylic acid; CI 13020; Methylrot; Acid Red2; Methyl Red free acid; Methyl Red, Free Acid; Methyl Red free acid ACS; Methyl red(to be removed); DSSTox_CID_22154; DSSTox_RID_79939; DSSTox_GSID_42154; Methyl red, CI 13020; SCHEMBL51823; KSC235Q0F; ARONIS014454; Methyl Red, JIS special grade; C.I. Acid Red 2 (8CI); CHEMBL1090439; DTXSID1042154; CTK1D5802; NSC9597; HMS3604O11; KS-000010JK; KS-000044VU; NSC-9597; NSC34729; STR04342; ZINC3877658; Tox21_301336; BBL000015; BDBM50206443; NSC-34729; NSC215212; SBB069547; STK391287; ZINC12358622; ZINC29786370; Methyl Red solution, for microbiology; Methyl Red solution, pH 4.2-6.2; Methyl Red, ACS reagent, crystalline; AKOS000121019; AKOS025117039; p-dimethylaminoazo-benzene 0-carboxyli; DB08209; MCULE-1428966837; NSC-215212; 2-(4-dimethylaminophenyl)azobenzoic acid; NCGC00187604-01; NCGC00255799-01; SC-46960; ST011991; Methyl Red, 0.1% w/v solution in ethanol; FT-0618353; M0056; M0067; M0421; M0702; T6985; C19459; A827705; Q412276; SR-01000196295; 2-[(E)-[4-(Dimethylamino)phenyl]azo]benzoic acid; J-610087; SR-01000196295-1; F3377-1162
Click to Show/Hide
|
||||
| Activity |
IC50 = 440000 nM
|
[8] | |||
| Compound Name |
Benzoic acid, 4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220939; 4-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]benzoic acid; SCHEMBL4094573; BDBM50206435; 4-[(4,6-Dichloro-s-triazine-2-yl)amino]benzoic acid; 4-(4,6-dichloro-1,3,5-triazin-2-ylamino)benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 476000 nM
|
[8] | |||
| Compound Name |
4-Amino-2-(6-hydroxy-3-oxoxanthen-9-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219901; SCHEMBL13384808; ZINC3861469; BDBM50206433; AKOS024306984; MCULE-3611857922; ST50308355; 2-(3-Oxo-6-hydroxy-3H-xanthene-9-yl)-4-aminobenzoic acid; 4-amino-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 519000 nM
|
[8] | |||
| Compound Name |
4-Hydroxy-7-(3-phenylureido)naphthalene-2-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219678; BDBM50206439
Click to Show/Hide
|
||||
| Activity |
IC50 = 529000 nM
|
[8] | |||
| Compound Name |
4-Amino-5-hydroxy-2,7-naphthalenedisulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-amino-5-hydroxynaphthalene-2,7-disulfonic acid; H-Acid; H acid; 1-Amino-8-hydroxynaphthalene-3,6-disulphonic acid; 2,7-NAPHTHALENEDISULFONIC ACID, 4-AMINO-5-HYDROXY-; Kyselina H; 1-Amino-8-naphthol-3,6-disulfonic acid; 1-Naphthol-8-amino-3,6-disulfonic acid; UNII-4WUM31ES4U; C.I. 35570; 4WUM31ES4U; CHEMBL60494; Kyselina 1-amino-8-naftol-3,6-disulfonova; Kyselina H [Czech]; EINECS 201-975-7; NSC 190492; 4-Amino-5-hydroxynaphthalene-2,7-disulphonic acid; BRN 2225829; Kyselina 1-amino-8-naftol-3,6-disulfonova [Czech]; Kyselina 8-amino-1-naftol-3,6-disulfonova [Czech]; 4-Amino-5-hydroxy-2,7-naphthalenedisulfonic acid monosodium salt hydrate; Kyselina 8-amino-1-naftol-3,6-disulfonova; EC 201-975-7; 2, 4-amino-5-hydroxy-; 4-14-00-02824 (Beilstein Handbook Reference); 4-amino-5-hydroxy-naphthalene-2,7-disulfonic acid; SCHEMBL150291; DTXSID0046981; CTK3I7184; KS-00000JR7; ZINC1648147; WLN: L66J BZ DSWQ HSWQ JQ; ANW-50124; BDBM50000035; MFCD00035728; NSC190492; STL280264; AKOS015855589; MCULE-9359743937; NSC-190492; AC-23997; BR-36813; DS-13009; 1-hydroxy-8-amino-3,6-disulphonaphthalene; DB-027360; AM20060605; FT-0648268; ST50826192; 2,2,4,4-TETRAMETHYL-3-PENTANONEOXIME; M-8841; 1-Amino-8-hydroxynaphthalene-3,6-disulfonic acid; 1-hydroxy-8-aminonaphthalene-3,6-disulphonic acid; 5-amino-4-hydroxynaphthalene-2,7-disulfonic acid; A843466; Q906915; 1-amino-8-hydroxy-naphthalene-3,6-disulphonic acid; 2,7-Naphthalenedisulfonicacid, 4-amino-5-hydroxy-; Q-200430; 4-azanyl-5-oxidanyl-naphthalene-2,7-disulfonic acid; 4-Amino-5-hydroxy-naphthalene-2,7-disulfonic acid; sodium salt; 4-Amino-5-hydroxy-naphthalene-2,7-disulfonic acidMonosodium salt; 4-Amino-5-hydroxy-2,7-naphthalenedisulfonic acid monosodium salt hydrate, 85%
Click to Show/Hide
|
||||
| Activity |
IC50 = 540000 nM
|
[8] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-(2-phenylethyl)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802465; BDBM50347707
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-[(2-methylphenyl)methyl]piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802457; BDBM50347709
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-[(3-chlorophenyl)methyl]piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802461; BDBM50347705
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-[(2-chlorophenyl)methyl]piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802460; BDBM50347711
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-[(4-methylphenyl)methyl]piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802459; BDBM50347706
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-(3-phenylpropyl)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802466; BDBM50347710
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
Carm1-IN-1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261261; BDBM50347703; ZINC29051656; AKOS030260402; CS-3970; HY-12759; (3E,5E)-1-BENZYL-3,5-BIS(3-BROMO-4-HYDROXYBENZYLIDENE)PIPERIDIN-4-ONE; (3E,5E)-1-benzyl-3,5-bis[(3-bromo-4-hydroxyphenyl)methylidene]piperidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-[(4-chlorophenyl)methyl]piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802462; BDBM50347708
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-phenacylpiperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802467; BDBM50347712
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
(3E,5E)-3,5-Bis[(3-bromo-4-hydroxyphenyl)methylidene]-1-[(3-methylphenyl)methyl]piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1802458; BDBM50347704
Click to Show/Hide
|
||||
| Activity |
IC50 > 667000 nM
|
[20] | |||
| Compound Name |
8-(p-Tolylamino)naphthalene-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269944; BDBM50328754; SR-01000201118; SR-01000201118-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 867400 nM
|
[5] | |||
| Compound Name |
2-((4-Hydroxyphenyl)(4-oxo-2,5-cyclohexadien-1-ylidene)methyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL222562; 2-((4-hydroxyphenyl)(4-oxocyclohexa-2,5-dienylidene)methyl)benzoic acid; 2-[(4-hydroxyphenyl)(4-oxocyclohexa-2,5-dienylidene)methyl]benzoic acid; SCHEMBL13723093; DTXSID10973276; ZINC4143879; BDBM50206430; 2-[(4-hydroxyphenyl)-(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]benzoic acid; AKOS024269712; MCULE-3671982063; Benzoic acid, 2-((4-hydroxyphenyl)(4-oxo-2,5-cyclohexadien-1-ylidene)methyl)-; o-Toluic acid, alpha-(p-hydroxyphenyl)-alpha-4-oxo-2,5-cyclohexadien-1-ylidene-; ST50977457; SR-01000117802; SR-01000117802-1; 2-[(4-HYDROXYPHENYL)(4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)METHYL]BENZOIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 = 885000 nM
|
[8] | |||
| Compound Name |
4-Hydroxy-7-(3-phenylthioureido)naphthalene-2-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384442; BDBM50206431
Click to Show/Hide
|
||||
| Activity |
IC50 = 990000 nM
|
[8] | |||
| Compound Name |
(2R)-2-Amino-N-ethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781841; SCHEMBL12955470; ZINC4206147; BDBM50158087; AKOS017426894
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[21] | |||
| Compound Name |
3-(Phenylsulfonyloxy)naphthalene-1-sulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270653; CBMicro_015200; ZINC3001606; BDBM50328747
Click to Show/Hide
|
||||
| Activity |
IC50 = 1029000 nM
|
[5] | |||
| Compound Name |
2-((4-Hydroxyphenyl)(4-oxocyclohexa-2,5-dienylidene)methyl)benzenesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221319; SCHEMBL16437131; ZINC6528568; BDBM50206425; SBB006448; STL280538; AKOS016371848; MCULE-5602849743; ST056177
Click to Show/Hide
|
||||
| Activity |
IC50 = 1050000 nM
|
[8] | |||
| Compound Name |
o-(2-Hydroxy-3,6-disulfo-1-naphthylazo)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270654; CBDivE_007972; CHEMBL2009763; SCHEMBL14418589; ZINC4428469; BDBM50328748; ZINC100177641; ZINC257347650; NCI60_000574; NCI60_004124; 4-((2-carboxyphenyl)diazenyl)-3-hydroxynaphthalene-2,7-disulfonate
Click to Show/Hide
|
||||
| Activity |
IC50 = 1063000 nM
|
[5] | |||
| Compound Name |
Alizarin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,2-dihydroxyanthracene-9,10-dione; Alizarin Red; Mordant Red 11; 1,2-Dihydroxyanthraquinone; Alizarin B; Turkey Red; 1,2-Anthraquinonediol; ALIZARINE; 1,2-Dihydroxy-9,10-anthracenedione; Alizarina; Alizarine Red; Alizarine B; Eljon Madder; Alizarine NAC; Alizerine NAC; Alizarine Red B; Alizarine Red L; Alizarine 3B; Eljon Madder M; Alizarine L paste; Turkey Red W; 1,2-Dihydroxy-9,10-anthraquinone; Alizarine Red IP; Alizarine indicator; Certiqual Alizarine; Alizarine Red B2; Alizarine Red IPP; Alizerine Red IPP; Mitsui Alizarine B; Sanyo Carmine L2B; Mitsui Alizarine BS; 1,2-Dihydroxyanthra-9,10-quinone; Certiqual Alizarine D; Alizarine Lake Red 2P; Alizarine Lake Red 3P; Alizarine Lake Red IPX; Pigment red 83; C.I. Mordant Red 11; C.I. Pigment Red 83; Anthraquinonic; C.I. Mordant Red 11C; C.I. Pigment Red 83C; D And C Orange Number 15; D and C Orange Number 15D; Deep Crimson Madder 10821; Deep Crimson Madder 10821E; 1,2-Dihydroxyanthrachinon; 9,10-Anthracenedione, 1,2-dihydroxy-; Alizarine Paste 20 percent Bluish; 1,2-Dihydroxy anthraquinone; 1,2-Dihydroxy-anthraquinone; Alizarine paste 20% bluish; C.I. 58000; C.I. 58000C; UNII-60MEW57T9G; MFCD00001201; Anthraquinone, 1,2-dihydroxy-; NSC7212; CHEMBL55814; 60MEW57T9G; Alizarin (C.I. 58000); DIHYDROXY-9,10-ANTHRACENEDIONE; 1,10-Anthracenedione, 2,9-dihydroxy-; NCGC00095227-01; Alizarin, 97%, pure; DSSTox_CID_25960; DSSTox_RID_81256; DSSTox_GSID_45960; Alizarinprimeveroside; Turkey Red (VAN); crimson madder; Rubia; rose madder; alizarin crimson; D and C Orange No. 15; CCRIS 3530; 1,2-Dihydroxyanthrachinon [Czech]; NSC 7212; EINECS 200-782-5; BRN 1914037; Hystazarin; CI 58000; Pincoffin; AI3-18244; 9,10-Anthracenedione, dihydroxy-; Alizarin, p.a.; Sanyo Carmine l2BT; ACMC-20mzub; ATHRAQUINONES A; Spectrum_000386; SpecPlus_000320; 9, 1,2-dihydroxy-; Spectrum2_000397; Spectrum3_000262; Spectrum4_001555; Spectrum5_000150; Epitope ID:116187; SCHEMBL18614; BSPBio_001704; CBDivE_014227; KBioGR_002050; KBioSS_000866; SPECTRUM210850; 4-08-00-03256 (Beilstein Handbook Reference); MLS002207283; ARONIS27045; DivK1c_006416; Alizarin, Dye content 97 %; SPBio_000613; DTXSID5045960; CTK0F1107; CTK0I0351; KBio1_001360; KBio2_000866; KBio2_003434; KBio2_006002; KBio3_001204; KS-00000WZC; HMS1923C03; HMS3651P05; 1,10-dihydroxy-2,9-anthraquinone; 2,9-dihydroxy-1,10-anthraquinone; 9,10-dihydroxy-1,2-anthraquinone; HY-N0563; KS-000048JK; NSC-7212; ZINC3860973; Tox21_111486; ANW-36201; BBL027327; BDBM50206434; CCG-38668; s2526; SBB006481; STK801841; AKOS001639988; Tox21_111486_1; 1,2-Dihydroxyanthra-9,10-quinone #; FS-3935; LN: L C666 BV IVJ EQ FQ1; MCULE-9793510419; NE55861; SDCCGMLS-0066502.P001; NCGC00095227-02; NCGC00095227-03; NCGC00095227-04; NCGC00095227-06; 1,2-bis(oxidanyl)anthracene-9,10-dione; AC-11708; NCI60_041501; SMR001306798; ST055352; SY012985; CS-0009103; D0242; FT-0621965; SW101224-2; C01474; A837539; AE-641/00185064; Q267813; SR-05000002485; 1,2-dihydroxy-9,10-dihydroanthracene-9,10-dione; SR-05000002485-1; W-104489; BRD-K73191876-001-04-7; F0905-1727
Click to Show/Hide
|
||||
| Activity |
IC50 = 1160000 nM
|
[8] | |||
| Compound Name |
Benzenesulfonic acid, 4-[[4-(dimethylamino)phenyl]azo]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220397; 4-dimethylaminoazobenzene-4'-sulfonic acid; p-((p-(Dimethylamino)phenyl)azo)benzenesulfonic acid; p-[[p-(Dimethylamino)phenyl]azo]benzenesulfonic acid; 4-((4-(dimethylamino)phenyl)diazenyl)benzenesulfonic acid; 4-[[4-(dimethylamino)phenyl]diazenyl]benzenesulfonic acid; Benzenesulfonic acid, 4-((4-(dimethylamino)phenyl)azo)-; Methyl orange (acid form); 4-{[4-(DIMETHYLAMINO)PHENYL]DIAZENYL}BENZENESULFONIC ACID; Benzenesulfonic acid, 4-(2-(4-(dimethylamino)phenyl)diazenyl)-; Benzenesulfonic acid, 4-[2-[4-(dimethylamino)phenyl]diazenyl]-; NSC 9595; EINECS 207-932-9; 4'-Sulfo-N,N-dimethyl-4-aminoazobenzene; 4-(4-Sulfophenylazo)-N,N-dimethylaniline; 4-(Dimethylamino)azobenzene-4'-sulfonic acid; 4-(4-Dimethylaminophenylazo)benzenesulfonic acid; CBDivE_014233; SCHEMBL296471; CHEMBL1092016; DTXSID3060112; CTK4J2245; NSC9595; 4-{[4-(Dimethylamino)phenyl]diazenyl}benzene-1-sulfonic acid; NSC-9595; ZINC3894737; BDBM50206429; STL268852; ZINC12405014; AKOS015909260; ZINC100035946; MCULE-5868906113; 4'-(Dimethylamino)azobenzene-4-sulfonic acid; p-(p'-Dimethylaminophenylazo)benzene sulfonate; 4-((4-(Dimethylamino)phenyl)azo)benzenesulphonic acid; 4-[[4-(Dimethylamino)phenyl]azo]benzenesulfonic acid; Benzenesulfonic acid, p-[[p-(dimethylamino)phenyl]azo]-; 4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzenesulfonic acid; Benzenesulfonic acid, p-((p-(dimethylamino)phenyl)azo)- (8CI); Benzenesulfonic acid,4-[2-[4-(dimethylamino)phenyl]diazenyl]-; 4-{2-[4-(dimethylamino)phenyl]diazen-1-yl}benzene-1-sulfonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 1220000 nM
|
[8] | |||
| Compound Name |
3-Hydroxy-4-[(3-nitrophenyl)sulfonylamino]naphthalene-1-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3351047; ZINC6089030; AKOS000592710; MCULE-7116178290
Click to Show/Hide
|
||||
| Activity |
IC50 = 1458000 nM
|
[5] | |||
| Compound Name |
1-[({4-[(4-Aminophenyl)sulfonyl]phenyl}amino)methyl]pyrimidine-2,4,5,6(1h,3h)-tetrone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
allantodapsone; NSC34238; NSC-34238; CHEMBL227725; NCIStruc1_001022; NCIStruc2_001134; SCHEMBL14286197; CTK5B8237; DTXSID70283924; NCI34238; ZINC1666223; BDBM50210465; CCG-37424; NCGC00013392; 1-[[4-(4-aminophenyl)sulfonylanilino]methyl]-1,3-diazinane-2,4,5,6-tetrone; NCGC00013392-02; NCGC00096508-01; NCI60_003037; 1-((4-((4-aminophenyl)sulfonyl)anilino)methyl)-2,4,5,6(1H,3H)-pyrimidinetetrone
Click to Show/Hide
|
||||
| Activity |
IC50 = 1825000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of Decamidine as a New and Potent PRMT1 Inhibitor. Medchemcomm. 2017 Feb 1;8(2):440-444. | ||||
| REF 2 | Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. | ||||
| REF 3 | Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1). Medchemcomm. 2016 Sep 1;7(9):1793-1796. | ||||
| REF 4 | Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L. Medchemcomm. 2013 May 1;4(5):822-826. | ||||
| REF 5 | Discovery and mechanistic study of a class of protein arginine methylation inhibitors. J Med Chem. 2010 Aug 26;53(16):6028-39. | ||||
| REF 6 | Target-based approach to inhibitors of histone arginine methyltransferases. J Med Chem. 2007 May 17;50(10):2319-25. | ||||
| REF 7 | Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011 Jun 15;19(12):3717-31. | ||||
| REF 8 | Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations. J Med Chem. 2007 Mar 22;50(6):1241-53. | ||||
| REF 9 | Development of second generation epigenetic agents. Medchemcomm. 2012;3:135-61. | ||||
| REF 10 | Oncoepigenomics: making histone lysine methylation count. Eur J Med Chem. 2012 Oct;56:179-94. | ||||
| REF 11 | 1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1). Bioorg Med Chem Lett. 2009 Dec 1;19(23):6725-32 | ||||
| REF 12 | Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem. 2014 Aug 14;57(15):6822-33. | ||||
| REF 13 | Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L. J Med Chem. 2012 Sep 27;55(18):8066-74. | ||||
| REF 14 | Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening. Eur J Med Chem. 2018 Sep 5;157:867-876. | ||||
| REF 15 | Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations. Bioorg Med Chem Lett. 2018 May 15;28(9):1476-1483. | ||||
| REF 16 | N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1). Bioorg Med Chem Lett. 2009 Feb 15;19(4):1218-23. | ||||
| REF 17 | Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem. 2017 Jul 27;60(14):6289-6304. | ||||
| REF 18 | Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents. Eur J Med Chem. 2012 Aug;54:647-59. | ||||
| REF 19 | Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation. J Med Chem. 2012 Sep 27;55(18):7978-87. | ||||
| REF 20 | Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32. | ||||
| REF 21 | Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. J Med Chem. 2016 Feb 11;59(3):1176-83. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.