Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T22977 | Target Info | |||
| Target Name | Superoxide dismutase Cu-Zn (SOD Cu-Zn) | ||||
| Synonyms |
hSod1; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; Superoxide dismutase
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | SOD1 | ||||
| Biochemical Class | Superoxide dismutase/reductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Fortunin E
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355357; BDBM50039027
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| Activity |
IC50 = 56600 nM
|
[1] | |||
| Compound Name |
13-Hydroxypodocarpa-8,11,13-triene-18-oic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355358; BDBM50039031
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| Activity |
IC50 = 58900 nM
|
[1] | |||
| Compound Name |
1-N,4-N-Bis(3-imidazol-1-ylpropyl)phthalazine-1,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179265; BDBM50398954
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| Activity |
IC50 = 65980 nM
|
[2] | |||
| Compound Name |
1,4-Bis[3-(imidazol-1-yl)propylamino]benzo[g]phthalazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL272641; BDBM50336560; N1,N4-bis(3-(1H-imidazol-1-yl)propyl)benzo[g]phthalazine-1,4-diamine
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|
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| Activity |
IC50 = 67900 nM
|
[3] | |||
| Compound Name |
4-Chloro-N-[2-(1H-imidazol-5-yl)ethyl]phthalazin-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179268; BDBM50398955
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|
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| Activity |
IC50 = 71460 nM
|
[2] | |||
| Compound Name |
4-Chloro-N-(3-imidazol-1-ylpropyl)phthalazin-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179266; BDBM50398953; AKOS011421410
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|
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| Activity |
IC50 = 83120 nM
|
[2] | |||
| Compound Name |
1,4-Bis(3'-Pyrazolylamino)Benzo[G]Phthalazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1672028; BDBM50336562; 1,4-Bis(3''-pyrazolylamino)benzo[g]phthalazine
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| Activity |
IC50 = 96600 nM
|
[3] | |||
| Compound Name |
Chembl4127450
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|
Investigative | Compound Info | ||
| Synonyms |
TQR0558; BDBM50275711; 3-(4-(4-chlorophenyl)piperazin-1-yl)-1-(4-methoxyphenyl)propan-1-one
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| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
Chembl4128846
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|
Investigative | Compound Info | ||
| Synonyms |
TQR0557; BDBM50275725; 1-(4-methoxyphenyl)-3-(4-(4-nitrophenyl)piperazin-1-yl)propan-1-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-Chloro-1-(3''-pyrazolylamino)benzo[g]phthalazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1672029; BDBM50336563
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|
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| Activity |
IC50 = 103300 nM
|
[3] | |||
| Compound Name |
1-N,4-N-Bis[2-(1H-imidazol-5-yl)ethyl]phthalazine-1,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179267; BDBM50398956
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|
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| Activity |
IC50 = 125320 nM
|
[2] | |||
| Compound Name |
1-[3-(Imidazol-1-yl)propylamino]-4-chlorobenzo[g]phthalazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL405899; BDBM50336561; N-(3-(1H-imidazol-1-yl)propyl)-4-chlorobenzo[g]phthalazin-1-amine
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|
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| Activity |
IC50 = 129300 nM
|
[3] | |||
| Compound Name |
Chembl4129006
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50275760
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|
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| Activity |
IC50 = 145800 nM
|
[4] | |||
| Compound Name |
N-(Pyridin-2-ylmethyl)-2-(3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl)ethanamine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335501
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|
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| Activity |
IC50 = 178500 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1,4-Bis[2-(imidazol-4-yl)ethylamino]benzo[g]phthalazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL273030; BDBM50336558; N1,N4-bis(2-(1H-imidazol-4-yl)ethyl)benzo[g]phthalazine-1,4-diamine
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|
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| Activity |
IC50 = 365800 nM
|
[3] | |||
| Compound Name |
2-(3,6,9,15-Tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl)ethanamine;hydrobromide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335499
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|
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| Activity |
IC50 = 381100 nM
|
[5] | |||
| Compound Name |
N-(Naphthalen-1-ylmethyl)-2-(3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl)ethanamine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335500
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|
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| Activity |
IC50 = 408000 nM
|
[6] | |||
| Compound Name |
N-(Pyridin-3-ylmethyl)-2-(3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl)ethanamine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335502
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|
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| Activity |
IC50 = 641000 nM
|
[5] | |||
| Compound Name |
1-[2-(Imidazol-4-yl)ethylamino]-4-chlorobenzo[g]phthalazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL272808; BDBM50336559; N-(2-(1H-imidazol-4-yl)ethyl)-4-chlorobenzo[g]phthalazin-1-amine
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|
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| Activity |
IC50 = 786900 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Prospects of an alternative treatment against Trypanosoma cruzi based on abietic acid derivatives show promising results in Balb/c mouse model. Eur J Med Chem. 2015 Jan 7;89:683-90. | ||||
| REF 2 | Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection. J Med Chem. 2012 Nov 26;55(22):9900-13. | ||||
| REF 3 | In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of Chagas disease. J Med Chem. 2011 Feb 24;54(4):970-9. | ||||
| REF 4 | Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi. J Med Chem. 2018 Jul 12;61(13):5643-5663. | ||||
| REF 5 | Scorpiand-like azamacrocycles prevent the chronic establishment of Trypanosoma cruzi in a murine model. Eur J Med Chem. 2013;70:189-98. | ||||
| REF 6 | In vitro activity of scorpiand-like azamacrocycle derivatives in promastigotes and intracellular amastigotes of Leishmania infantum and Leishmania braziliensis. Eur J Med Chem. 2013 Apr;62:466-77. | ||||
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