Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46456 | Target Info | |||
| Target Name | Retinoic acid receptor RXR-gamma (RXRG) | ||||
| Synonyms |
Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; NR2B3
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| Target Type | Successful Target | ||||
| Gene Name | RXRG | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4163199
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50340649
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| Activity |
EC50 = 50000 nM
|
[1] | |||
| Compound Name |
5-Methyl-4-{[(2-oxo-4-phenyl-6-propyl-2H-chromen-7-yl)oxy]methyl}-2-furoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094117; Oprea1_021094; Oprea1_331299; ZINC1902725; BDBM50234436; STL458817; AKOS001020999; MCULE-4708873375; EU-0010131; SR-01000480098; SR-01000480098-1
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| Activity |
EC50 = 51000 nM
|
[2] | |||
| Compound Name |
4-[(Z)-N-Ethoxy-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2110180; BDBM50408855
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[(Z)-N-[(2-Methylpropan-2-yl)oxy]-C-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)carbonimidoyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2110182; BDBM50408856
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[[(E)-Tert-Butoxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162827; BDBM50074298
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics. J Med Chem. 2018 Jun 28;61(12):5442-5447. | ||||
| REF 2 | Scaffold hopping from synthetic RXR modulators by virtual screening and de novo design. Medchemcomm. 2018 Jun 6;9(8):1289-1292. | ||||
| REF 3 | Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells. J Med Chem. 1999 Feb 25;42(4):742-50. | ||||
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