Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T42247 | Target Info | |||
| Target Name | Melanoma inhibitor of apoptosis protein (ML-IAP) | ||||
| Synonyms |
UNQ5800/PRO19607/PRO21344; RNF50; RING-type E3 ubiquitin transferase BIRC7; RING finger protein 50; MLIAP; Livin; Kidney inhibitor of apoptosis protein; KIAP; Baculoviral IAP repeat-containing protein 7
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| Target Type | Patented-recorded Target | ||||
| Gene Name | BIRC7 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-{(1s)-1-Cyclohexyl-2-Oxo-2-[(2s)-2-(4-Phenyl-1,3-Benzothiazol-2-Yl)pyrrolidin-1-Yl]ethyl}-N~2~-Methyl-L-Alaninamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093339; SCHEMBL11987416; BDBM50314467; Q27456834
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| Activity |
Ki = 53000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-(4-fluoronaphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089023; SCHEMBL13576669; BDBM50314450
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| Activity |
Ki = 68000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(4-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091484; SCHEMBL11987420; BDBM50314472
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| Activity |
Ki = 68000 nM
|
[1] | |||
| Compound Name |
(2S)-N-((1S)-2-((2S)-2-(5-Fluoro-4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090867; SCHEMBL13576703; BDBM50314457
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| Activity |
Ki = 68000 nM
|
[1] | |||
| Compound Name |
(2S)-N-((1S)-2-((2S)-2-(5-Cyano-4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091216; SCHEMBL13576700; BDBM50314459
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| Activity |
Ki = 69000 nM
|
[1] | |||
| Compound Name |
(S)-2-(Methylamino)-N-((S)-2-((S)-2-(4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091045; SCHEMBL13576664; BDBM50314449
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| Activity |
Ki = 100000 nM
|
[1] | |||
| Compound Name |
N-{(1s)-1-Cyclohexyl-2-[(2s)-2-(4-Naphthalen-1-Yl-1,3-Thiazol-2-Yl)pyrrolidin-1-Yl]-2-Oxoethyl}-N~2~-Methyl-L-Alaninamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091044; SCHEMBL13576665; BDBM50314448; Q27455387
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| Activity |
Ki = 110000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-((S)-2-(4-(Benzo[b]thiophen-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090866; SCHEMBL13576692; BDBM50314456
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| Activity |
Ki = 120000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(Benzo[d]isoxazol-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094001; SCHEMBL13576714; BDBM50314455
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|
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| Activity |
Ki = 130000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-(3-fluorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090431; SCHEMBL11987424; BDBM50314474
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|
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| Activity |
Ki = 130000 nM
|
[1] | |||
| Compound Name |
(2S)-N-((1S)-1-Cyclohexyl-2-((2S)-2-(4-(2-fluorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091485; SCHEMBL11987423; BDBM50314473
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|
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| Activity |
Ki = 130000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(7-phenylthiazolo[5,4-d]pyrimidin-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091442; SCHEMBL11987443; BDBM50314478
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| Activity |
Ki = 130000 nM
|
[1] | |||
| Compound Name |
(2S)-N-((1S)-2-((2S)-2-(5-(3-Hydroxyprop-1-ynyl)-4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092185; BDBM50314463
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| Activity |
Ki = 140000 nM
|
[1] | |||
| Compound Name |
(2S)-N-((1S)-2-((2S)-2-(5-(3-Methoxyprop-1-ynyl)-4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093598; BDBM50314462
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|
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| Activity |
Ki = 140000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(3-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093708; SCHEMBL11987418; BDBM50314471
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| Activity |
Ki = 140000 nM
|
[1] | |||
| Compound Name |
(2S)-N-((1S)-2-((2S)-2-(5-Ethynyl-4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090770; SCHEMBL13576701; BDBM50314460
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|
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| Activity |
Ki = 160000 nM
|
[1] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-((1S)-2-((2S)-2-(4-(naphthalen-1-yl)-5-(prop-1-ynyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092184; SCHEMBL13576702; BDBM50314461
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|
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| Activity |
Ki = 160000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-3,3-Dimethyl-1-oxo-1-((S)-2-(4-(quinolin-4-yl)thiazol-2-yl)pyrrolidin-1-yl)butan-2-yl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093691; BDBM50314453
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|
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| Activity |
Ki = 180000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(Benzofuran-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093692; SCHEMBL13576671; BDBM50314454
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|
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| Activity |
Ki = 200000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(pyridin-3-yl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089693; SCHEMBL11987417; BDBM50314468
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|
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| Activity |
Ki = 200000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-N-((1S)-2-((2S)-2-(5-Chloro-4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091215; SCHEMBL13576679; BDBM50314458
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|
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| Activity |
Ki = 210000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-3,3-Dimethyl-1-((S)-2-(4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091762; SCHEMBL13576685; BDBM50314447
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|
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| Activity |
Ki = 220000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(pyridin-4-yl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089694; SCHEMBL11987421; BDBM50314469
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|
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| Activity |
Ki = 460000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-Benzylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092174; SCHEMBL11987413; BDBM50314466
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|
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| Activity |
Ki = 710000 nM
|
[1] | |||
| Compound Name |
(2S)-N-((1S)-2-((2S)-2-(4-(2-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089695; SCHEMBL11987422; BDBM50314470
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|
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| Activity |
Ki = 730000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-phenylthiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089012; SCHEMBL13576682; BDBM50314446
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| Activity |
Ki = 1200000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-methylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092172; SCHEMBL11987412; BDBM50314464
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|
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| Activity |
Ki = 2700000 nM
|
[1] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-isopropylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092173; SCHEMBL11987415; BDBM50314465
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| Activity |
Ki = 2800000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2229-33. | ||||
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