Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T30081 | Target Info | |||
| Target Name | Thymidine kinase 1 (TK1) | ||||
| Synonyms |
Thymidine kinase, cytosolic
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| Target Type | Successful Target | ||||
| Gene Name | TK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 37 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-((2R,4R,5R)-5-Ethoxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL290727; BDBM50282062
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4R,5R)-5-Tert-Butoxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39080; BDBM50282071
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4R,5R)-5-Benzyloxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41145; BDBM50282065
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4R,5R)-4-Hydroxy-5-propoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288522; BDBM50282070
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4R,5R)-4-Hydroxy-5-methoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41584; BDBM50282068; 1-[(2R,4R,5R)-4-hydroxy-5-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4R,5R)-4-Hydroxy-5-phenethyloxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41411; BDBM50282075
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[(2R,4R,5R)-4-Hydroxy-5-(3-phenyl-propoxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL38663; BDBM50282074
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4S,5S)-5-Ethoxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL416236; BDBM50282064
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4S,5S)-4-Hydroxy-5-propoxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41167; BDBM50282069
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4S,5S)-5-Tert-Butoxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39235; BDBM50282073
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-((2R,4S,5S)-5-Benzyloxy-4-hydroxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291076; BDBM50282066
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3''-(4-(2-Pyridine)-1,2,3-triazole-1-yl)-2''-deoxythymidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091719; SCHEMBL19196298; BDBM50314841; J3.539.977A; 3'-[4-(2-Pyridyl)-1H-1,2,3-triazole-1-yl]-3'-deoxythymidine; 3''-Deoxy-3''-(4-pyridin-2-yl-1,2,3-triazol-1-yl)-beta-D-thymidine
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| Activity |
IC50 = 53000 nM
|
[2] | |||
| Compound Name |
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(4-phenyltriazol-1-yl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090132; SCHEMBL19182465; BDBM50314836; 3''-(4-Phenyl-1,2,3-triazol-1-yl)-3''-deoxythymidine; 3'-(4-Phenyl-1H-1,2,3-triazol-1-yl)-3'-deoxythymidine; 3''-Deoxy-3''-(4-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine; 1-[(2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
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| Activity |
IC50 = 54000 nM
|
[3] | |||
| Compound Name |
3'-Azido-3'-deoxy-4-thiothymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1790742; Thymidine, 3'-azido-3'-deoxy-4-thio-; 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-4-sulfanylidenepyrimidin-2-one; N3ddThdS; N3ddThdS3; DTXSID00148552; BDBM50367920; 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-4-thioxo-pyrimidin-2-one
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| Activity |
Ki = 54000 nM
|
[4] | |||
| Compound Name |
1-(4-Benzylamino-but-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318978; BDBM50132257; 1-[(Z)-4-(Benzylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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| Activity |
IC50 = 57000 nM
|
[5] | |||
| Compound Name |
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-[4-(2-phenylethyl)triazol-1-yl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096828; BDBM50317618; 3''-(4-(2-Phenyl-ethyl)-1,2,3-triazole-1-yl)-2''-deoxythymidine
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| Activity |
IC50 = 60000 nM
|
[2] | |||
| Compound Name |
5-(2-Bromo-vinyl)-1-((1S,2S,4S,5R)-4-hydroxy-5-hydroxymethyl-bicyclo[3.1.0]hex-2-yl)-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL146350; BDBM50135086
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| Activity |
Ki = 62900 nM
|
[6] | |||
| Compound Name |
5-Bromo-1-((1R,3S,4S,6S)-4-hydroxy-5-hydroxymethyl-bicyclo[3.1.0]hex-2-yl)-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413063; BDBM50135087; 5-Bromo-1-((1S,2S,4S,5R)-4-hydroxy-5-hydroxymethyl-bicyclo[3.1.0]hex-2-yl)-1H-pyrimidine-2,4-dione
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| Activity |
Ki = 69800 nM
|
[6] | |||
| Compound Name |
1-[(2R,4S,5S)-4-[4-(4-Chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089867; BDBM50314839; 3''-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3''-deoxy-beta-D-thymidine
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| Activity |
IC50 = 71000 nM
|
[3] | |||
| Compound Name |
1-[(Z)-4-[3-(Trifluoromethyl)benzoylamino]-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431234; BDBM50132255; N-[4-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-but-2-enyl]-3-trifluoromethyl-benzamide
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|
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| Activity |
IC50 = 72000 nM
|
[5] | |||
| Compound Name |
1-[(2R,4S,5R)-5-(Hydroxymethyl)-4-(methyldisulfanyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450901; SCHEMBL4023606; BDBM50279778; 3'-S-(Methylthio)-3'-thiothymidine; 3'-Deoxy-3'-methyldisulfanyl thymidine
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| Activity |
IC50 = 73000 nM
|
[7] | |||
| Compound Name |
1-[(2R,4S,5S)-4-[4-(3,4-Dichlorophenyl)triazol-1-yl]-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090868; BDBM50314840; 3''-Deoxy-3''-(4-(3,4-dichlorophenyl)-1,2,3-triazol-1-yl)-beta-D-thymidine
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| Activity |
IC50 = 75000 nM
|
[3] | |||
| Compound Name |
1-[(2R,4S,5S)-4-(4-Benzyltriazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090133; SCHEMBL19196299; BDBM50314837; 3''-(4-Benzyl-1,2,3-triazol-1-yl)-3''-deoxythymidine; 3''-(4-Benzyl-1,2,3-triazol-1-yl)-3''-deoxy-beta-D-thymidine
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|
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| Activity |
IC50 = 78000 nM
|
[2] | |||
| Compound Name |
1-((1R,3S,4S,6S)-4-Hydroxy-5-hydroxymethyl-bicyclo[3.1.0]hex-2-yl)-5-iodo-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344107; BDBM50135088; 1-((1S,2S,4S,5R)-4-Hydroxy-5-hydroxymethyl-bicyclo[3.1.0]hex-2-yl)-5-iodo-1H-pyrimidine-2,4-dione
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|
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| Activity |
Ki = 85800 nM
|
[6] | |||
| Compound Name |
3''-(4-Pentyl-1,2,3-triazol-1-yl)-3''-deoxythymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096815; BDBM50317619
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|
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| Activity |
IC50 = 86000 nM
|
[2] | |||
| Compound Name |
3''-(4-(3-Chloro-propyl)-1,2,3-triazol-1-yl)-3''-deoxythymidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098660; SCHEMBL19180837; BDBM50317622; 1-[(2R,4S,5S)-5-(hydroxymethyl)-4-(4-propyltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
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| Activity |
IC50 = 105000 nM
|
[2] | |||
| Compound Name |
1-[(2R,4S,5S)-4-[5-(4-Chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091210; BDBM50314843; 3''-(5-(4-Chlorophenyl)-1,2,3-triazol-1-yl)-3''-deoxy-beta-D-thymidine
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| Activity |
IC50 = 109000 nM
|
[3] | |||
| Compound Name |
1-(4-Aminomethyl-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL124682; BDBM50131911; 1-[3-(Aminomethyl)-3-deoxy-beta-D-erythro-pentofuranosyl]thymine; 1-[3-(aminomethyl)-3-deoxy-ss-D-ribofuranosyl]-5-methylpyrimidine-2,4-(1H, 3H)-dione
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| Activity |
Ki = 110000 nM
|
[8] | |||
| Compound Name |
3''-(4-Tert-Butyl-1,2,3-triazol-1-yl)-3''-deoxythymidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098218; BDBM50317620
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|
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| Activity |
IC50 = 114000 nM
|
[2] | |||
| Compound Name |
2'-Deoxyguanosine
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|
Investigative | Compound Info | ||
| Synonyms |
deoxyguanosine; Guanosine, 2'-deoxy-; Guanine deoxyriboside; 2-Deoxyguanosine; 2'-DEOXY-GUANOSINE; Guanine deoxy nucleoside; 2;-Deoxyguanosine; UNII-G9481N71RO; Guanine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-; 9H-Purin-6-ol, 2-amino-9-(2-deoxy-9-beta-D-ribofuranosyl)-; G9481N71RO; 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine; C00330; Desoxyguanosine; 2'-Deoxyguanosine hydrate, 99+%; EINECS 213-505-8; Deoxyguanosine-14C; MFCD00150760; desoxyguanosin; deoxy-guanosine; 9-(2-Deoxy-beta-D-ribofuranosyl)guanine hydrate; NSC22837; MFCD00080300; 2'-Desoxyguanosine; 2'-deoxy guanosine; 2''''-Deoxyguanosine; Guanine-2'-deoxyriboside; bmse000003; SCHEMBL20615; 961-07-9 (anhydrous); CHEMBL68908; SCHEMBL21795388; CTK1C4229; CTK4E2719; guanosine-1-15N, 2'-deoxy-; DTXSID30883626; ZINC404256; ACT02951; 2'-Deoxyguanosine monohydrate (dG); 3177AH; ANW-51699; BBL000985; BDBM50422404; s9007; SBB003059; STK361810; AKOS001715540; AKOS025116629; AKOS025117348; Guanosine,2'-deoxy-,monohydrate(9ci); CCG-267114; CS-3151; MCULE-5458121764; VZ21866; guanosine-N,1,3-15N3, 2'-deoxy-; guanosine-N,1,7-15N3, 2'-deoxy; NCGC00161975-01; 9-(2-Deoxy-beta-D-ribofuranosyl)guanine; AS-56838; BR-75712; HY-17563; SC-09157; SC-83576; ST055520; ST066876; Guanosine, 2'-deoxy- (6CI,8CI,9CI); AB0213764; DB-006105; guanosine-1,3,7,9-15N4, 2'-deoxy-; D0052; Guanosine, 2'-deoxy-, labeled with carbon-14; guanosine-2-13C-N,1,7-15N3, 2'-deoxy; S-7530; 9-(2-deoxy-b-D-erythro-pentofuranosyl)-Guanine; 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-guanine; Q422488; SR-01000147728; SR-01000147728-1; 9-(2-deoxy-beta-delta-erythro-pentofuranosyl)-Guanine; 9-(2-Deoxy-beta-delta-erythro-pentofuranosyl)guanine; 2-amino-9-(2-deoxy-9-beta-D-ribofuranosyl)-9H-purin-6-ol; 452E7995-3178-4132-A1ED-F81A3701094B; 6H-purin-6-one, 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,9-dihydro-; 6H-Purin-6-one,2-amino-9-(2-deoxy-a-D-erythro-pentofuranosyl)-1,9-dihydro-; 9-[(4S,2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-aminohydropurin-6-one
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| Activity |
IC50 = 115000 nM
|
[9] | |||
| Compound Name |
1-[(Z)-4-(Diphenylacetylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102986; SCHEMBL17485749; BDBM50132256; N-[4-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-but-2-enyl]-2,2-diphenyl-acetamide
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| Activity |
IC50 = 115000 nM
|
[5] | |||
| Compound Name |
1-[(Z)-4-(4-Biphenylylacetylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL102650; SCHEMBL19203481; BDBM50132252; 2-Biphenyl-4-yl-N-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-but-2-enyl]-acetamide
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| Activity |
IC50 = 119000 nM
|
[5] | |||
| Compound Name |
1-[(Z)-4-(9H-Xanthene-9-ylcarbonylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL322466; SCHEMBL19203484; BDBM50132250
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| Activity |
IC50 = 131000 nM
|
[5] | |||
| Compound Name |
1-(4,5-Dihydroxy-tetrahydro-furan-2-yl)-5-methylsulfanyl-1H-pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL268232; BDBM50027352
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| Activity |
Ki = 160000 nM
|
[10] | |||
| Compound Name |
3''-(4-Cyclopentylmethyl-1,2,3-triazol-1-yl)-3''-deoxy-beta-D-thymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090134; SCHEMBL19196754; BDBM50314838
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|
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| Activity |
IC50 = 177000 nM
|
[3] | |||
| Compound Name |
1-[4-(4-Benzyl-piperazin-1-yl)-but-2-enyl]-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441814; BDBM50132258; 1-[(Z)-4-(4-Benzylpiperazino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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| Activity |
IC50 = 180000 nM
|
[5] | |||
| Compound Name |
1-[(Z)-4-(4-Chlorophenylacetylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105288; BDBM50132249; 2-(4-Chloro-phenyl)-N-[4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-but-2-enyl]-acetamide
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| Activity |
IC50 = 198000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 59 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sorivudine
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|
Approved | Compound Info | ||
| Synonyms |
Usevir (TN)
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| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
Stavudine
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Approved | Compound Info | ||
| Synonyms |
DdeThd; DdeTyd; Dideoxydidehydrothymidine; Estavudina; STV; Sanilvudine; Stavudinum; Zent; Zerit; Zerit Xr; Zerut XR; BMY 27857; BMY27857; D 1413; D 4T; BMY-27857; Bristol-Myers Brand of Stavudine; Bristol-Myers Squibb Brand of Stavudine; D 4T (nucleoside); Estavudina [INN-Spanish]; Sanilvudine (JAN); Stavudine, Monosodium Salt; Stavudinum [INN-Latin]; Zerit (TN); Zerit(TM); D4T & GM-CSF; D4TMBY-27857-3; Stavudine (USAN/INN); Stavudine [USAN:BAN:INN]; Stavudine [USAN:INN:BAN]; Thymine, 1-(2,3-dideoxy-beta-D-glycero-pent-2-enofuranosyl)-(7CI,8CI); 1-(2,3-Dideoxy-beta-D-glycero-2-pentenofuranosyl)thymine; 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine; 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione; 1-[5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione & Colony-stimulating factor 2; 2',3' Didehydro 3' deoxythymidine; 2',3'-Anhydrothymidine; 2',3'-DIDEHYDRO-3'-DEOXYTHYMIDINE (DDI); 2',3'-Didehydro-2',3'-dideoxythmidine; 2',3'-Didehydro-3'-deoxythimidine; 2',3'-Didehydro-3'-deoxythymidine; 3'-Azido-3'-deoxythymidine & Granulocyte-macrophage colony-stimulating factor; 3'-Deoxy-2',3'-didehydrothymidine; 3'-Deoxy-2'-thymidinene; D4T
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| Activity |
Ki = 580000 nM
|
[4] | |||
| Compound Name |
Cytarabine
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Approved | Compound Info | ||
| Synonyms |
Alexan; AraC; Arabinocytidine; Arabinofuranosylcytosine; Arabinosylcytosine; Arabitin; Aracytidine; Aracytin; Aracytine; Arafcyt; Citarabina; Cytarabin; Cytarabina; Cytarabinoside; Cytarabinum; Cytarbel; Cytonal; Cytosar; Cytosinearabinoside; DepoCyte; Depocyt; Erpalfa; Iretin; Spongocytidine; Tarabine; Udicil; Arabinosyl Cytosine; Cytarabine liposome injection; Cytosine arabinofuranoside; Cytosine arabinose; Cytosine arabinoside; AR3; BTB15125; CHX 3311; U 19920A; Ara-C; Ara-Cytidine; Beta-Ara C; Beta-Arabinosylcytosine; Beta-cytosine arabinoside; Citarabina [INN-Spanish]; Cytarabinum [INN-Latin]; Cytosar-U; Cytosine arabinoside (VAN); Depocyt (TN); Depocyt (liposomal); Intrathecal (injected into the spinal fluid) DepoCyt; U-19920; Beta-D-Arabinosylcytosine; Cytosar-U (TN); Cytosine beta-D-arabinofuranoside; Cytosine beta-D-arabinofuranoside hydrochloride; Cytosine beta-D-arabinoside; Cytosine-beta-arabinoside; Intrathecal cytarabine (also known as ara-C); U-19,920; CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9); Cytarabine (JP15/USP/INN); Cytarabine [USAN:INN:BAN:JAN]; Cytosine 1-beta-D-arabinofuranoside; Cytosine, beta-D-arabinoside; Cytosine-beta-D-arabinofuranoside; Cytosine-1-beta-D-arabinofuranoside; Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine; (beta-D-Arabinofuranosyl)cytosine; 1-.beta.-D-arabinofuranosyl-cytosine; 1-Arabinofuranosylcytosine; 1-beta-D-Arabinofaranosylcytosine; 1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 1-beta-D-Arabinofuranosylcytosine; 1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside; 1-beta-D-Arabinosylcytosine; 1beta-Arabinofuranasylcytosine; 1beta-D-Arabinofuranosylcytosine; 1beta-D-Arabinosylcytosine; 2(1H)-Pyrimidinone, 4-amino-1-D-arabinofuranosyl-[CAS]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine; 4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone; 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; 4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
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| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
1-(4-Aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL341264; BDBM50131909; 1-((2R,4R,5S)-4-aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione; 1-[(2R,4R,5S)-4-(aminomethyl)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione; 1-[3-(Aminomethyl)-2,3-dideoxy-ss-D-erythro-pentafuranosyl]-5-methylpyrimidine-2,4-(1H, 3H)-dione
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| Activity |
Ki = 220000 nM
|
[8] | |||
| Compound Name |
[(2S,3S,4R,5R)-3-(Aminomethyl)-4-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161001
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| Activity |
Ki = 280000 nM
|
[8] | |||
| Compound Name |
3''-(4-Propyl-1,2,3-triazol-1-yl)-3''-deoxythymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098217; SCHEMBL19180833; BDBM50317621; 1-[(2R,4S,5S)-5-(hydroxymethyl)-4-(4-pentyltriazol-1-yl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
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| Activity |
IC50 = 311000 nM
|
[2] | |||
| Compound Name |
1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(2S,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-3-yl]thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091873; BDBM50314850
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| Activity |
IC50 = 316000 nM
|
[3] | |||
| Compound Name |
2'',3''-Dideoxy-3''-(trichloromethyldithio)thymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL469885; SCHEMBL3618062; BDBM50242978
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| Activity |
IC50 = 365000 nM
|
[7] | |||
| Compound Name |
3''-(4-Butyl-1,2,3-triazol-1-yl)-3''-deoxy-beta-D-thymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089805; SCHEMBL19182534; BDBM50314835; 1-[(2R,4S,5S)-4-(4-butyltriazol-1-yl)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
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||||
| Activity |
IC50 = 366000 nM
|
[3] | |||
| Compound Name |
2'',3''-Dideoxy-3''-(2-hydroxyethyldithio)thymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL470689; SCHEMBL3616937; BDBM50242983
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||||
| Activity |
IC50 = 405000 nM
|
[7] | |||
| Compound Name |
2'',3''-Dideoxy-3''-(2-aminoethyldithio)thymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL487410; BDBM50243089
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||||
| Activity |
IC50 = 418000 nM
|
[7] | |||
| Compound Name |
1-(4,5-Bis-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL124260; 3'-Deoxy-3'-C-(hydroxymethyl)thymidine; Thymidine, 3'-deoxy-3'-(hydroxymethyl)-; SCHEMBL4951039; CTK0F5143; BDBM50131913; 1-(2,3-Dideoxy-3-hydroxymethyl-beta-D-erythro-pentofuranosyl)thymine; 1-[(2R,4R,5S)-4,5-bis(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
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| Activity |
Ki = 420000 nM
|
[8] | |||
| Compound Name |
5'-O-Benzoyl-3'-deoxythymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL444549; Thymidine, 3'-deoxy-,5'-benzoate (9CI); 5'-O-benzoyl-3'-dT; SCHEMBL5054200; CTK4B3182; DTXSID20153663; BDBM50013114; Thymidine, 3'-deoxy-, 5'-benzoate; [(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl benzoate
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| Activity |
Ki = 425000 nM
|
[4] | |||
| Compound Name |
2',3'-Didehydro-2',3'-dideoxyuridine
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Investigative | Compound Info | ||
| Synonyms |
1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione; CHEMBL89637; 1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2',3'-Dideoxy-2',3'-didehydrouridine; ddeUrd; 2',3'-Dideoxyuridinene; SCHEMBL543443; DTXSID50208453; ZINC137875; BDBM50013115; MFCD03424302; AKOS025401704; AC-24683; CS-0100830; Uridine, 2',3'-didehydro-2',3'-dideoxy-; 1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione (ddeUrd)
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| Activity |
Ki = 445000 nM
|
[4] | |||
| Compound Name |
5-Methyl-1-[4-(4-methyl-piperazin-1-yl)-but-2-enyl]-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL321097; BDBM50132254; 1-[(Z)-4-(4-Methylpiperazino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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| Activity |
IC50 = 491000 nM
|
[5] | |||
| Compound Name |
9-(2''-O-Pentanoyl-beta-D-arabinofuranosyl)guanine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL401029; BDBM50206499
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| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
1-[(2R,4S,5S)-5-(Hydroxymethyl)-4-(5-phenyltriazol-1-yl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090869; SCHEMBL19196060; BDBM50314842; 3''-Deoxy-3''-(5-phenyl-1,2,3-triazol-1-yl)-beta-D-thymidine
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| Activity |
IC50 >= 500000 nM
|
[3] | |||
| Compound Name |
6-[4-(6-Fluorohexoxy)phenyl]-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]furo[2,3-d]pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL393560; BDBM50228390
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| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
5-[(Z)-2-Bromoethenyl]-1-[(3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL605255; BDBM50366680
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| Activity |
IC50 > 500000 nM
|
[13] | |||
| Compound Name |
6-(2-Fluorophenyl)-3-[(4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]furo[2,3-d]pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL376642; BDBM50205238; 3-(2''-deoxy-beta-D-ribofuranosyl)-6-(2-fluorophenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
3-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(3-hydroxyphenyl)furo[2,3-d]pyrimidin-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL375147; BDBM50205239; 3-(2''-deoxy-beta-D-ribofuranosyl)-6-(3-hydroxyphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
3-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(3-methoxyphenyl)furo[2,3-d]pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL220256; BDBM50205242; 3-(2''-deoxy-beta-D-ribofuranosyl)-6-(3-methoxyphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
9-beta-d-Arabinofuranosylguanine
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Investigative | Compound Info | ||
| Synonyms |
9-(beta-D-Arabinofuranosyl)guanine; Ara-G hydrate; 9-Arabinofuranosylguanine; Ara-G; 9-beta-Arabinosylguanine; 9-(b-d-arabinofuranosyl)guanine; UNII-0Z99WX0GPF; 0Z99WX0GPF; CHEMBL240933; MFCD00065486; 9-(BETA-D-ARABINOFURANOSYL)-GUANINE; 2-amino-9-(beta-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one; Guanine arabinoside; 9-b-D-Arabinofuranosylguanine; NSC 76352; Guanine, 9-(beta-D-arabinofuranosyl)-; Arabinofuranosyl-guanine; 6H-Purin-6-one, 2-amino-9-beta-D-arabinofuranosyl-1,9-dihydro-; 9--d-arabinofuranosylguanine; SCHEMBL34912; 9- -D-arabinofuranosylguanine; SCHEMBL11529318; Arabinofuranosyl-guanine (ara-G); 9-beta-D-arabinofuranosylguanosine; DTXSID301019130; HMS3263D20; Guanine 9-beta-D-Arabinofuranoside; BCP12606; KS-00000DP6; ZINC6585367; Tox21_501219; BDBM50206506; AKOS016003883; CCG-222523; LP01219; SDCCGSBI-0633806.P001; VZ31092; NCGC00261904-01; NCGC00487230-02; 9-beta-D-Arabinofuranosyl guanine hydrate; AC-32194; Ara-G hydrate, >=98% (HPLC), solid; DS-14591; A2739; J-700337; 2-Amino-6-hydroxy-9-(beta-D-arabinofuranosyl)purine; Q27140338; 6H-Purin-6-one,2-amino-9-b-D-arabinofuranosyl-1,9-dihydro-
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| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
3'-[3-[3-(Trifluoromethyl)-4-chlorophenyl]thioureido]-5'-O-trityl-3'-deoxythymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092055; BDBM50314846
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| Activity |
IC50 > 500000 nM
|
[3] | |||
| Compound Name |
6-(4-Fluorophenyl)-3-(2-deoxy-beta-D-ribofuranosyl)furo[2,3-d]pyrimidine-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL220065; BDBM50205241; 3-(2''-deoxy-beta-D-ribofuranosyl)-6-(4-fluorophenyl)-2,3-dihydrofuro[2,3-d]p yrimidin-2-one
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
6-[3-(6-Fluorohexoxy)phenyl]-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]furo[2,3-d]pyrimidin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL236165; BDBM50228387
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| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
N2-Octanoyl-9-(2''-O-octanoyl-beta-D-arabinofuranosyl)guanine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL241166; BDBM50206500
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| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
9-(2''-O-Octanoyl-beta-D-arabinofuranosyl)guanine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL241793; BDBM50206501
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| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
5-[(E)-2-Bromoethenyl]-1-[(2R,4S,5S)-4-[4-(4-chlorophenyl)triazol-1-yl]-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091988; BDBM50314845; 3''-(4-Chlorophenyl-1,2,3-triazol-1-yl)-3''-deoxy-beta-(E)-5-(2-bromovinyl)-2''-deoxyuridine
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| Activity |
IC50 > 500000 nM
|
[3] | |||
| Compound Name |
6-[3-(2-Fluoroethoxy)phenyl]-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]furo[2,3-d]pyrimidin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219733; BDBM50205236; 3-(2''-deoxy-beta-D-ribofuranosyl)-6-(3-fluoroethoxyphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2-one
Click to Show/Hide
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| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
N3-Octyl-1-(beta-D-arabinofuranosyl)thymine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL241196; BDBM50206489
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| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
1-[2''-O-(6-Aminohexanoyl)-beta-D-arabinofuranosyl]-5(E)-(2-bromovinyl)uracil
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL240717; BDBM50206492
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| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
3-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(4-hydroxyphenyl)furo[2,3-d]pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL235956; BDBM50228386; 3-(2''-deoxy-beta-D-ribofuranosyl)-6-(4-hydroxyphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2(3H)-one
Click to Show/Hide
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| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
1-[2''-O-(4-Aminobutanoyl)-beta-D-arabinofuranosyl]-5(E)-(2-bromovinyl)uracil
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400233; BDBM50206497
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| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
5-[(E)-2-Bromoethenyl]-1-[(2R,4S,5S)-5-(hydroxymethyl)-4-(4-phenyltriazol-1-yl)oxolan-2-yl]pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091931; BDBM50314844; 3''-Deoxy-3''-(4-phenyl-1,2,3-triazol-1-yl)-beta-(E)-5-(2-bromovinyl)-2''-deoxyuridine
Click to Show/Hide
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| Activity |
IC50 > 500000 nM
|
[3] | |||
| Compound Name |
6-[4-(2-Fluoroethoxy)phenyl]-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]furo[2,3-d]pyrimidin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL235958; BDBM50228389
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| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
1-(4-Dibenzylamino-but-2-enyl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL316971; BDBM50132251; 1-[(Z)-4-(Dibenzylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
3-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-(4-methoxy-phenyl)-3H-furo[2,3-d]pyrimidin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL235957; SCHEMBL12913113; BDBM50228388; 6-(4-Methoxyphenyl)-3-(2-deoxy-beta-D-ribofuranosyl)furo[2,3-d]pyrimidine-2(3H)-one; 3-(2''-deoxy-beta-D-ribofuranosyl)-6-(4-methoxyphenyl)-2,3-dihydrofuro[2,3-d]pyrimidin-2(3H)-one
Click to Show/Hide
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| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
5-Methyl-1-[4-(trityl-amino)-but-2-enyl]-1H-pyrimidine-2,4-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL322230; BDBM50132253; 1-[(Z)-4-(Tritylamino)-2-butenyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Click to Show/Hide
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
1-[(2R,4S,5S)-4-(Fluoromethyl)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL127523; CTK7J7621; BDBM50131915; 3'-deoxy-3'-(fluoromethyl)thymidine; 1-(4-Fluoromethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione; 1-[2,3-Dideoxy3-C-(fluoromethyl)-2,3-dideoxy-.beta.-D-erythro-pentofuranosyl]thymine; 1-[(2R,4S,5S)-4-(fluoromethyl)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
Click to Show/Hide
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| Activity |
Ki = 970000 nM
|
[8] | |||
| Compound Name |
[(2S,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)oxolan-2-yl]methyl benzoate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88993; SCHEMBL10465192; CTK0J1934; DTXSID10558764; BDBM50013116; 5'-O-benzoyl-2',3'-dideoxy-uridine; Uridine, 2',3'-dideoxy-, 5'-benzoate; [(2S,5R)-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl benzoate; Benzoic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (ddUrd)
Click to Show/Hide
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| Activity |
Ki = 975000 nM
|
[4] | |||
| Compound Name |
1-(2''-O-Octanoyl-beta-D-arabinofuranosyl)thymine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL240124; BDBM50206494
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
1-(2''-O-Octyl-beta-D-arabinofuranosyl)cytosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400234; BDBM50206485
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Decanoic acid 2-[5-((E)-2-bromo-vinyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400618; CHEMBL28291; BDBM50100411; BDBM50206484; 2'beta-(Decanoyloxy)-5-[(E)-2-bromoethenyl]-2'-deoxyuridine
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Chembl285105
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143826; BDBM50100406
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[13] | |||
| Compound Name |
Dodecanoic acid 4-hydroxy-5-hydroxymethyl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392957; BDBM50206505; 2'beta-(Decanoyloxy)thymidine; CHEMBL286972; BDBM50100412; 1-(2''-O-decanoyl-beta-D-arabinofuranosyl)thymine
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Octanoic acid 2-[5-(2-bromo-vinyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238635; CHEMBL28396; BDBM50100407; BDBM50206488; 2'beta-(Octanoyloxy)-5-[(E)-2-bromoethenyl]-2'-deoxyuridine; 1-(2''-O-octanoyl-beta-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
4-Amino-1-(4-hydroxy-5-hydroxymethyl-3-octyloxy-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143823; CHEMBL282529; 2'beta-(Octyloxy)-2'-deoxycytidine; BDBM50100408
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[13] | |||
| Compound Name |
2'beta-(Dodecanoyloxy)thymidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400410; BDBM50206502; CHEMBL26529; BDBM50100409; 1-(2''-O-dodecanoyl-beta-D-arabinofuranosyl)thymine
Click to Show/Hide
|
||||
| Activity |
IC50 >= 1000000 nM
|
[11] | |||
| Compound Name |
Spongothymidine
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|
Investigative | Compound Info | ||
| Synonyms |
Arabinosylthymine; Thymine arabinoside; 1-beta-D-Arabinofuranosylthymine; UNII-NS9U4BEG7Y; ara-T; Spongothymidin; THYMINE-beta-D-ARABINOFURANOSIDE; NS9U4BEG7Y; CHEMBL103283; 1-(b-D-Arabinofuranosyl)thymine; 1-(beta-D-arabinofuranosyl)thymine; MFCD00065474; Thymine 1-beta-D-arabinofuranoside; EINECS 210-083-7; NSC 68929; BRN 0090166; Thymine-beta-D -arabinofuranoside; Thymine, 1-beta-D-arabinofuranosyl-; 1-beta-D-Arabinofuranosyl-5-methyl-(1H,3H)-pyrimidine-2,4-dione; Thymine-b-d-arabinofuranoside; 4-24-00-01308 (Beilstein Handbook Reference); SCHEMBL1619684; CTK8G3460; ZINC5765081; 2,4(1H,3H)-Pyrimidinedione, 1-.beta.-D-arabinofuranosyl-5-methyl-; BDBM50132291; Thymine, 1-.beta.-D-arabinofuranoside; C16744; 605T232; Thymine, 1-beta-D-arabinofuranosyl- (VAN) (8CI); Q27149733; 2,4(1H,3H)-Pyrimidinedione, 1-beta-D-arabinofuranosyl-5-methyl- (9CI)
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Pentanoic acid 4-hydroxy-5-hydroxymethyl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392346; BDBM50206503; 2'beta-(Valeryloxy)thymidine; CHEMBL280754; BDBM50100410; 1-(2''-O-pentanoyl-beta-D-arabinofuranosyl)thymine
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
1-(3-Benzyloxy-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL241195; 2'beta-(Benzyloxy)thymidine; BDBM50206487; 1-(2''-O-benzyl-beta-D-arabinofuranosyl)thymine
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
1-(4-Hydroxy-5-hydroxymethyl-3-octyloxy-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400411; BDBM50206490; 2'beta-(Octyloxy)thymidine; CHEMBL418021; BDBM50100414; 1-(2''-O-octyl-beta-D-arabinofuranosyl)thymine
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Methoxy-acetic acid 2-[5-(2-bromo-vinyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399413; CHEMBL26672; BDBM50100415; BDBM50206483; 2'beta-(Methoxyacetoxy)-5-[(E)-2-bromoethenyl]-2'-deoxyuridine
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
3'-(Azidomethyl)-3'-deoxythymidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL340604; CTK7J7622; BDBM50131908; 1-[3-C-(Azidomethyl)-2,3-dideoxy-.beta.-D-erythro-pentofuranosyl]thymine; 1-(4-Azidomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione; 1-[(2R,4R,5S)-4-(azidomethyl)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
Click to Show/Hide
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||||
| Activity |
Ki = 1040000 nM
|
[8] | |||
| Compound Name |
2',3'-Dideoxy-4-thiouridine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
ddUrdS; 4-Thio-ddU; CHEMBL89055; SCHEMBL5317524; DTXSID50153651; uridine, 2',3'-dideoxy-4-thio-; BDBM50013119; 1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one; 1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-pyrimidin-2-one
Click to Show/Hide
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||||
| Activity |
Ki = 1275000 nM
|
[4] | |||
| Compound Name |
3'-Deoxy-4-thiothymidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Ddthds; Thymidine, 3'-deoxy-4-thio-; CHEMBL87127; SCHEMBL1144933; DTXSID90153650; BDBM50013109; 1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-4-sulfanylidenepyrimidin-2-one; 1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-4-thioxo-pyrimidin-2-one; 1-(5-Hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one (ddThdS)
Click to Show/Hide
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||||
| Activity |
Ki = 1600000 nM
|
[4] | |||
| Compound Name |
2',3'-Didehydro-3'-deoxy-4-thiothymidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86861; Ddethds; 4-Thio-D4T; DTXSID30208557; BDBM50013110; 2',3',-Didehydro-3'-deoxy-4-thiothymidine; Thymidine, 2',3'-didehydro-3'-deoxy-4-thio-; 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)-4-thiothymine
Click to Show/Hide
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||||
| Activity |
Ki = 1690000 nM
|
[4] | |||
| Compound Name |
2',3'-Didehydro-2',3'-dideoxy-4-thiouridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ddeUrdS; 4-Thio-D4U; CHEMBL86455; DTXSID80153649; BDBM50013118; uridine, 2',3'-didehydro-2',3'-dideoxy-4-thio-; 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-4-thioxo-pyrimidin-2-one; 1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one (ddeUrdS)
Click to Show/Hide
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||||
| Activity |
Ki = 1690000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | (2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase. Bioorg Med Chem Lett. 1993 Aug;3(8):1571-6. | ||||
| REF 2 | 3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations. Bioorg Med Chem. 2010 May 1;18(9):3261-9. | ||||
| REF 3 | 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2010 Apr 8;53(7):2902-12. | ||||
| REF 4 | Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. J Med Chem. 1990 Jan;33(1):258-63. | ||||
| REF 5 | Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: replacement of a triphenylmethoxy moiety with substituted amines and carboxamides. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3027-30. | ||||
| REF 6 | Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine. J Med Chem. 2003 Nov 6;46(23):5045-54. | ||||
| REF 7 | Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides. Bioorg Med Chem. 2008 Jul 15;16(14):6824-31. | ||||
| REF 8 | 3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem. 2003 Aug 28;46(18):3811-21. | ||||
| REF 9 | Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2002 Sep 12;45(19):4254-63. | ||||
| REF 10 | Synthesis and antiviral activity of 1-(2-deoxy-beta-D-ribofuranosyl)-5-(methylmercapto)-2-pyrimidinone. J Med Chem. 1981 Jan;24(1):109-12. | ||||
| REF 11 | Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem. 2007 Apr 15;15(8):3065-81. | ||||
| REF 12 | A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. J Med Chem. 2007 Dec 27;50(26):6627-37. | ||||
| REF 13 | Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors. Bioorg Med Chem Lett. 2001 May 21;11(10):1329-32. | ||||
| REF 14 | Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography. J Med Chem. 2007 Mar 8;50(5):1041-9. | ||||
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