Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27137 | Target Info | |||
| Target Name | Metabotropic glutamate receptor 1 (mGluR1) | ||||
| Synonyms |
mGLUR1; Glutamate receptor mGLU1; GPRC1A
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| Target Type | Discontinued Target | ||||
| Gene Name | GRM1 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 52 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Glutamic Acid
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Approved | Compound Info | ||
| Synonyms |
Aciglut; Glu; Glusate; Glut; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton; Gulutamine; Acide glutamique; Acido glutamico; Acidum glutamicum; Acidum glutaminicum; Glutamic acid polymer; Glutaminic acid; E 620; A-Aminoglutaric acid; A-Glutamic acid; Acide glutamique [INN-French]; Acido glutamico [INN-Spanish]; Acidum glutamicum [INN-Latin]; D-Glutamiensuur; Glutamic Acid [USAN:INN]; Glutamic acid (VAN); Glutaminic acid (VAN); Gulutamine (USP); L-Glutamic acid hydrochloride; L-Glutaminic acid; L-Glutaminsaeure; L-glu; L-glutamate; Alpha-Aminoglutaric acid (VAN); Alpha-L-Glutamic acid polymer; Glutamic Acid (L-glutamic acid); Glutamic acid (H-3); H-Glu-OH; L-2-Aminoglutaric acid; L-Glutamic acid (9CI); L-Glutamic acid (JAN); L-Glutamic acid, homopolymer; L-a-Aminoglutaric acid; L-alpha-Aminoglutaric acid; Poly-L-glutamate; Sodium Glutamate (L-glutamic Acid); Glutamic acid, L-, peptides; L-Glutamic acid, homopolymer (9CI); Poly(alpha-L-glutamic acid); Glutamic acid, L-(7CI,8CI); L-(+)-glutamic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid
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| Activity |
EC50 = 156000 nM
|
[1] | |||
| Compound Name |
STX-107
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Phase 2 | Compound Info | ||
| Synonyms |
2-Methyl-4-(pyridin-3-ylethynyl)thiazole; MTEP; mGluR5 Antagonist, MTEP; 329205-68-7; 2-methyl-4-(pyridin-3-ylethynyl)thiazole; CHEMBL292065; 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine; 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine; 3-[2-(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine; 3-(2-(2-methylthiazol-4-yl)ethynyl)pyridine; 3-[2-(2-Methylthiazol-4-yl)ethynyl]pyridine; 3-(2-Methyl-thiazol-4-ylethynyl)-pyridine; SCHEMBL187254; GTPL3336; CTK1B8867; DTXSID30430775; ZINC1489321; IN1238; BDBM50122758; FCH3417361; API0006876; ACN-027361; KB-274670
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
LY354740
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Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
Eglumetad; Eglumegad; 176199-48-7; (1S,2S,5R,6S)-2-aminobicyclo[310]hexane-2,6-dicarboxylic acid; Eglumegad [INN]; UNII-ONU5A67T2S; LY-354740; LY 354740; ONU5A67T2S; CHEMBL8759; Eglumegad (INN); (1S,2S,5R,6S)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; (1R,4S,5S,6S)-4-aminobicyclo[310]hexane-4,6-dicarboxylic acid; (1S,2S,5R,6S)-2-Amino-bicyclo[310]hexane-2,6-dicarboxylic acid; [3H]Eglumegad; LY366563; Eglumetad [USAN:INN]; (+)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; 40F; PubChem18158; Eglumegad; Eglumegad [USAN]; Eglumegad hydrate; Eglumetad hydrate; LY 314582; LY 366563; LY314582; Eglumegad (USAN); LY-314582; LY-354740 monohydrate; LY-366563; Eglumetad (INN/USAN); (1R,4S,5S,6S)-4-aminobicyclo[310]hexane-4,6-dicarboxylic acid hydrate; (1S,2S,5R,6S)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid monohydrate; 2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; 4-aminobicyclo[310]hexane-4,6-dicarboxylic acid; [3H]eglumegad
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
SIB-1757
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Investigative | Compound Info | ||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
LY-389795
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88999; LY389795; LY-389795; GTPL3349; BDBM50089897; LY 389795; (4S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid(LY389795)
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
LY-379268
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Investigative | Compound Info | ||
| Synonyms |
LY 379268; LY-379268; CHEMBL275079; LY379268; 191471-52-0; SCHEMBL2454646; GTPL1394; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; CTK8F0567; DTXSID90436637; ZINC3952369; BDBM50074749; FCH888149; AKOS006306876; API0003234; NCGC00159572-01; LS-98795; RT-013615; LY-379,268; B7061; J-012378; 4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; (1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
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| Activity |
Ki ~ 100000 nM
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[3] | |||
| Compound Name |
Ro64-5229
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Investigative | Compound Info | ||
| Synonyms |
Ro 64-5229
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate
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Investigative | Compound Info | ||
| Synonyms |
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid; (2R,4R)-APDC; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid; 169209-63-6; 2R,4R-APDC; CHEMBL40086; CHEBI:40139; EN300-88063; 2R, 4R-APDC monohydrate; 52A; 4-amino-2,4-pyrrolidinedicarboxylic acid; AC1NSJRT; AC1Q4UAD; SCHEMBL158843; 2R, 4R-APDC; (2R,3R)-APDC; GTPL1392; CTK0E5090; DTXSID10415500; MolPort-003-982-102; BDBM50052398; ZINC32628523; SBB067830; MFCD16875409; AKOS015916056; AKOS015854214; RTC-065564; FCH3884669; NCGC00025040-02; LY314593; AJ-85443; SC-48823; TC-065564; B6634
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| Activity |
Ki ~ 100000 nM
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[3] | |||
| Compound Name |
SIB-1893
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Investigative | Compound Info | ||
| Synonyms |
SIB 1893; SIB-1893; 2-methyl-6-(2-phenylethenyl)pyridine; 6266-99-5; SIB1893; 2-methyl-6-[(E)-2-phenylethenyl]pyridine; 7370-21-0; CHEMBL88612; MLS002607995; (E)-2-methyl-6-styrylpyridine; [E]-2-Methyl-6-[2-phenylethenyl]pyridine; (E)-2-Methyl-6-[2-phenylethenyl]pyridine; SR-01000076143; Lopac0_001171; Pyridine,2-methyl-6-(2-phenylethenyl)-; AC1NSKMI; AC1Q4VO3; GTPL1432; CHEBI:93178; BDBM86715; MolPort-003-959-634; HMS3263L03; ZINC3941522; 2-[(E)-Styryl]-6-methylpyridine; NSC36665; SIB 1893, >99%, solid; Tox21_501171
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| Activity |
Ki ~ 100000 nM
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[3] | |||
| Compound Name |
N,N-Diethyl-1-methyl-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3122206; BDBM50448145
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
[1-Methyl-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyridin-3-yl]-morpholin-4-ylmethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3122226; BDBM50448151
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
alpha-Methyl-4-carboxyphenylglycine
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Investigative | Compound Info | ||
| Synonyms |
(RS)-MCPG; alpha-Mcpg; 4-(1-amino-1-carboxyethyl)benzoic acid; (+/-)-alpha-Methyl-4-carboxyphenylglycine; (R,S)-MCPG; Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-; CHEMBL299683; (+/-)-alpha-Methyl-(4-carboxyphenyl)glycine; (rs)-alpha-methyl-4-carboxyphenylglycine; Benzeneacetic acid, a-amino-4-carboxy-a-methyl-; (+/-)-MCPG; alpha-Amino-4-carboxy-alpha-methylbenzeneacetic acid; ACMC-20cchr; 4-(1-AMINO-1-CARBOXY-ETHYL)-BENZOIC ACID; Lopac0_000747; SCHEMBL715285; (+-)-MCPG; (+/-)MCPG; CTK4C5052; KS-00001CLO; DTXSID80861398; HMS3262E16; BCP18268; Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-, (+-)-; Tox21_500747; BDBM50030627; MFCD00210205; (RS)-?-Methyl-4-carboxyphenylglycine; AKOS005066801; CCG-204832; CS-5708; LP00747; SDCCGSBI-0050725.P002; (y)-alpha-Methyl-4-carboxyphenylglycine; (?)-alpha-Methyl-4-carboxyphenylglycine; alpha-Methyl-2-(4-carboxyphenyl)glycine; NCGC00015676-03; NCGC00015676-04; NCGC00015676-05; NCGC00015676-06; NCGC00015676-09; NCGC00024542-02; NCGC00024542-03; NCGC00024542-04; NCGC00261432-01; BS-15439; (r,s)-alpha-methyl-4-carboxyphenylglycine; HY-100371; EU-0100747; ST50825577; Benzeneacetic acid,a-amino-4-carboxy-a-methyl-; M 4796; L000020; SR-01000075733; J-008240; SR-01000075733-1; 4-(1-Amino-1-carboxy-ethyl)-benzoic acid(S-M4CPG); Q27268302
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| Activity |
Ki = 50000 nM
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[5] | |||
| Compound Name |
1-Methyl-N-[(3-methyl-1,2-oxazol-5-yl)methyl]-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3122205; BDBM50448146
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
N-Ethyl-1-methyl-6-[(6-methylpyridin-2-yl)methoxy]pyrazolo[3,4-b]pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3122222; BDBM50448147
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-hexyl-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319732; BDBM50072173; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-hexylcyclopropane-1-carboxylic acid
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| Activity |
IC50 = 54900 nM
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[6] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-butyl-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL95868; BDBM50072177; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-butylcyclopropane-1-carboxylic acid
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| Activity |
IC50 = 57000 nM
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[6] | |||
| Compound Name |
(S)-4-((1-Carboxyethyl)amino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL58247; 4-[[(1S)-1-carboxyethyl]amino]benzoic acid; 4-{[(1S)-1-carboxyethyl]amino}benzoic acid; SCHEMBL350279; KS-00001CM5; BDBM50071162; ZINC52969665; 4-((S)-1-Carboxy-ethylamino)-benzoic acid; (2S)-2-[(4-Carboxyphenyl)amino]propanoic acid
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| Activity |
IC50 = 57000 nM
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[7] | |||
| Compound Name |
(2S)-2-(3''-Carboxymethylbicyclo[1.1.1]pentyl)glycine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL467234; BDBM50254389
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| Activity |
Ki = 59000 nM
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[8] | |||
| Compound Name |
2-[(1R,2R,3S)-2-Carboxy-3-phenylcyclopropyl]-L-glycine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2114116; BDBM50407823
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| Activity |
Ki = 60000 nM
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[5] | |||
| Compound Name |
N-(4-Fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2408581; Oprea1_073219; Oprea1_662240; ZINC51866; BDBM50438310; STK674207; AKOS005593567; MCULE-2340011568; ST4037492; SR-01000519434; SR-01000519434-1; (4-fluorophenyl)-4,5,6,7-tetrahydrobenzothiazol-2-ylamine
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| Activity |
IC50 = 64000 nM
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[9] | |||
| Compound Name |
4-Carboxyphenylglycine
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Investigative | Compound Info | ||
| Synonyms |
(RS)-4-Carboxyphenylglycine; 4-[amino(carboxy)methyl]benzoic acid; 4-Carboxylphenylglycine; 4-CPG; 4-(Amino(carboxy)methyl)benzoic acid; (RS)-4CPG; (R)-4CPG; CHEMBL328984; (S)-4-Carboxyphenylglycine;4CPG; 4-(Amino-carboxy-methyl)-benzoic acid; 2-(4-Carboxyphenyl)glycine; Benzeneacetic acid, alpha-amino-4-carboxy-, (+-)-; SCHEMBL2266884; CTK2H8632; DTXSID70864035; BDBM50030629; MFCD00673852; NSC644612; 4-(amino-carboxy-methyl)benzoic acid; AKOS023158559; NSC-644612; (R,S)-4-Carboxy-3-hydroxyphenylglycine; NCI60_015099; FT-0694231; (+-)- alpha-amino-4-carboxy-Benzeneacetic acid; 4-(Amino-carboxy-methyl)-benzoic acid(S-4CPG); L001308; SR-01000597634; SR-01000597634-1
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| Activity |
IC50 = 65000 nM
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[10] | |||
| Compound Name |
4-(Amino-carboxy-methyl)-2-hydroxy-5-methyl-benzoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329905; SCHEMBL7396587; BDBM50290679; 2-(4-Carboxy-3-hydroxy-6-methylphenyl)glycine; 4-[amino(carboxy)methyl]-2-hydroxy-5-methylbenzoic acid
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| Activity |
IC50 = 73000 nM
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[11] | |||
| Compound Name |
(S)-4-(Amino(carboxy)methyl)cubane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021372; SCHEMBL7711939; BDBM50400856; CS-0091145
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| Activity |
IC50 = 76000 nM
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[12] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1S,2R)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389555; BDBM50220149; (2S,1''S,2''R)-2-(2''-sulfonocyclopropyl)glycine
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| Activity |
Ki = 77000 nM
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[13] | |||
| Compound Name |
L-Homocysteic acid
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Investigative | Compound Info | ||
| Synonyms |
(2S)-2-Amino-4-sulfobutanoic acid; L-2-Amino-4-sulfobutyric acid; L-HOMOCYSTEATE; Homocysteic acid; (S)-2-amino-4-sulfobutanoic acid; UNII-YW13F86W9W; CHEMBL230951; YW13F86W9W; (2~{S})-2-azanyl-4-sulfo-butanoic acid; L-2-Amino-4-sulfobutyrate; SCHEMBL157695; (S)-2-amino-4-sulfobutyric acid; ZINC2567965; (2S)-2-amino-4-sulfobutyric acid; BDBM50220147; MFCD00066018; PDSP1_001269; PDSP2_001253; C16511; H-2740; Q15410991; UNII-HYA2G5T79L component VBOQYPQEPHKASR-VKHMYHEASA-N
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| Activity |
Ki = 87000 nM
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[13] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-propyl-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99462; BDBM50072168; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-propylcyclopropane-1-carboxylic acid
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
5-(4-Chlorophenyl)-1-(cyclohexylmethyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246610; BDBM50214072
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
6-Methyl-1-phenyl-5-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL248210; BDBM50214084
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
2-(2,6-Dichloro-phenyl)-7-ethyl-5-(2-methoxy-phenyl)-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid dimethylaminomethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL89293; SCHEMBL13319998; BDBM50089892
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| Activity |
Ki ~ 100000 nM
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[3] | |||
| Compound Name |
4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL8839; LY-389795; SCHEMBL2450641; CTK1A0220; DTXSID40436647; BDBM50074750; (1beta,5beta)-4-Amino-2-thiabicyclo[3.1.0]hexane-4beta,6beta-dicarboxylic acid; (1R,4S,5S,6S)-4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; 2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylicacid, 4-amino-, (1R,4S,5S,6S)-
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| Activity |
EC50 ~ 100000 nM
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[15] | |||
| Compound Name |
4-(6-Methyl-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL398944; BDBM50214080
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyclopropylcyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1253501; BDBM50326794; (+/-)(1R,2S,3S)-3-[(S)-amino(carboxy)-methyl]-1,10-bi(cyclopropyl)-2-carboxylic acid
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| Activity |
EC50 ~ 100000 nM
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[16] | |||
| Compound Name |
5-(4-Chlorophenyl)-6-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245991; BDBM50214081
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-ethyl-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL439775; BDBM50072172; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-ethylcyclopropane-1-carboxylic acid
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
2-[(3-Methylphenyl)amino]-7,8-dihydroquinazolin-5(6H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2408582; 2-(3-methylanilino)-7,8-dihydro-6H-quinazolin-5-one; BDBM50438309; STK356892; ZINC16650533; AKOS002302399; MCULE-5550372453; ST50798695; 2-(m-tolylamino)-7,8-dihydroquinazolin-5(6h)-one; 2-[(3-methylphenyl)amino]-6,7,8-trihydroquinazolin-5-one
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
6-Methyl-1,5-di(pyrazin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399460; BDBM50214070
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-phenethyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319279; BDBM50072176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-methyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97574; BDBM50072171; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-methylcyclopropane-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-isobutyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97200; BDBM50072170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyclohexylcyclopropane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1253502; BDBM50326793; (+/-)(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyclohexylcyclopropanecarboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-(3-Chlorophenyl)-6-methyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443753; Oprea1_314669; ZINC74342; BDBM50214086; STK711981; AKOS001737275; MCULE-2108828516; EU-0085236; SR-01000522414; SR-01000522414-1; 5-(3-chlorophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
9-Dimethylamino-3-(4-cyclohexylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374135; BDBM50177087
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(HYDIA)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330097; BDBM50089895
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(Amino-carboxy-methyl)-3-methyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334160; SCHEMBL7140374; BDBM50138781; (1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-cyclopropanecarboxylic acid; (S)-Amino[(1S)-2beta-methyl-3alpha-carboxycyclopropane-1beta-yl]acetic acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(S)-2-Amino-3-(4-butyl-3-hydroxy-isoxazol-5-yl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315663; (R)-Bu-HIBO; (S)-4-Butylhomoibotenic acid; BDBM85348; BDBM50063485; 2-Amino-3-(4-butyl-3-hydroxy-isoxazol-5-yl)-propionic acid(S-Bu-HIBO)
Click to Show/Hide
|
||||
| Activity |
Ki = 110000 nM
|
[3] | |||
| Compound Name |
(1R,2S,4R,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46527; BDBM50064246; (1R,4R)-2beta-Aminobicyclo[2.1.1]hexane-2,5beta-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 121000 nM
|
[18] | |||
| Compound Name |
trans-ACPD
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(1R,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid; (1R,3S)-ACPD; CHEMBL36988; trans-(+/-)-ACPD monohydrate; (+/-)-trans-ACPD; (inverted exclamation markA)-trans-ACPD; 1-Amino-1,3-cyclopentanedicarboxylic acid; t-ACPD; 1-Amino-1,3-dicarboxycyclopentane; NSC 27386; (+/-)-1-AMINOCYCLOPENTANE-trans-1,3-DICARBOXYLIC ACID; 1,3-Cyclopentanedicarboxylic acid, 1-amino-, trans-; SCHEMBL4835874; CTK1H5156; 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1R,3S)-rel-; DTXSID201017343; BCP18261; ZINC2530680; BDBM50060136; MFCD11046039; AKOS006272258; CS-5853; HY-19434; AJ-190/40848563; (1R,3S)-1-Amino-cyclopentane-1,3-dicarboxylic acid; 1-Amino-cyclopentane-1,3-dicarboxylic acid(trans-ACPD); 1-Amino-cyclopentane-1,3-dicarboxylic acid(trans-(1R,3R)-ACPD); trans-(+/-)-1-Amino-1,3-cyclopentanedicarboxylic acid monohydrate
Click to Show/Hide
|
||||
| Activity |
EC50 = 127000 nM
|
[19] | |||
| Compound Name |
(2R,4R)-4-Amino-1-naphthalen-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61281; SCHEMBL8973223; BDBM50071155; (2R,4R)-4-amino-1-(naphthalen-2-ylmethyl)pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 133000 nM
|
[7] | |||
| Compound Name |
Iflwvshrwaivqf-sgihwfkdsa-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115160; BDBM50407827; 2-[(1R,2R,3S)-2-Carboxy-3-phenylcyclopropyl]-D-glycine
Click to Show/Hide
|
||||
| Activity |
Ki = 135000 nM
|
[5] | |||
| Compound Name |
2-[(1S,2R,3R)-2-Carboxy-3-phenylcyclopropyl]-D-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115152; BDBM50407819
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[5] | |||
| Compound Name |
(S)-2-Amino-4-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL126608; Homoquisqualic acid; SCHEMBL13319913; BDBM50038038; 2-Amino-4-(3-hydroxy-5-oxo-5H-[1,2,4]oxadiazol-2-yl)-butyric acid(S-homoquisqualic acid)
Click to Show/Hide
|
||||
| Activity |
Ki = 184000 nM
|
[3] | |||
| Compound Name |
(RS)-4-Carboxy-3-hydroxyphenylglycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-[amino(carboxy)methyl]-2-hydroxybenzoic acid; (RS)-4C3HPG; CHEMBL444589; 4-(Amino(carboxy)methyl)-2-hydroxybenzoic acid; Benzeneacetic acid, a-amino-4-carboxy-3-hydroxy-; (s)-4C3HPG; (+/-)-4-carboxy-3-hydroxyphenylglycine; 4-Chpgly; 4-[(S)-AMINO(CARBOXY)METHYL]-2-HYDROXYBENZOIC ACID; (RS)-4C3H-PG; 4-Carboxy-3-hydroxyphenylglycine; 4C3HPG; alpha-Amino-4-carboxy-3-hydroxybenzeneacetic acid; ACMC-20cesn; (+-)-alpha-Amino-4-carboxy-3-hydroxybenzeneacetic acid; Benzeneacetic acid, alpha-amino-4-carboxy-3-hydroxy-; SCHEMBL12648353; CTK4B8962; DTXSID60928397; Benzeneacetic acid, alpha-amino-4-carboxy-3-hydroxy-, (+-)-; HMS3266G05; HMS3266G09; HMS3411E05; HMS3675E05; BDBM50030628; 2-(4-Carboxy-3-hydroxyphenyl)glycine; AKOS024457427; 4-(Amino-carboxy-methyl)-2-hydroxy-benzoic acid; L000843; SR-01000597631; J-006476; SR-01000597631-1; BRD-A80383043-001-01-7; Q27165658; 4-(Amino-carboxy-methyl)-2-hydroxy-benzoic acid(S-4C3HPG)
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 86 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PCCG-4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2S,1'S,2'S,3 R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
1-benzyl-APDC
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60238; 171336-76-8; (2R,4R)-1-BENZYL-4-AMINO-PYRROLIDINE-2,4-DIcarboxylic acid; GTPL1436; SCHEMBL8061968; CTK0A8043; DTXSID60573467; ZINC39952128; BDBM50071161; DB-064818; AJ-101168; FT-0772028; 4-amino-1-(phenylmethyl)pyrrolidine-2,4-dicarboxylic acid; (2R,4R)-4-amino-1-benzylpyrrolidine-2,4-dicarboxylic acid; (2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid; (2R)-1-Benzyl-4-aminopyrrolidine-2beta,4alpha-dicarboxylic acid; 4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid(1-benzyl-APDC)
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
LY307452
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
LY-307452; LY-307,452; LY 307452
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[3] | |||
| Compound Name |
(R,S)-4-phosphonophenylglycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(RS)-PPG; 120667-15-4; 2-amino-2-(4-phosphonophenyl)acetic acid; CHEMBL277475; AC1ND7MS; (RS)PPG; (RS) PPG; C8H10NO5P; (RS)-4-Phosphonophenylglycine; GTPL1406; SCHEMBL9150881; CTK8F0597; (R,S)-4-PPG; MolPort-003-983-668; BN0429; BDBM50004881; AKOS015911887; Amino-(4-phosphono-phenyl)-acetic acid; NCGC00025051-02; RT-015313; V2034; Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG); SR-01000597406; 667P154; L000025; SR-01000597406-1; J-004376
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[3] | |||
| Compound Name |
D-aspartic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
D-Aspartic acid; 1783-96-6; (R)-2-aminosuccinic acid; D-Aspartate; H-D-Asp-OH; (-)-Aspartic acid; (R)-Aspartic acid; Aspartic acid D-form; (2R)-2-aminobutanedioic acid; Aspartic acid, D-; D-(-)-Aspartic acid; (R)-(-)-Aminosuccinic acid; D-Asp; D-Aminosuccinic acid; NSC 97922; D-Asparaginsaeure; UNII-4SR0Q8YD1X; BRN 1723529; Tocris-0213; EINECS 217-234-6; 4SR0Q8YD1X; (R)-2-aminobutanedioic acid; CHEMBL29757; CHEBI:17364; CKLJMWTZIZZHCS-UWTATZPHSA-N; MFCD00063081; NCGC00024498-02; (R)-2-Aminobutanedioate; D(-)-Aspartic acid, 99+%; D-aspartate; [3H]D-aspartic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[21] | |||
| Compound Name |
MPPG
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MPPG; 169209-65-8; 2-amino-2-(4-phosphonophenyl)propanoic acid; CHEMBL86508; AC1N11KO; GTPL1415; SCHEMBL12648709; CTK8F0596; DTXSID80398316; MolPort-003-983-629; MPPG, >=97% (NMR), solid; BDBM50089910; MFCD00672651; BN0344; AKOS024458668; API0007557; (RS)- -Methyl-4-phosphonophenylglycine; NCGC00024826-02; (RS)-; A-Methyl-4-phosphonophenylglycine; RT-013949; 2-Amino-2-(4-phosphono-phenyl)-propionic acid; L000410; SR-01000597457; J-010517; SR-01000597457-1; 2-Amino-2-(4-phosphono-phenyl)-propionic acid(RS-MPPG)
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
homo-AMPA
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107768; homo-AMPA; HomoAMPA; AC1N6KQF; 2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid; GTPL3359; SCHEMBL3731488; CTK8G0203; HMS3267O13; BDBM50052551; NCGC00024946-02; SR-01000597464; SR-01000597464-1; 2-amino-4-(5-methyl-3-oxo-1,2-oxazol-4-yl)butanoic acid; 2-Amino-4-(3-hydroxy-5-methylisoxazole-4-yl)butyric acid; 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid; a-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolebutanoic acid; 2-amino-4-(5-methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)butanoic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[21] | |||
| Compound Name |
D-glutamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
D-glutamate; D-Glu
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[21] | |||
| Compound Name |
L-aspartic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
L-Asp; L-aspartate; Aspatofort
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[21] | |||
| Compound Name |
L-AP4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2S)-2-Amino-4-phosphonobutanoic acid; 23052-81-5; (2S)-2-amino-4-phosphonobutanoic acid; L-(+)-2-Amino-4-phosphonobutyric acid; L-APB; (S)-2-amino-4-phosphonobutanoic acid; CHEMBL33567; L-AP-4; S-2-amino-4-phosphonobutyrate; [3H]AP4; L-2-amino-4-phosphonobutiric acid; L-1-amino-4-phosphonobutanoic acid; Tocris-0103; NCIStruc2_000128; NCIStruc1_000162; SCHEMBL1969235; GTPL1410; GTPL1412; AC1L456H; MolPort-002-514-399; NCI30079; ZINC2033983; BN0084; CCG-37553; NCGC00013365
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[8] | |||
| Compound Name |
(S)-AMPA
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-AMPA; 83643-88-3; (S)-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; UNII-9280SC28GD; CHEMBL276815; 9280SC28GD; (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid; AMPA, L-; AMQ; glutamate-AMPA; 1ftm; Tocris-0254; Tocris-0169; Tocris-1074; S-AMPA; 1p1q; L-AMPA; Lopac-G-017; AC1L4JUQ; Biomol-NT_000216; (S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; SCHEMBL667915; BPBio1_001304; CTK7I3476; BDBM17662; BDBM85214; UUDAMDVQRQNNHZ-YFKPBYRVSA-N; MolPort-003-940-001; MolPort-003-983-512; HMS3266E09
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[21] | |||
| Compound Name |
2-[(1R,2R,3R)-2-Carboxy-3-phenylcyclopropyl]-L-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2114115; BDBM50407824
Click to Show/Hide
|
||||
| Activity |
Ki = 205000 nM
|
[5] | |||
| Compound Name |
(2R)-3-(3''-Carboxybicyclo[1.1.1]pentyl)alanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450025; BDBM50254338
Click to Show/Hide
|
||||
| Activity |
Ki = 210000 nM
|
[8] | |||
| Compound Name |
(2S,3S)-3-(Carboxymethyl)azetidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2S,3S)-trans-3-(Carboxymethyl)-azetidine-2-acetic Acid; CHEMBL314690; CTK8F0661; ZINC4262470; BDBM50288204; ST50824727; J-011895; (2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 210000 nM
|
[22] | |||
| Compound Name |
(R)-1-Amino-indan-1,5-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358882; Tocris-0904; Lopac-A-254; SCHEMBL13745377; ZINC20684; BDBM50084136; 1alpha-Aminoindan-1,5-dicarboxylic acid; NCGC00015024-01; NCGC00015024-02; NCGC00024861-01
Click to Show/Hide
|
||||
| Activity |
IC50 = 214000 nM
|
[23] | |||
| Compound Name |
(1S,2S,4S,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42148; BDBM50064247; (1S,4S)-2beta-Aminobicyclo[2.1.1]hexane-2,5beta-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 232000 nM
|
[18] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60164; BDBM50071167; (2R,4R)-4-amino-1-[(2,6-dichlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 238500 nM
|
[7] | |||
| Compound Name |
(S)-Hibo
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88184; NSC_194385; 2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid; BDBM85355; CTK5D3927; BDBM50089901; PDSP1_001437; PDSP2_001421; 5-Isoxazolepropanoicacid, a-amino-2,3-dihydro-3-oxo-; 2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid(S-HIBO)
Click to Show/Hide
|
||||
| Activity |
Ki = 250000 nM
|
[3] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1S,2R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230852; BDBM50220150; (2R,1''S,2''R)-2-(2''-sulfonocyclopropyl)glycine
Click to Show/Hide
|
||||
| Activity |
Ki = 254000 nM
|
[13] | |||
| Compound Name |
(2S,3S,4S)-2-Amino-3,4-dihydroxy-pentanedioic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL28259; BDBM50084962; (3S,4S)-3,4-Dihydroxy-L-glutamic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 257000 nM
|
[24] | |||
| Compound Name |
2-[(1R,2S,3S)-2-Carboxy-3-phenylcyclopropyl]-L-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2114112; BDBM50407822
Click to Show/Hide
|
||||
| Activity |
Ki = 260000 nM
|
[5] | |||
| Compound Name |
2-[(1R,2S,3S)-2-Carboxy-3-phenylcyclopropyl]-D-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115157; BDBM50407830
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
2-[(1S,2R,3R)-2-Carboxy-3-phenylcyclopropyl]-L-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2114105; BDBM50407826
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
2-[(1R,2S,3R)-2-Carboxy-3-phenylcyclopropyl]-D-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115156; BDBM50407831
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
2-[(1R,2R,3R)-2-Carboxy-3-phenylcyclopropyl]-D-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115159; BDBM50407820
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
(2R,1S,2R,3S)-2-(2-Carboxy-3-phenylcyclopropyl)glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2114110; PCCG-13; CTK7I3043; BDBM50407825; AKOS026748543; M02254; 2-[(1S,2R,3S)-2-Carboxy-3-phenylcyclopropyl]-D-glycine; (2R,1'S,2'R3'S)-2-(2'-Carboxy-3'-phenulcyclopropyl)glycine; (1R,2S,3S)-2-[(R)-amino(carboxy)methyl]-3-phenylcyclopropane-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
2-[(1S,2S,3S)-2-Carboxy-3-phenylcyclopropyl]-L-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2114106; BDBM50407828
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
2-[(1S,2S,3S)-2-Carboxy-3-phenylcyclopropyl]-D-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115153; BDBM50407829
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
2-[(1S,2S,3R)-2-Carboxy-3-phenylcyclopropyl]-D-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115151; BDBM50407821
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
2-[(1R,2S,3R)-2-Carboxy-3-phenylcyclopropyl]-L-glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2114109; BDBM50407818
Click to Show/Hide
|
||||
| Activity |
Ki > 270000 nM
|
[5] | |||
| Compound Name |
(S)-3-Carboxy-4-hydroxyphenylglycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-3C4HPG; (S)-5-(amino(carboxy)methyl)-2-hydroxybenzoic acid; CHEMBL128772; Tocris-0329; SCHEMBL12648660; CTK8F2025; HMS3411E13; HMS3675E13; ZINC2567735; BDBM50053586; AKOS015926398; NCGC00024539-01; NCGC00024539-02; SR-01000597640; J-007159; SR-01000597640-1; 5-((S)-Amino-carboxy-methyl)-2-hydroxy-benzoic acid; 5-[(S)-AMINO(CARBOXY)METHYL]-2-HYDROXYBENZOIC ACID; Benzeneacetic acid, alpha-amino-3-carboxy-4-hydroxy-, (alphaS)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 290000 nM
|
[25] | |||
| Compound Name |
(2R,4R)-4-Amino-1-methylpyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL300330; SCHEMBL14278713; CTK1A0056; DTXSID10658238; BDBM50071164; ZINC29571185; (2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxylic acid; 2,4-Pyrrolidinedicarboxylicacid, 4-amino-1-methyl-, (2R,4R)-
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-biphenyl-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL293434; SCHEMBL8973026; BDBM50071150; (2R,4R)-4-amino-1-[(2-phenylphenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(3-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60008; SCHEMBL8973090; BDBM50071168; (2R,4R)-4-amino-1-[(3-chlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL40123; SCHEMBL187449; BDBM50069111; ZINC13797034; 2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid; (2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[3] | |||
| Compound Name |
3-[(R)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97083; (R)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid; SCHEMBL2266688; CTK7I3071; (R)-(?)-CBPG; BDBM50052255; ZINC12506682; AKOS026740796; CS-0078705; EN300-88067; 1-[(R)-amino(carboxy)methyl]bicyclo[1.1.1]pentane-3-carboxylic acid; 3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 300000 nM
|
[26] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(3,4-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59686; SCHEMBL8972863; BDBM50071163; (2R,4R)-4-amino-1-[(3,4-dichlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(naphthalen-1-ylmethyl)pyrrolidine-2,4-dicarboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302411; SCHEMBL8973459; BDBM50071159; (2R,4R)-4-Amino-1-naphthalen-1-ylmethyl-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292553; SCHEMBL8972917; BDBM50071152; (2R,4R)-4-amino-1-(2-phenylethyl)pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(2,4-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59920; BDBM50071153; (2R,4R)-4-amino-1-[(2,4-dichlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(3-phenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406215; SCHEMBL8973322; BDBM50071154; (2R,4R)-4-amino-1-(3-phenylpropyl)pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(4-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61964; SCHEMBL8973457; BDBM50071157; (2R,4R)-4-amino-1-[(4-chlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418650; SCHEMBL8973301; BDBM50071160; (2R,4R)-4-amino-1-(cyclohexylmethyl)pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1R,2S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389556; BDBM50220153; (2R,1''R,2''S)-2-(2''-sulfonocyclopropyl)glycine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[13] | |||
| Compound Name |
(2R,4R)-4-Amino-1-benzhydrylpyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1169414; SCHEMBL8973161; BDBM50366533
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1R,2R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389557; BDBM50220145; (2S,1''R,2''R)-2-(2''-sulfonocyclopropyl)glycine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[13] | |||
| Compound Name |
(1S,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
cis-ACPD; CHEMBL29726; Cis-1-aminocyclopentane-1,3-dicarboxylic acid; (+/-)-trans-ACPD; 1-amino-cis-cyclopentane-1,3-dicarboxylic acid; 1S, 3R-ACPD; (1S,3S)-ACPD; Tocris-0186; Tocris-0187; Tocris-0284; 1,3-Cyclopentanedicarboxylicacid, 1-amino-, (1S,3S)-; 1R,3R-ACPD; 1R,3S-ACPD; 1S,3S-ACPD; (+/-)-1-AMINOCYCLOPENTANE-cis-1,3-DICARBOXYLIC ACID; SCHEMBL481144; CTK0H2865; YFYNOWXBIBKGHB-FFWSUHOLSA-; ZINC1641373; BDBM50004863; MFCD00153759; AKOS006273106; NCGC00024487-01; NCGC00024488-01; NCGC00024488-02; B6219; 1-Aminocyclopentane-cis-1,3-dicarboxylic acid; M01251; A824378; SR-01000597676; 1-Amino-cyclopentane-1,3-dicarboxylic acid (APCD); SR-01000597676-1; (1S,3S)-1-Amino-cyclopentane-1,3-dicarboxylic acid; (1S,3S)-1-azanylcyclopentane-1,3-dicarboxylic acid; Q27458657; 1-Amino-cyclopentane-1,3-dicarboxylic acid(cis-(1S,3S)-ACPD)
Click to Show/Hide
|
||||
| Activity |
EC50 > 300000 nM
|
[18] | |||
| Compound Name |
(2S)-(3''-Phosphonomethylbicyclo[1.1.1]pentyl)glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445241; BDBM50254391
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[8] | |||
| Compound Name |
(2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304034; SCHEMBL8973013; BDBM50071158; (2R,4R)-4-amino-1-[(4-phenylphenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-ethylpyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59830; CTK1A0057; DTXSID80658240; BDBM50071156; ZINC26157741; (2R,4R)-4-Amino-1-ethyl-pyrrolidine-2,4-dicarboxylic acid; 2,4-Pyrrolidinedicarboxylicacid, 4-amino-1-ethyl-, (2R,4R)-
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1S,2S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230949; BDBM50220151; (2R,1''S,2''S)-2-(2''-sulfonocyclopropyl)glycine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[13] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1R,2R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230950; BDBM50220154; (2R,1''R,2''R)-2-(2''-sulfonocyclopropyl)glycine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[13] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1S,2S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389558; BDBM50220146; (2S,1''S,2''S)-2-(2''-sulfonocyclopropyl)glycine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[13] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(3,3-diphenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60302; BDBM50071166; (2R,4R)-4-amino-1-(3,3-diphenylpropyl)pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304919; SCHEMBL8972526; BDBM50071151; (2R,4R)-4-amino-1-(2,2-diphenylethyl)pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(2-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418462; SCHEMBL8973329; BDBM50071165; (2R,4R)-4-amino-1-[(2-chlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
2-Amino-3-(4-bromo-3-hydroxyisoxazol-5-YL)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73698; (RS)-4-Bromo-homo-ibotenic acid; (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID; Bromohomoibotenic acid; 2-amino-3-(4-bromo-3-oxo-1,2-oxazol-5-yl)propanoic acid; SCHEMBL5280594; SCHEMBL13957643; CTK5E3726; DTXSID30991699; (+/-)-4-Bromohomoibotenic acid; BDBM50017244; AB44069; (+/-)-4-Bromohomoibotenic acid, solid; ST50405217; 3-(4-Bromo-3-hydroxy-1,2-oxazol-5-yl)alanine; Q27458524; 2-azaniumyl-3-(4-bromo-3-oxo-1,2-oxazol-5-yl)propanoate; 2-Amino-3-(4-bromo-3-hydroxy-isoxazol-5-yl)-propionic acid; 5-Isoxazolepropanoicacid, a-amino-4-bromo-2,3-dihydro-3-oxo-; (R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)propionic acid; 2-AMINO-3-(4-BROMO-3-HYDROXYISOXAZOL-5-YL)PROPANOICACID; 2-amino-3-(4-bromo-3-oxo-2,3-dihydroisoxazol-5-yl)propanoic acid; 2-AMINO-3-(4-BROMO-3-HYDROXY-1,2-OXAZOL-5-YL)PROPANOIC ACID
Click to Show/Hide
|
||||
| Activity |
Ki = 329000 nM
|
[27] | |||
| Compound Name |
(2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-4-yl)-2-methylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313713; BDBM50089891; 2-Amino-3-(3-hydroxy-5-oxo-[1,2,4]oxadiazol-4-yl)-2-methyl-propionic acid(S-MetQUIS)
Click to Show/Hide
|
||||
| Activity |
Ki = 500000 nM
|
[3] | |||
| Compound Name |
2-Amino-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39215; ABHD-I; SCHEMBL6738759; BDBM50076394
Click to Show/Hide
|
||||
| Activity |
IC50 = 630000 nM
|
[28] | |||
| Compound Name |
Amino-(2-chloro-3,5-dihydroxy-phenyl)-acetic acid(S-CHPG)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316451; BDBM50089900
Click to Show/Hide
|
||||
| Activity |
Ki = 750000 nM
|
[3] | |||
| Compound Name |
Cl-HIBO
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72366; 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid; (RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID; SCHEMBL1055865; 4-CHLOROHOMOIBOTENIC ACID; CTK8F8718; (2S)-2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid; BDBM50128264; AKOS024456741; AB17833; C-355; SR-01000597512; SR-01000597512-1; (R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionate; 2-Amino-3-(4-chloro-3-hydroxy-isoxazol-5-yl)-propionic acid; 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid.; 2-AMINO-3-(4-CHLORO-3-HYDROXY-1,2-OXAZOL-5-YL)PROPANOIC ACID
Click to Show/Hide
|
||||
| Activity |
Ki = 860000 nM
|
[27] | |||
| Compound Name |
(1S,3R)-1-Amino-3-(carboxymethyl)cyclopentane-1-carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315032; SCHEMBL13319985; CTK0H1515; DTXSID10434110; BDBM50089911; AKOS006271974; (1s,3r)-1-amino-1-carboxycyclopentane-3-acetic acid; Cyclopentaneaceticacid, 3-amino-3-carboxy-, (1R,3S)-; 1-Amino-3-carboxymethyl-cyclopentanecarboxylic acid(1S,3R-homo-ACPD)
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
2-Aminooctanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DL-ALPHA-AMINOSUBERIC ACID; Octanedioic acid, 2-amino-; DL-2-Aminosuberic Acid; 2-Amino-octanedioic acid; DL-2-Aminoctanedioic acid; DL-2-Aminooctanedioic Acid; H-D-Asu-OH; CHEMBL320957; (S)-2-Aminooctanedioic acid;L-alpha-Aminosuberic acid; D-alpha-Aminosuberic acid;(R)-2-Aminooctanedioic acid; aminosuberic acid; L-a-Aminosubericacid; alpha-aminosuberic acid; H-DL-Asu-OH.nH2O; DL-2-amino suberic acid; SCHEMBL127239; CTK8B9843; DTXSID60275757; 0126AB; ANW-63286; BDBM50052552; MFCD00063122; AKOS015893070; AS-58788; SC-10114; DB-044930; A1279; FT-0637883; 4,4-methylenebis(2-tert-butyl-6-methylphenol); 054A077; J-018004
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[21] | |||
| Compound Name |
(RS)-Apica
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-amino-5-phosphono-2,3-dihydroindene-1-carboxylic acid; CHEMBL277961; (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid; (S)-MPPG (cyclic); 1-Amino-5-phosphono-indan-1-carboxylic acid; 1H-Indene-1-carboxylicacid; SCHEMBL2799885; CTK8F2086; BDBM50089893; AKOS024456371; NCGC00024982-02; SR-01000597477; J-010657; J-013076; SR-01000597477-1; 1-Amino-5-phosphono-indan-1-carboxylic acid(RS-APICA)
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334842; SCHEMBL3261303; (2R)-2-amino-4-(4-oxo-1,2,5-thiadiazol-3-yl)butanoic Acid; BDBM50118479
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[29] | |||
| Compound Name |
(2R)-(3'-Phosphonomethylbicyclo[1.1.1]pentyl)glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467235; BDBM50254392; (2R)-(3''-Phosphonomethylbicyclo[1.1.1]pentyl)glycine
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[8] | |||
| Compound Name |
(2R)-2-(3''-Carboxymethylbicyclo[1.1.1]pentyl)glycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448885; BDBM50254390
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[8] | |||
| Compound Name |
D-2-Aminoadipic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(R)-2-Aminohexanedioic acid; (2R)-2-aminohexanedioic acid; D-a-Aminoadipic acid; (R)-2-Aminoadipic acid; D-alpha-aminoadipic acid; A-Aminoadipic acid; Hexanedioic acid, 2-amino-, (2R)-; (R)-2-Amino-hexanedioic acid; Hexanedioic acid, 2-amino-, (-)- and (+)-; D-Homoglutamic acid; D-2-Aminoadipic acid, 98%; MFCD00063118; alpha-Aminoadipate, D-; H-D-2-Aad-OH; d-2-aminoadipate; D-Aad; D-Ho-Glu; 2-Aminohexanedioic acid (-)- and (+)-; Lopac-A-7275; KSC493Q2H; SCHEMBL2022365; CHEMBL1169505; BDBM85356; CTK3J3823; KS-00000JOF; DTXSID90227062; ZINC1678992; ANW-43726; AKOS016842486; CS-W016142; NCGC00015087-01; AC-22381; AS-14204; SC-10039; AB0014153; M-3011; Q27117011; Z2767445962; UNII-1K7B1OED4N component OYIFNHCXNCRBQI-SCSAIBSYSA-N
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| Activity |
EC50 > 1000000 nM
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[21] | |||
| Compound Name |
(S)-2-Amino-5-phosphonopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
L-AP5; 5-phosphono-L-norvaline; CHEMBL71898; 2-Amino-5-phosphono-pentanoic acid; L(+)-2-Amino-5-phosphonopentanoic acid; Tocris-0107; SCHEMBL1662220; CTK7I3523; ZINC1854168; BDBM50017229; (s)-2-amino-5-phosphonovaleric acid; (S)-2-amino-5-phosphonopentanoicacid; AKOS024456367; (2S)-2-azaniumyl-5-phosphonopentanoate; (S)-2-Amino-5-phosphono-pentanoic acid; NCGC00024472-01; L-(+)-2-Amino-5-phosphonopentanoic acid; (2~{S})-2-azanyl-5-phosphono-pentanoic acid; SR-01000597696; SR-01000597696-1; UNII-39PJ29YY8Z component VOROEQBFPPIACJ-BYPYZUCNSA-N
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| Activity |
Ki > 1000000 nM
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[3] | |||
| Compound Name |
(1R,4S,5R,6S)-3-Azabicyclo[3.3.0]octane-4,6-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL371301; Azabicyclo-ODD; BDBM50180145
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| Activity |
EC50 > 1000000 nM
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[30] | |||
| Compound Name |
(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL297150; BDBM50078596; 4-Amino-2,4-dicarboxy-pyrrolidin-1-yl-ammonium(1-Amino-APDC)
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| Activity |
Ki > 1000000 nM
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[3] | |||
| Compound Name |
(2S)-2-Amino-4-(4-oxo-1,2,5-thiadiazol-3-yl)butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL131922; BDBM50118480
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| Activity |
EC50 > 1000000 nM
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[29] | |||
| Compound Name |
(RS)-3-Hydroxyphenylglycine
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Investigative | Compound Info | ||
| Synonyms |
2-Amino-2-(3-hydroxyphenyl)acetic acid; Amino(3-hydroxyphenyl)acetic acid; m-Hydroxyphenylglycine; CHEMBL88124; (S)-(3-Hydroxyphenyl)glycine; DL-2-(3-Hydroxyphenyl)glycine; Benzeneacetic acid, a-amino-3-hydroxy-; 2-(3-hydroxyphenyl)glycine; (RS)-3H-PG; SCHEMBL1512921; CTK4G7931; ALBB-016006; Amino(3-hydroxyphenyl)acetic acid #; BDBM50089914; AKOS000179898; AKOS017259239; Glycine, 2-(m-hydroxyphenyl)-, DL-; AB06901; MCULE-6517923716; 2-azaniumyl-2-(3-hydroxyphenyl)acetate; NCGC00024536-02; Amino-(3-hydroxy-phenyl)-acetic acid(S-HPG); W-7471; L001190; SR-01000597637; J-018571; SR-01000597637-1; benzeneacetic acid, alpha-amino-3-hydroxy-, hydrochloride
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| Activity |
Ki = 1000000 nM
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[3] | |||
| Compound Name |
(R)-Ampa
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Investigative | Compound Info | ||
| Synonyms |
D-AMPA; UNII-F45TJ02EL1; CHEMBL14815; F45TJ02EL1; (R)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid; 4-Isoxazolepropanoic acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo-, (alphaR)-; (2R)-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid; Ampa, D-; (R)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; (-)-Ampa; Tocris-0253; Biomol-NT_000215; BPBio1_001302; SCHEMBL2458874; SCHEMBL13957590; CTK7I3077; HMS3266E07; ZINC3870314; BDBM50026947; AKOS006272257; SB38934; NCGC00024516-01; NCGC00024516-02; B6237; SR-01000597719; SR-01000597719-1; Q27277614; (R)-?-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; (r)-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; UNII-J090588E6X component UUDAMDVQRQNNHZ-RXMQYKEDSA-N; (R)-2-ammonio-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoate; (R)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid; 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid(D-AMPA)
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| Activity |
EC50 > 1000000 nM
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[21] | |||
| Compound Name |
2-Aminoheptanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
dl-2-Aminopimelic acid; 2-AMINOPIMELIC ACID; 2-Aminopimelate; dl-alpha-Aminopimelic acid; DL-2-Aminopimelate; DL-2-Aminoheptanedioic acid; alpha-Aminopimelic acid; (+/-)-2-Aminopimelic acid; 2-Amino-heptanedioic acid; (+-)-2-Aminopimelic acid; Heptanedioic acid, 2-amino-; DL-alpha-Aminopimelic acid;H-DL-Apm-OH; CHEMBL111050; DL-Heptyline; D,L-alpha-Aminopimelic acid; heptyline; aminopimelic acid; DL-2-Aminopimelic Acid(alpha-); a-aminopimelic acid; EINECS 211-011-7; NSC 402480; DL-2-AminopimelicAcid; H-DL-Apim(2)-OH; DL-2-amino pimelic acid; 2-Aminoheptanedioic acid #; 2-Aminopimelic acid, DL-; Heptanedioic acid,2-amino-; d,l-2-aminoheptanedioic acid; dl-.alpha.-Aminopimelic acid; SCHEMBL116556; CTK8B9845; DTXSID00978316; (+/-)-2-Aminoheptanedioic acid; 2-Amino-(+-)-Heptanedioic acid; ()-2-Aminopimelic acid; ANW-63293; BDBM50052549; CCG-49889; KM0656; MFCD00053314; NSC402480; AKOS016003609; MCULE-2486712857; NSC-402480; VZ23774; Heptanedioic acid, 2-amino-, (+-)-; KS-0000170J; (+/-)-2-Aminopimelic acid, >=99%; AS-47823; SC-10081; DB-054281; Heptanedioic acid, 2-amino-, (.+/-.)-; A0404; FT-0611264; FT-0658289; 627H769; SR-01000639310-1; W-204236; Q27894420; DB946E0D-C5D0-47E2-A9AA-3E29D190922E
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| Activity |
EC50 > 1000000 nM
|
[21] | |||
| Compound Name |
alpha-Amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL280585; 2-amino-2-(5-methyl-3-oxo-1,2-oxazol-4-yl)acetic acid; Amaa acid; 2-Amino-3-hydroxy-5-methyl-4-isoxazoleacetic acid; SCHEMBL5290687; CTK5E3723; DTXSID20998293; BDBM50004852; alpha-amino-5-methyl-3-hydroxy-4-isoxazoleacetic acid; Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-acetic acid; Amino(3-hydroxy-5-methyl-1,2-oxazol-4-yl)acetic acid; 4-Isoxazoleacetic acid,a-amino-2,3-dihydro-5-methyl-3-oxo-; 2-Amino-2-(5-methyl-3-oxo-2,3-dihydroisoxazol-4-yl)acetic acid; Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-acetic acid (D-AMAA); 4-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo-, (+-)-
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| Activity |
EC50 > 1000000 nM
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[21] | |||
| Compound Name |
(1r,3r)-1-Aminocyclopentane-1,3-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
cis-ACPD; CHEMBL107845; 1,3-Cyclopentanedicarboxylicacid, 1-amino-, (1R,3R)-; 1-amino-cis-cyclopentane-1,3-dicarboxylic acid; (+/-)-trans-ACPD; (+/-)-1-AMINOCYCLOPENTANE-cis-1,3-DICARBOXYLIC ACID; Lopac-A-155; SCHEMBL719389; (1R,3R)-ACPD; CTK0H4120; KS-00001DF6; NSC27386; ZINC2504585; BDBM50060133; HY-19434A; MFCD00672631; NSC-27386; AKOS017344537; NCGC00015010-01; CS-0015533; (1R,3R)-1-Amino-cyclopentane-1,3-dicarboxylic acid; 1,3-Cyclopentanedicarboxylicacid,1-amino-,(1R,3R)-; 1-Amino-cyclopentane-1,3-dicarboxylic acid(cis-(1R,3R)-ACPD)
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| Activity |
EC50 > 1000000 nM
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[19] | |||
| Compound Name |
(2S)-3-(3''-Carboxybicyclo[1.1.1]pentyl)alanine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL444718; BDBM50254337
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| Activity |
Ki > 1000000 nM
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[8] | |||
| Compound Name |
(1R,2S,4R,5S)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43857; BDBM50064245; (1R,4R)-2beta-Aminobicyclo[2.1.1]hexane-2,5alpha-dicarboxylic acid
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| Activity |
EC50 > 1000000 nM
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[18] | |||
| Compound Name |
(1S,2S)-4-Aminocyclopentane-1,2,4-tricarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329236; SCHEMBL13319984; ZINC2575698; BDBM50060134; (1S,2S)-4-Amino-cyclopentane-1,2,4-tricarboxylic acid; (1S)-4-Aminocyclopentane-1alpha,2beta,4beta-tricarboxylic acid; 4-Amino-cyclopentane-1,2,4-tricarboxylic acid(3S,4S-ACPT-III)
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| Activity |
Ki > 1000000 nM
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[3] | |||
| Compound Name |
(1S,2S)-1-Amino-2-(carboxymethyl)cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CTK0H1302; CHEMBL3347671; DTXSID20472068; ZINC32629480; AKOS026740805; Cyclopropaneaceticacid, 2-amino-2-carboxy-, (1S,2S)-
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| Activity |
EC50 > 1000000 nM
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[29] | |||
| Compound Name |
2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313394; SCHEMBL13319983; BDBM50089898; (2S,7S)-2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid
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| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
2-Amino-6-(3-hydroxy-5-methylisoxazol-4-yl)hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111441; BDBM50052554; 2-Amino-6-(3-hydroxy-5-methyl-isoxazol-4-yl)-hexanoic acid
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| Activity |
EC50 > 1000000 nM
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[21] | |||
| Compound Name |
2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315268; (S)-Homo-AMPA; NCGC00024946-01; Tocris-1026; SCHEMBL12506417; BDBM50060719; (s)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid; (S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid; 2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid(S-homo-AMPA)
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| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
L-2-Aminoadipic acid
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Investigative | Compound Info | ||
| Synonyms |
(S)-2-aminohexanedioic acid; L-alpha-Aminoadipic acid; (2S)-2-aminohexanedioic acid; L-alpha-Aminoadipate; L-2-Aminoadipate; L-Homoglutamic acid; l-2-amino adipic acid; homoglutamic acid; (S)-2-Aminoadipic acid; UNII-88ZH74L7SR; hexanedioic acid, 2-amino-, (2S)-; h-2-aad-oh; l-a-aminoadipic acid; h-l-2-aad-oh; MFCD00002636; L-2-Aminohexanedioate; CHEMBL88804; 88ZH74L7SR; L-2-Aminoadipic acid, 98%; A-aminoadipic acid; Adipic acid, 2-amino-; alpha-Aminoadipate, L-; 2-Aminoadipic acid, L-; L-alpha-Aminoadipatic acid; Hexanedioic acid, 2-amino-, (S)-; l-a-aminohexanoic acid; (S)-Aminoadipic Acid; L-2-amino-adipic acid; aminoadipic acid, l-2-; l-alpha-amino-adipic acid; L -alpha-aminoadipic acid; (2S)-2-aminoadipic acid; l-alpha-aminohexanedioic acid; Lopac0_000091; SCHEMBL97323; KSC493I2B; (S)-2-amino-hexanedioic acid; (2S)-2-Amino-hexanedioic Acid; CTK3J3420; DTXSID801017096; HMS3260C04; KS-00000YV4; ZINC1532798; Tox21_500091; ANW-43725; BDBM50052553; AKOS015920301; CCG-204186; LP00091; SDCCGSBI-0050079.P002; L-2-Aminoadipic acid, >=98% (TLC); NCGC00093593-01; NCGC00093593-02; NCGC00093593-03; NCGC00093593-04; NCGC00260776-01; AS-13597; BR-25294; SC-10038; AB0013911; EU-0100091; A 7275; C00956; M-3010; 118A907; SR-01000075684; J-002657; SR-01000075684-1; Q27104392; Aad; (S)-2-Aminohexanedioic acid; L-Homoglutamic acid; 9EF7020B-8995-4D0E-BE44-34D8F18766DF; UNII-1K7B1OED4N component OYIFNHCXNCRBQI-BYPYZUCNSA-N
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| Activity |
Ki > 1000000 nM
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[3] | |||
| Compound Name |
2-Amino-5-(3-hydroxy-5-methyl-isoxazol-4-yl)-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL324686; BDBM50052555
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| Activity |
EC50 > 1000000 nM
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[21] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Metabotropic glutamate receptors: novel targets for drug development. J Med Chem. 1995 Apr 28;38(9):1417-26. | ||||
| REF 2 | 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem. 2003 Jan 16;46(2):204-6. | ||||
| REF 3 | Ligands for glutamate receptors: design and therapeutic prospects. J Med Chem. 2000 Jul 13;43(14):2609-45. | ||||
| REF 4 | Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator. J Med Chem. 2014 Feb 13;57(3):861-77. | ||||
| REF 5 | Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. J Med Chem. 1996 May 24;39(11):2259-69. | ||||
| REF 6 | 2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2849-54. | ||||
| REF 7 | Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid. Bioorg Med Chem Lett. 1998 Aug 4;8(15):1985-90. | ||||
| REF 8 | Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands. Bioorg Med Chem. 2009 Jan 1;17(1):242-50. | ||||
| REF 9 | Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4493-500. | ||||
| REF 10 | 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J Med Chem. 1995 Sep 15;38(19):3717-9. | ||||
| REF 11 | (+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg Med Chem Lett. 1997 Nov 4;7(21):2777-80. | ||||
| REF 12 | Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem. 2011 Apr 28;54(8):2529-91. | ||||
| REF 13 | Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisom... J Med Chem. 2007 Sep 20;50(19):4630-41. | ||||
| REF 14 | Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4303-7. | ||||
| REF 15 | Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42(6):1027-40. | ||||
| REF 16 | A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorg Med Chem. 2010 Aug 15;18(16):6089-98. | ||||
| REF 17 | Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88. | ||||
| REF 18 | Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist. J Med Chem. 1998 May 7;41(10):1641-50. | ||||
| REF 19 | Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40(19):3119-29. | ||||
| REF 20 | A novel class of antagonists for metabotropic glutamate receptors, 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylates. Bioorg Med Chem Lett. 1996 Apr 9;6(7):763-6. | ||||
| REF 21 | A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. J Med Chem. 1996 Aug 2;39(16):3188-94. | ||||
| REF 22 | Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA). Bioorg Med Chem Lett. 1996 Nov 5;6(21):2559-64. | ||||
| REF 23 | Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity. J Med Chem. 1999 Dec 30;42(26):5390-401. | ||||
| REF 24 | First enantiospecific synthesis of a 3,4-dihydroxy-L-glutamic acid [(3S,4S)-DHGA], a new mGluR1 agonist. Bioorg Med Chem Lett. 2000 Jan 17;10(2):129-33. | ||||
| REF 25 | Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists. J Med Chem. 1996 Sep 27;39(20):3998-4006. | ||||
| REF 26 | (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. J Med Chem. 1996 Jul 19;39(15):2874-6. | ||||
| REF 27 | Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem. 2003 May 22;46(11):2246-9. | ||||
| REF 28 | Synthesis of conformationally-constrained stereospecific analogs of glutamic acid as antagonists of metabotropic receptors. Bioorg Med Chem Lett. 1995 Nov 16;5(22):2627-32. | ||||
| REF 29 | A highly selective agonist for the metabotropic glutamate receptor mGluR2. Medchemcomm. 2011;2:1120-4. | ||||
| REF 30 | Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3. J Med Chem. 2006 Jan 12;49(1):172-8. | ||||
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