Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T26617 | Target Info | |||
| Target Name | Lactase-phlorizin hydrolase (LCT) | ||||
| Synonyms |
Lactase-glycosylceramidase; LCT; Glycosyl-hydrolase
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| Target Type | Literature-reported Target | ||||
| Gene Name | LCT | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 16 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Miglitol
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Approved | Compound Info | ||
| Synonyms |
Diastabol; Glyset; Plumarol; Seibule; Glyset (TN); SK-983; Bay-m-1099; Miglitol (JAN/USAN/INN); (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
Migalastat
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Approved | Compound Info | ||
| Synonyms |
DDIG; D-Galactitol, 1,5-dideoxy-1,5-imino; (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-iminogalactitol; 2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
Miglustat
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Approved | Compound Info | ||
| Synonyms |
BuDNJ; Butyldeoxynojirimycin; Miglustatum; NBV; Vevesca; Zavesca; Miglustat [USAN]; OGT 918; SC 48334; SC48334; Miglustat, Hydrochloride; N-Butyl deoxynojirimycin; N-Butyl dnj; N-Butyldeoxynojirimycin; N-Butylmoranoline; NB-DNJ; OGT-918; SC-48334; Zavesca (TN); Miglustat (USAN/INN); N-Bu-DNJ; N-Butyl-DNJ; N-Butyl-deoxynojirimycin; N-(n-Butyl)deoxynojirimycin; N-butyl-1-deoxynojirimycin; N-(n-butyl)-1,5-dideoxy-1,5-imino-D-glucitol; (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-N-butylimino-D-glucitol
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Deoxynojirimycin
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Phase 3 | Compound Info | ||
| Synonyms |
1-DEOXYNOJIRIMYCIN; 19130-96-2; DUVOGLUSTAT; deoxynojirimycin; Moranoline; (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Deoxy-1,5-imino-D-mannitol; Moranolin; UNII-FZ56898FLE; D-1-deoxynojirimycin; 1,5-Dideoxy-1,5-imino-D-glucitol; CHEMBL307429; C6H13NO4; FZ56898FLE; CHEBI:44369; 1-Deoxy-Nojirimycin; 5-Amino-1,5-dideoxy-D-glucopyranose; DNJ; AK151410; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-
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| Activity |
IC50 = 62000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[5-(2-Fluoro-1,1'-biphenyl-4-ylmethoxy)pentyl]-2beta-(hydroxymethyl)piperidine-3beta,4alpha,5beta-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354637; SCHEMBL17132922; BDBM50028257
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-phenyl-2-(trifluoromethyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354626; SCHEMBL17132920; BDBM50028181
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(3-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354631; SCHEMBL19224268; BDBM50028251
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| Activity |
IC50 = 60000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5S)-1-[5-[(2-Fluoro-4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354636; SCHEMBL17132918; BDBM50028256
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|
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| Activity |
IC50 = 60000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(4-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354038; SCHEMBL17132919; BDBM50028218
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| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5S)-1-[4,4-Difluoro-5-[(4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354633; SCHEMBL19224270; BDBM50028253
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| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5S)-1-[2,2-Difluoro-5-[(4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354620; SCHEMBL17132927; BDBM50028175
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(1S)-1-(4-phenylphenyl)ethoxy]pentyl]piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354628; SCHEMBL19224266; BDBM50028248
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5S)-1-[2,2-Difluoro-5-[(4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354632; SCHEMBL19224269; BDBM50028252
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-phenyl-3-(trifluoromethyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354635; SCHEMBL17133008; BDBM50028255
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[[4-phenyl-2-(trifluoromethyl)phenyl]methoxy]pentyl]piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354634; SCHEMBL17132966; BDBM50028254
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|
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| Activity |
IC50 = 125000 nM
|
[2] | |||
| Compound Name |
N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-ido-1-deoxynojirimycin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1086996; SCHEMBL17132912; BDBM50312527; ZINC49054534; (2S)-1-[5-(1-Adamantylmethoxy)pentyl]-2beta-(hydroxymethyl)piperidine-3beta,4alpha,5beta-triol
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| Activity |
IC50 = 200000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 7 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Lucerastat
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|
Phase 3 | Compound Info | ||
| Synonyms |
141206-42-0; UNII-GVS3YDM418; N-Butyldeoxygalactonojirimycin; GVS3YDM418; CHEMBL1086997; N-(n-Butyl)deoxygalactonojirimycin; (2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; Lucerastat [INN]; N-Butyl-DGJ; NB-DGJ; N-Bu-DGJ; AC1L9UXN; N- Butyldeoxygalactonojirimycin; SCHEMBL6821044; N-Butyl-deoxy-galactonojirimycin; CDP-923; N-N-Butyl Deoxygalactonojirimycin; OGT-923; DTXSID60161601; MolPort-039-015-418; ZX-AT009021; ZINC13719785; BDBM50312528; N-Butyl-D-galacto-1-deoxynojirimycin; AKOS027384398; NCGC00181326
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|
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| Activity |
IC50 = 1000000 nM
|
[1] | |||
| Compound Name |
N-[5-(Adamantan-1-yl-methoxy)-pentyl]-D-galacto-1-deoxynojirimycin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088158; BDBM50312529
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|
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| Activity |
IC50 = 375000 nM
|
[1] | |||
| Compound Name |
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3S,4R,5S)-
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL179409; 1-Deoxy-L-altrostatin; L-altro-1-Deoxynojirimycin; SCHEMBL4619759; BDBM50163445; ZINC13612564; (2s,3s,4r,5s)-2-(hydroxymethyl)piperidin-3,4,5-triol; (2S,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; (2S,3S,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
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| Activity |
IC50 = 400000 nM
|
[1] | |||
| Compound Name |
N-Butyl-L-ido-1-deoxynojirimycin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1076754; SCHEMBL20576705; ZINC3957104; BDBM50312526; (2S,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
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|
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| Activity |
IC50 = 1000000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088291; N-Butyl-L-altro-1-deoxynojirimycin; BDBM50312530; ZINC11681341; 1-Butyl-2beta-(hydroxymethyl)piperidine-3alpha,4alpha,5beta-triol
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3R,4R,5S)-
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Investigative | Compound Info | ||
| Synonyms |
1-deoxy-L-idonojirimycin; CHEMBL175901; L-ido-1-Deoxynojirimycin; SCHEMBL4330678; 1,5-dideoxy-1,5-imino-l-iditol; ZINC3870514; BDBM50312525; (2S,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; (2S,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-altro-1-deoxynojirimycin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088292; BDBM50312531
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|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem. 2010 Jan 28;53(2):689-98. | ||||
| REF 2 | Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. J Med Chem. 2014 Nov 13;57(21):9096-104. | ||||
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