Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46781 | Target Info | |||
| Target Name | Aurora kinase B (AURKB) | ||||
| Synonyms |
Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; STK5; STK12; Aurora/IPL1-related kinase 2; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK2; ARK-2; AIRK2; AIM1; AIM-1; AIK2
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| Target Type | Clinical trial Target | ||||
| Gene Name | AURKB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 96 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Miltefosine
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Approved | Compound Info | ||
| Synonyms |
HDPC; HePC; Hexadecylphosphocholine; Hexadecylphosphorylcholine; Impavido; Miltefosina; Miltefosinum; Miltex; Baxter Oncology brand of miltefosine; Baxter brand of miltefosine; Miltefosin C; Prasfarma brand of miltefosine; D 18506; IN1227; D-18506; H-1850; M-7200; Miltefosina [INN-Spanish]; Miltefosine (INN); Miltefosine[INN:BAN]; Miltefosinum [INN-Latin]; N-Hexadecylphosphorylcholine; TF-002; Choline hydroxide, hexadecyl hydrogen phosphate, inner salt; Choline, hexadecyl hydrogen phosphate, inner salt; Hexadecyl 2-(trimethylazaniumyl)ethyl phosphate; Choline phosphate, hexadecyl ester, hydroxide, inner salt; Choline phosphate, hexadecyl ester, hydroxide, inner salt (6CI); Hexadecyl 2-(trimethyl-.lambda.~5~-azanyl)ethyl hydrogen phosphate; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt; Ethanaminium, 2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, innner salt; 1-Hexadecylphosphorylcholine; 2-(((Hexadecyloxy)hydroxyphosphinyl)oxy)-N,N,N-trimethylethanaminium hydroxide, inner salt; 3,5-Dioxa-4-phosphaunacosan-1-aminium, 4-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, 4-oxide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Benznidazole
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Approved | Compound Info | ||
| Synonyms |
BENZNIDAZOLE; Radanil; Benzonidazole; 22994-85-0; Benznidazol; benzonidazol; Benznidazolum;Ro 07-1051; Rochagan; UNII-YC42NRJ1ZD; Benznidazolum [INN-Latin]; Benznidazol [INN-Spanish]; Ro 71051; NSC 299972; Benznidazole [INN]; CCRIS 2200
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Pentamidine
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Approved | Compound Info | ||
| Synonyms |
Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (*Isethionate); Pentacarinat (*Isethionate); Pentam 300 (*Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (*Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080994; SCHEMBL2934634; BDBM50311953
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477817; SCHEMBL5520662; SCHEMBL5520668; BDBM50263132
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389745; BDBM50218709
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-(2-Chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide
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Investigative | Compound Info | ||
| Synonyms |
Aurora A Inhibitor I; 2,4-Bisanilinopyrimidine, 10; TC-S 7010; TCS7010; compound 10 [PMID: 19402633]; AuroraAinhibitorI; Aurora-A-inhibitor-I; Aurora Inhibitor, 35; Aurora A Inhibitor I/; C31H31ClFN7O2; MLS006011045; CHEMBL502124; GTPL8466; SCHEMBL15458953; BDBM31837; CTK4A9531; KS-00001DXT; DTXSID60657630; BCPP000376; HMS3265K21; HMS3265K22; HMS3265L21; HMS3265L22; HMS3654N08; BCP02101; ABP000607; ANW-58929; s1451; ZINC42803194; AKOS015995069; BCP9000341; CCG-270154; CS-0011; NCGC00346525-01; NCGC00346525-07; NCGC00346525-09; NCGC00346525-10; HY-70061; SMR004702837; DB-060777; FT-0714298; SW220199-1; X7384; W-5640; BRD-K53561341-001-01-8; Q27076171
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468125; 3-{[2-(2-Fluorophenyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione; SCHEMBL4371574; BDBM50259601
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080995; SCHEMBL2934911; BDBM50311954
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
2-(4-Tert-Butylphenyl)-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651472; SCHEMBL4057846; BDBM50335339; 2-(4-tert-butylphenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
Clc1ccc(NC(=O)Nc2ccc(COc3ccc4nc(NCCN5CCOCC5)oc4c3)cc2)cc1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808569; BDBM50175496
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| Activity |
IC50 = 50400 nM
|
[10] | |||
| Compound Name |
Tert-butyl N-[2-oxo-2-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]ethyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084745; BDBM50237660
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| Activity |
IC50 = 51000 nM
|
[11] | |||
| Compound Name |
Methyl 3-[[2-hydroxy-5-[4-[[(5-methyl-1,2-oxazol-3-yl)amino]methyl]triazol-1-yl]benzoyl]amino]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794450; BDBM50160896
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| Activity |
IC50 = 54800 nM
|
[12] | |||
| Compound Name |
Chembl4276766
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Investigative | Compound Info | ||
| Synonyms |
BDBM50469176
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| Activity |
IC50 ~ 60000 nM
|
[13] | |||
| Compound Name |
N-(4-Methoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036868; BDBM50385177
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| Activity |
IC50 = 62000 nM
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[14] | |||
| Compound Name |
Methyl 3-[1-[4-hydroxy-3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]triazol-4-yl]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3321770; BDBM50053303
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| Activity |
IC50 = 63200 nM
|
[15] | |||
| Compound Name |
2-[2-(3-Methoxyphenyl)-2-oxoethyl]-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651485; SCHEMBL4057322; BDBM50335328; 2-[2-(3-methoxyphenyl)-2-oxoethyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
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| Activity |
IC50 = 67000 nM
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[9] | |||
| Compound Name |
2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL521155; BDBM50268223
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| Activity |
IC50 = 69000 nM
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[16] | |||
| Compound Name |
2-[(4-Fluorophenyl)methyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651476; SCHEMBL4056619; BDBM50335329; 2-(4-Fluorobenzyl)-4-(5-methyl-1H-pyrazol-3-ylamino)-2Hphthalazin-1-one
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| Activity |
IC50 = 69000 nM
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[9] | |||
| Compound Name |
2-(1,3-Dimethyl-1H-pyrazole-4-yl)-6-chloro-7-[4-(phenylcarbamoyl)phenoxy]-3H-imidazo[4,5-b]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3087784; BDBM50443500
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| Activity |
IC50 = 76840 nM
|
[17] | |||
| Compound Name |
2-(2,5-Difluorobenzyl)-4-(5-methyl-1H-pyrazol-3-ylamino)phthalazin-1(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL516231; SCHEMBL4057841; BDBM50249453; 2-[(2,5-difluorophenyl)methyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
2-Benzyl-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651461; SCHEMBL4059036; BDBM50335335; 2-benzyl-4-(5-methyl-1h-pyrazol-3-ylamino)-2h-phthalazin-1-one
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456294; Calicoferol I; USFQLAVWHQCNDG-AYEIPMSGSA-; BDBM50358248; LMST03020180
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| Activity |
IC50 ~ 100000 nM
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[18] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075867; BDBM50237551
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
Calicoferol E
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456936; (8S)-3-hydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one; BDBM50358246; LMST03020157
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| Activity |
IC50 ~ 100000 nM
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[18] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-(4-methylphenyl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036726; BDBM50385172
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-1-oxopropan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083222; BDBM50237547
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
7-Iodoindirubin-3-acetoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395077; BDBM50218891
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| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
4-(5-Methyl-1H-pyrazol-3-ylamino)-2-(2-oxo-2-phenylethyl)phthalazin-1(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL474651; SCHEMBL4061131; BDBM50249420; 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenacylphthalazin-1-one; 4-(5-Methyl-1H-pyrazol-3-ylamino)-2-(2-oxo-2-phenyl-ethyl)-2H-phthalazin-1-one
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
7-Chloroindirubin-3-acetoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397719; BDBM50218886
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| Activity |
IC50 ~ 100000 nM
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[19] | |||
| Compound Name |
N-(2-Chloro-4-methoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109956; SCHEMBL12492280; BDBM50446462
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| Activity |
IC50 ~ 100000 nM
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[20] | |||
| Compound Name |
7-Bromoindirubin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214173; CHEMBL397718; (2'Z)-7-bromoindirubin; (2''Z)-7-bromoindirubin; SCHEMBL22300869; cid_11845789; (3Z)-7-bromo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50191440; BDBM50218890; UNM-0000305768
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| Activity |
IC50 ~ 100000 nM
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[19] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036728; BDBM50385170
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| Activity |
IC50 ~ 100000 nM
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[14] | |||
| Compound Name |
7-Iodoindirubin-3-methoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL244191; BDBM50218903
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| Activity |
IC50 ~ 100000 nM
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[19] | |||
| Compound Name |
N-(2,4-Dimethoxyphenyl)-2-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109960; BDBM50446466
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| Activity |
IC50 ~ 100000 nM
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[20] | |||
| Compound Name |
2-(3-Methylphenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651471; SCHEMBL4058382; BDBM50335333; 4-(5-methyl-1h-pyrazol-3-ylamino)-2-m-tolyl-2h-phthalazin-1-one
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
Tert-butyl N-[(2R)-4-methylsulfanyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077333; BDBM50237662
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109402; BDBM50446565
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| Activity |
IC50 ~ 100000 nM
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[21] | |||
| Compound Name |
2-[(3,5-Difluorophenyl)methyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651462; SCHEMBL4059402; BDBM50335336; 2-(3,5-Difluorobenzyl)-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-one
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
CID 66548650
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109958; SCHEMBL12492059; BDBM50446455; N-(2-methoxyphenyl)-2-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(4-Chlorophenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036727; BDBM50385173
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Methoxy-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109968; SCHEMBL12491567; BDBM50446461
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(2-Methoxyphenyl)-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109957; SCHEMBL12492106; BDBM50446458; N-(2-methoxyphenyl)-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Chembl4289343
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50469174
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-(2-Methoxyphenyl)-2-(1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109953; SCHEMBL12492757; BDBM50446460; N-(2-methoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-1-oxopropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080555; BDBM50237555
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
7-Bromoindirubin-3-methoxime
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243556; BDBM50218902
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Tert-butyl N-[2-[[4-(2,6-dimethylanilino)quinazolin-6-yl]amino]-2-oxoethyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066232; BDBM50237552
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-(1h-Pyrazol-3-ylamino)-2-p-tolyl-2h-phthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651470; SCHEMBL4058178; BDBM50335332; 2-(4-methylphenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087241; BDBM50237556
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-(2-Ethoxyphenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109954; SCHEMBL12491978; BDBM50446468; N-(2-Ethoxyphenyl)-2-(1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[1-(Difluoromethyl)pyrazol-4-yl]-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109959; SCHEMBL12492476; BDBM50446454
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Calicoferol C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515982; BDBM50358249
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
2-(4-Fluorophenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651473; SCHEMBL4063395; BDBM50335334; 2-(4-Fluorophenyl)-4-(5-methyl-1H-pyrazol-3-ylamino)-2Hphthalazin-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
7-Fluoroindirubin-3-methoxime
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397720; BDBM50218901
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-(1,5-Dimethylpyrazol-4-yl)-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109961; BDBM50446452
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Calicoferol B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL464351; BDBM50358250
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
2-(4-Chlorophenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452355; SCHEMBL4057120; BDBM50249237; 2-(4-chlorophenyl)-4-(5-methyl-1H-pyrazol-3-ylamino)phthalazin-1(2H)-one; 2-(4-Chloro-phenyl)-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Chembl4282545
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50469173
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065828; BDBM50237657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Tert-butyl N-[(2R,3S)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074450; BDBM50237658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[2-(4-Methoxyphenyl)-2-oxoethyl]-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651484; SCHEMBL4056160; BDBM50335337; 2-[2-(4-methoxyphenyl)-2-oxoethyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
7-Chloroindirubin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243777; CHEMBL378191; (2'Z)-7-chloroindirubin; (2''Z)-7-chloroindirubin; SCHEMBL21440315; cid_11847137; (3Z)-7-chloro-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50191445; BDBM50218889; UNM-0000305769
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
3-Chloro-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109969; SCHEMBL12492390; BDBM50446465
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-phenylpyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036725; BDBM50385171
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-(4-Methoxyphenyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651469; SCHEMBL4057976; BDBM50335331; 2-(4-Methoxyphenyl)-4-(5-methyl-1H-pyrazol-3-ylamino)-2Hphthalazin-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-Methoxy-5-(trifluoromethyl)phenyl]-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109965; BDBM50446456
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Chembl4285937
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50469186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Abelcet
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Amphotericin B lipid complex; amphotericin b; Amphotericin b liposomal complex; Ambisome; Amphotec; Fungilin; Fungizone; Ampho-Moronal; NSC-527017; amophotericin B; Amphotreicin B; Amphotercin B; Ampotericin B; Amphotericitin B; Fungilin In Orabase; Amphotericin b, liposome; CHEMBL267345; BDBM50457967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
CID 68290918
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109972; SCHEMBL12492104; BDBM50446464
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(2-Chlorophenyl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109955; BDBM50446467
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092491; BDBM50237567
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091010; BDBM50237550
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
7-Fluoroindirubin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2'Z)-7-fluoroindirubin; CHEMBL210446; CHEMBL243986; (2''''Z)-7-Fluoroindirubin; SCHEMBL22300875; cid_11847138; (3Z)-7-fluoro-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50024791; BDBM50218896; UNM-0000305767
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Tert-butyl N-[(2R,3S)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-3-methyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061283; BDBM50237602
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-(5-Methyl-1H-pyrazol-3-ylamino)-2-[2-oxo-2-(4-trifluoromethylphenyl)ethyl]-2H-phthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651486; SCHEMBL4057597; BDBM50335338; 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-[2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]phthalazin-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Calicoferol A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(22E)-(8S)-3-hydroxy-9,10-seco-1,3,5(10),22-cholestatetraen-9-one; LMST03020605; CHEMBL518060; BDBM50358244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[2-Chloro-4-(4-methoxypiperidinocarbonyl)phenyl]-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109970; SCHEMBL12492037; BDBM50446463
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-chloro-4-fluoroanilino)quinazolin-6-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094922; BDBM50237659
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Tert-butyl N-[(2R,3S)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]pentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100234; BDBM50237671
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070037; BDBM50237548
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(3Z)-7-Iodo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL379160; 7-iodoindirubin; (2'Z)-7-iodoindirubin; (2''Z)-7-iodoindirubin; CHEMBL395078; SCHEMBL22300068; BDBM50191449
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(2-Chlorophenyl)-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109966; SCHEMBL12492860; BDBM50446457
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
7-Chloroindirubin-3-methoxime
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243776; BDBM50218887
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(4-Ethoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036867; BDBM50385176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1,3-Dimethyl-7-(1-methylbenzimidazol-2-yl)pyrido[2,3-d]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036871; BDBM50385180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Chembl4290414
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50469182
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
4-[(5-Methyl-1h-Pyrazol-3-Yl)amino]-2-Phenylphthalazin-1(2h)-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1615165; SCHEMBL4060475; BDBM50335330; ZINC43128171; CCG-208655; NCGC00263596-03; Q27464317; 4-(5-Methyl-2H-pyrazole-3-ylamino)phenyl-2H-phthalazin-1-one; 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one; 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Tert-butyl N-[(2R)-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]propan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102666; BDBM50237663
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-(2-Methoxyphenyl)-2-(1,3-Oxazol-5-Yl)-1h-Pyrrolo[3,2-C]pyridin-6-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109962; SCHEMBL12491755; BDBM50446459; Q27456705; N-(2-Methoxyphenyl)-2-(5-oxazolyl)-1H-pyrrolo[3,2-c]pyridine-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
3-Chloro-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109967; SCHEMBL12491973; BDBM50446437; 3-Chloro-N,N-dimethyl-4-(2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-ylamino)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
24-Exomethylenecalicoferol E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922225; BDBM50358245
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
Tert-butyl N-[(2R)-4-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]pentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064791; BDBM50237661
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-Cyclohexyl-6-(1H-indazol-5-yl)imidazo[2,1-b]thiazol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682556; SCHEMBL3668038; BDBM50337381; n-cyclohexyl-6-(1h-indazol-5-yl)imidazo[2,1-b][1,3]thiazol-5-amine
Click to Show/Hide
|
||||
| Activity |
Ki = 1800000 nM
|
[23] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Aryl thiosemicarbazones for the treatment of trypanosomatidic infections. Eur J Med Chem. 2018 Feb 25;146:423-434. | ||||
| REF 2 | ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. | ||||
| REF 3 | Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. | ||||
| REF 4 | Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6575-7. | ||||
| REF 5 | 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4420-3. | ||||
| REF 6 | Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem. 2007 Aug 23;50(17):4162-76. | ||||
| REF 7 | A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. J Med Chem. 2009 May 28;52(10):3300-7. | ||||
| REF 8 | Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. | ||||
| REF 9 | Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase. J Med Chem. 2011 Jan 13;54(1):312-9. | ||||
| REF 10 | Design and synthesis of novel benzoxazole analogs as Aurora B kinase inhibitors. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3067-3072. | ||||
| REF 11 | Design, synthesis, and biological evaluation of novel 4-anilinoquinazoline derivatives bearing amino acid moiety as potential EGFR kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:393-405. | ||||
| REF 12 | Design, synthesis, and evaluation of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives as Aurora kinase inhibitors. Bioorg Med Chem. 2016 May 1;24(9):2114-24. | ||||
| REF 13 | Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors. Eur J Med Chem. 2018 Sep 5;157:1361-1375. | ||||
| REF 14 | 2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines. Eur J Med Chem. 2012 Jul;53:254-63. | ||||
| REF 15 | Click approach to the discovery of 1,2,3-triazolylsalicylamides as potent Aurora kinase inhibitors. Bioorg Med Chem. 2014 Sep 1;22(17):4855-66. | ||||
| REF 16 | Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors. Eur J Med Chem. 2009 Apr;44(4):1788-93. | ||||
| REF 17 | Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells. J Med Chem. 2013 Nov 27;56(22):9122-35. | ||||
| REF 18 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. Bioorg Med Chem. 2011 Nov 15;19(22):6873-80. | ||||
| REF 19 | An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. | ||||
| REF 20 | Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem. 2013 Dec 27;56(24):10045-65. | ||||
| REF 21 | Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia. J Nat Prod. 2014 Feb 28;77(2):218-26. | ||||
| REF 22 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 23 | Scaffold oriented synthesis. Part 4: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1480-3. | ||||
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