Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23172 | Target Info | |||
| Target Name | Janus kinase 3 (JAK-3) | ||||
| Synonyms |
Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK
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|
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| Target Type | Successful Target | ||||
| Gene Name | JAK3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 43 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Brivanib
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|
Phase 3 | Compound Info | ||
| Synonyms |
Brivanib; 649735-46-6; BMS-540215; Brivanib (BMS-540215); BMS 540215; UNII-DDU33B674I; Brivanib [USAN]; BMS540215; DDU33B674I; CHEMBL377300; (2R)-1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]propanol; Brivanib (USAN); (2R)-1-[4-[(4-FLUORO-2-METHYL-1H-INDOL-5-YL)OXY]-5-METHYL-PYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL]OXYPROPAN-2-OL; (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
BMS-645737
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Investigative | Compound Info | ||
| Synonyms |
651744-16-0; BMS-645737; BMS645737; 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine; UNII-86H6HFH34L; 86H6HFH34L; CHEMBL261592; 6-(5-methyl-1,3,4-oxadiazol-2-yl)-n-{2-methyl-1h-pyrrolo[2,3-b]pyridin-5-yl}-5-(propan-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine; 5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo-[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine; C20H20N8O
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Oxindole 94
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|
Investigative | Compound Info | ||
| Synonyms |
SB 202190; 152121-30-7; SB202190; SB-202190; FHPI; SB202190 (FHPI); UNII-PVX798P8GI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; CHEBI:79090; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; PVX798P8GI; SB 202190, Immobilized; C20H14FN3O; Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-; 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; 4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-Chloro-N-(3-quinoxalin-2-ylphenyl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463405; CHEMBL3645538; BDBM107121; US8592415, 5; 4-chloro-N-[3-(quinoxalin-2-yl)phenyl]butanamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
p38 MAP Kinase Inhibitor IX
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259922; Kinome_3519; SCHEMBL16576573; CTK8G2239; BDBM50376226; 4-methyl-N-(1,2-oxazol-3-yl)-3-[(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-(Dimethylamino)-N-(3-quinoxalin-2-ylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463296; CHEMBL3645535; BDBM107118; US8592415, 2; N2,N2-dimethyl-N1-(3-quinoxalin-2-ylphenyl)glycinamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463291; CHEMBL3645548; BDBM107134; US8592415, 19; 3-chloro-N-[3-(quinoxalin-2-yl)phenyl]propanamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[3-(2-Quinoxalinyl)phenyl]methanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
N-[3-(quinoxalin-2-yl)phenyl]methanesulfonamide; N-(3-quinoxalin-2-ylphenyl)methanesulfonamide; MLS001165982; SCHEMBL1463425; CHEMBL1553519; KS-00001ZVU; BDBM107130; HMS2855A24; ZINC1399325; MFCD03617716; AKOS005099938; MCULE-3207290219; SMR000550249; US8592415, 15; 7T-0022
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(3-Quinoxalin-2-ylphenyl)-2-(1,2,4-triazol-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1464125; CHEMBL3645539; BDBM107123; US8592415, 7; N-[3-(quinoxalin-2-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104074; CHEMBL104466; RP-127963; 4-[(6,7-dimethoxyquinoxalin-2-yl)amino]cyclohexan-1-ol; SCHEMBL842647; SCHEMBL842648; SCHEMBL3393843; CTK0I9204; DTXSID30430871; Cyclohexanol, 4-[(6,7-dimethoxy-2-quinoxalinyl)amino]-, trans-; BDBM50132391; BDBM50132407; cis-4-(6, 7-Dimethoxyquinoxalin-2-ylamino)-cyclohexanol; cis-4-(6,7-Dimethoxyquinoxalin-2-ylamino)-cyclohexanol; 4-((R)-6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol; Trans-4-((6,7-dimethoxyquinoxalin-2-yl)amino)cyclohexanol; trans-4-(6,7-dimethoxy-quinoxalin-2-ylamino)-cyclohexanol; 2-(4alpha-Hydroxycyclohexane-1alpha-ylamino)-6,7-dimethoxyquinoxaline; 2-(4beta-Hydroxycyclohexane-1alpha-ylamino)-6,7-dimethoxyquinoxaline
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-[3-(2-Quinoxalinyl)phenyl]-2-furamide
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Investigative | Compound Info | ||
| Synonyms |
N-[3-(quinoxalin-2-yl)phenyl]furan-2-carboxamide; MLS000100130; regid4258715; N-(3-quinoxalin-2-ylphenyl)furan-2-carboxamide; SCHEMBL1462285; CHEMBL1572928; KS-00003DPA; BDBM107127; HMS2167I24; HMS3320K16; ZINC1399317; AKOS005099816; MCULE-1007454916; SMR000081936; US8592415, 12; 7T-0013
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-(4-Methylpiperazin-1-yl)-N-(3-quinoxalin-2-ylphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1464066; CHEMBL3645546; BDBM107132; US8592415, 17; 2-(4-methylpiperazin-1-yl)-N-[3-(quinoxalin-2-yl)phenyl]acetamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[4-(2-Quinoxalinyl)phenyl]cyclopropanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
N-[3-(quinoxalin-2-yl)phenyl]cyclopropanecarboxamide; N-(3-quinoxalin-2-ylphenyl)cyclopropanecarboxamide; SCHEMBL1463399; CHEMBL3645544; KS-00003DPB; BDBM107129; MFCD12910763; ZINC43796862; AKOS005099847; MCULE-7559936835; US8592415, 14; 7T-0015
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-Methyl-N'-[3-(2-quinoxalinyl)phenyl]thiourea
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|
Investigative | Compound Info | ||
| Synonyms |
1-methyl-3-(3-quinoxalin-2-ylphenyl)thiourea; MLS001165984; SMR000550248; 3-methyl-1-[3-(quinoxalin-2-yl)phenyl]thiourea; SCHEMBL1462401; CHEMBL1537091; REGID_for_CID_409246; BDBM67663; cid_1485416; KS-00001ZVR; REGID_for_CID_1485416; HMS2852P03; ZINC1399314; AKOS005099784; MCULE-4454820641; 1-methyl-3-[3-(2-quinoxalinyl)phenyl]thiourea; 1-methyl-3-[3-(quinoxalin-2-yl)phenyl]thiourea; 7T-0009
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[3-(2-Quinoxalinyl)phenyl]-2-thiophenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
n-[3-(quinoxalin-2-yl)phenyl]thiophene-2-sulfonamide; N-(3-quinoxalin-2-ylphenyl)thiophene-2-sulfonamide; SCHEMBL1462283; CHEMBL3645543; KS-00001ZVS; BDBM107128; ZINC1399318; AKOS005099846; MCULE-1175160761; US8592415, 13; 7T-0014
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6-(5-Methyl-1,3,4-oxadiazol-2-yl)-5-propan-2-yl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258694; BDBM50377357
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-4-methyl-N-(1,2-oxazol-3-yl)benzamide; CHEMBL383172; 5-Cyanopyrimidine Derivative 3b; SCHEMBL16576397; BDBM16326; 3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-N-isoxazol-3-yl-4-methylbenzamide
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
BMS-605541; CHEMBL377734; BMS 605541; SCHEMBL2861987; BDBM50189603; AKOS034831603
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
N-(3-Quinoxalin-2-ylphenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
MLS000537362; SCHEMBL1462316; CHEMBL1446198; BDBM107122; HMS1599D07; HMS2400O23; ZINC555918; AKOS003653098; MCULE-9745117709; N-[3-(2-quinoxalinyl)phenyl]propanamide; SMR000143800; N-[3-(quinoxalin-2-yl)phenyl]propionamide; ST45104659; US8592415, 6; SR-01000287574; SR-01000287574-1
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(4-Methoxyphenyl)-N'-[3-(2-quinoxalinyl)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
1-(4-methoxyphenyl)-3-[3-(quinoxalin-2-yl)phenyl]urea; 1-(4-methoxyphenyl)-3-(3-quinoxalin-2-ylphenyl)urea; SCHEMBL1463272; CHEMBL3645542; KS-00001ZVQ; BDBM107126; ZINC1399313; AKOS005099783; MCULE-4650809137; US8592415, 10; 7T-0007
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185140; SCHEMBL21585709; BDBM50324797; 3-(1-(4-chlorobenzyl)-1H-indol-3-yl)-N-(pyridin-4-yl)propanamide; 3-[1-(4-Chloro-benzyl)-1H-indol-3-yl]-N-pyridin-4-yl-propionamide
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| Activity |
IC50 = 52000 nM
|
[9] | |||
| Compound Name |
Chembl4283458
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20944732; BDBM412681; US10399979, Compound 17e
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| Activity |
IC50 = 61570 nM
|
[10] | |||
| Compound Name |
JAK inhibitor 17b
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4284499; SCHEMBL20944633; GTPL10148; BDBM412675; US10399979, Compound 17b; 4-(Cyclohexylmethyl)-7,8-dimethoxy-1,4-dihydro-5H-benzo[c]pyrrolo[2,3-h][1,6]naphthyridin-5-one
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| Activity |
IC50 = 76900 nM
|
[10] | |||
| Compound Name |
4-[4-(4-Fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazol-2-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314285; BDBM50045570
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| Activity |
IC50 = 78300 nM
|
[3] | |||
| Compound Name |
Disodium;2-[4-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120985
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Sodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314273
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[5-(4-Fluorophenyl)-3-methyl-2-(2H-triazol-4-yl)imidazol-4-yl]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120960; BDBM50045572
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-Fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314271; SCHEMBL6217129; BDBM50045555
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-Tert-butyl-3-[[5-cyano-2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885292; BDBM50208591
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R,3R,4R,5S,6R)-3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]-6-(hydroxymethyl)oxane-2,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314270; BDBM50045576
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120963; BDBM50045575
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Disodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314275
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-Ethynyl-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314272; BDBM50045556
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[2-(4-Ethynylphenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-methylsulfanylpyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314286; BDBM50045571
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-Fluorophenyl)-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]imidazo[1,2-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120970; SCHEMBL13823117; BDBM50045580
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[5-(4-Fluorophenyl)-2-[1-[(3S,4S)-3-fluoropiperidin-4-yl]triazol-4-yl]-3-methylimidazol-4-yl]pyridine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120986
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120983; BDBM50045574
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-[2-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-5-(4-fluorophenyl)-3-methylimidazol-4-yl]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120969; BDBM50045578
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
7-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314274; BDBM50045558
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120995; BDBM50045573
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-Amino-N-benzyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938646; BDBM50361832
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|
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| Activity |
IC50 ~ 125000 nM
|
[13] | |||
| Compound Name |
2-Oxo-2-(3-(quinoxalin-2-yl)phenylamino)ethyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1462379; CHEMBL3648434; BDBM107143; US8592415, 28; [2-oxo-2-(3-quinoxalin-2-ylanilino)ethyl] acetate
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| Activity |
IC50 = 150000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 14 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(2-Aminoethyl)-2-(4-piperidinyl)-1H-benzoimidazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622826; BDBM50124147
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| Activity |
IC50 = 232500 nM
|
[14] | |||
| Compound Name |
N-(6-(6,7-Dimethoxyquinolin-4-yloxy)-1-methyl-1H-indazol-3-yl)-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL462168; SCHEMBL4381571; BDBM50245420; N-[6-(6,7-dimethoxyquinolin-4-yl)oxy-1-methylindazol-3-yl]-3-(trifluoromethyl)benzamide; Benzamide, N-[6-[(6,7-dimethoxy-4-quinolinyl)oxy]-1-methyl-1H-indazol-3-yl]-3-(trifluoromethyl)-
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| Activity |
IC50 = 25000000 nM
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[15] | |||
| Compound Name |
1-(2-Naphthyl)-2-propen-1-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL154693; 1-naphthalen-2-ylprop-2-en-1-ol; SCHEMBL1334975; l-naphthalen-2-yl-prop-2-en-1-ol; BDBM50421421; 1-(naphthalen-2-yl)prop-2-en-1-ol; AKOS014752415
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| Activity |
IC50 = 2.00E+12 nM
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[16] | |||
| Compound Name |
1-(6,7-Dimethoxynaphthalen-2-yl)-3-morpholin-4-ylpropan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542762
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| Activity |
IC50 = 5.01E+12 nM
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[16] | |||
| Compound Name |
1-(6-Methoxynaphthalen-2-yl)-3-morpholin-4-ylpropan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542522
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| Activity |
IC50 = 6.31E+13 nM
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[16] | |||
| Compound Name |
(E)-2-Methyl-5-morpholin-4-yl-1-phenylpent-1-en-3-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL543226; NSC617822; NSC-617822
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| Activity |
IC50 = 7.94E+13 nM
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[16] | |||
| Compound Name |
(E)-1-(2-Chlorophenyl)-5-morpholin-4-ylpent-1-en-3-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225385
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| Activity |
IC50 = 7.94E+13 nM
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[16] | |||
| Compound Name |
3-(Morpholin-4-yl)-1-(naphthalen-1-yl)propan-1-one hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL552585; MCULE-3221695752; Z1695906688
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| Activity |
IC50 = 3.16E+14 nM
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[16] | |||
| Compound Name |
3-(Morpholin-4-yl)-1-(naphthalen-2-yl)propan-1-one hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL543939; AKOS033438684; MCULE-7276231311; NE55266; Z1575143818
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| Activity |
IC50 = 5.01E+14 nM
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[16] | |||
| Compound Name |
3-(Azepan-1-yl)-1-naphthalen-2-ylpropan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL544872
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| Activity |
IC50 = 1.26E+15 nM
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[16] | |||
| Compound Name |
3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL541346; SCHEMBL4922813; DTXSID60492684; 1-Propanone,3-(dimethylamino)-1-(2-naphthalenyl)-,hydrochloride; NSC12246; NSC-12246; NSC130889; AKOS027441642; JS-2998; NSC-130889; KS-0000276A; 3-(dimethylamino)-1-(2-naphthyl)-1-propanone hydrochloride; 3-(dimethylamino)-1-naphthalen-2-ylpropan-1-one,hydrochloride; 3-(Dimethylamino)-1-(naphthalen-2-yl)propan-1-one--hydrogen chloride (1/1)
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| Activity |
IC50 = 1.58E+15 nM
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[16] | |||
| Compound Name |
3-Morpholin-4-yl-1-phenanthren-3-ylpropan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL543228; DTXSID00639576; NSC402417; NSC-402417; 3-(Morpholin-4-yl)-1-(phenanthren-3-yl)propan-1-one--hydrogen chloride (1/1)
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| Activity |
IC50 = 2.00E+15 nM
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[16] | |||
| Compound Name |
ZM 39923 hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
jak3 inhibitor iv; ZM 39923 HCl; ZM39923 hydrochloride; ZM39923 (hydrochloride); ZM39923 HCl; ZM 39923; CHEMBL538798; 3-(benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-one hydrochloride; 3-BENZYLISOPROPYLAMINO-1-NAPHTHALEN-2-YL-PROPAN-1-ONE HYDROCHLORIDE; 3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one hydrochloride; 3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-one;hydrochloride; 3-[benzyl(propan-2-yl)amino]-1-(naphthalen-2-yl)propan-1-one hydrochloride; SR-01000075509; ZM 39923-hydrochloride; C23H25NO.ClH; MLS002153398; ZM-39923 HCl; SCHEMBL17318371; CTK8G0412; KS-00000HAI; 2-Naphthyl-(N-isopropyl,N-benzyl)-beta-aminoethylketone, HCI; DTXSID301017077; BCP15841; EX-A2190; Tox21_500844; 2819AH; MFCD04974534; s8004; 3-(N-Benzyl-N-isopropyl)amino-1-(naphthalen-2-yl)propan-1-one hydrochloride; AKOS024456551; CCG-206763; CS-4951; LP00844; SB16473; NCGC00094173-01; NCGC00261529-01; ZM39923 HCl;ZM-39923 HCl; AC-30261; AK468727; AS-74455; HY-12589; SMR001230777; ZM 39923 hydrochloride, >98% (HPLC); EU-0100844; SW219203-1; ZM 39923 hydrochloride; Jak3 inhibitor IV; JAK3 Inhibitor IV - CAS 58753-54-1; A13509; Z 4626; SR-01000075509-1; SR-01000075509-3; 2-Naphthyl-(N-isopropyl,N-benzyl)-b-aminoethylketone, HCI; 3-benzylisopropylamino-1-naphthalen-2-ylpropan-1-one HCl; N-Benzyl-N-isopropyl-3-(2-naphthyl)but-3-en-1-amine,HCl; 3-(N-Benzyl-N-isopropyl)amino-1-(naphthalen-2-yl)propan-1-one, hydrochloride
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| Activity |
IC50 = 1.26E+16 nM
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[16] | |||
| Compound Name |
1-(2-Naphthalenyl)-2-propen-1-one
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Investigative | Compound Info | ||
| Synonyms |
ZM 449829; 1-naphthalen-2-ylprop-2-en-1-one; 1-(2-naphthyl)prop-2-en-1-one; 1-(naphthalen-2-yl)prop-2-en-1-one; ZM449829; jak3 inhibitor v; 2'-Acrylonaphthone; (2-Naphthylvinyl Ketone); 2-acryloylnaphthalene; Thr1 inhibitor, 1; 2-Propen-1-one, 1-(2-naphthalenyl)-; 2-naphthyl vinyl ketone; BiomolKI_000064; BiomolKI2_000005; BMK1-G4; SCHEMBL149980; CHEMBL154580; SCHEMBL13158925; BDBM85122; CTK1D2398; HMS3412I18; HMS3676I18; BCP07020; ZINC1487935; HSCI1_000051; MFCD04974535; AKOS006293213; CCG-100668; JAK3 Inhibitor V - CAS 932258; NCGC00092279-01; NCGC00092279-02; NCGC00092279-03; BS-16843; HY-13450; DB-082069; ZM-449829; A4517; CS-0006905; FT-0762943; X5808; EC-000.2458; BRD-K95676198-001-02-6; BRD-K95676198-001-03-4; Q27165369
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| Activity |
IC50 = 1.26E+16 nM
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[16] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-... J Med Chem. 2006 Apr 6;49(7):2143-6. | ||||
| REF 2 | Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]t... Bioorg Med Chem Lett. 2008 May 1;18(9):2985-9. | ||||
| REF 3 | Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38alpha MAPK, CK1 and JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3412-8. | ||||
| REF 4 | US patent application no. 8592415B2, Selective kinase inhibitors | ||||
| REF 5 | Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2652-7. | ||||
| REF 6 | Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3097-100. | ||||
| REF 7 | 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48(20):6261-70. | ||||
| REF 8 | Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9. | ||||
| REF 9 | Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5203-6. | ||||
| REF 10 | Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series. J Med Chem. 2018 Dec 13;61(23):10440-10462. | ||||
| REF 11 | Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors. Eur J Med Chem. 2016 Nov 29;124:896-905. | ||||
| REF 12 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 13 | Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors. J Med Chem. 2011 Dec 22;54(24):8440-50. | ||||
| REF 14 | Benzimidazole Derivatives as Potent JAK1-Selective Inhibitors. J Med Chem. 2015 Sep 24;58(18):7596-602. | ||||
| REF 15 | Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4844-8. | ||||
| REF 16 | Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. | ||||
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