Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39610 | Target Info | |||
| Target Name | Calmodulin (CALM) | ||||
| Synonyms |
CaM; CALM2
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| Target Type | Successful Target | ||||
| Gene Name | CALM | ||||
| Biochemical Class | Calmodulin-dependent secretion | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 13 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Promethazine
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Approved | Compound Info | ||
| Synonyms |
Antiallersin; Aprobit; Avomine; Camergan; Dimapp; Diphergan; Diprazin; Diprazine; Diprozin; Fargan; Fenazil; Fenetazina; Fenetazine; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Metaryl; Pelpica; Phargan; Phenargan; Phenerzine; Phensedyl; Pilothia; Pilpophen; Pipolphene; Proazaimine; Proazamine; Procit; Promacot; Promazinamide; Promergan; Promesan; Prometasin; Prometazin; Prometazina; Prometazine; Prometh; Promethacon; Promethaine; Promethazin; PromethazineHcl; Promethazinum; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; Remsed; Romergan; Rumergan; Tanidil; Thiergan; Valergine; Vallergine; Lilly 01516; Lilly 1516; RP 3277; SKF 1498; WY 509; A-91033; Atosil (TN); Avomine (TN); Fargan (TN); Farganesse (TN); Lergigan (TN); Phenergan (TN); Phenoject-50; Pro-50; Prometazina [INN-Spanish]; Promethazine [INN:BAN]; Promethazinum [INN-Latin]; Promethegan (TN); Prothiazine (TN); Receptozine (TN); Romergan (TN); Zipan-25; Dimethylamino-isopropyl-phenthiazin; Dimethylamino-isopropyl-phenthiazin [German]; Promethazine (JAN/INN)
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| Activity | Calmodulin 1 |
IC50 = 60000 nM
|
[1] | ||
| Compound Name |
Hesperidin
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Approved | Compound Info | ||
| Synonyms |
hesperidin; 520-26-3; Cirantin; Hesperidoside; Hesper bitabs; Hesperetin-rutinosid; Hesperidine; UNII-E750O06Y6O; CCRIS 3940; (S)-(-)-Hesperidin; EINECS 208-288-1; NSC 44184; BRN 0075140; Hesperidin, (2S)-; Hesperetin 7-rutinoside; MLS001304066; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one; CHEBI:28775; USAF CF-3; Hesperidin, (S)-(-)-; Hesperitin-7-rhamnoglucoside; E750O06Y6O; C28H34O15; HESPERIDINE
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| Activity | Calmodulin 1 |
IC50 = 70000 nM
|
[2] | ||
| Compound Name |
Clozapine
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Approved | Compound Info | ||
| Synonyms |
Asaleptin; CLOZARIL; Clorazil; Clozapin; Clozapina; Clozapinum; Fazaclo; Iprox; Leponex; Lepotex; Fazaclo ODT; C 6305; HF1854; Clopine (TN); Clozapina [INN-Spanish]; Clozapine(tautomer); Clozapinum [INN-Latin]; Clozaril (TN); Denzapine (TN); Fazaclo (TN); Froidir (TN); HF-1854; KS-1166; Klozapol (TN); LEX-123; LX 100-129; Leponex (TN); W-801; Zaponex (TN); Clozapine [USAN:INN:BAN]; Clozapine (JAN/USP/INN); 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine; 8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine; 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
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| Activity | Calmodulin 1 |
IC50 = 140000 nM
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[1] | ||
| Compound Name |
flavone
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Investigative | Compound Info | ||
| Synonyms |
Flavone; FLAVONE; 525-82-6; 2-Phenylchromone; 2-Phenyl-4H-chromen-4-one; 2-Phenyl-4-chromone; Asmacoril; 2-Phenyl-4H-1-benzopyran-4-one; 2-Phenyl-4-benzopyron; 4H-1-Benzopyran-4-one, 2-phenyl-; Chromocor; Cromaril; 2-phenylchromen-4-one; Phenylchromone; 2-Phenyl-chromen-4-one; 2-Phenyl-gamma-benzopyrone; 2-Phenylbenzopyran-4-one; Cromarile; 2-Phenyl-4H-benzopyran-4-one; Flavon; 2-Phenylchrome; UNII-S2V45N7G3B; NSC 19028; 2-Phenyl-4H-chromen-4-on; CCRIS 4288; NSC19028; EINECS 208-383-8; NSC-19028; BRN 0157598
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| Activity | Calmodulin 1 |
IC50 = 102280 nM
|
[2] | ||
| Compound Name |
3-[2-(4-Ethoxy-3-methoxyphenyl)ethyl]-5-methoxyphenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796018; BDBM50346814
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| Activity | Calmodulin 1 |
IC50 = 54690 nM
|
[3] | ||
| Compound Name |
4-[(3,5-Dimethoxyphenyl)methyl]-2-methoxyphenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796021; BDBM50346812
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| Activity | Calmodulin 1 |
IC50 = 54730 nM
|
[3] | ||
| Compound Name |
3-Hydroxyflavone
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Investigative | Compound Info | ||
| Synonyms |
Flavonol; 3-Hydroxy-2-phenyl-4H-chromen-4-one; Flavon-3-ol; 3-Hydroxy-2-phenylchromone; 4H-1-Benzopyran-4-one, 3-hydroxy-2-phenyl-; FLAVONE, 3-HYDROXY-; 3-hydroxy-2-phenylchromen-4-one; UNII-ZTG9LSS5QH; MFCD00006832; ZTG9LSS5QH; NSC57653; CHEMBL294009; 3-hydroxy-2-phenyl-4H-1-benzopyran-4-one; NSC-57653; F0013-0884; flavonols; FLAVONE,3-HYDROXY-; NSC58585; SR-01000401360; EINECS 209-416-9; NSC 57653; NSC 58585; 3-hydroxyflavon; HSDB 7572; 3-hydroxy-2-phenyl-chromen-4-one; Spectrum_000328; SpecPlus_000831; Spectrum2_001392; Spectrum3_001432; Spectrum4_001845; Spectrum5_000350; ACMC-209m0e; Oprea1_038914; Oprea1_692205; SCHEMBL20246; 3-Hydroxyflavone, >=98%; 4-Hydroxy-3-oxylatoflavylium; BSPBio_003164; KBioGR_002250; KBioSS_000808; MLS002207277; BIDD:ER0553; DivK1c_006927; SPECTRUM1501012; SPBio_001404; MEGxp0_001695; DTXSID4060365; ACon1_000167; CTK3J2720; KBio1_001871; KBio2_000808; KBio2_003376; KBio2_005944; KBio3_002384; ZINC57675; HMS3740M15; KUC106685N; KS-00000VN5; WLN: T66 BO EVJ CR& DQ; ANW-32796; BDBM50187668; CCG-38858; NCI-57653; s4790; SBB000767; AKOS000599906; MCULE-8535739842; SDCCGMLS-0066736.P001; NCGC00095653-01; NCGC00095653-02; NCGC00095653-03; 3-Hydroxy-2-phenyl-4H-chromen-4-one #; AK163706; AS-19638; SMR000112317; ST086622; SY048803; KSC-11-207-16; DB-053103; HY-107825; CS-0030701; EU-0001678; FT-0615841; Y2009; VU0053575-3; C01495; H-5000; 3-Hydroxy-2-phenyl-4H-1-benzopyran-4-one, 9CI; Q5919049; SR-01000401360-1; SR-01000401360-2; BRD-K55150756-001-05-7; B48D3495-6D21-4742-8A87-D3DE07DC9554
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| Activity | Calmodulin 1 |
IC50 = 55200 nM
|
[2] | ||
| Compound Name |
2-[(3,5-Dimethoxyphenyl)methyl]-6-methoxyphenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796020; BDBM50346813
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| Activity | Calmodulin 1 |
IC50 = 56150 nM
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[3] | ||
| Compound Name |
(E)-1-(3-Hydroxy-5-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796024; BDBM50346808
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| Activity | Calmodulin 1 |
IC50 = 57270 nM
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[3] | ||
| Compound Name |
4-[3-(4-Methoxyphenyl)propyl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796025; BDBM50346807; 4-[3-(4-methoxyphenyl)-propyl]-phenol
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| Activity | Calmodulin 1 |
IC50 = 62680 nM
|
[3] | ||
| Compound Name |
3-[2-(1,3-Benzodioxol-5-yl)ethyl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796016; BDBM50346817
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|
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| Activity | Calmodulin 1 |
IC50 = 75890 nM
|
[3] | ||
| Compound Name |
4-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219553; CTK2I6367; 3',5-Dimethoxybibenzyl-3,4'-diol; BDBM50346823; MCULE-7300361213; 3',4-dihydroxy-3,5'-dimethoxybibenzyl; Phenol, 4-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxy-; NCGC00386002-01!4-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol
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| Activity | Calmodulin 1 |
IC50 = 114180 nM
|
[3] | ||
| Compound Name |
1,3-Dimethoxy-5-[2-(4-methoxyphenyl)ethyl]benzene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL467338; NSC631356; 3,4',5-Trimethoxybibenzyl; CTK7A3672; BDBM50346816; NSC-631356; NCI60_010233; 5-[2-(4-Methoxyphenyl)Ethyl]-1,3-Dimethoxy Benzene
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| Activity | Calmodulin 1 |
IC50 = 146350 nM
|
[3] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II. Eur J Med Chem. 2016 Jun 30;116:36-45. | ||||
| REF 2 | Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches. Bioorg Med Chem. 2011 Jan 1;19(1):542-6. | ||||
| REF 3 | Synthesis, biological evaluation, and docking studies of gigantol analogs as calmodulin inhibitors. Eur J Med Chem. 2011 Jul;46(7):2699-708. | ||||
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