Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39486 | Target Info | |||
| Target Name | Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) | ||||
| Synonyms |
Dual specificity tyrosine-phosphorylation-regulated kinase 2
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| Target Type | Patented-recorded Target | ||||
| Gene Name | DYRK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
AZ191; AZ-191; AZ 191; CHEMBL3421968; C24H27N7O; GTPL9268; HMS3653O14; BCP12820; EX-A1800; BDBM50081174; s7338; ZINC96170450; AKOS025293491; CCG-268996; CS-4277; Compound 19 [PMID25738750]; NCGC00389251-01; AZ191, >=98% (HPLC); DA-35314; HY-12277; FT-0760408; SW219875-1; Y1892; A14314; Q27074662
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| Activity |
IC50 = 190000 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44. | ||||
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