Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38338 | Target Info | |||
| Target Name | Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) | ||||
| Synonyms |
Voltage-gated calcium channel alpha subunit Cav2.2; Voltage-dependent N-type calcium channel alpha-1B subunit; N-type Ca2+ channel; Calcium channel, L type, alpha-1 polypeptide isoform 5; CACNA1B; Brain calcium channel III; BIII
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|
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| Target Type | Successful Target | ||||
| Gene Name | CACNA1B | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 42 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4227653
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461296
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|
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
Chembl4285527
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL15781041; BDBM50465795
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|
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
Chembl4227740
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461278
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|
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| Activity |
IC50 = 59000 nM
|
[1] | |||
| Compound Name |
Chembl4289288
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL15772461; BDBM50465791
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|
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| Activity |
IC50 = 61000 nM
|
[2] | |||
| Compound Name |
Chembl4226597
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461284
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|
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| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
Chembl4227450
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461276
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|
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| Activity |
IC50 = 69000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[6-(Benzylamino)-9-methylpurin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206248; SCHEMBL17450135; BDBM50400567; (R)-2-(6-(Benzylamino)-9-methyl-9H-purin-2-ylamino)butan-1-ol
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|
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| Activity |
EC50 ~ 70000 nM
|
[3] | |||
| Compound Name |
Chembl4225757
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461283
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|
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| Activity |
IC50 = 77000 nM
|
[1] | |||
| Compound Name |
Olomoucine II
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL786673; CHEMBL1094304; HMS3229J03; BDBM50366800; ZINC12504456; DB04662; 6-(2-Hydroxybenzylamino)-2-((1R)-(hydroxymethyl)propyl)amino)-9-isopropylpurine; Q27095411
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| Activity |
EC50 = 80000 nM
|
[3] | |||
| Compound Name |
Chembl4226924
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461275
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|
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| Activity |
IC50 = 98000 nM
|
[1] | |||
| Compound Name |
(R)-2-(6-(Phenethylamino)-9-propyl-9H-purin-2-ylamino)butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206261; SCHEMBL17628576; BDBM50400582; (2R)-2-[[6-(2-phenylethylamino)-9-propylpurin-2-yl]amino]butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[(6-Anilino-9-propylpurin-2-yl)amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206263; SCHEMBL17628640; BDBM50400581; (R)-2-(6-(Phenylamino)-9-propyl-9H-purin-2-ylamino)butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[6-(Benzhydrylamino)-9-propylpurin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206260; SCHEMBL19763770; BDBM50400583
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[9-Propyl-6-[[4-(trifluoromethyl)phenyl]methylamino]purin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206252; SCHEMBL17628603; BDBM50400572
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-2-(6-(Cyclopropylmethylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206253; SCHEMBL17628636; BDBM50400571; (2R)-2-[[6-(cyclopropylmethylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[9-Methyl-6-[(4-phenylphenyl)methylamino]purin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206245; SCHEMBL17628612; BDBM50400578; (R)-2-(6-(Biphenyl-4-ylmethylamino)-9-methyl-9H-purin-2-ylamino)butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[6-(Benzhydrylamino)-9-methylpurin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206246; SCHEMBL17639872; BDBM50400577
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[6-(Cyclopropylmethylamino)-9-methylpurin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206250; SCHEMBL17628634; BDBM50400574; (R)-2-(6-(Cyclopropylmethylamino)-9-methyl-9H-purin-2-ylamino)butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[9-Propyl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206243; SCHEMBL17628604; BDBM50400580; (R)-2-(9-Propyl-6-(pyridin-3-ylmethylamino)-9H-purin-2-ylamino)butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-2-(9-Isopropyl-6-(3-(trifluoromethyl)benzylamino)-9H-purin-2-ylamino)butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206240; SCHEMBL17628628; BDBM50400568; (2R)-2-[[9-propan-2-yl-6-[[3-(trifluoromethyl)phenyl]methylamino]purin-2-yl]amino]butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4225227
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461291
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|
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[6-[(4-Phenylphenyl)methylamino]-9-propylpurin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206259; SCHEMBL17628611; BDBM50400584; (R)-2-(6-(Biphenyl-4-ylmethylamino)-9-propyl-9H-purin-2-ylamino)butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[(6-Anilino-9-methylpurin-2-yl)amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206249; SCHEMBL17628589; BDBM50400575; (R)-2-(9-Methyl-6-(phenylamino)-9H-purin-2-ylamino)butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[9-Propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL455389; SCHEMBL13633363; BDBM50358220; (R)-2-(9-Isopropyl-6-(pyridin-3-ylmethylamino)-9H-purin-2-ylamino)butan-1-ol
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-2-(6-(Benzhydrylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206255; SCHEMBL17628581; BDBM50400569; (2R)-2-[[6-(benzhydrylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-2-(9-Methyl-6-(phenethylamino)-9H-purin-2-ylamino)butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206247; SCHEMBL17628638; BDBM50400576; (2R)-2-[[9-methyl-6-(2-phenylethylamino)purin-2-yl]amino]butan-1-ol
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[6-(Cyclopropylmethylamino)-9-propylpurin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206244; SCHEMBL17628622; BDBM50400579
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(R)-2-(9-Isopropyl-6-(phenethylamino)-9H-purin-2-ylamino)butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206254; SCHEMBL17628596; BDBM50400570; (2R)-2-[[6-(2-phenylethylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[[9-Methyl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206251; SCHEMBL17628590; BDBM50400573
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-Azepan-1-ylmethyl-2-methyl-1,2,3,4-tetrahydro-isoquinolin-5-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80274; BDBM50071613
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(R)-2-(6-(Biphenyl-4-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461557; SCHEMBL17628573; BDBM50378235; (2R)-2-[[6-[(4-phenylphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4225787
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461299
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|
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| Activity |
IC50 = 103000 nM
|
[1] | |||
| Compound Name |
Chembl4226823
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461297
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|
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| Activity |
IC50 = 105000 nM
|
[1] | |||
| Compound Name |
Chembl4228579
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461298
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|
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| Activity |
IC50 = 106000 nM
|
[1] | |||
| Compound Name |
Chembl4225492
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461285
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|
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| Activity |
IC50 = 113000 nM
|
[1] | |||
| Compound Name |
Chembl4224756
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461302
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|
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| Activity |
IC50 = 117000 nM
|
[1] | |||
| Compound Name |
N-[(1S)-1-[4-[[4-(1H-Imidazole-4-ylmethylamino)phenyl](isoamyl)amino]piperidinocarbonyl]-3-methylbutyl]hexahydro-1H-azepine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309463; BDBM50080311
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|
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| Activity |
IC50 = 120000 nM
|
[5] | |||
| Compound Name |
Chembl4225354
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461300
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|
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| Activity |
IC50 = 130000 nM
|
[1] | |||
| Compound Name |
Chembl4225815
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461287
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|
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| Activity |
IC50 = 143000 nM
|
[1] | |||
| Compound Name |
Chembl4224750
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461279
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|
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| Activity |
IC50 = 144000 nM
|
[1] | |||
| Compound Name |
Chembl4225288
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461293
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|
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| Activity |
IC50 = 167000 nM
|
[1] | |||
| Compound Name |
Chembl4226080
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461304
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|
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| Activity |
IC50 = 185000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 18 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Olomoucine
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|
Terminated | Compound Info | ||
| Synonyms |
olomoucine; 101622-51-9; 4erk; UNII-6A839B2HYS; 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6A839B2HYS; CHEMBL280074; 2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol; 6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine; 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine; Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-; OLO; 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine
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| Activity |
EC50 > 1000000 nM
|
[3] | |||
| Compound Name |
BOHEMINE
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Investigative | Compound Info | ||
| Synonyms |
bohemine; 189232-42-6; 3-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)propan-1-ol; 3-{[6-(benzylamino)-9-(propan-2-yl)-9h-purin-2-yl]amino}propan-1-ol; CHEMBL83980; CHEBI:86007; 2-(3-Hydroxypropylamino)-6-benzylamino-9-isopropylpurine; [6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine; 2-[(3-hydroxypropyl)amino]-6-benzylamino-9-isopropylpurine; 3-{[6-(benzylamino)-9-isopropyl-9H-purin-2-yl]amino}propan-1-ol; purine deriv. 1; AC1L1DN2; SCHEMBL1443403; GTPL5938; BDBM10633; CTK8A4395; DTXSID00274365; EX-A931
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| Activity |
EC50 > 1000000 nM
|
[3] | |||
| Compound Name |
Indirubin-3'-monoxime
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Investigative | Compound Info | ||
| Synonyms |
INDIRUBIN-3'-MONOXIME; indirubin-3'-oxime; 160807-49-8; indirubin-3-oxime; Indirubin-3monoxime; Indirubin-3-monoxime; 3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one; CHEBI:43645; Indirubin 3'-monoxime; indirubin-3'-monooxime; Indirubin-3& CHEMBL216543; CHEMBL126077; (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME; UNM-0000305771; 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one; 667463-82-3; IXM; SR-01000075929; Indirubin-3; Indirubin 3-oxime; Tocris-1813; BiomolKI_000070; Indirubin-3-oxime
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| Activity |
EC50 > 1000000 nM
|
[3] | |||
| Compound Name |
Chembl4224963
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461286
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|
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| Activity |
IC50 = 202000 nM
|
[1] | |||
| Compound Name |
Chembl4224809
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461277
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|
||||
| Activity |
IC50 = 205000 nM
|
[1] | |||
| Compound Name |
Chembl4228834
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|
Investigative | Compound Info | ||
| Activity |
IC50 = 218000 nM
|
[1] | |||
| Compound Name |
Chembl4226136
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461281
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|
||||
| Activity |
IC50 = 244000 nM
|
[1] | |||
| Compound Name |
Chembl4225014
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461280
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|
||||
| Activity |
IC50 = 253000 nM
|
[1] | |||
| Compound Name |
Chembl4226078
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461294
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|
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| Activity |
IC50 = 283000 nM
|
[1] | |||
| Compound Name |
Chembl4229102
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461303
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|
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| Activity |
IC50 = 368000 nM
|
[1] | |||
| Compound Name |
Chembl4226327
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461295
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|
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| Activity |
IC50 = 432000 nM
|
[1] | |||
| Compound Name |
(S)-Seliciclib
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Investigative | Compound Info | ||
| Synonyms |
(S)-ROSCOVITINE; UNII-8C43G94891; CHEMBL133342; 8C43G94891; Seliciclib, (S)-; Seliciclib (2S)-form [MI]; S-Roscovitine; Tube002; Lopac-R-7772; SCHEMBL2907488; HMS3229N15; ZINC602192; (2S)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol; 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; BDBM50056163; HSCI1_000094; SDCCGSBI-0207196.P002; NCGC00015900-01; NCGC00162340-01; NCGC00162340-02; BRD-K57810622-001-01-5; Q27270168; UNII-AIR55KO85E component BTIHMVBBUGXLCJ-HNNXBMFYSA-N; (2S)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol; (S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)butan-1-ol; (S)-2-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol; (s)-2-(6-benzylamino-9-isopropyl-9h-purin-2-ylamino)butan-1-ol; (2S)-2-{[6-(Benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol
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|
||||
| Activity |
EC50 = 570000 nM
|
[3] | |||
| Compound Name |
8-Bromo-5H-indolo[3,2-c]quinolin-6(11H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206256; SCHEMBL22478919; BDBM50400588; CS-0062548
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|
||||
| Activity |
EC50 > 1000000 nM
|
[3] | |||
| Compound Name |
6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine
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|
Investigative | Compound Info | ||
| Synonyms |
Iso-Olomoucine; Isoolomoucine; 2-[[6-(benzylamino)-7-methylpurin-2-yl]amino]ethanol; CHEMBL1882973; p21-Activated Kinase Inhibitor III, IPA-3; 2-[[7-methyl-6-[(phenylmethyl)amino]-2-purinyl]amino]ethanol; Ethanol,2-[[7-methyl-6-[(phenylmethyl)amino]-7H-purin-2-yl]amino]-; Ethanol, 2-[[7-methyl-6-[(phenylmethyl)amino]-7H-purin-2-yl]amino]-; Olomoucine, Iso-; ACMC-20enxw; BiomolKI_000047; BiomolKI2_000053; BMK1-E11; SCHEMBL12981789; CTK4A0019; DTXSID40333581; ZINC2556333; BDBM50400585; HSCI1_000009; CCG-100651; NCGC00163384-01; FT-0608483; J-000452; 2-(2-Hydroxyethylamino)-6-benzylamino-7-methylpurine; BRD-K86509404-001-02-0; BRD-K86509404-001-03-8; Q27165202; 2-[[6-(benzylamino)-7-methyl-purin-2-yl]amino]ethanol; 2-((6-(Benzylamino)-7-methyl-7H-purin-2-yl)amino)ethanol; 2-(6-(benzylamino)-7-methyl-7H-purin-2-ylamino)ethanol
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| Activity |
EC50 > 1000000 nM
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[3] | |||
| Compound Name |
(2R)-2-[[6-(Dibenzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206257; BDBM50400587
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| Activity |
EC50 > 1000000 nM
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[3] | |||
| Compound Name |
N9-Isopropyl-olomoucine
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Investigative | Compound Info | ||
| Synonyms |
9-Isopropylolomoucine; N9-Isopropylolomoucine; CHEMBL86066; 2-(2'-Hydroxyethylamino)-6-benzylamino-9-isopropylpurine; 2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]ethanol; purine deriv. 4; Bio2_000427; N9-isopropylolomucine; Kinome_2868; Olomoucine N9-isoppropyl; BiomolKI_000045; BiomolKI2_000051; BMK1-E9; BSPBio_001193; KBioGR_000533; KBioSS_000533; SCHEMBL1216905; BDBM10636; CTK8A5315; KBio2_000533; KBio2_003101; KBio2_005669; KBio3_000965; KBio3_000966; DTXSID80425015; 2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]ethanol; Bio2_000907; HMS1362K15; HMS1792K15; HMS1990K15; HMS3403K15; ZINC2573787; HSCI1_000050; MFCD01310377; AKOS025401894; CCG-100649; IDI1_002182; NCGC00163383-01; NCGC00163383-02; NCGC00163383-03; AC-26950; N9-Isopropylolomoucine, >=98% (HPLC); J-009553; BRD-K71726959-001-03-4; BRD-K71726959-001-05-9; Q27164978; 2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylamino)ethanol; 2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]ethanol; 2-[[9-Isopropyl-6-(benzylamino)-9H-purine-2-yl]amino]ethanol; 2-{[6-(benzylamino)-9-isopropyl-9H-purin-2-yl]amino}ethanol; 6-(benzylamino)-2-[(2-hydroxyethyl)amino]-9-isopropylpurine; 6-BENZYLAMINO-2-(2-HYDROXYETHYLAMINO)-9-ISOPROPYLPURINE; 2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}ethan-1-ol; Ethanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
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| Activity |
EC50 > 1000000 nM
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[3] | |||
| Compound Name |
Dimethylamino-olomoucine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206258; BDBM50400586
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| Activity |
EC50 > 1000000 nM
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[3] | |||
| Compound Name |
Aftin-4
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Investigative | Compound Info | ||
| Synonyms |
(2R)-2-({6-[BENZYL(METHYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)BUTAN-1-OL; Aftin 4; N6-methyl-(R)-roscovitine; Aftin4; CHEMBL1235702; SCHEMBL19111944; BDBM10909; BCP29117; EX-A4242; (2R)-2-[[6-[benzyl(methyl)amino]-9-propan-2-ylpurin-2-yl]amino]butan-1-ol; DB04776; BS-18191; HY-111267; CS-0034791; Q27095514; R-2-[6-(Benzyl-methyl-amino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol; (2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)butan-1-ol; (2R)-2-({6-[Benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-1-butanol; (R)-2-((6-(benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
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| Activity |
EC50 > 1000000 nM
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[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorg Med Chem. 2018 Jul 15;26(11):3046-3059. | ||||
| REF 2 | Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Ca v 2.2) blockers for the treatment of pain. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3780-3783. | ||||
| REF 3 | Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. ACS Med Chem Lett. 2012 Oct 1;3(12):985-90. | ||||
| REF 4 | Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2415-8. | ||||
| REF 5 | Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2453-8. | ||||
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