Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48040 | Target Info | |||
| Target Name | DNA repair protein complementing XP-A cells (XPA) | ||||
| Synonyms |
Xeroderma pigmentosum group A-complementing protein; XPAC; XPA protein
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| Target Type | Literature-reported Target | ||||
| Gene Name | XPA | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[(4Z)-4-[[5-[4-[(4-Fluorophenyl)methylcarbamoyl]phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069684; SCHEMBL19644232; BDBM50241678
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-((4Z)-4-{[5-(3-Carboxyphenyl)-2-furyl]methylene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL481937; SCHEMBL19652472; BDBM50241705; ZINC27527773; AKOS000112712; SR-01000435463; SR-01000435463-1
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(5-{(Z)-[1-(3-Carboxyphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}-2-furyl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060264; SCHEMBL19652471; BDBM50241704; ZINC22238474; AKOS000112704; SR-01000435474; SR-01000435474-1
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-((4Z)-4-{[5-(4-Carboxyphenyl)-2-furyl]methylene}-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL481763; SCHEMBL19652473; BDBM50241701; ZINC27548730; AKOS001651999
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Schembl20840316
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL520941; AC1NT6TZ; SCHEMBL19644261; HMS598C17; DTXSID40417370; BDBM50241717; AKOS000112732; ZINC100148066; CCG-222138; X80, >=98% (HPLC); BIM-0041706.P001; SR-01000435460; SR-01000435460-1
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Chloro-N-(cyclopropylmethyl)-5-[5-[(Z)-[1-[3-(cyclopropylmethylcarbamoyl)phenyl]-3-methyl-5-oxopyrazol-4-ylidene]methyl]furan-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093387; SCHEMBL19644352; BDBM50241674
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(4Z)-4-[[5-[4-(Cyclopropylmethylcarbamoyl)phenyl]furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104617; SCHEMBL19644439; BDBM50241712
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction. J Med Chem. 2017 Oct 12;60(19):8055-8070. | ||||
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