Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27889 | Target Info | |||
| Target Name | Angiotensin-converting enzyme 2 (ACE2) | ||||
| Synonyms |
Processed angiotensinconverting enzyme 2; Metalloprotease MPROT15; Angiotensinconverting enzyme homolog; Angiotensinconverting enzyme 2; ACErelated carboxypeptidase; ACEH; ACE2
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| Target Type | Clinical trial Target | ||||
| Gene Name | ACE2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(2-Aminoethyl)-1-aziridineethanamine
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Investigative | Compound Info | ||
| Synonyms |
UNII-K93WMR7E2S; K93WMR7E2S; CHEMBL398940; N-(2-((2-Aminoethyl)amino)ethyl)aziridine; N'-[2-(aziridin-1-yl)ethyl]ethane-1,2-diamine; Aziridine, 1-(2-((2-aminoethyl)amino)ethyl)- (8CI); N-(2-aminoethyl)-1-aziridine-ethanamine; N-[2-[(2-Aminoethyl)amino]ethyl]aziridine; NSC174041; NSC 174041; Aziridine, 1-[2-[(2-aminoethyl)amino]ethyl]-; 1,2-Ethanediamine,N1-[2-(1-aziridinyl)ethyl]-; SCHEMBL1690928; DTXSID70177990; 1, N-[2-(1-aziridinyl)ethyl]-; BDBM50233798; ZINC19366387; AKOS006278502; NSC-174041; n-(2-aminoethyl)-1 aziridine-ethanamine; N-[2-(aziridin-1-yl)ethyl]ethane-1,2-diamine; N(1)-(2-(1-aziridinyl)ethyl)-1,2-ethanediamine; N(1)-[2-(aziridin-1-yl)ethyl]ethane-1,2-diamine; 1,2-Ethanediamine, N-(2-(1-aziridinyl)ethyl)- (9CI)
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| Activity |
IC50 = 57000 nM
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[1] | |||
| Compound Name |
(E)-3-[5-(5-Chloro-2-methylphenyl)furan-2-yl]-2-[(5-methyl-1H-1,2,4-triazol-3-yl)sulfanyl]prop-2-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
MLS000778724; CHEMBL252417; SMR000415505; BDBM52871; cid_1382255; HMS2752M04; ZINC9289312; STK570161; AKOS005496571; AKOS032385268; CID 1382255; S-166659
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| Activity |
IC50 = 62000 nM
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[1] | |||
| Compound Name |
N-(Carboxymethyl)-N-(3-Phenylpropyl)glycyl-N-Methyl-L-Histidinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235416; SCHEMBL12198648; BDBM50005641; Q27463133
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1681-7. | ||||
| REF 2 | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid- hydrolysis. Eur J Med Chem. 2014 May 22;79:184-93. | ||||
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