Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46685 | Target Info | |||
| Target Name | CDC-like kinase 1 (CLK1) | ||||
| Synonyms |
Dual specificity protein kinase CLK1; CLK; CDClike kinase 1
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CLK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[5-[4-(2H-Tetrazol-5-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087125; BDBM50236545
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| Activity |
EC50 = 70000 nM
|
[1] | |||
| Compound Name |
4-[3-[4-(2H-Tetrazol-5-yl)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102553; BDBM50236536
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| Activity |
EC50 = 85000 nM
|
[1] | |||
| Compound Name |
Chembl4276946
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Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[3-(1H-Indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084605; BDBM50236537
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| Activity |
EC50 = 117000 nM
|
[1] | |||
| Compound Name |
4-[5-(4-Nitrophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075959; BDBM50236547
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| Activity |
EC50 = 187000 nM
|
[1] | |||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[3-(4-Hydroxyphenyl)-1H-indol-5-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073972; BDBM50236539
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
4-[3-(4-Hydroxyphenyl)-1H-indazol-5-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083661; BDBM50236538
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
N,5-Bis(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070354; BDBM50236549
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|
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
4-[3-(4-Aminophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092345; BDBM50236551
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
N-(3-Hydroxyphenyl)-5-(4-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097535; BDBM50236548
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| Activity |
EC50 > 1000000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma. J Med Chem. 2017 Mar 9;60(5):2052-2070. | ||||
| REF 2 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 3 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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