Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35565 | Target Info | |||
| Target Name | Alkaline phosphatase (ALPPL2) | ||||
| Synonyms |
Placental alkaline phosphatase-like; PLAP-like; Germ cell alkaline phosphatase; GCAP; Alkaline phosphatase, placental-like; Alkaline phosphatase, germ cell type; Alkaline phosphatase Nagao isozyme; ALPPL; ALPG; ALP-1
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| Target Type | Literature-reported Target | ||||
| Gene Name | ALPPL2 | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Methoxy-11-oxo-11H-pyrido(2,1-b)quinazoline-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
Ro 21-7634; UNII-1QSS0Q62W5; 1QSS0Q62W5; CHEMBL163713; 2-methoxy-11-oxopyrido[2,1-b]quinazoline-8-carboxylic acid; 2-Methoxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid; BRN 0889274; SCHEMBL11002651; CTK5B7510; DTXSID80212422; ZINC6018803; 11H-Pyrido(2,1-b)quinazoline-8-carboxylic acid, 2-methoxy-11-oxo-; BDBM50404861; Ro-21-7634
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-Methoxy-8-(2H-tetrazol-5-yl)pyrido[2,1-b]quinazolin-11-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL162480; SCHEMBL11264243; BDBM50404877
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| Activity |
IC50 = 140000 nM
|
[1] | |||
| Compound Name |
2-Methyl-11-oxo-11H-pyrido(2,1-b)quinazoline-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
UNII-KR595247MT; CHEMBL165674; 11H-Pyrido(2,1-b)quinazoline-8-carboxylic acid, 2-methyl-11-oxo-; KR595247MT; BRN 0751538; 2-Methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid; SCHEMBL11009173; CTK2F5098; 2-methyl-11-oxopyrido[2,1-b]quinazoline-8-carboxylic acid; DTXSID60212420; BDBM50404867; ZINC27859073; Q27282393
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| Activity |
IC50 = 160000 nM
|
[1] | |||
| Compound Name |
11-Oxopyrido[2,1-b]quinazoline-7-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL165344; SCHEMBL11240930; BDBM50404879; ZINC27859086
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| Activity |
IC50 = 170000 nM
|
[1] | |||
| Compound Name |
12H-Benzo(g)pyrido(2,1-b)quinazoline-2-carboxylic acid, 12-oxo-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL165865; 12-Oxo-12H-benzo(g)pyrido(2,1-b)quinazoline-2-carboxylic acid; BRN 0755415; 12-Oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-2-carboxylic acid; DTXSID40212468; BDBM50404871; ZINC27861651
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| Activity |
IC50 = 180000 nM
|
[1] | |||
| Compound Name |
Benzyl-phosphonothioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123163; Phosphonothioic acid, (phenylmethyl)- (9CI); SCHEMBL6310521; BDBM50131861; benzyl-dihydroxy-sulfanylidene-$l^{5}-phosphane
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| Activity |
Ki = 200000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 28 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
ZAPRINAST
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|
Terminated | Compound Info | ||
| Activity |
IC50 = 6250000 nM
|
[1] | |||
| Compound Name |
BUFROLIN
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Investigative | Compound Info | ||
| Synonyms |
Bufrolin; 54867-56-0; UNII-46C1PX266N; ICI-74917; CHEMBL150764; 46C1PX266N; Bufrolinum; Bufroline; Bufrolino; Bufrolin [INN:BAN]; Bufrolinum [INN-Latin]; Bufroline [INN-French]; Bufrolino [INN-Spanish]; AC1Q5RDE; AC1L2HFD; SCHEMBL2109492; CTK1H2392; DTXSID60203353; ZINC4215124; 6-butyl-4,10-dihydroxy-1,7-phenanthroline-2,8-dicarboxylic acid; BDBM50020876; 6-Butyl-1,4,7,10-tetrahydro-4,10-dioxo-1,7-phenanthroline-2,8-dicarbonsaeure; 6-butyl-4,10-dioxo-1,7-dihydro-1,7-phenanthroline-2,8-dicarboxylic acid
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| Activity |
IC50 = 970000 nM
|
[1] | |||
| Compound Name |
2-Methyl-8-(2H-tetrazol-5-yl)pyrido[2,1-b]quinazolin-11-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL163810; BDBM50404868
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|
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| Activity |
IC50 = 210000 nM
|
[1] | |||
| Compound Name |
2,3-Dihydroxy-11-oxopyrido[2,1-b]quinazoline-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL353583; BDBM50404866
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| Activity |
IC50 = 220000 nM
|
[1] | |||
| Compound Name |
2-(2H-Tetrazol-5-yl)-12H-benzo[g]pyrido[2,1-b]quinazolin-12-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL162063; BDBM50404865
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| Activity |
IC50 = 230000 nM
|
[1] | |||
| Compound Name |
6-(2H-Tetrazol-5-yl)-13,15-dioxa-2,8-diazatetracyclo[8.7.0.03,8.012,16]heptadeca-1(17),2,4,6,10,12(16)-hexaen-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL161930; BDBM50404872
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| Activity |
IC50 = 230000 nM
|
[1] | |||
| Compound Name |
8-(2H-Tetrazol-5-yl)pyrido[2,1-b]quinazolin-11-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL163354; SCHEMBL11663336; BDBM50404876; ZINC27856085
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|
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| Activity |
IC50 = 280000 nM
|
[1] | |||
| Compound Name |
2-Hydroxy-11-oxopyrido[2,1-b]quinazoline-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL350836; SCHEMBL11007275; BDBM50404870; ZINC27856080
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| Activity |
IC50 = 280000 nM
|
[1] | |||
| Compound Name |
Methyl 6-dihydroxyphosphinothioylhexanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123931; 6-Thiophosphono-hexanoic acid methyl ester; SCHEMBL6310927; BDBM50131865
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| Activity |
Ki = 330000 nM
|
[2] | |||
| Compound Name |
2,3-Dimethoxy-8-(2H-tetrazol-5-yl)pyrido[2,1-b]quinazolin-11-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL148958; BDBM50404878
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|
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| Activity |
IC50 = 340000 nM
|
[1] | |||
| Compound Name |
11-Oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
11-Oxo-11H-pyrido(2,1-b)quinazoline-8-carboxylic acid; CHEMBL162444; 11-oxopyrido[2,1-b]quinazoline-8-carboxylic acid; BRN 0018573; 2-25-00-00238 (Beilstein Handbook Reference); SCHEMBL11245977; 11H-Pyrido(2,1-b)quinazoline-8-carboxylic acid, 11-oxo-; DTXSID50212419; ZINC3643560; BBL004844; BDBM50404873; HTS027785; MFCD01690082; STL124145; AKOS005716821; MCULE-7603343969; BS-11717; BB 0242673; 11-oxo-11H-pyrido[2,1-b]quinazoline8-carboxylic acid; 11-Oxo-11H-pyrido[2,1-b]quinazoline-8-carb oxylic acid
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| Activity |
IC50 = 350000 nM
|
[1] | |||
| Compound Name |
7-(Phosphonomethyl)-1-naphthoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123495; BDBM50131868; 7-Phosphonomethyl-naphthalene-1-carboxylic acid
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| Activity |
Ki = 390000 nM
|
[2] | |||
| Compound Name |
2,3-Dimethoxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350714; BDBM50404864; STL518655; ZINC12901175; AKOS032438788; MCULE-8123098489
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|
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| Activity |
IC50 = 410000 nM
|
[1] | |||
| Compound Name |
Phenylsulfanylmethyl-phosphonothioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331460; BDBM50131863
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|
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| Activity |
Ki = 460000 nM
|
[2] | |||
| Compound Name |
Benzylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
Benzyl-phosphonic acid; Phosphonic acid, (phenylmethyl)-; phenylmethylphosphonic acid; Phosphonic acid, P-(phenylmethyl)-; Phenylmethanephosphonic acid; CHEMBL299737; Phenyl-methanephosphonic acid anion; MFCD00039519; Benzylphosphonic acid, 98%; AI3-22857; ACMC-1B2TF; alpha-Toluenephosphonic acid; Benzylphosphonic acid, 97%; SCHEMBL44318; BMK1-H2; DTXSID2064498; CTK3J2229; Phosphonic acid,P-(phenylmethyl)-; ZINC2168364; BDBM50080274; SBB057481; AKOS006221427; MCULE-2255375115; VZ31388; BP-21653; DB-022623; FT-0636281; ST51003159; 57717-EP2305682A1; 57717-EP2308879A1; Q27458263
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| Activity |
Ki = 580000 nM
|
[2] | |||
| Compound Name |
Butyl-phosphonothioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331046; SCHEMBL2046134; SCHEMBL10766287; BDBM50131870; butyl-dihydroxy-sulfanylidene-$l^{5}-phosphane
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| Activity |
Ki = 600000 nM
|
[2] | |||
| Compound Name |
3-Methoxy-8-(2H-tetrazol-5-yl)pyrido[2,1-b]quinazolin-11-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL349966; BDBM50404875
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|
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| Activity |
IC50 = 620000 nM
|
[1] | |||
| Compound Name |
12-Oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL422193; 12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxylic acid, 12-oxo-; SCHEMBL17099654; CTK1I8150; DTXSID90499601; ALBB-008807; BDBM50404874; MFCD12028089; STK505589; ZINC27854657; AKOS015856403; AS-71294; BB 0262051; CS-0060673; 12-OXO-12H-5,13-DIAZATETRACENE-4-CARBOXYLIC ACID
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| Activity |
IC50 = 710000 nM
|
[1] | |||
| Compound Name |
11-Oxo-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
11-oxopyrido[2,1-b]quinazoline-6-carboxylic acid; MLS000068179; SMR000013792; 11-oxo-10-hydropyridino[2,1-b]quinazoline-6-carboxylic acid; CHEMBL353565; cid_646625; SCHEMBL18631335; BDBM38257; CTK7I9797; 11H-Pyrido[2,1-b]quinazoline-6-carboxylic acid, 11-oxo-; HMS1695B14; HMS2339J11; HMS3436F15; ZINC801649; 3683AE; SBB011795; AKOS000300388; MCULE-1463740523; BB 0242674; ST50280263; 11-oxo-6-pyrido[2,1-b]quinazolinecarboxylic acid; SR-01000368588; 11-ketopyrido[2,1-b]quinazoline-6-carboxylic acid; SR-01000368588-1; 11-oxidanylidenepyrido[2,1-b]quinazoline-6-carboxylic acid; 11-Oxo-11H-pyrido[2,1-b]quinazoline-6-carb oxylic acid
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| Activity |
IC50 = 800000 nM
|
[1] | |||
| Compound Name |
7-(Dihydroxyphosphinothioylmethyl)naphthalene-1-carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL122519; SCHEMBL6304046; BDBM50131866; 7-Thiophosphonomethyl-naphthalene-1-carboxylic acid
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| Activity |
Ki = 1500000 nM
|
[2] | |||
| Compound Name |
6-Thiophosphono-hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123990; SCHEMBL6303631; BDBM50131867; 6-dihydroxyphosphinothioylhexanoic acid
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| Activity |
Ki = 1500000 nM
|
[2] | |||
| Compound Name |
Propylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
Propane-1-phosphonic acid; Propyl-phosphonic acid; CHEMBL125296; MFCD00012294; 1-propanephosphonic acid; n-propylphosphonic acid; ACMC-20ajt9; Phosphonic acid, P-propyl-; Propylphosphonic acid, 95%; SCHEMBL55254; PROPANE-1-PHOSPHONICACID; CTK4I9544; ZINC2539468; BDBM50131864; AKOS015892844; 1-propylphosphonic-acid cyclic anhydride; 1-propyl phosphonic acid cyclic anhydride; DB-051398; FT-0635391; 24531-EP2281818A1; 24531-EP2314590A1; 24531-EP2371811A2; Propylphosphonic anhydride (T3P), 50% wt. in ethyl acetate
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| Activity |
Ki = 1550000 nM
|
[2] | |||
| Compound Name |
6-Phosphonohexanoic Acid
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Investigative | Compound Info | ||
| Synonyms |
6-Phosphonohexanoicacid; 6-Phosphono-hexanoic acid; CHEMBL122539; Hexanoic acid, 6-phosphono-; ACMC-20alxq; 6- Phosphonohexanoic acid; 6-Phosphonohexanoic acid; SCHEMBL504411; 6-Phosphonohexanoic acid, 97%; CTK1G8931; DTXSID50448397; BDBM50131860; MFCD10000902; ZINC13525538
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| Activity |
Ki = 7000000 nM
|
[2] | |||
| Compound Name |
2,3,4,11-Tetrahydro-1H-pyrido[2,1-b]quinazoline-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL434479; BDBM50404863
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| Activity |
IC50 > 10000000 nM
|
[1] | |||
| Compound Name |
4-Oxopyrido[1,2-a]pyrimidine-7-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL165564; BDBM50404869
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| Activity |
IC50 > 10000000 nM
|
[1] | |||
| Compound Name |
Methylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
Methanephosphonic acid; Phosphonic acid, methyl-; METHYL PHOSPHONIC ACID; MFCD00002137; UNII-329W4YM10Z; CHEMBL122938; 329W4YM10Z; Methanephosphonic acid, 98%; CH5O3P; PHOSPHONOMETHYL GROUP; HSDB 6762; EINECS 213-607-2; NSC 119358; Methyl-phosphonic acid; ACMC-20ake9; AI3-51156; EC 213-607-2; Methylphosphonic acid, 98%; DTXSID5047748; CTK5I0336; BDBM50131862; NSC119358; ZINC84544184; AKOS017343694; NSC-119358; SC-70367; DB-009772; AM20120404; FT-0628284; Methylphosphonic acid, 99.0-101.0% (T); C20396; L000171; J-522698; Q15634110
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| Activity |
Ki = 11000000 nM
|
[2] | |||
| Compound Name |
Methylphosphonothiolate
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Investigative | Compound Info | ||
| Synonyms |
Methylphosphonothioic acid; Methyl-phosphonothioic acid; CHEMBL122577; BRN 2345158; Phosphonothioic acid, methyl-; SCHEMBL26114; DTXSID70208652; methyl(sulfanylidene)phosphonous acid; BDBM50131869; AKOS006277926; dihydroxy-methyl-sulfanylidene-lambda5-phosphane; dihydroxy-methyl-sulfanylidene-$l^{5}-phosphane
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| Activity |
Ki = 19000000 nM
|
[2] | |||
| Compound Name |
Click to Show/Hide
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Compound Info | |||
| Activity |
IC50 = 9680000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Alkaline phosphatase inhibition by a series of pyrido[2,1-b]quinazolines: A possible relationship with cromolyn-like antiallergy activity. J Med Chem. 1982 Jun;25(6):742-5. | ||||
| REF 2 | A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors. J Med Chem. 2003 Aug 14;46(17):3703-8. | ||||
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