Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46216 | Target Info | |||
| Target Name | Bromodomain-containing protein 9 (BRD9) | ||||
| Synonyms |
Rhabdomyosarcoma antigen MU-RMS-40.8
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | BRD9 | ||||
| Biochemical Class | Bromodomain | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
GSK2801
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|
Investigative | Compound Info | ||
| Synonyms |
KB-146016
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-[7-Methoxy-1-(2-methylsulfonylphenyl)indolizin-3-yl]ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770214; BDBM50148334
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Chloro-2-methyl-5-[[(3S,5S)-1-methyl-5-phenylpiperidin-3-yl]amino]pyridazin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061691; BDBM50234938
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| Activity |
IC50 ~ 50118.72 nM
|
[2] | |||
| Compound Name |
ClC=1C(N(N=CC=1NC1CCN(CC1)C)C)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063947; SCHEMBL17916728; BDBM50234928
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| Activity |
IC50 ~ 50118.72 nM
|
[2] | |||
| Compound Name |
ClC=1C(N(N=CC=1NC1CN(CCC1)C)C)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099456; SCHEMBL17912366; BDBM50234943; 4-Chloro-2-methyl-5-((1-methylpiperidin-3-yl)amino)pyridazin-3(2H)-one
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| Activity |
IC50 ~ 50118.72 nM
|
[2] | |||
| Compound Name |
4-Chloro-2-methyl-5-(propan-2-ylamino)pyridazin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071581; BDBM50234941
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|
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| Activity |
IC50 ~ 50118.72 nM
|
[2] | |||
| Compound Name |
4-Chloro-2-methyl-5-[[(3S)-1-methylpiperidin-3-yl]amino]pyridazin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061142; SCHEMBL17912368; BDBM50234945; ZINC134330973
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| Activity |
IC50 ~ 50118.72 nM
|
[2] | |||
| Compound Name |
4-Chlorol-2-methyl-5-[[(3~{R})-1-methylpiperidin-3-yl]amino]pyridazin-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072538; 4-chlorol-2-methyl-5-[[(3~{R})-1-methylpiperidin-3-yl]amino]pyridazin-3-one; SCHEMBL17916701; BDBM50234944; ZINC134330948
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|
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| Activity |
IC50 ~ 50118.72 nM
|
[2] | |||
| Compound Name |
4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059509; BDBM50249797
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(1,4-Dimethyl-7-morpholin-4-yl-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)-4-isobutylbenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1360726; HMS1884K08; ZINC8604825; BDBM50468532; AKOS000481572; MCULE-4350056049; NCGC00129526-01; G221-0874
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| Activity |
IC50 = 204000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2016 Feb 25;59(4):1410-24. | ||||
| REF 2 | Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem. 2017 Jan 26;60(2):695-709. | ||||
| REF 3 | Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins. J Med Chem. 2017 Aug 24;60(16):6998-7011. | ||||
| REF 4 | Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem. 2018 Jul 15;155:337-352. | ||||
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