Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46937 | Target Info | |||
| Target Name | P2Y purinoceptor 12 (P2RY12) | ||||
| Synonyms |
SP1999; P2Y12 platelet ADP receptor; P2Y12; P2Y(cyc); P2Y(ADP)P2Y purinoceptor 12; P2Y(ADP); P2Y(AC); P2T(AC); P2RY12; Nucleotide P2Y(12) receptor; Adenosine P2Y12 receptor; ADPG-R; ADP-glucose receptor
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | P2RY12 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 49 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID:23368907C16
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BPTU; 870544-59-5; GTPL5808; BMS-646786; MolPort-046-033-632; BCP29138; EX-A2593; ZINC95588286; BDBM50429537; AKOS032962872; CS-8114; HY-13831; DS-20243; AK689499; 1-(2-[2-
Click to Show/Hide
|
||||
| Activity |
Ki ~ 70000 nM
|
[1] | |||
| Compound Name |
(S)-4-(2,6-Diphenylisonicotinamido)-5-oxo-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549594; BDBM50298121
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-(2-(4,6-Diphenylpicolinamido)acetyl)piperazin-1-yl propionate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549797; BDBM50298122
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-4-(4-(4-(Methoxymethyl)piperidin-1-yl)-6-phenylpicolinamido)-5-oxo-5-(4-(pentyloxycarbonyl)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539733; BDBM50298132
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
7-(3-Benzenesulfonyl-propoxy)-1-methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88698; SCHEMBL10655614; BDBM50000911; 7-[3-(benzenesulfonyl)propoxy]-1-methyl-3H-imidazo[4,5-b]quinolin-2-one; 1-Methyl-1,3-dihydro-7-[3-(phenylsulfonyl)propoxy]-2H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 = 50300 nM
|
[3] | |||
| Compound Name |
1,3-Dihydro-7-[4-(1H-tetrazol-5-yl)butoxy]-2H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90120; BDBM50000943; 7-[4-(1H-Tetrazol-5-yl)-butoxy]-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 = 51000 nM
|
[3] | |||
| Compound Name |
2-Morpholin-4-yl-7-(pyridin-2-ylmethoxy)-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64555; SCHEMBL7362287; BDBM50044222; 2-morpholin-4-yl-7-(pyridin-2-ylmethoxy)chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 53000 nM
|
[4] | |||
| Compound Name |
(S)-5-(4-(Heptyloxycarbonyl)piperazin-1-yl)-5-oxo-4-(6-phenylpicolinamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564981; BDBM50298148
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[2] | |||
| Compound Name |
[(3Ar,4R,6R,6aR)-4-(6-aminopurin-9-yl)-2-(2-phenylethynyl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162187; BDBM50371586
Click to Show/Hide
|
||||
| Activity |
IC50 = 57070 nM
|
[5] | |||
| Compound Name |
(S)-5-(4-((2-Cyclopentylethoxy)carbonyl)piperazin-1-yl)-4-(4-(4-hydroxypiperidin-1-yl)-6-phenylpicolinamido)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540736; BDBM50298162
Click to Show/Hide
|
||||
| Activity |
IC50 = 57800 nM
|
[2] | |||
| Compound Name |
7-Allyloxy-8-methyl-2-morpholin-4-yl-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302875; SCHEMBL7316808; BDBM50044205; 8-methyl-2-morpholin-4-yl-7-prop-2-enoxychromen-4-one; 2-Morpholino-7-[(2-propenyl)oxy]-8-methyl-4H-1-benzopyran-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[4] | |||
| Compound Name |
(3,8-Dimethyl-2-morpholin-4-yl-4-oxo-4H-chromen-7-yloxy)-acetic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292047; SCHEMBL7324297; BDBM50044195; methyl 2-(3,8-dimethyl-2-morpholin-4-yl-4-oxochromen-7-yl)oxyacetate
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[4] | |||
| Compound Name |
(S)-5-(4-(Allyloxycarbonyl)piperazin-1-yl)-4-(4-butoxy-6-phenylpicolinamido)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563429; BDBM50298163
Click to Show/Hide
|
||||
| Activity |
IC50 = 61700 nM
|
[2] | |||
| Compound Name |
(S)-5-Oxo-4-(6-phenylpicolinamido)-5-(4-(propoxycarbonyl)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563041; BDBM50298164
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[2] | |||
| Compound Name |
5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yl)-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88265; BDBM50000922
Click to Show/Hide
|
||||
| Activity |
EC50 = 63100 nM
|
[3] | |||
| Compound Name |
2-Morpholino-7-(2-naphthylmethoxy)-8-methyl-4H-1-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62470; BDBM50044198; 8-methyl-2-morpholin-4-yl-7-(naphthalen-2-ylmethoxy)chromen-4-one; 8-Methyl-2-morpholin-4-yl-7-(naphthalen-2-ylmethoxy)-chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[4] | |||
| Compound Name |
7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-2-morpholin-4-yl-8-propyl-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62500; SCHEMBL9533715; BDBM50044201; 7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-morpholin-4-yl-8-propylchromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[4] | |||
| Compound Name |
1-(2,4-Difluorophenyl)-3-[2-[3-(trifluoromethyl)phenoxy]pyridin-3-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333774; SCHEMBL3150129; BDBM50429569
Click to Show/Hide
|
||||
| Activity |
Ki ~ 70000 nM
|
[1] | |||
| Compound Name |
1-[2-(2-Tert-butylphenoxy)pyridin-3-yl]-3-(4-tert-butylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333771; SCHEMBL3154400; BDBM50429536
Click to Show/Hide
|
||||
| Activity |
Ki ~ 70000 nM
|
[1] | |||
| Compound Name |
1-[2-(2-Tert-butylphenyl)sulfanylpyridin-3-yl]-3-(4-methylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333767; SCHEMBL3150533; BDBM50429538
Click to Show/Hide
|
||||
| Activity |
Ki ~ 70000 nM
|
[1] | |||
| Compound Name |
1-(4-Tert-butylphenyl)-3-[2-(2-propan-2-ylphenoxy)pyridin-3-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333772; SCHEMBL3257113; BDBM50429535
Click to Show/Hide
|
||||
| Activity |
Ki ~ 70000 nM
|
[1] | |||
| Compound Name |
1-[2-(2-Propan-2-ylphenoxy)pyridin-3-yl]-3-[4-(trifluoromethoxy)phenyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333773; SCHEMBL3151339; BDBM50429534
Click to Show/Hide
|
||||
| Activity |
Ki ~ 70000 nM
|
[1] | |||
| Compound Name |
(S)-5-Oxo-4-(6-phenylpicolinamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557062; BDBM50298114
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[2] | |||
| Compound Name |
N-Methyl-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90168; BDBM50000888; N-Methyl-4-[[(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyramide
Click to Show/Hide
|
||||
| Activity |
EC50 = 71600 nM
|
[3] | |||
| Compound Name |
(S)-5-Oxo-4-(4-phenylpyrimidine-2-carboxamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559689; BDBM50298123
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[2] | |||
| Compound Name |
2-Morpholino-7-[[2-(4-phenylpiperazino)ethyl]oxy]-8-methyl-4H-1-benzopyran-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60443; SCHEMBL8881859; BDBM50044212; 8-Methyl-2-morpholin-4-yl-7-[2-(4-phenyl-piperazin-1-yl)-ethoxy]-chromen-4-one; 8-methyl-2-morpholin-4-yl-7-[2-(4-phenylpiperazin-1-yl)ethoxy]chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 75000 nM
|
[4] | |||
| Compound Name |
7-Benzyloxy-3,8-dimethyl-2-morpholin-4-yl-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291376; SCHEMBL7322397; BDBM50044187; 3,8-dimethyl-2-morpholin-4-yl-7-phenylmethoxychromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 75000 nM
|
[4] | |||
| Compound Name |
3,8-Dimethyl-2-morpholin-4-yl-7-(naphthalen-1-ylmethoxy)-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62064; SCHEMBL7325246; BDBM50044203; 3,8-dimethyl-2-morpholin-4-yl-7-(naphthalen-1-ylmethoxy)chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 75000 nM
|
[4] | |||
| Compound Name |
(S)-4-(4,6-Diphenylpicolinamido)-5-oxo-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551484; BDBM50298167
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[2] | |||
| Compound Name |
(S)-4-(4-(Benzylamino)-6-phenylpicolinamido)-5-(4-(ethoxycarbonyl)piperazin-1-yl)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553572; BDBM50298169
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[2] | |||
| Compound Name |
Methyl 4-(1,3-dimethyl-2-oxoimidazo[4,5-b]quinolin-7-yl)oxybutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90102; BDBM50000924; 4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid methyl ester(HCl); 4-[[(1,3-Dimethyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyric acid methyl ester
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 87500 nM
|
[3] | |||
| Compound Name |
(S)-5-Oxo-4-(4-phenylpicolinamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562546; BDBM50298128
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(S)-5-Oxo-4-(2-phenylpyrimidine-4-carboxamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552921; BDBM50298118
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(S)-5-Oxo-4-(picolinamido)-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560809; BDBM50298127
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
7-[3-(1H-Tetrazol-5-yl)-propoxy]-1,3-dihydro-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88835; BDBM50000878; 1,3-Dihydro-7-[3-(1H-tetrazol-5-yl)propoxy]-2H-imidazo[4,5-b]quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(2-(6-Phenylpicolinamido)acetyl)piperazin-1-yl propionate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549307; BDBM50298124
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(S)-4-(4,6-Diphenylpicolinamido)-5-oxo-5-(4-m-tolylpiperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557553; BDBM50298129
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(S)-5-(4-(Methoxycarbonyl)piperazin-1-yl)-5-oxo-4-(6-phenylpicolinamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549308; BDBM50298125
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(S)-4-(4-(Diethylamino)-6-phenylpicolinamido)-5-(4-(ethoxycarbonyl)piperazin-1-yl)-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561406; BDBM50298173
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(4S)-5-Oxo-4-[(3-phenylbenzoyl)amino]-5-(4-propanoyloxypiperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551750; BDBM50298126; (S)-4-biphenyl-3-ylcarboxamido-5-oxo-5-(4-(propionyloxy)piperazin-1-yl)pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(S)-5-Oxo-4-(6-phenylpicolinamido)-5-(4-m-tolylpiperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560084; BDBM50298130
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(2-Oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313609; SCHEMBL10374710; BDBM50000898; 4-[(2-oxo-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-7-yl)oxy]butanoic acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(S)-5-(4-(Octyloxycarbonyl)piperazin-1-yl)-5-oxo-4-(6-phenylpicolinamido)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564150; BDBM50298131
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91579; BDBM50000895; 4-[[(1,3-Dimethyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyric acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(4S)-4-[(3,5-Diphenylbenzoyl)amino]-5-oxo-5-(4-propanoyloxypiperazin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561692; BDBM50298119
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90601; SCHEMBL10657313; BDBM50000904; 5-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]pentanoic acid; 5-[[(1-Methyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]valeric acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-(2-Oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91224; SCHEMBL10657144; BDBM50000889; 5-[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]pentanoic Acid; 5-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]pentanoic acid; 5-[[(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]valeric acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 106000 nM
|
[3] | |||
| Compound Name |
4-(1-Methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]quinolin-7-yloxy)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421885; SCHEMBL10658509; BDBM50000930; 4-[(1-methyl-2-oxo-3H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoic acid; 4-[(2,3-dihydro-1-methyl-2-oxo-1H-imidazo[4,5-b]quinolin-7-yl)oxy]butanoic acid; 4-[[(1-Methyl-2,3-dihydro-2-oxo-1H-imidazo[4,5-b]quinolin)-7-yl]oxy]butyric acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 106000 nM
|
[3] | |||
| Compound Name |
Tetrasodium;[chloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(propylamino)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphinothioyl]oxy-oxidophosphoryl]methyl]-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(propylamino)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphinothioyl]oxyphosphinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746451; BDBM50500437
Click to Show/Hide
|
||||
| Activity |
IC50 = 156000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 28 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Tetrasodium;[chloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphinothioyl]oxy-oxidophosphoryl]methyl]-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphinothioyl]oxyphosphinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3746177; BDBM50500448
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
Adenosine 5'-[dichloro-[beta,gamma-methylene]triphosphoric acid]
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160356; BDBM50167269; 5'-Adenylic acid, anhydride with (dichloromethylene)bis[phosphonic acid]
Click to Show/Hide
|
||||
| Activity |
IC50 = 316227.77 nM
|
[7] | |||
| Compound Name |
(4-Nitrobenzotriazol-1-yl)-phenylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077194; BDBM50260841
Click to Show/Hide
|
||||
| Activity |
IC50 = 650000 nM
|
[8] | |||
| Compound Name |
1-Benzyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075841; BDBM50260812
Click to Show/Hide
|
||||
| Activity |
IC50 = 810000 nM
|
[8] | |||
| Compound Name |
2-Benzyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065540; BDBM50260835
Click to Show/Hide
|
||||
| Activity |
IC50 = 820000 nM
|
[8] | |||
| Compound Name |
1-(4-Methylphenyl)sulfonyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087693; BDBM50260836
Click to Show/Hide
|
||||
| Activity |
IC50 = 860000 nM
|
[8] | |||
| Compound Name |
1-(3-Chloropropyl)-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079813; BDBM50260833
Click to Show/Hide
|
||||
| Activity |
IC50 = 910000 nM
|
[8] | |||
| Compound Name |
4-Nitro-2-octylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077654; BDBM50260840
Click to Show/Hide
|
||||
| Activity |
IC50 = 920000 nM
|
[8] | |||
| Compound Name |
2-Heptyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075411; BDBM50260831
Click to Show/Hide
|
||||
| Activity |
IC50 = 930000 nM
|
[8] | |||
| Compound Name |
4-Nitro-1-octylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067755; BDBM50260832
Click to Show/Hide
|
||||
| Activity |
IC50 = 940000 nM
|
[8] | |||
| Compound Name |
2-Hexyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087845; BDBM50260839
Click to Show/Hide
|
||||
| Activity |
IC50 = 940000 nM
|
[8] | |||
| Compound Name |
1-Heptyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075331; BDBM50260830
Click to Show/Hide
|
||||
| Activity |
IC50 = 950000 nM
|
[8] | |||
| Compound Name |
4-Nitro-2-pentylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071889; BDBM50260820
Click to Show/Hide
|
||||
| Activity |
IC50 = 1020000 nM
|
[8] | |||
| Compound Name |
1-Hexyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093411; BDBM50260821
Click to Show/Hide
|
||||
| Activity |
IC50 = 1040000 nM
|
[8] | |||
| Compound Name |
1-Butyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075142; BDBM50260818
Click to Show/Hide
|
||||
| Activity |
IC50 = 1050000 nM
|
[8] | |||
| Compound Name |
2-Butyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078992; BDBM50260838
Click to Show/Hide
|
||||
| Activity |
IC50 = 1070000 nM
|
[8] | |||
| Compound Name |
4-Nitro-1-pentylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076196; SCHEMBL11596553; BDBM50260819
Click to Show/Hide
|
||||
| Activity |
IC50 = 1070000 nM
|
[8] | |||
| Compound Name |
2-(3-Chloropropyl)-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060620; BDBM50260834
Click to Show/Hide
|
||||
| Activity |
IC50 = 1260000 nM
|
[8] | |||
| Compound Name |
4-Nitro-1-propylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100042; BDBM50260817
Click to Show/Hide
|
||||
| Activity |
IC50 = 1300000 nM
|
[8] | |||
| Compound Name |
4-Nitro-2-propylbenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062156; BDBM50260811
Click to Show/Hide
|
||||
| Activity |
IC50 = 1320000 nM
|
[8] | |||
| Compound Name |
1-Ethyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102781; BDBM50260837
Click to Show/Hide
|
||||
| Activity |
IC50 = 1500000 nM
|
[8] | |||
| Compound Name |
2-Ethyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076556; BDBM50260816
Click to Show/Hide
|
||||
| Activity |
IC50 = 1620000 nM
|
[8] | |||
| Compound Name |
1-Methyl-7-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-nitro-1-methylbenzotriazole; CHEMBL4084826; 1-methyl-7-nitro-1H-benzotriazole; 1H-Benzotriazole, 1-methyl-7-nitro-; CTK8G9387; ZINC3163041; BDBM50260815; STK370132; AKOS005445427; MCULE-4755695417; ST51060899; 1-Methyl-7-nitro-1H-1,2,3-benzotriazole #
Click to Show/Hide
|
||||
| Activity |
IC50 = 1800000 nM
|
[8] | |||
| Compound Name |
1-Methyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073608; 1-Methyl-4-nitro-1H-benzotriazole; 1H-Benzotriazole, 1-methyl-4-nitro-; SCHEMBL11593131; DTXSID70345016; BDBM50260813; MFCD00464867; 1-Methyl-4-nitro-1H-1,2,3-benzotriazole #
Click to Show/Hide
|
||||
| Activity |
IC50 = 1840000 nM
|
[8] | |||
| Compound Name |
2-Methyl-4-nitrobenzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099652; SCHEMBL2494303; ZINC2532334; BDBM50260814; MFCD04122507; AKOS006292943; MCULE-8437171942; 2-methyl-4-nitro-2h-1,2,3-benzotriazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 1960000 nM
|
[8] | |||
| Compound Name |
4-Nitro-1H-1,2,3-benzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Nitro-1H-benzotriazole; 4-nitro-2H-benzotriazole; 4-Nitrobenzotriazole; nitro-1h-benzotriazole; 4-nitro-1h-benzo[d][1,2,3]triazole; UNII-S75GE4B24J; MLS000540987; S75GE4B24J; SMR000126045; nitrobenzotriazole; 7-Nitro-1H-benzotriazole; 2H-Benzotriazole, 4-nitro-; NSC44657; EINECS 228-579-7; 7-Nitrobenzotriazole; Benzotriazole, 4-nitro-; 4-Nitro 1H-benzotriazole; 1H-Benzotriazole,7-nitro-; 1H-Benzotriazole, 4-nitro-; cid_80533; SCHEMBL103130; SCHEMBL854375; CHEMBL1456115; BDBM70499; CTK5B6965; DTXSID70212198; HMS2334D24; ALBB-016077; BCP04118; KS-00000O7P; ZINC5425412; ANW-55970; MFCD00160033; NSC-44657; SBB017079; STK523155; 1H-1,2,3-benzotriazole, 4-nitro-; 7-Nitro-1H-1,2,3-benzotriazole #; AKOS003193925; MCULE-6970289510; NCGC00246589-01; AK-46489; ST026570; DB-058100; CS-0043845; FT-0680465; R2362; 5R-0658; AE-641/30196004; J-515858; Z2235413189
Click to Show/Hide
|
||||
| Activity |
IC50 = 2060000 nM
|
[8] | |||
| Compound Name |
1H-Benzotriazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzotriazole; 2H-Benzotriazole; 1H-Benzo[d][1,2,3]triazole; 1,2,3-BENZOTRIAZOLE; 1H-1,2,3-Benzotriazole; Azimidobenzene; Aziminobenzene; Benztriazole; Benzisotriazole; Benzene azimide; 2,3-Diazaindole; Cobratec #99; 1,2-Aminoazophenylene; Cobratec 99; 1,2,3-Triaza-1H-indene; 1,2,3-Triazaindene; 1,2,-Aminozophenylene; NCI-C03521; NSC-3058; 1,2,3-1h-benzotriazole; U-6233; UNII-86110UXM5Y; 1,2,3-Benztriazole; MFCD00005699; 2H-benzo[d][1,2,3]triazole; 86110UXM5Y; 1H-Benzotriazol; DSSTox_CID_147; 1H-Benzotriazole, 99%; DSSTox_RID_75400; DSSTox_GSID_20147; Benzotriazole (VAN); benzotriazol; CCRIS 78; Pseudoazimidobenzene; Cobratec 35G; HSDB 4143; 1,2,3-Benzotriazole,1H-benzo[d][1,2,3]triazole; EINECS 202-394-1; azaindazole; BRN 0112133; aza-indazole; AI3-15984; 1 h-benzotriazole; 1,3-Triazaindene; 1,3-Benzotriazole; Cobratec No. 99; 1,2-Aminozophenylene; PubChem16004; ACMC-209ruz; 1H-1,3-Benzotriazole; 1,3-Triaza-1H-indene; 1H-Benzotriazole (VAN8C; EC 202-394-1; WLN: T56 BMNNJ; SCHEMBL8956; 1,2,3-Benzotriazole(BTA); 4-26-00-00093 (Beilstein Handbook Reference); KSC486M6D; MLS002302971; CHEMBL84963; 1H-benzo-[1,2,3]triazole; DTXSID6020147; BDBM36293; CTK1A4424; CTK3I6661; NSC3058; Benzotriazole, analytical standard; HMS3091M10; ZINC332008; Benzotriazole, reagent grade, 97%; CS-D1407; KS-00000K8O; STR01561; Tox21_201501; Tox21_302934; ANW-40377; BDBM50234613; SBB060070; STL281967; Benzotriazole, ReagentPlus(R), 99%; 1H-Benzotriazole, >=98.0% (N); AKOS000119181; AKOS025396849; MCULE-2848618742; PS-3644; NCGC00091322-01; NCGC00091322-02; NCGC00091322-03; NCGC00256574-01; NCGC00259052-01; AK-44446; BP-21454; SC-15698; SMR001252218; AB0008382; DB-022595; B0094; BB 0243857; FT-0606217; FT-0698151; ST51046317; Benzotriazole, Vetec(TM) reagent grade, 98%; 3334-EP2270010A1; 3334-EP2270113A1; 3334-EP2272828A1; 3334-EP2272935A1; 3334-EP2280000A1; 3334-EP2281563A1; 3334-EP2281818A1; 3334-EP2284920A1; 3334-EP2289883A1; 3334-EP2292586A2; 3334-EP2292593A2; 3334-EP2292597A1; 3334-EP2292611A1; 3334-EP2298753A1; 3334-EP2301918A1; 3334-EP2301921A1; 3334-EP2301924A1; 3334-EP2301926A1; 3334-EP2305651A1; 3334-EP2308562A2; 3334-EP2308839A1; 3334-EP2308840A1; 3334-EP2308849A1; 3334-EP2308850A1; 3334-EP2308854A1; 3334-EP2314575A1; 3334-EP2315502A1; 3334-EP2316459A1; 3334-EP2371811A2; 3334-EP2372804A1; 3334-EP2377847A1; 3334-EP2378585A1; Z-2915; 22608-EP2315502A1; 81449-EP2275411A2; 81449-EP2305687A1; AB00374479-06; AC-907/34124039; Q220672; W-100172; Z57127352; F2190-0645
Click to Show/Hide
|
||||
| Activity |
IC50 = 7430000 nM
|
[8] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 = 251188.64 nM
|
[7] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists. J Med Chem. 2013 Feb 28;56(4):1704-14 | ||||
| REF 2 | Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4657-63. | ||||
| REF 3 | Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains. J Med Chem. 1992 Jul 10;35(14):2672-87. | ||||
| REF 4 | Synthesis and biological evaluation of antiplatelet 2-aminochromones. J Med Chem. 1993 Jul 9;36(14):2026-32. | ||||
| REF 5 | Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor. J Med Chem. 2008 Feb 28;51(4):1007-25. | ||||
| REF 6 | New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors. Eur J Med Chem. 2016 Jan 1;107:204-18. | ||||
| REF 7 | State of affairs: Design and structure-activity relationships of reversible P2Y12 receptor antagonists. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2739-2754. | ||||
| REF 8 | Facile alkylation of 4-nitrobenzotriazole and its platelet aggregation inhibitory activity. Bioorg Med Chem. 2017 Oct 15;25(20):5260-5267. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.