Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40488 | Target Info | |||
| Target Name | Matrix metalloproteinase-10 (MMP-10) | ||||
| Synonyms |
Transin-2; Stromelysin-2; STMY2; SL-2
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| Target Type | Patented-recorded Target | ||||
| Gene Name | MMP10 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2,5-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104863; BDBM50037061; 2-(2,5-Dimethoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
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| Activity |
IC50 = 53000 nM
|
[1] | |||
| Compound Name |
2-(2,4-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104611; BDBM50037075; 2-(2,4-Dimethoxyphenyl)isothiazolo[5,4-b]pyridin-3(2H)-one
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| Activity |
IC50 = 62000 nM
|
[1] | |||
| Compound Name |
N-Phenyl-4-[(4h-1,2,4-Triazol-3-Ylsulfanyl)methyl]-1,3-Thiazol-2-Amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1511860; MLS001003711; HMS2683M19; BDBM50233887; ZINC13683603; AKOS033640205; MCULE-7057035395; SMR000347505; SR-01000034919; SR-01000034919-1; Z18740505
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| Activity |
IC50 = 83000 nM
|
[2] | |||
| Compound Name |
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394285; SCHEMBL12425758; BDBM50140176; (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enehydroxamic acid
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-N-Hydroxy-2,5-bis(4-(trifluoromethyl)phenylsulfonamido)pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL496702; BDBM50260913
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| Activity |
Ki = 337000 nM
|
[4] | |||
| Compound Name |
2,3-Bis(2,4-dimethoxyphenylsulfonamido)-N-hydroxypropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL521689; BDBM50260884
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| Activity |
Ki = 372000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Heteroaryl-fused 2-phenylisothiazolone inhibitors of cartilage breakdown. J Med Chem. 1994 Sep 16;37(19):3071-8. | ||||
| REF 2 | Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach. J Med Chem. 2017 Jan 26;60(2):608-626. | ||||
| REF 3 | Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. Bioorg Med Chem. 2016 Feb 15;24(4):686-92. | ||||
| REF 4 | Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3333-7. | ||||
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