Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35527 | Target Info | |||
| Target Name | Arachidonate 12-lipoxygenase (12-LOX) | ||||
| Synonyms |
Platelet-type lipoxygenase 12; Lipoxin synthase 12-LO; LOG12; Arachidonate 12-lipoxygenase, 12S-type; 12S-lipoxygenase; 12S-LOX; 12LO; 12-lipoxygenase
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| Target Type | Literature-reported Target | ||||
| Gene Name | ALOX12 | ||||
| Biochemical Class | Oxygenase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 76 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Zileuton
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Approved | Compound Info | ||
| Synonyms |
Leutrol; Zileutonum; Ziluton; Zyflo; Abbott brand of zileuton; Zyflo CR; Zyflo Filmtab; A 64077; Abbot 64077; Abbott 64077; A-64077; ABBOTT-64077; ABT-077; CTI-02; ZYFLO (TN); ZYFLO, Zileuton; Zileutonum [INN-Latin]; Zyflo (TN); Zileuton (USP/INN); Zileuton [USAN:INN:BAN]; N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea; N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea; (+-)-1-(1-Benzo(b)thien-2-ylethyl)-1-hydroxyurea; (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; (+/-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea; 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
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| Activity |
IC50 = 55000 nM
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[1] | |||
| Compound Name |
JASPAQUINOL
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Investigative | Compound Info | ||
| Synonyms |
jaspaquinol; Jasplaquinol; CHEMBL425166; SCHEMBL6833479; BDBM50240936
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
SPONGIADIOXIN A
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Investigative | Compound Info | ||
| Synonyms |
SPONGIADIOXIN A; CHEMBL185828; 329040-77-9; Dibenzo[b,e][1,4]dioxin-1-ol, 3,4,6,8-tetrabromo-; BDBM50150784
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| Activity |
IC50 = 50000 nM
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[3] | |||
| Compound Name |
NSC-94258
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Investigative | Compound Info | ||
| Synonyms |
7-Hydroxyflavone; 6665-86-7; 7-Hydroxy-2-phenyl-4H-chromen-4-one; Flavone, 7-hydroxy-; 7-Hydroxy-2-phenyl-4-benzopyrone; 4H-1-Benzopyran-4-one, 7-hydroxy-2-phenyl-; 7-hydroxy-2-phenylchromen-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-; 7-Hydroxy-2-phenyl-chromen-4-one; NSC 94258; UNII-ZE72458E4L; EINECS 229-705-3; NSC-94258; MLS002695239; CHEBI:2268; CHEMBL276915; MQGPSCMMNJKMHQ-UHFFFAOYSA-N; ZE72458E4L; NSC94258; MFCD00006835; 7-Hydroxy-2-phenyl-4H-1-benzopyran-4-one; H-5100; SR-01000359106; 7-Hydroxyflavone, 11; 7-Hydroxy-flavone,
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
2-bromophenol
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Investigative | Compound Info | ||
| Synonyms |
2-BROMOPHENOL; 95-56-7; o-Bromophenol; Phenol, 2-bromo-; BROMOPHENOL; 2-Bromfenol; 2-Bromo-phenol; Phenol, o-bromo-; o-bromo-phenol; 2-bromo phenol; Phenol, bromo-; 2-Bromfenol [Czech]; NSC 6970; bromophenol, 2-; UNII-A0UB206YF0; 2-Bromophenol, 98%; EINECS 202-432-7; 1-Bromo-2-hydroxybenzene; BRN 1905115; CHEMBL186007; A0UB206YF0; 2-BROMO-1-HYDROXYBENZENE; VADKRMSMGWJZCF-UHFFFAOYSA-N; MFCD00002146; 32762-51-9; ortho-bromophenol; 2BR; bromphenol; bromo-phenol; bromo phenol; 2-bromanylphenol; HSDB 7648; ortho-bromo-phenol; EINECS 251-200-1
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
3,7-dihydroxy-flavone
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Investigative | Compound Info | ||
| Synonyms |
3,7-dihydroxyflavone; 7-Hydroxyflavonol; 492-00-2; 3,7-dihydroxy-2-phenyl-4H-chromen-4-one; 5-Deoxygalangin; 4H-1-Benzopyran-4-one, 3,7-dihydroxy-2-phenyl-; UNII-O948D0K9BQ; O948D0K9BQ; CHEMBL210276; 3,7-dihydroxy-2-phenylchromen-4-one; 3,7-dihydroxy-flavone; 7,3'-dihydroxyflavonol; SR-01000314616; Resogalangin; SPBio_001803; Spectrum_001462; SpecPlus_000778; AC1NU2BD; Spectrum4_001767; Spectrum3_001623; Spectrum2_001652; Spectrum5_000353; 3,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; Oprea1_793720; KBioSS_001942; KBioGR_002253
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
4-Methyl-2-[5-(2-methylphenyl)-1H-pyrazol-3-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
MLS000099089; SMR000070479; Oprea1_416132; Oprea1_488713; CHEMBL1488723; SCHEMBL10357282; BDBM56150; cid_5405417; ZINC13126656; AKOS000603258; MCULE-7146164517; J3.557.722J; 4-methyl-2-[5-(o-tolyl)-1H-pyrazol-3-yl]phenol; BRD-K22424638-001-08-4; 2-[5-(2-Methylphenyl)-1H-pyrazole-3-yl]-4-methylphenol; (6E)-4-methyl-6-[5-(o-tolyl)-3-pyrazolin-3-ylidene]cyclohexa-2,4-dien-1-one
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
N-[(5-Chloro-8-hydroxyquinolin-7-yl)-(4-fluorophenyl)methyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1593083; SCHEMBL2598265; BDBM50350416; NCGC00182905-03
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| Activity |
IC50 ~ 50000 nM
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[6] | |||
| Compound Name |
N-[1-(5-Chloro-8-hydroxyquinolin-7-yl)ethyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
MLS002391517; CHEMBL1555876; SMR001355486; HMS2201L18; HMS3358J20; BDBM50350407; NCGC00183704-01; SR-01000863981; SR-01000863981-2
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| Activity |
IC50 ~ 50000 nM
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[6] | |||
| Compound Name |
3-(4-Methoxyphenyl)-3,4-dihydro-2H-chromene-7,8-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL391341; NSC611816; SCHEMBL10565973; 7,8-dihydroxy-4''-methylisoflavan; BDBM50222301; NSC-611816; 3-(4-Methoxyphenyl)-7,8-dihydroxychroman; 3-(4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-7,8-diol
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| Activity |
IC50 = 70000 nM
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[4] | |||
| Compound Name |
N-[(5-Chloro-8-methoxyquinolin-7-yl)-(furan-2-yl)methyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1528943; MLS002391516; SCHEMBL2598292; HMS2193K07; HMS3344O02; BDBM50350419; NCGC00183694-01; SMR001355485
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| Activity |
IC50 ~ 75000 nM
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[6] | |||
| Compound Name |
N-[(5-Chloro-8-hydroxy-2-piperidin-1-ylquinolin-7-yl)-(furan-2-yl)methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1593604; BDBM50350415; NCGC00183709-01
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| Activity |
IC50 ~ 75000 nM
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[6] | |||
| Compound Name |
N-[(5-Bromofuran-2-yl)-(5-chloro-8-hydroxyquinolin-7-yl)methyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1410433; SCHEMBL2598337; BDBM50350412; NCGC00182906-03
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| Activity |
IC50 ~ 75000 nM
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[6] | |||
| Compound Name |
N-[(2,5-Dichloro-8-hydroxyquinolin-7-yl)-(furan-2-yl)methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1319062; MLS002391526; HMS2193K19; HMS3352N19; BDBM50350413; NCGC00183715-01; SMR001355494
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| Activity |
IC50 ~ 75000 nM
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[6] | |||
| Compound Name |
N-[1-(5-Fluoro-8-hydroxyquinolin-7-yl)ethyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1370315; MLS002391527; HMS2193K13; HMS3351F04; BDBM50350409; NCGC00183716-01; SMR001355495
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| Activity |
IC50 ~ 75000 nM
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[6] | |||
| Compound Name |
N-[[5-Chloro-2-(dimethylamino)-8-hydroxyquinolin-7-yl]-(furan-2-yl)methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1448145; BDBM50350414; NCGC00183714-01
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| Activity |
IC50 ~ 75000 nM
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[6] | |||
| Compound Name |
N-[(4-Chloro-1-hydroxynaphthalen-2-yl)-(furan-2-yl)methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
MLS002391513; SMR001355482; SCHEMBL2599361; CHEMBL1528315; BDBM79311; cid_44142338; HMS2201A17; HMS3356D03; NCGC00183710-01; N-[(4-chloro-1-hydroxy-2-naphthyl)-(2-furyl)methyl]acetamide; N-[(4-chloro-1-hydroxy-2-naphthalenyl)-(2-furanyl)methyl]acetamide; N-[(4-chloranyl-1-oxidanyl-naphthalen-2-yl)-(furan-2-yl)methyl]ethanamide
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| Activity |
IC50 ~ 75000 nM
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[6] | |||
| Compound Name |
4-(Trifluoromethyl)benzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270220; MLS002607760; SCHEMBL1531999; BDBM50329327; NCGC00185045-01; SMR001522634; Q27165004; 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl-4-(trifluoromethyl)benzoate
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
6,7-Methylenedioxy-2-t-butylbenzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL238812; BDBM50222289
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
Benzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271011; 4-[(5-naphthalen-1-yl-1,3,4-oxadiazol-2-yl)sulfanyl]but-2-ynyl benzoate; 4-((5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-yl)thio)but-2-yn-1-yl benzoate; MLS002607765; SCHEMBL1531649; ZINC2400771; BDBM50329323; STL005393; AKOS022094698; MCULE-8367785231; NCGC00185050-01; SMR001522639; Q27164993; 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl benzoate; 4-{[5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}but-2-yn-1-yl benzoate
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
7-Hydroxy-2-isobutyl-4H-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396673; BDBM50222313
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
2-Isobutyl-3-hydroxy-4H-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL239022; BDBM50222274
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
3,5-Dihydroxyflavone
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Investigative | Compound Info | ||
| Synonyms |
3,5-dihydroxy-2-phenylchromen-4-one; 3,5-dihydroxy-2-phenyl-4H-chromen-4-one; 3,5,-Dihydroxyflavone; CHEMBL239276; dihydroxyflavone; SCHEMBL290081; SPECTRUM1505147; CTK5C5011; ZINC57647; DTXSID30419823; BDBM50222291; MFCD00143074; AKOS024285110; MCULE-5859398695; 3,5-dihydroxy-2-phenyl-chromen-4-one; NCGC00096043-01; ST081626; 3,5-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; SR-05000002503; 4H-1-Benzopyran-4-one, 3,5-dihydroxy-2-phenyl-; SR-05000002503-1
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-3,4-dihydro-2H-chromene-7,8-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL239053; NSC603663; HIR-11; SCHEMBL10563966; BDBM153381; BDBM50222304; NSC-603663; 7,8-dihydroxy-3'',4''-dimethoxyisoflavan; 3-(3,4-Dimethoxyphenyl)-3,4-dihydro-2H-1-benzopyran-7,8-diol
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
2,6-Dibromophenol
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Investigative | Compound Info | ||
| Synonyms |
Phenol, 2,6-dibromo-; 2,6-Dibromo-phenol; UNII-27MIP05EAV; MFCD00002152; 2,6-dibromo-pheno; 2,6-Bis(Bromanyl)phenol; 27MIP05EAV; CHEMBL111507; HSDB 7652; NSC 6214; EINECS 210-161-0; ACMC-1AU9I; 2,6-Dibromophenol, 99%; KSC493E5T; SCHEMBL416446; DTXSID0060561; CTK3J3259; KS-00000JJJ; NSC6214; ZINC334875; ACT11780; EBD22566; HY-Y1667; NSC-6214; ANW-33596; BDBM50150789; RW1225; SBB101028; AKOS009152462; 2,6-Dibromophenol, analytical standard; AS06977; CS-W009153; LS11453; MCULE-3282492293; AC-23653; AK-30552; AS-14432; BR-30552; SC-13249; SY014521; DB-005881; AM20060859; D3384; FT-0610560; ST50826657; EN300-29657; A19919; C16247; M-5637; 608D333; AJ-087/41885654; Q209273; W-105226; Z1250100725
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-Bromophenol
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Investigative | Compound Info | ||
| Synonyms |
p-Bromophenol; Phenol, 4-bromo-; p-Bromohydroxybenzene; 4-Bromo-phenol; p-Bromophenic acid; Phenol, p-bromo-; para-bromophenol; 4-bromo phenol; UNII-LAO4J0183I; MFCD00002313; CHEMBL57284; LAO4J0183I; 4-Bromophenol, 97%; 4-bromphenol; CCRIS 632; NSC 4970; EINECS 203-394-4; parabromophenol; parabromphenol; 4bromophenol; para bromophenol; AI3-14903; p-bromo phenol; p-bromo-phenol; p-bromophenol;; 4-bromopbenol; bromophenol-4; 4-bromanylphenol; HSDB 7650; 1,4-bromophenol; 4-bromohydroxybenzene; [O]c1ccc(Br)cc1; PubChem19708; 4-Bromophenol, 99%; ACMC-2098jl; SCHEMBL17443; KSC174Q1T; BIDD:ER0009; DTXSID3051543; CTK0H4819; NSC4970; 4-Bromophenol, analytical standard; ZINC404316; BCP17755; EBD44644; KS-000002LO; NSC-4970; STR02366; ANW-15343; BDBM50150779; SBB040917; STL281864; AKOS000118965; LS11445; MCULE-4578744293; PS-3353; BR-77152; SC-17542; DB-023687; 4-Bromophenol, purum, >=98.0% (HPLC); AM20050178; B0787; B3910; FT-0612047; ST50214520; 06B412; C14453; K-0536; 88240-EP2272817A1; 88240-EP2284148A1; 88240-EP2289868A1; 88240-EP2298731A1; 88240-EP2305648A1; A801434; J-001587; J-514834; Q26421193; Z57127362; F0001-0119
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
7-Hydroxy-2-propylchromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL241363; 7-hydroxy-2-propyl-4H-chromen-4-one; Maybridge1_002254; 4H-1-Benzopyran-4-one, 7-hydroxy-2-propyl-; Oprea1_100104; HMS547O10; ZINC133002; BDBM50222311; BTB 10040; CCG-46184; MFCD00100589; MCULE-5977339715; 7-hydroxy-2-propyl-4H-benzopyran-4-one; SR-01000635896-1
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
3-Fluorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271116; MLS002607766; SCHEMBL1531886; BDBM50329324; NCGC00185051-01; SMR001522640; Q27164160; 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 3-fluorobenzoate
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
7-Hydroxy-2-pentyl-4H-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL241366; SCHEMBL3658287; 7-hydroxy-2-pentylchromen-4-one; BDBM50222286
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
4-Bromophenetole
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Investigative | Compound Info | ||
| Synonyms |
p-Bromophenetole; 1-Bromo-4-ethoxybenzene; Benzene, 1-bromo-4-ethoxy-; 4-Bromophenyl ethyl ether; 4-bromoethoxybenzene; p-Bromoethoxybenzene; p-Ethoxybromobenzene; 1-Bromo-4-ethoxy-benzene; p-Ethoxyphenyl bromide; p-Bromophenol ethyl ether; Phenetole, p-bromo-; UNII-T0L17BX1WR; 4-bromo phenetole; MFCD00000098; 4-ethoxybromobenzene; 1-BROMO-4-ETHYLOXYBENZENE; NSC 8053; T0L17BX1WR; CHEMBL187292; OTAVA-BB 1786453; p-bromophenetol; 4-bromophenetol; phenetyl bromide; 4-bromo phenetol; NSC8053; EINECS 209-629-7; 4-ethoxybromo-benzene; PubChem3138; 1-ethoxy-4-bromobenzene; p-bromophenyl ethyl ether; 4-Bromophenetole, 97%; 4-Bromophenetole, 98%; ethyl 4-bromophenyl ether; 4-Bromophenetole (4BP); ACMC-209m7v; 2-METHYLGLUTARICACID; SCHEMBL18358; KSC271S0F; Phenetole, p-bromo- (8CI); 4-ETHOXY BROMO BENZENE; DTXSID6060426; CTK1H1902; ZINC407014; ACT08100; KS-00000D7H; NSC-8053; ANW-33065; BDBM50150786; SBB059353; AKOS000119004; AS03448; MCULE-7760251246; VZ28620; AK-47317; BC002408; BR-47317; DS-14348; SC-05560; SY001830; DB-028768; AM20060683; ST50406518; M-5946; W-105361; Q27289511; F0001-1538
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
7-Hydroxy-2-t-butyl-4H-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL241365; 2-t-butyl-7-hydroxychromone; SCHEMBL8493156; BDBM50222302
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
3-Hydroxyflavone
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Investigative | Compound Info | ||
| Synonyms |
Flavonol; 3-Hydroxy-2-phenyl-4H-chromen-4-one; Flavon-3-ol; 3-Hydroxy-2-phenylchromone; 4H-1-Benzopyran-4-one, 3-hydroxy-2-phenyl-; FLAVONE, 3-HYDROXY-; 3-hydroxy-2-phenylchromen-4-one; UNII-ZTG9LSS5QH; MFCD00006832; ZTG9LSS5QH; NSC57653; CHEMBL294009; 3-hydroxy-2-phenyl-4H-1-benzopyran-4-one; NSC-57653; F0013-0884; flavonols; FLAVONE,3-HYDROXY-; NSC58585; SR-01000401360; EINECS 209-416-9; NSC 57653; NSC 58585; 3-hydroxyflavon; HSDB 7572; 3-hydroxy-2-phenyl-chromen-4-one; Spectrum_000328; SpecPlus_000831; Spectrum2_001392; Spectrum3_001432; Spectrum4_001845; Spectrum5_000350; ACMC-209m0e; Oprea1_038914; Oprea1_692205; SCHEMBL20246; 3-Hydroxyflavone, >=98%; 4-Hydroxy-3-oxylatoflavylium; BSPBio_003164; KBioGR_002250; KBioSS_000808; MLS002207277; BIDD:ER0553; DivK1c_006927; SPECTRUM1501012; SPBio_001404; MEGxp0_001695; DTXSID4060365; ACon1_000167; CTK3J2720; KBio1_001871; KBio2_000808; KBio2_003376; KBio2_005944; KBio3_002384; ZINC57675; HMS3740M15; KUC106685N; KS-00000VN5; WLN: T66 BO EVJ CR& DQ; ANW-32796; BDBM50187668; CCG-38858; NCI-57653; s4790; SBB000767; AKOS000599906; MCULE-8535739842; SDCCGMLS-0066736.P001; NCGC00095653-01; NCGC00095653-02; NCGC00095653-03; 3-Hydroxy-2-phenyl-4H-chromen-4-one #; AK163706; AS-19638; SMR000112317; ST086622; SY048803; KSC-11-207-16; DB-053103; HY-107825; CS-0030701; EU-0001678; FT-0615841; Y2009; VU0053575-3; C01495; H-5000; 3-Hydroxy-2-phenyl-4H-1-benzopyran-4-one, 9CI; Q5919049; SR-01000401360-1; SR-01000401360-2; BRD-K55150756-001-05-7; B48D3495-6D21-4742-8A87-D3DE07DC9554
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-Hydroxy-2-isobutyl-4H-benzopyran-4-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395115; BDBM50222312; ZINC28875393
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-Hydroxy-2-pentyl-4H-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241794; SCHEMBL957193; BDBM50222288
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Ethyl-3-hydroxy-4H-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238815; BDBM50222298; 2-ethyl-3-hydroxy-4 H-benzopyran-4-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-Thiophenecarboxylic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270312; MLS002607747; SCHEMBL1531812; BDBM50329321; NCGC00185032-01; SMR001522621; Q27164331; 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl thiophene-3-carboxylate
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Isobutyl-6,7-methylenedioxybenzopyran-4-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL238813; BDBM50222292
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(3-(2-Methoxybenzamido)phenyl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381113; Cambridge id 6712889; Oprea1_861177; MLS001206985; HMS2837B08; ZINC780710; BDBM50182509; STK390346; Thiophene-2-carboxylic acid [3-(2-methoxy-benzoylamino)-phenyl]-amide; AKOS000595757; MCULE-4291013618; SMR000519009; ST50274667; AB00117089-01; (2-methoxyphenyl)-N-[3-(2-thienylcarbonylamino)phenyl]carboxamide; N-(3-{[(2-methoxyphenyl)carbonyl]amino}phenyl)thiophene-2-carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
13-Keto-9Z,11E-octadecadienoic acid
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Investigative | Compound Info | ||
| Synonyms |
(9Z,11E)-13-Oxooctadeca-9,11-dienoic acid; 13-OXO-ODE; 13-oxo-9Z,11E-ODE; 13-OxoODE; 13-KODE; 13-ketooctadecadienoic acid; CHEMBL1378466; 13-ketoODE; 13-Oxo-9Z,11E-octadecadienoic acid; (9Z,11E)-13-Oxooctadeca-9,11-dienoate; (E,Z)-13-Oxo-9,11-octadecadienoic acid; 9,11-Octadecadienoic acid, 13-oxo-, (E,Z)-; 13-Ketooctadecadienoioc acid; BSPBio_001333; BML1-E02; SCHEMBL2513742; HMS1791C15; HMS1989C15; HMS3402C15; ZINC4655398; 13-ketooctadeca-9,11-dienoic acid; Eicosanoids_13-oxoODE_C18H30O3; BDBM50045522; LMFA02000016; 13-Keto-octadeca-9Z,11E-dienoic acid; NCGC00161271-01; NCGC00161271-02; NCGC00161271-03; C14765; (9z,11e)-13-oxo-octadeca-9,11-dienoic acid; 9,11-Octadecadienoic acid, 13-oxo-, (9Z,11E)-; Q27104960
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3-Hydroxy-2-propyl-4H-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394258; BDBM50222281
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(3-(2-Methylbenzamido)phenyl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202582; Oprea1_623197; MLS001206558; HMS2814A10; ZINC884414; BDBM50182510; STK259254; Thiophene-2-carboxylic acid [3-(2-methyl-benzoylamino)-phenyl]-amide; ZINC00884414; AKOS000461241; MCULE-9039046377; SMR000517906; ST50267492; AB00116817-01; SR-01000365943; SR-01000365943-1; (2-methylphenyl)-N-[3-(2-thienylcarbonylamino)phenyl]carboxamide; N-(3-{[(2-methylphenyl)carbonyl]amino}phenyl)thiophene-2-carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-Hydroxy-2-isopropyl-4H-benzopyran-4-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL240713; BDBM50222314
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4H-1-Benzopyran-4-one, 2-(1,1-dimethylethyl)-6-hydroxy-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL147999; ACMC-20n61s; SCHEMBL7574697; CTK0B1618; DTXSID60449673; BDBM50222280; ZINC12353725; 2-tert-Butyl-6-hydroxy-chromen-4-one; 6-hydroxy-2-t-butyl-4H-benzopyran-4-one; 2-TERT-BUTYL-6-HYDROXYCHROMEN-4-ONE
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Ethyl-6-hydroxy-4H-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL394459; BDBM50222299
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl benzo[b]thiophene-2-carboxylate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270810; SCHEMBL1531989; BDBM50329322; NCGC00185053; NCGC00185053-01
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3,4-Difluorobenzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271220; MLS002607749; SCHEMBL1531932; BDBM50329325; ZINC36381500; NCGC00185034-01; SMR001522623; Q27163921; 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl 3,4-difluorobenzoate
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-{[5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}but-2-yn-1-yl 4-fluorobenzoate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270608; MLS002607777; SCHEMBL1531857; BBL019158; BDBM50329329; MFCD07039044; STL140809; ZINC36381526; AKOS005715806; MCULE-6985006049; NCGC00185064-01; SMR001522651; H4992; AP-853/43261189; Q27164848; 4-(5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl4-Fluorobenzoate
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
6-Hydroxyflavone
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Investigative | Compound Info | ||
| Synonyms |
6-hydroxy-2-phenylchromen-4-one; 6-Hydroxy-2-phenyl-4-benzopyrone; 6-Monohydroxyflavone; 6-Hydroxy-2-phenyl-4H-chromen-4-one; 6-Hydroxy-2-phenyl-chromen-4-one; MLS000738065; UNII-148S6Z78H6; 6-Hydroxyflavone, 98%; MFCD00017329; NSC-26744; CHEMBL138649; 4H-1-Benzopyran-4-one, 6-hydroxy-2-phenyl-; NSC26744; 148S6Z78H6; EINECS 229-704-8; NSC 26744; 6-Hydroxyflavone (6-HF); Diisononyladipate; 6-hydroxy-flavone; 6-Hydroxy flavone; 6-Hydroxyflavone, 10; ACMC-1B9IO; BIDD:ER0190; SCHEMBL676594; MEGxp0_001697; DTXSID8022327; ACon1_002026; ZINC57677; HMS2764K07; HMS3885I17; ACT08319; HY-N7110; ANW-75600; BDBM50081950; s3634; SBB000766; AKOS002670169; CCG-214625; MCULE-9337240832; NCGC00179903-01; NCGC00179903-03; 6-Hydroxy-2-phenyl-4H-chromen-4-one #; AS-57550; SC-08572; SMR000393737; 6-hydroxy-2-phenyl-4-oxo-4H-1-benzopyran; DB-054947; CS-0030698; FT-0621167; ST50307711; 4H-1-Benzopyran-4-one,6-hydroxy-2-phenyl-; C14137; Q2817908; BRD-K04253610-001-01-6
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Texasin
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
6,7-Dihydroxy-4'-methoxyisoflavone; 6,7-Dihydroxy-3-(4-methoxyphenyl)-4-benzopyrone; FORMONETIN; CHEMBL239028; 6,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one; EINECS 212-980-9; TEXASIN(RG); C10536; 6,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one; SCHEMBL4728656; DTXSID10237860; ZINC6484559; BDBM50222287; LMPK12050101; 6,7-dihydroxy-4''-methoxyisoflavone; AC-31488; FT-0764584; Q27108415
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6,7-Dihydroxy-3-(1,3-benzodioxol-5-yl)-4H-1-benzopyran-4-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL239030; SCHEMBL10562034; BDBM50222294; 6,7-dihydroxy-3'',4''-methylenedioxyisoflavone; 3-(1,3-benzodioxol-5-yl)-6,7-dihydroxychromen-4-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-Bromophenol
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Investigative | Compound Info | ||
| Synonyms |
m-Bromophenol; Phenol, 3-bromo-; 3-bromo phenol; 3-Bromo-phenol; Phenol, m-bromo-; UNII-VMU0X6956Y; MFCD00002253; 3-Bromophenol, 98%; CHEMBL185651; VMU0X6956Y; OTAVA-BB 1287431; meta bromophenol; meta-bromophenol; 3 bromophenol; 3-bromanylphenol; HSDB 7649; meta-bromo-phenol; EINECS 209-706-5; 3-bromophenyl alcohol; PubChem3824; ACMC-1CUCG; 3-BROM-PHENOL; 1-bromo-3-hydroxy-benzene; CHEMWISH IC03776; SCHEMBL49927; KSC269I4J; DTXSID9060449; ARKPHARMLTD ARK-02495; CTK1G9444; 3-BROMO-1-HYDROXYBENZENE; ZINC388034; ACT00927; KS-000002OV; STR02996; ANW-33162; BDBM50150795; STL280238; AKOS000118744; AS00214; MCULE-7883689277; PS-4040; BC002623; BR-44013; SC-05579; DB-006384; 3-Bromophenol, purum, >=97.5% (HPLC); AM20060304; B0629; FT-0601041; FT-0615113; ST50826980; 91B208; M-5873; A832171; Q-200364; Q26421128; F0001-1548; Z1262252924
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1,6-Bis[4-(2-methoxyphenyl)piperazin-1-yl]hexane-1,6-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202698; 1,6-bis(4-(2-methoxyphenyl)piperazin-1-yl)hexane-1,6-dione; BDBM50182511; STK441584; ZINC13681960; AKOS003307903; MCULE-1579990351; ST50922757; 1,6-bis[4-(2-methoxyphenyl)piperazinyl]hexane-1,6-dione
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(5-Chloro-2-methoxyphenyl)-3-methyl-1-benzofuran-2-carboxamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL383552; Cambridge id 6671738; ZINC136457; BDBM50182506; STK702551; AKOS000663286; MCULE-6598711495; ST029413; AB00115329-01; Z28182807; N-(5-chloro-2-methoxyphenyl)-3-methylbenzofuran-2-carboxamide; N-(5-chloro-2-methoxyphenyl)(3-methylbenzo[d]furan-2-yl)carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
7-Hydroxy-2-isopropyl-4H-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241364; 7-hydroxy-2-isopropylchromone; SCHEMBL14243496; BDBM50222310
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6,7-Methylenedioxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238814; BDBM50222305; 6,7-methylenedioxy-2-phenylbenzopyran-4-one; 6-phenyl-[1,3]dioxolo[4,5-g]chromen-8-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-Chloro-4-ethoxy-N-(2-(pyrrolidin-1-yl)phenyl)benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370583; 3-chloro-4-ethoxy-N-[2-(pyrrolidin-1-yl)phenyl]benzamide; Oprea1_097634; SCHEMBL14825204; ZINC464460; BDBM50182504; STK355741; AKOS000464957; MCULE-7702536148; ST51028442; (3-chloro-4-ethoxyphenyl)-N-(2-pyrrolidinylphenyl)carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Ethyl 1-(3-(3,5-dimethylphenylamino)-3-oxopropyl)piperidine-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL204926; Oprea1_515664; Oprea1_601346; MLS000689098; HMS2708O21; ZINC4725186; BDBM50182513; STK232605; AKOS000551083; MCULE-4345541428; SMR000283136; ST50015926; SR-01000481777; SR-01000481777-1; BRD-K62871870-001-07-6; ethyl 1-{2-[N-(3,5-dimethylphenyl)carbamoyl]ethyl}piperidine-4-carboxylate; ethyl 1-{3-[(3,5-dimethylphenyl)amino]-3-oxopropyl}piperidine-4-carboxylate
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-([1,2,4]Triazolo[4,3-a]quinolin-1-ylthio)-N-phenethylacetamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL204917; ZINC1128596; BDBM50182505; AKOS000812429; MCULE-2488923601; VU0618158-1; F3394-0504; Z275024050; N-(2-phenylethyl)-2-([1,2,4]triazolo[4,3-a]quinolin-1-ylthio)acetamide; N-(2-phenylethyl)-2-{[1,2,4]triazolo[4,3-a]quinolin-1-ylsulfanyl}acetamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4H-1-Benzopyran-4-one, 6-hydroxy-2-propyl-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL240505; 6-hydroxy-2-propyl-4h-chromen-4-one; SCHEMBL7573134; CTK2D7764; DTXSID80453015; BDBM50222283; 6-HYDROXY-2-PROPYLCHROMEN-4-ONE; 6-hydroxy-2-propyl-4H-benzopyran-4-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-{[5-(1-Naphthyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-2-butynyl 2-thiophenecarboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270217; SMR000035823; regid862462; MLS000039387; MLS002583125; SCHEMBL1531887; HMS2406F05; ZINC2413450; BDBM50329320; STK208703; AKOS003365867; MCULE-8631402189; NCGC00064876-02; NCGC00064876-03; NCGC00064876-04; AP-853/41543948
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3,6-Dihydroxyflavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,6-dihydroxy-2-phenyl-4H-chromen-4-one; 3,6-dihydroxy-2-phenylchromen-4-one; 6-Hydroxyflavonol; 3,6-dihydroxy-flavone; 4H-1-Benzopyran-4-one, 3,6-dihydroxy-2-phenyl-; CHEMBL210411; MFCD00143082; ACMC-1C7FZ; Oprea1_396152; SCHEMBL1627936; 3,6-Dihydroxy-2-phenylchromone; CTK4A5918; ZINC57648; DTXSID90350940; BDBM50187657; STL512574; AKOS024307412; MCULE-8833300798; AS-64082; D5191; FT-0734795; ST50319482; Y1999; J-002077
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-Hydroxy-2-t-butyl-4H-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239023; BDBM50222282
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-(5-(Naphthalen-2-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl-4-fluorobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270314; SCHEMBL1531980; BDBM50329328; NCGC00187935-01
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2,4-Dibromophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Phenol, 2,4-dibromo-; 2,4-Dibromo-phenol; 2,4-dibromphenol; 2,4-bis(bromanyl)phenol; UNII-IA75T5C9TG; MFCD00002149; IA75T5C9TG; CHEMBL186858; 2,4-Dibromophenol, 99%; NSC 6213; EINECS 210-436-5; BRN 1861291; AI3-15480; HSDB 7651; Phenol,4-dibromo-; 2,4-Dibromo phenol; Emery 9331; ACMC-1BGA9; 2,4-Dibromophenol, 95%; 4-06-00-01061 (Beilstein Handbook Reference); KSC357E6L; BIDD:ER0577; SCHEMBL395736; ARONIS022807; DTXSID1052290; CTK2F7265; KS-00000MMW; KS-00004DYU; 2,4-DBP; NSC6213; ZINC358476; NSC-6213; ANW-33863; BDBM50150792; FR-612; SBB058506; STK061556; AKOS000118746; 2,4-Dibromophenol, analytical standard; CS-W010206; LS11451; MCULE-8488585485; NE10146; PS-7460; AC-17043; AK-88987; BP-11833; SC-81070; DB-024169; 2,4-Dibromophenol 10 microg/mL in Methanol; D0265; FT-0609990; ST45036390; 2,4-Dibromophenol 100 microg/mL in Methanol; C14521; A833300; AN-329/40869004; Q209199; W-105131
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Ethyl 2-(4-phenylbutanoylamino)benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201191; ethyl 2-(4-phenylbutanamido)benzoate; ZINC363478; BDBM50182508; AKOS003305718; MCULE-6788538258; ST50721901; AB00121620-01
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
6,7-Dihydroxy-2-t-butylbenzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL394257; BDBM50222300
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
2-(Benzylthio)-N-(3-chloro-2-methylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202034; ZINC454526; BDBM50182497; STK267357; AKOS001279441; MCULE-3022018855; ST51079632; AB00108839-01; 2-(benzylsulfanyl)-N-(3-chloro-2-methylphenyl)acetamide; N-(3-chloro-2-methylphenyl)-2-(phenylmethylthio)acetamide
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
4-Bromobenzyl alcohol
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Investigative | Compound Info | ||
| Synonyms |
(4-Bromophenyl)methanol; p-Bromobenzyl alcohol; Para-Bromobenzyl Alcohol; 4-bromobenzylalcohol; Benzenemethanol, 4-bromo-; MFCD00004650; (4-bromophenyl)-methanol; Benzyl alcohol, p-bromo-; (4-Bromo-phenyl)-methanol; (4-bromophenyl)methan-1-ol; 4-Bromobenzyl alcohol, 99%; CHEMBL184410; 4-HYDROXYMETHYL-1-BROMOBENZENE; p-Bromo-benzyl alcohol; CCRIS 5119; EINECS 212-851-7; 4-Bromophenylmethanol; 4-bromo-benzylalcohol; 4-bromobenzyl-alcohol; PubChem3748; ACMC-1BL3V; (4-Bromophenyl)methanol #; ASISCHEM V60455; KSC492I8P; SCHEMBL104349; RARECHEM AL BD 0075; CTK3J2487; VEDDBHYQWFOITD-UHFFFAOYSA-; DTXSID50236276; OTAVA-BB 1782769; ZINC404753; ACT13272; EBD35045; KS-000002MU; ANW-38685; BDBM50150787; SBB064717; AKOS000249367; AS03954; CS-W004067; DB02822; MCULE-6643975109; PS-5313; (4-Bromophenyl)methanol;Brombenzylalcohol; AC-17025; AC-26171; AK-93775; BC002554; SC-07090; SY006440; AB0019780; DB-017995; AM20050135; FT-0617870; FT-0617871; ST50406657; V0282; A22470; B-3820; W-104028; Q27093776; Z1741959491
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Morusin
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Investigative | Compound Info | ||
| Synonyms |
Mulberrochromene; TCMDC-124149; UNII-T4VGD5NP9B; NSC649220; T4VGD5NP9B; CHEMBL464006; Morusin, 3; NSC 649220; MLS000697591; MEGxp0_001039; SCHEMBL2562778; ACon1_001205; cid_5281671; DTXSID70211641; HMS2271K05; BCP16494; HY-N0622; ZINC5195808; BDBM50242014; LMPK12110912; MFCD09953814; AKOS032962066; CS-6885; NSC-649220; AK169967; SMR000470930; FT-0686661; N2266; W1523; A14647; C10106; BRD-K40169295-001-01-2; Q27107393
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| Activity |
IC50 = 100000 nM
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[10] | |||
| Compound Name |
2-Isopropyl-3-hydroxy-4H-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL238816; BDBM50222275
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
4-(Trifluoromethoxy)benzoic acid 4-[[5-(1-naphthalenyl)-1,3,4-oxadiazol-2-yl]thio]but-2-ynyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270113; MLS002607759; SCHEMBL1531945; BDBM50329326; NCGC00185044-01; SMR001522633; Q27164786; 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl-4-(trifluoromethoxy)benzoate
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
6-Hydroxy-2-pentyl-4H-benzopyran-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395346; BDBM50222306
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
N-[1-(5-Chloro-8-hydroxyquinolin-7-yl)ethyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1323844; MLS002391522; SCHEMBL4037903; HMS2201H16; HMS3356E16; BDBM50350408; NCGC00183686-01; SMR001355491
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| Activity |
IC50 ~ 150000 nM
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[6] | |||
| Compound Name |
15-Oxo-puupehenoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1165243; BDBM50320453
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| Activity |
IC50 ~ 150000 nM
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[2] | |||
| Compound Name |
N-[(5-Chloro-8-hydroxyquinolin-7-yl)-(4-methylphenyl)methyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
MLS002264522; SMR001317822; BAS 01923190; Oprea1_064781; Oprea1_561078; SCHEMBL2598275; CHEMBL1323467; BDBM77605; cid_3136132; HMS2209M05; AKOS000538955; MCULE-8252777978; NCGC00182961-03; N-[(5-chloro-8-hydroxy-7-quinolyl)-(p-tolyl)methyl]propanamide; N-[(5-chloro-8-hydroxy-7-quinolyl)-(p-tolyl)methyl]propionamide; N-[(5-chloro-8-hydroxy-7-quinolinyl)-(4-methylphenyl)methyl]propanamide; N-[(5-chloro-8-hydroxy-7-quinolyl)(4-methylphenyl)methyl]propanamide; N-[(5-chloranyl-8-oxidanyl-quinolin-7-yl)-(4-methylphenyl)methyl]propanamide
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| Activity |
IC50 ~ 150000 nM
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[6] | |||
| Compound Name |
N-((5-Chloro-8-hydroxyquinolin-7-yl)methyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1437477; BDBM50350410; NCGC00183712-01
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| Activity |
IC50 ~ 150000 nM
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[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 10 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-[(2-Methoxybenzyl)oxy]-7-methyl-4-phenyl-2H-chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202482; 5-((2-methoxybenzyl)oxy)-7-methyl-4-phenyl-2H-chromen-2-one; Oprea1_643728; Oprea1_819431; ZINC1155627; BDBM50182515; STL458475; AKOS016365000; MCULE-8213212498; 5-(2-methoxybenzyloxy)-7-methyl-4-phenyl-2H-chromen-2-one
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| Activity |
IC50 > 200000 nM
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[8] | |||
| Compound Name |
N''-[(2-Chloro-4-methylbenzoyl)oxy]-3-methylbenzenecarboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL201969; SCHEMBL10036388; BDBM50182514; AKOS003353366; MCULE-1327678962
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| Activity |
IC50 > 200000 nM
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[8] | |||
| Compound Name |
Pyridine-2,6-dicarboxylic acid bis-(phenethyl-amide)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL383793; SMR000513481; Oprea1_075523; Oprea1_153653; MLS001075798; MLS001207478; HMS2194F18; HMS3336C09; ZINC816644; BDBM50182512; STK371281; AKOS000577293; MCULE-4741646226; N,N'-Diphenethyl-2,6-pyridinedicarboxamide; N2,N6-diphenethylpyridine-2,6-dicarboxamide; ST50923076; N~2~,N~6~-diphenethyl-2,6-pyridinedicarboxamide; SR-01000408184; N,N'-bis(2-phenylethyl)-2,6-pyridinedicarboxamide; N,N'-bis(2-phenylethyl)pyridine-2,6-dicarboxamide; SR-01000408184-1; N-(2-phenylethyl){6-[N-(2-phenylethyl)carbamoyl](2-pyridyl)}carboxamide
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| Activity |
IC50 > 200000 nM
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[8] | |||
| Compound Name |
Halenaquinol sulfate
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Investigative | Compound Info | ||
| Synonyms |
Halenaquinol Sulfate Sodium; CHEMBL455880
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| Activity |
IC50 > 200000 nM
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[11] | |||
| Compound Name |
2-(4-Chloro-2-methylphenoxy)-N-[2-hydroxy-5-(propan-2-yl)phenyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202560; Oprea1_667959; ZINC307976; BDBM50182500; STK184320; AKOS003255387; MCULE-8804263745; 2-(4-chloro-2-methylphenoxy)-N-(2-hydroxy-5-isopropylphenyl)acetamide
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| Activity |
IC50 > 200000 nM
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[8] | |||
| Compound Name |
2-(3-Chlorophenoxy)-N-(4-methylbenzyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL201368; 2-(3-chlorophenoxy)-N-[(4-methylphenyl)methyl]propanamide; BDBM50182503; STK134096; AKOS003297436; AKOS017065277; MCULE-3427061928; ST50943912; 2-(3-Chloro-phenoxy)-N-(4-methyl-benzyl)-propionamide
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| Activity |
IC50 > 200000 nM
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[8] | |||
| Compound Name |
2-Phenoxy-N-{[4-(pyridin-4-ylmethyl)phenyl]carbamothioyl}acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL201812; Oprea1_585139; ZINC1183098; BDBM50182498; STK003450; AKOS003224499; MCULE-4992459652; AB00112239-01; 1-(2-phenoxyacetyl)-3-(4-(pyridin-4-ylmethyl)phenyl)thiourea
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| Activity |
IC50 > 200000 nM
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[8] | |||
| Compound Name |
N-(5-Butyramido-2-chlorophenyl)benzofuran-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370234; Oprea1_155280; ZINC798601; BDBM50182502; AKOS000603099; MCULE-1459716428; ST50023358; N-[3-(benzo[d]furan-2-ylcarbonylamino)-4-chlorophenyl]butanamide
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| Activity |
IC50 > 200000 nM
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[8] | |||
| Compound Name |
2-Chloro-N-{2-methyl-4-[(phenylsulfanyl)methyl]phenyl}benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202533; ZINC2085192; BDBM50182507; STL120986; AKOS003248622; MCULE-5923565433; AB00117838-01; AH-487/40936377; 2-chloro-N-(2-methyl-4-(phenylthiomethyl)phenyl)benzamide
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| Activity |
IC50 > 200000 nM
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[8] | |||
| Compound Name |
N-Benzyl-3-((2,3-dihydro-1H-inden-5-yloxy)methyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202366; N-benzyl-3-[(2,3-dihydro-1H-inden-5-yloxy)methyl]benzamide; MLS000579321; HMS2554O08; ZINC2836241; BDBM50182499; SMR000198603
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| Activity |
IC50 > 500000 nM
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[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors. J Med Chem. 1993 Nov 12;36(23):3580-94. | ||||
| REF 2 | Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. | ||||
| REF 3 | Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. | ||||
| REF 4 | Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Bioorg Med Chem. 2007 Dec 1;15(23):7408-25. | ||||
| REF 5 | A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorg Med Chem. 2016 Mar 15;24(6):1183-90. | ||||
| REF 6 | Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem. 2011 Aug 11;54(15):5485-97. | ||||
| REF 7 | Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. J Med Chem. 2010 Oct 28;53(20):7392-404. | ||||
| REF 8 | Novel human lipoxygenase inhibitors discovered using virtual screening with homology models. J Med Chem. 2006 Feb 23;49(4):1356-63. | ||||
| REF 9 | Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes. Bioorg Med Chem. 2014 Aug 1;22(15):4293-7. | ||||
| REF 10 | Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro. J Nat Prod. 2011 Apr 25;74(4):614-9. | ||||
| REF 11 | Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. | ||||
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