Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17067 | Target Info | |||
| Target Name | Isopeptidase T (USP5) | ||||
| Synonyms |
Ubiquitin-specific-processing protease 5; Ubiquitin thioesterase 5; Ubiquitin carboxyl-terminal hydrolase 5; ISOT; Deubiquitinating enzyme 5
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| Target Type | Preclinical Target | ||||
| Gene Name | USP5 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
LDN-91946
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Investigative | Compound Info | ||
| Synonyms |
compound 7
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| Activity |
Ki = 100000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4129140
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3709928; BDBM50271098; 3-acetyl-2-(4-bromophenyl)-1-[2-(3,4-dichlorophenyl)ethyl]-4-hydroxy-2H-pyrrol-5-one
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| Activity |
IC50 > 200000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol. 2007 Nov;3(11):697-705. | ||||
| REF 2 | Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. J Med Chem. 2018 Jan 25;61(2):422-443. | ||||
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