Target Poor or Non Binder(s) Information

Target General Information

Target ID

T48330

Target Info

Target Name

Large neutral amino acids transporter 1 (SLC7A5)

Synonyms

y+ system cationic amino acid transporter; Solute carrier family 7 member 5; MPE16; Large neutral amino acids transporter small subunit 1; LAT1; L-type amino acid transporter LAT1; L-type amino acid transporter 1; Integral membrane protein E16; HLAT1; CD98LC; CD98 light chain; 4F2LC; 4F2 light chain; 4F2 LC

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Target Type

Literature-reported Target

Gene Name

SLC7A5

Biochemical Class

Amino acid-polyamine-organocation

UniProt ID

Q01650

Poor Binders of This Target (in total, 26 binders)

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Compound Name

L-Tyrosine

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Approved

Compound Info

Synonyms

DTY; Rxosine; Tirosina; Tyr; Tyrosine; Tyrosinum; Tirosina [Spanish]; Tyrosine Power; Tyrosinum [Latin]; Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs; L-Tyrosin; L-Tyrosine hydrochloride; Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide; P-Tyrosine; TYR NH3+ COOH; Tyrosine (VAN); Tyrosine [USAN:INN]; Free-Form L-Tyrosine; H-Tyr-OH; L-Tyrosine (9CI); L-Tyrosine (JAN); L-Tyrosine, homopolymer; L-Tyrosine, monomer; L-p-Tyrosine; Melanin synthesized from Tyr substrate catalyzed by tyrosinase, brominated with N-bromosuccinimide; Tyrosine (USP/INN); Beta-(p-Hydroxyphenyl)alanine; Melanin synthesized from Tyr substrate catalyzed by tyrosinase for 6 hrs, oxidized with hydrogen peroxide, <3 kd fraction; Tyrosine, L-(8CI); DD69927C-C6A8-4BC6-8E9A-0AB423B176E7; L-(-)-Tyrosine; Melanin synthesized from Tyr substrate catalyzed by tyrosinase, sulfonated using sulfur trioxide/DMF complex for 1.5-7 hours; Alpha-Amino-beta-(4-hydroxyphenyl)propionic acid; L-2-Amino-3-p-hydroxyphenylpropanoic acid; (-)-alpha-Amino-p-hydroxyhydrocinnamic acid; (S)-2-Amino-3-(4-hydroxyphenyl)propionic acid; (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid; (S)-3-(p-Hydroxyphenyl)alanine; (S)-Tyrosine; (S)-alpha-Amino-4-hydroxybenzenepropanoic acid; 2-Amino-3-(p-hydroxyphenyl)propionic acid; 3-(4-Hydroxyphenyl)-L-alanine; 3-(p-Hydroxyphenyl)alanine; 4-Hydroxy-L-phenylalanine; 4ts1

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Activity

IC50 = 68000 nM

[1]

Compound Name

L-Phenylalanine

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Approved

Compound Info

Synonyms

Endophenyl; Fenilalanina; Phe; Phenylalanine; Phenylalaninum; Fenilalanina [Spanish]; Phenylalaninum [Latin]; Antibiotic FN 1636; CB 3208; NCI9959; Alpha-Aminohydrocinnamic acid; Beta-Phenylalanine; L-Antibiotic FN 1636; L-PHENYLALININE; N-Formylmelphalan; Phenylalanine (VAN); H-Phe-OH; L-Phenylalanine (JP15); Phenylalanine (USP/INN); Phenylalanine [USAN:INN:JAN]; Beta-Phenyl-L-alanine; N-Formyl-L-sarcolysin; N-Formyl-L-p-sarcolysin; L-PHENYL ALANINE (SEE ALSO 22839-47-0, ASPARTAME; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine; L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-(9CI); (2S)-2-amino-3-phenylpropanoic acid; (L)-Phenylalanine; (S)-(-)-Phenylalanine; (S)-2-Amino-3-phenylpropanoic acid; (S)-2-Amino-3-phenylpropionic acid; (S)-Phenylalanine; (S)-alpha-Amino-benzenepropanoic acid; (S)-alpha-Amino-beta-phenylpropionic acid; (S)-alpha-Aminohydrocinnamic acid; 1F9436B3-8B0D-4AC6-A004-4249B0BDA436; 3-Phenyl-L-alanine; 3-Phenylalanine; 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-formamidopropanoic acid

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Activity

IC50 = 69000 nM

[1]

Compound Name

Levodopa

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Approved

Compound Info

Synonyms

Levodopa (optimized formulation, Parkinson's disease); More effective levodopa (Parkinson's disease), Orion; Levodopa (optimized formulation, Parkinson's disease), Orion

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Activity

IC50 = 100000 nM

[2]

Compound Name

L-Tryptophan

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Approved

Compound Info

Synonyms

Ardeytropin; Kalma; LTR; Lyphan; Optimax; Pacitron; Sedanoct; Triptofano; Trofan; Trp; Tryptacin; Tryptan; Tryptophane; Tryptophanum; Triptofano [Spanish]; Tryptophane [French]; Tryptophanum [Latin]; EH 121; MT1; T 0254; Alti-Tryptophan; L-TRYPTOPHAN SIGMA GRADE; L-Trp; L-Tryptofan; L-Tryptophane; L-Ttp; TRP NH3+ COOH; TRP-01; Tryptophan (VAN); Tryptophan [USAN:INN]; H-Trp-oh; Indole-3-alanine; L-Tryptophan (9CI); L-Tryptophan (JP15); Tryptophan (H-3); Tryptophan (USP/INN); L-b-3-Indolylalanine; L-beta-3-Indolylalanine; Tryptophan, L-(8CI); Alanine, 3-indol-3-yl; Alpha'-Amino-3-indolepropionic acid; L-(-)-Tryptophan; L-(-)-Tryptophane; L-a-Aminoindole-3-propionic acid; L-alpha-Aminoindole-3-propionic acid; L-alpha-amino-3-indolepropionic acid; Alpha-Amino-beta-(3-indolyl)-propionic acid; Alpha-amino-beta-(3-indolyl)-pr opionic acid; Propionic acid, 2-amino-3-indol-3-yl; S(-)-1-alpha-Aminoindole-3-propionic acid; (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid; (L)-TRYPTOPHAN; (S)-(-)-2-Amino-3-(3-indolyl)propionic Acid; (S)-(-)-Tryptopha n; (S)-(-)-Tryptophan; (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid; (S)-2-Amino-3-(3-indolyl)propionic acid; (S)-Tryptophan; (S)-a-Amino-1H-indole-3-propanoic acid; (S)-a-Amino-b-indolepropionic acid; (S)-a-Aminoindole-3-propionic acid; (S)-alpha-Amino-1H-indole-3-propanoic acid; (S)-alpha-Amino-beta-indolepropionic acid; (S)-alpha-Aminoindole-3-propionic acid; (S)-alpha-amino-beta-(3-indolyl)-propionic acid; 1-beta-3-Indolylalanine; 151A3008-4CFE-40C9-AC0B-467EF0CB50EA; 1H-Indole-3-alanine; 1H-Indole-3-alanine (VAN); 1beta-3-Indolylalanine; 2-Amino-3-(lH-indol-3-yl)-propanoic acid; 2-Amino-3-indolylpropanoic acid; 2-amino-3-indol-3-ylpropionic acid; 3-Indol-3-ylalanine

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Activity

IC50 = 160000 nM

[1]

Compound Name

L-valine

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Investigative

Compound Info

Synonyms

L-valine; valine; 72-18-4; (S)-Valine; H-Val-OH; (S)-2-Amino-3-methylbutanoic acid; 2-Amino-3-methylbutyric acid; (2S)-2-amino-3-methylbutanoic acid; (S)-2-Amino-3-methylbutyric acid; L-alpha-Amino-beta-methylbutyric acid; Valinum [Latin]; Valina [Spanish]; Valine (VAN); Valine [USAN:INN]; Butanoic acid, 2-amino-3-methyl-; VALINE, L-; L(+)-alpha-Aminoisovaleric acid; (S)-alpha-Amino-beta-methylbutyric acid; Butanoic acid, 2-amino-3-methyl-, (S)-; 2-Amino-3-methylbutyric acid, (S)-; 2-Amino-3-methylbutanoic acid, (S)-; L-valin

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Activity

IC50 = 68000 nM

[1]

Compound Name

L-leucine

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Investigative

Compound Info

Synonyms

leucine; 61-90-5; (S)-2-Amino-4-methylpentanoic acid; H-Leu-OH; (S)-Leucine; (2S)-2-amino-4-methylpentanoic acid; (S)-(+)-Leucine; Leucin; L-Norvaline, 4-methyl-; (S)-2-Amino-4-methylvaleric acid; L-leucin; L-alpha-Aminoisocaproic acid; Leucin [German]; LEUCINE, L-; Leucine (VAN); leu; Leucinum; (2S)-alpha-leucine; L-(-)-2-Amino-4-methylpentanoic acid; 2-amino-4-methylvaleric acid; Leucinum [INN-Latin]; Leucine [USAN:INN]; L-Leuzin; Leucina [INN-Spanish]; Leucina [Latin,Spanish]; alpha-Aminoisocaproic acid

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Activity

IC50 = 85000 nM

[1]

Compound Name

Meta-Tyrosine

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Investigative

Compound Info

Synonyms

L-m-Tyrosine; 587-33-7; 3-HYDROXY-L-PHENYLALANINE; Meta-Tyrosine; (S)-2-amino-3-(3-hydroxyphenyl)propanoic acid; m-Tyrosine; 3-tyrosine; m-L-Tyrosine; 3-Hydroxyphenylalanine; UNII-D5YF57V4QW; 3-(m-Hydroxyphenyl)alanine; L-mTyr; (2S)-2-amino-3-(3-hydroxyphenyl)propanoic acid; L-M-TYR; D5YF57V4QW; L-Phenylalanine, 3-hydroxy-; MFCD00063059; AK-86473; L-META-TYROSINE; 3-(3-HYDROXYPHENYL)-L-ALANINE; D-3-hydroxyphenylalanine; L-PHE(3-OH)-OH; (2S)-2-azaniumyl-3-(3-hydroxyphenyl)propanoate; Tyrosine, meta-; MTY; m-Tyrosine, L-

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Activity

IC50 = 130000 nM

[1]

Compound Name

L-isoleucine

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Investigative

Compound Info

Synonyms

l-isoleucine; Isoleucine; 73-32-5; (2S,3S)-2-Amino-3-methylpentanoic acid; H-Ile-OH; (S)-Isoleucine; 2S,3S-Isoleucine; (S,S)-Isoleucine; 2-Amino-3-methylvaleric acid; erythro-L-Isoleucine; L-(+)-Isoleucine; L-Ile; alpha-Amino-beta-methylvaleric acid; 443-79-8; Isoleucine (VAN); Isoleucinum [Latin]; Isoleucina [Spanish]; Valeric acid, 2-amino-3-methyl-; Norvaline, 3-methyl-; L-Norvaline, 3-methyl-, erythro-; ISOLEUCINE, L-; Acetic acid, amino-sec-butyl-; Pentanoic acid, 2-amino-3-methyl-; CCRIS 5229; iso-leucine

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Activity

IC50 = 140000 nM

[1]

Compound Name

L-methionine

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Investigative

Compound Info

Synonyms

Acimethin; Cymethion

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Activity

IC50 = 170000 nM

[1]

Compound Name

(S)-2-amino-3-cyclohexylpropanoic acid

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Investigative

Compound Info

Synonyms

27527-05-5; (S)-2-amino-3-cyclohexylpropanoic acid; L-Cyclohexylalanine; H-Cha-OH; (2S)-2-amino-3-cyclohexylpropanoic acid; 3-Cyclohexyl-L-alanine; L-3-Cyclohexylalanine; (S)-2-Amino-3-cyclohexylpropionic acid; BETA-CYCLOHEXYL-ALANINE; L-beta-Cyclohexylalanine; UNII-GYR4SF0FVQ; GYR4SF0FVQ; CHEMBL383208; Cyclohexanepropanoic acid, alpha-amino-, (alphaS)-; 2-AMINO-3-CYCLOHEXYL-PROPIONIC ACID; 3-cyclohexylalanine; b-cyclohexyl alanine; beta-cyclohexylalanine; PubChem5760; beta-cyclohexyl alanine; AC1LEHTM; AC1Q5QKA

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Activity

IC50 = 200000 nM

[1]

Compound Name

3-(3-Pyridyl)-L-alanine

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Investigative

Compound Info

Synonyms

L-3-PYRIDYLALANINE; (S)-2-Amino-3-(pyridin-3-yl)propanoic acid; H-3-PAL-OH; 3-(3-Pyridyl)alanine; 3-Pyridin-3-yl-L-alanine; L-3-(3-PYRIDYL)-ALANINE; 3'-PYRIDYL-L-ALA; (2S)-2-amino-3-(pyridin-3-yl)propanoic acid; (2S)-2-amino-3-pyridin-3-ylpropanoic acid; UNII-5HW88A35AQ; 5HW88A35AQ; CHEMBL4242404; BETA-(3-PYRIDYL)-L-ALANINE; MFCD00079676; (2S)-2-Amino-3-pyridin-3-yl-propanoic acid; beta-(3-Pyridyl)alanine; H-ALA(3-PYRI)-OH; H-Ala(3-pyridyl)-OH.HCl; 3-(3-Pyridinyl)-L-alanine; H-3-(3-pyridyl)-Ala-OH; SCHEMBL124365; beta-(3-Pyridyl)alanine, L-; 3-(3-pyridyl)-(S)-alanine; CTK1A2984; DTXSID10182386; KS-00000LV1; ZINC4222893; BDBM50463186; AKOS016843851; AC-9955; AM83722; PS-3751; AB0010786; DB-003003; EN300-94617; 3-Pyridinepropanoic acid, alpha-amino-, (+-)-; 090P988; 3-(3-Pyridyl)-L-alanine, >=98.0% (HPLC); Q27452230; 3-PYRIDINEPROPANOIC ACID, ALPHA-AMINO-, (ALPHAS)-; H-Ala(3-pyridyl)-OH inverted exclamation mark currencyHCl; UNII-82667X5OWF component DFZVZEMNPGABKO-ZETCQYMHSA-N

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Activity

IC50 = 69000 nM

[1]

Compound Name

Chembl4242607

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Investigative

Compound Info

Synonyms

BDBM50463203

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Activity

IC50 = 76000 nM

[1]

Compound Name

(2S)-2-Amino-3-[3-(hydroxymethyl)phenyl]propanoic acid

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Investigative

Compound Info

Synonyms

CHEMBL4251478; m- Hydroxymethylphenylalanin; SCHEMBL1512890; 3-(hydroxymethyl)-phenylalanine; BDBM50463191

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Activity

IC50 = 83000 nM

[1]

Compound Name

m-Acetylphenylalanine

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Investigative

Compound Info

Synonyms

CHEMBL4239335; 3-Acetylphenylalanine; L-Phenylalanine, 3-acetyl-; SCHEMBL455836; CTK1D1705; DTXSID80467970; BDBM50463201; (2S)-3-(3-acetylphenyl)-2-aminopropanoic acid

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Activity

IC50 = 92000 nM

[1]

Compound Name

Chembl4241017

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Investigative

Compound Info

Synonyms

BDBM50463196

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Activity

IC50 = 95000 nM

[1]

Compound Name

Chembl4240451

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Investigative

Compound Info

Synonyms

BDBM50463200

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Activity

IC50 = 96000 nM

[1]

Compound Name

3-(4-Pyridyl)-L-alanine

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Investigative

Compound Info

Synonyms

L-4-PYRIDYLALANINE; (S)-2-Amino-3-(pyridin-4-yl)propanoic acid; (2S)-2-amino-3-(pyridin-4-yl)propanoic acid; H-4-Pal-OH; UNII-X1XF0A3CPO; X1XF0A3CPO; beta-(4-Pyridyl)-L-alanine; 3-(4-Pyridyl)-alanine; CHEMBL4249170; H-D-Ala(4-pyridyl)-OH.HCl; 4'-Pyridyl-L-Ala; 4-Pyridylalanine, L-; 3-Pyridin-4-ylalanine; H-Ala(4-Pyri)-OH; beta-(4-pyridyl)-alanine; 3-pyridin-4-yl-L-alanine; D-3-(4-pyridyl)-alanine; SCHEMBL122533; CTK3J1689; DTXSID60958619; KS-00002A0S; ZINC2385772; ANW-42982; BDBM50463209; MFCD01860883; AKOS005137939; AC-9961; PS-3753; SC-19508; 3-(4-Pyridyl)-L-alanine, >=98.0%; AB0014668; (2S)-2-azaniumyl-3-pyridin-4-ylpropanoate; EN300-77287; K-8273; 535P492; 4-Pyridinepropanoic acid, alpha-amino-, (alphaS)-; UNII-AY9J934TFO component FQFVANSXYKWQOT-ZETCQYMHSA-N; 4-Pyridinepropanoicacid, a-amino-, dihydrochloride, (aS)- (9CI)

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Activity

IC50 = 100000 nM

[1]

Compound Name

(S)-2-Amino-3-(3-aminophenyl)propanoic acid

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Investigative

Compound Info

Synonyms

3-aminophenylalanine; 3-Amino-L-Phenylalanine; CHEMBL4247184; (2S)-2-amino-3-(3-aminophenyl)propanoic acid; L-Phenylalanine, 3-amino-; SCHEMBL288636; CTK5A6466; ZINC2046238; 8400AB; BDBM50463199

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Activity

IC50 = 101000 nM

[1]

Compound Name

Chembl4248453

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Investigative

Compound Info

Synonyms

SCHEMBL3152192; BDBM50463210

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Activity

IC50 = 110000 nM

[1]

Compound Name

D-Methionine

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Investigative

Compound Info

Synonyms

H-D-Met-OH; (R)-Methionine; methionine; D-Methionin; D-Metionien; METHIONINE, D-; MRx-1024; (R)-2-amino-4-(methylthio)butanoic acid; R-Methionine; UNII-868496F25R; MFCD00002622; D-2-Amino-4-(methylthio)butyric acid; D-2-Amino-4-(methylthio)butanoic acid; CHEMBL1234268; Methionine D-; (2R)-2-amino-4-(methylsulfanyl)butanoic acid; D-Methionine, 99+%; (R)-2-Amino-4-(methylmercapto)butyric acid; 868496F25R; D-Metionien [Australian]; EINECS 206-483-6; NSC 45689; L-Methionine;; Methionine d-form; D-Met; D-Met-OH; bmse000450; D-Methionine;MRX-1024; KSC222Q8N; SCHEMBL126688; CTK1C2886; DTXSID90883369; D-Methionine, >=98% (HPLC); ACT04819; KS-00000A8Q; ZINC1532766; ANW-28004; BDBM50463194; SBB006710; AKOS015852500; AC-8661; AM81977; CS-7880; DB02893; EBD2198096; NCGC00163337-01; (R)-2-Amino-4-(methylthio)butyric acid; AC-12369; DS-15125; HY-13694; SC-09743; D-Methionine, puriss., >=99.0% (NT); DB-038140; M0102; C00855; Z-3842; 93481-EP2295437A1; 93481-EP2298775A1; 93481-EP2305641A1; 348M674; J-300192; Q-101531; Q27093862; UNII-73JWT2K6T3 component FFEARJCKVFRZRR-SCSAIBSYSA-N

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Activity

IC50 = 120000 nM

[1]

Compound Name

alpha-Methyl-L-phenylalanine

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Investigative

Compound Info

Synonyms

(S)-2-Amino-2-methyl-3-phenylpropanoic acid; alpha-methyl-L-Phe; alpha-Methylphenylalanine; (2S)-2-amino-2-methyl-3-phenylpropanoic acid; L-ALPHA-METHYLPHENYLALANINE; ALPHA-BENZYL-L-ALA; (S)-2-Amino-2-methyl-3-phenylpropionic acid; (S)-alpha-Methylphenylalanine; L-Phenylalanine, alpha-methyl-; CHEMBL4249392; (S)-2-amimo-2-methyl-3-phenylpropanoic acid; 2-Methyl-L-phenylalanine monohydrate; (S)-alpha-Methylphenylalanine hydrate, 98%, 98% ee; Phenylalanine, alpha-methyl-, (S)-; a-Methyl-L-phenylalanine; alpha-methyl phenylalanine; Phenylalanine, a-methyl-; H-(Me)Phe-OH.nH2O; (R)-2-Amino-2- Methyl-3-Phenylpropanoic Acid; rac-alpha-methyl-phenylalanine; SCHEMBL122296; CTK4I8005; DTXSID40945921; ZINC8076066; ANW-25085; BDBM50463205; MFCD00145244; SBB006742; AKOS015914444; AB03937; AC-4460; AS-46870; SC-14196; ST50405408; Z5774; B-8044; J-015044; (S)-()-2-AMINO-2-METHYL-3-PHENYLPROPANOIC ACID; (S)-(-)-2-AMINO-2-METHYL-3-PHENYLPROPIONIC ACID; UNII-67265D2JSG component HYOWVAAEQCNGLE-JTQLQIEISA-N; alpha-Methyl-L-phenylalanine, >=97.5% (HPLC), purum, >=97.0% (HPLC)

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Activity

IC50 = 130000 nM

[1]

Compound Name

3-[(2S)-2-Amino-2-carboxyethyl]benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL4238000; m-Carboxyphenylalanin; Phenylalanine,3-carboxy-; SCHEMBL1061213; CTK4E8063; ZINC2557958; BDBM50463212; (S)-3-(2-AMINO-2-CARBOXYETHYL)BENZOIC ACID

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Activity

IC50 = 130000 nM

[1]

Compound Name

Chembl4244666

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Investigative

Compound Info

Synonyms

(R)-3-(2-Amino-2-carboxy-ethyl)-benzoic acid methyl ester; BDBM50463192; SB32582; (R)-2-Amino-3-(3-(methoxycarbonyl)phenyl)propanoic acid

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Activity

IC50 = 150000 nM

[1]

Compound Name

3-(2-Pyridyl)-L-alanine

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Investigative

Compound Info

Synonyms

L-2-Pyridylalanine; H-2-Pal-OH; (S)-2-Amino-3-(pyridin-2-yl)propanoic acid; L-3-(2-pyridyl)-alanine; 3-(2-Pyridyl)-alanine; 2'-Pyridyl-L-Ala; (2S)-2-amino-3-pyridin-2-ylpropanoic acid; CHEMBL4243343; MFCD06809729; MFCD00237827; 2-Aza-L-phenylalanine; 3-(2-pyridyl)alanine; H-Ala(2-Pyri)-OH; (2S)-2-amino-3-(pyridin-2-yl)propanoic acid; beta-(2-Pyridyl)-L-alanine; KSC491O9J; SCHEMBL126509; 3-PYRIDIN-2-YLALANINE; H- Ala(2-pyridyl)-OH.2HCl; CTK3J1794; KS-00000LUR; DTXSID70958620; H-3-(2-pyridyl)-Ala-OH.2HCl; ZINC2560974; ANW-61288; BDBM50463195; AKOS015891614; AC-5878; AM83719; CS-W005897; AK-49740; DS-15138; DB-038222; EN300-77282; 3-(2-Pyridyl)-L-alanine, >=98.0% (TLC); 535P516; 2-Pyridinepropanoicacid, a-amino-, methyl ester, dihydrochloride, (aR)- (9CI)

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Activity

IC50 = 160000 nM

[1]

Compound Name

(S)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid

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Investigative

Compound Info

Synonyms

H-HIS(BZL)-OH; 1-benzyl-l-histidine; Poly(1-benzylhistidine); L-Histidine, 1-(phenylmethyl)-; (2S)-2-amino-3-(1-benzylimidazol-4-yl)propanoic acid; Nim-Benzyl-L-histidine; CHEMBL4240267; Poly(1-benzyl-L-histidine); 1-Benzylhistidin; PubChem16228; H-His-(Bzl)-OH; N-Im-benzyl-L-histidine; SCHEMBL41832; CTK1C4741; DTXSID30185435; (S)-2-Amino-3-(1-Benzyl-1H-Imidazol-4-Yl) Propanoic Acid; ZINC402754; BDBM50463190; MFCD00038630; AKOS016010221; AS-60409; K-5208; 086H419; J-010447; (2S)-2-amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid

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Activity

IC50 = 170000 nM

[1]

Compound Name

1-Methyl-L-histidine

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Investigative

Compound Info

Synonyms

1-Methylhistidine; pi-methylhistidine; N1-Methyl-L-histidine; L-1-Methylhistidine; H-His(1-Me)-OH; (S)-2-Amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid; 1 methylhistidine; N(tele)-methyl-L-histidine; 1-Methyl-Histidine; UNII-583O01BJ32; 1-MHis; 1-N-Methyl-L-histidine; 1-methyl histidine (L-form); CHEMBL1233327; L-Histidine, 1-methyl- (9CI); Histidine, 1-methyl-, L- (8CI); 583O01BJ32; 3-(1-Methylimidazol-4-yl)-L-alanine; (2S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid; L-Histidine, 1-methyl-; EINECS 206-368-0; NSC 524367; O-Methyl-His-OH; Ntau-Methyl-L-histidine; Histidine, N-tau-methyl-; bmse000449; Histidine, 1-methyl-, L-; SCHEMBL52216; 3-Methyl-L-histidine (archaic); CTK1C4746; DTXSID50186848; KS-000018PS; ZINC2563973; ANW-60602; BDBM50463197; MFCD00005295; AKOS016843072; CS-W017722; DB04151; HY-W017006; AS-57334; 1-Methyl-L-histidine, >=98.0% (TLC); DB-008068; V0979; 332M809; J-019123; Q27094989; ABB55D30-E94C-412D-9B7A-E423FA8C1620

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IC50 = 190000 nM

[1]

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Non Binders of This Target (in total, 12 non binders)

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Compound Name

D-tryptophan

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Investigative

Compound Info

Synonyms

D-Tryptophan; 153-94-6; H-D-Trp-OH; D(+)-Tryptophan; (R)-Tryptophan; D-TRYPTOPHANE; (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid; D-Trytophane; H-D-Typ-OH; Tryptophan, D-; D-Trp; UNII-7NS97N9H1G; D-(+)-Tryptophan; (R)-2-Amino-3-(3-indolyl)propionic acid; EINECS 205-819-9; NSC 97942; (R)-(+)-2-Amino-3-(3-indolyl)propionic Acid; 7NS97N9H1G; CHEMBL292303; DTR; CHEBI:16296; QIVBCDIJIAJPQS-SECBINFHSA-N; MFCD00005647; D-alpha-Amino-3-indolepropionic acid; NCGC00093372-02; DSSTox_RID_82038; DSSTox_CID_26989; D(+)-Tryptophan,

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IC50 = 380000 nM

[1]

Compound Name

D-histidine

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Investigative

Compound Info

Synonyms

D-Histidine; 351-50-8; H-D-His-OH; (R)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid; D-Histidin; D-His; (R)-2-Amino-3-(4-imidazolyl)propionic acid; (2R)-2-amino-3-(1H-imidazol-4-yl)propanoic acid; CHEBI:27947; (2R)-2-amino-3-(1H-imidazol-5-yl)propanoic acid; MFCD00065963; D-alpha-Amino-beta-(4-imidazolyl)propionic acid; (R)-alpha-Amino-1H-imidazole-4-propionic acid; Q-101530; D-Histamine; EINECS 206-513-8; PubChem12316; 2ez7; AC1L2FID; AC1Q4UAU; AC1Q5R0N; SCHEMBL59365; KSC222G6N; CHEMBL104875; GTPL4679; Jsp006338; KS-00000ACN

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IC50 = 460000 nM

[1]

Compound Name

D-Leucine

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Investigative

Compound Info

Synonyms

H-D-Leu-OH; (R)-Leucine; (2R)-2-amino-4-methylpentanoic acid; (R)-2-Amino-4-methylpentanoic acid; (R)-(-)-Leucine; Leucine, D-; D-Homo-valine; D-2-Amino-4-methylvaleric acid; D-Leu; D-Leucin; D-Leuzin; UNII-965COD96YA; MFCD00063088; 965COD96YA; Leucine,d; D-Leucine, 99%; NCGC00163335-01; DSSTox_CID_26347; DSSTox_RID_81551; DSSTox_GSID_46347; EINECS 206-327-7; NSC 77687; AI3-52422; (D)-leucine; d-leu42; PubChem12374; SCHEMBL42012; KSC223K2T; CHEMBL1232258; DTXSID6046347; CTK1C3529; D-2-Amino-4-methylpentanoic acid; ZINC388396; (R)-2-Amino-4-methylvaleric acid; ACT04820; BCP30475; CS-D1369; D-Leucine, ReagentPlus(R), 99%; HY-Y0378; Tox21_112049; ANW-27466; BDBM50463213; SBB006736; (R)-2-amino-4-methyl-pentanoic acid; AKOS015841823; Tox21_112049_1; AC-8658; AM81870; DB01746; MCULE-8280206722; (2R)-2-Amino-4-methyl-pentanoic acid; KS-00000K97; (2R)-2-azanyl-4-methyl-pentanoic acid; NCGC00013565-03; NCGC00163335-02; NCGC00163335-03; AS-12286; SC-09637; D-Leucine, Vetec(TM) reagent grade, 97%; L0027; C01570; S-1329; A821449; Q16081973; F1905-7150; Z966690616; D-2-Amino-4-methylpentanoic acid;(R)-Leucine;H-D-Leu-OH; UNII-1QSS9D5DR6 component ROHFNLRQFUQHCH-RXMQYKEDSA-N

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Activity

IC50 = 220000 nM

[1]

Compound Name

alpha-Benzyl-D-methionine

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Investigative

Compound Info

Synonyms

CHEMBL4247580; BDBM50463206

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Activity

IC50 = 240000 nM

[1]

Compound Name

(R)-2-Amino-3-cyclohexylpropanoic acid

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Investigative

Compound Info

Synonyms

H-D-CHA-OH; D-Cyclohexylalanine; 3-Cyclohexyl-D-alanine; D-3-Cyclohexylalanine; (2R)-2-amino-3-cyclohexylpropanoic acid; BETA-CYCLOHEXYL-D-ALANINE; UNII-CX76B5H6YN; CX76B5H6YN; CHEMBL441123; (R)-2-AMINO-3-CYCLOHEXYL-PROPIONIC ACID; (R)-3-Cyclohexylalanine; MFCD00153485; 3-Cyclohexylalanine, D-; h-D-cha-oh, AldrichCPR; SCHEMBL503347; (R)-D-CYCLOHEXYLALANINE; CS-B1050; KS-000001ZB; ANW-75177; BDBM50179724; ZINC12502778; AKOS016842822; AB04112; DS-2120; (R)-alpha-aminocyclohexanepropionic acid; (2R)-2-azaniumyl-3-cyclohexylpropanoate; AC-25313; ST092364; (2R)-2-azanyl-3-cyclohexyl-propanoic acid; AB0061683; Z4912; 17C025; M-8703; (2R)?-?2-?Amino-?3-?cyclohexylpropanoic acid; A831989; Q27467924; CYCLOHEXANEPROPANOIC ACID, ALPHA-AMINO-, (ALPHAR)-; UNII-3B09YU0I30 component ORQXBVXKBGUSBA-MRVPVSSYSA-N

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Activity

IC50 = 260000 nM

[1]

Compound Name

4-(Methoxycarbonyl)-L-phenylalanine

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Investigative

Compound Info

Synonyms

CHEMBL4245490; (S)-2-Amino-3-(4-(methoxycarbonyl)phenyl)propanoic acid; SCHEMBL1768596; 4-methyloxycarbonyl-l-phenylalanine; BDBM50463204; ZINC39117766; (2S)-2-amino-3-(4-methoxycarbonylphenyl)propanoic acid

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Activity

IC50 = 260000 nM

[1]

Compound Name

D-Tyrosine

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Investigative

Compound Info

Synonyms

H-D-Tyr-OH; D-Tyr; (R)-2-amino-3-(4-hydroxyphenyl)propanoic acid; 3-(4-Hydroxyphenyl)-D-alanine; D-tyrosinyl radical; (2R)-2-amino-3-(4-hydroxyphenyl)propanoic acid; D-Tyrosin; MFCD00063073; UNII-WQ5G9JQ7GC; WQ5G9JQ7GC; CHEMBL1076637; (R)-3-(p-Hydroxyphenyl)alanine; D-Tyrosine, 98%; (R)-2-Amino-3-(p-hydroxyphenyl)propionic acid; D-(+)-Tyrosine; d-p-Tyrosine; Tyrosine, d-; (D)-Tyrosine; EINECS 209-112-6; PubChem13030; (R)-TYROSINE; SCHEMBL20787; KSC270A8B; ZINC2234; CTK1H0080; DTXSID50883441; ACT04817; CS-D1377; HY-Y0444; D-Tyrosine, ReagentPlus(R), 99%; ANW-32348; BDBM50463198; SBB012381; AKOS015854094; AB02505; AC-8668; AM82303; DB03839; MCULE-6003337645; KS-0000024J; NCGC00142608-01; NCGC00142608-02; AS-11715; SC-09925; ST069332; D-Tyrosine, puriss., >=99.0% (NT); D-Tyrosine, Vetec(TM) reagent grade, 99%; C06420; K-9919; M02937; T-9000; (R)-2-Amino-3-(4-hydroxyphenyl)propionic acid; (2R)-2-azanyl-3-(4-hydroxyphenyl)propanoic acid; 556T025; A830718; J-300275; Q16082044; Q27115118; Z1762997038; 1168FFD2-192C-4DB4-9161-4BF71A6C98C9; UNII-A9BAT9B32M component OUYCCCASQSFEME-MRVPVSSYSA-N; (R)-2-Amino-3-(4-hydroxyphenyl)propionic acid, 3-(4-Hydroxyphenyl)-D-alanine

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Activity

IC50 = 380000 nM

[1]

Compound Name

(S)-2-Amino-3-(3-(aminomethyl)phenyl)propanoic acid

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Investigative

Compound Info

Synonyms

L-3-Aminomethylphe; L-3-Aminomethylphenylalanine; (2S)-2-amino-3-[3-(aminomethyl)phenyl]propanoic acid; CHEMBL4244201; 3-Aminomethyl-L-phenylalanine; SCHEMBL485684; CTK8G0462; DTXSID00376136; Phenylalanine, 3-(aminomethyl)-; ZINC4241976; 8401AB; BDBM50463185; MFCD06213215; PS-12801; (S)-2-Amino-3-(3-(aminomethyl)phenyl)propanoicacid

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Activity

IC50 = 470000 nM

[1]

Compound Name

Chembl4248655

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Investigative

Compound Info

Synonyms

BDBM50463189

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Activity

IC50 = 680000 nM

[1]

Compound Name

(R)-2-Amino-2-methyl-3-phenylpropanoic acid

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Investigative

Compound Info

Synonyms

ALPHA-METHYL-D-PHENYLALANINE; alpha-methyl-D-Phe; D-Phenylalanine, alpha-methyl-; CHEMBL4250045; D-ALPHA-METHYL PHENYLALANINE; ALPHA-BENZYL-D-ALA; (2R)-2-amino-2-methyl-3-phenylpropanoic acid; (R)-alpha-Methylphenylalanine hydrate, 98%, 98% ee; a-methyl-d-phenylalanine; H-D-(ME)PHE-OH; (S)-2-Amino-2- Methyl-3-Phenylpropanoic Acid; (R)-alpha-Methylphenylalanine; SCHEMBL202327; (R)-alpha-methyl phenylalanine; (r)-alpha-methylphenyl-alanine; CTK7I3010; ZINC8076086; ANW-63949; BDBM50463193; MFCD00153491; AKOS016843198; AB04114; AC-4461; DS-16370; SC-46109; (R)-2-amimo-2-methyl-3-phenylpropanoic acid; K-5315; 350M844; alpha-Methyl-D-phenylalanine, >=98.0% (HPLC); J-010914; (R)-2-AMINO-2-METHYL-3-PHENYLPROPIONIC ACID; UNII-67265D2JSG component HYOWVAAEQCNGLE-SNVBAGLBSA-N

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Activity

IC50 = 810000 nM

[1]

Compound Name

D-Alloisoleucine

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Investigative

Compound Info

Synonyms

D-allo-isoleucine; (2R,3S)-2-amino-3-methylpentanoic acid; Allo-D-isoleucine; Alloisoleucine, D-; H-D-Allo-Ile-OH; DL-Allo-isoleucine; UNII-886W169S1R; threo-D-Isoleucine; MFCD00066445; D-allo-Isoleucine, 97%; CHEMBL4239366; 886W169S1R; 4-04-00-02777 (Beilstein Handbook Reference); EINECS 216-143-9; BRN 1721794; MFCD00004268; MFCD00065934; D-allo-Ile; D-allo-Ile-OH; delta-allo-Isoleucine; H-DL-allo-lle-OH; dextro,laevo-isoleucine; PubChem12311; (-)-D-allo-isoleucine; SCHEMBL288159; CTK0H4929; DL-allo-Isoleucine, >=99.0%; DTXSID901019590; ZINC388314; KS-00000AB4; ANW-21305; BDBM50463207; AKOS006239314; AKOS015842026; AM81860; CS-W009266; (+/-)-2-Amino-3-methylpentanoic acid; AC-22373; AS-12098; BR-72869; SC-09606; 509a359; A7213; D-ALLO-2-AMINO-3-METHYLPENTANOIC ACID; C21092; K-0034; Z-3613; J-018234; W-108068; Q27109362; UNII-05T3WT3PJ1 component AGPKZVBTJJNPAG-CRCLSJGQSA-N

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Activity

IC50 > 3000000 nM

[1]

Compound Name

D-Valine

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Investigative

Compound Info

Synonyms

H-D-Val-OH; (R)-Valine; Valine, D-; D-2-Aminoisovaleric Acid; (R)-2-Amino-3-methylbutanoic acid; D-valin; (2R)-2-amino-3-methylbutanoic acid; NSC 20654; D-Val; UNII-Y14I1443UR; MFCD00064219; CHEMBL1232398; Y14I1443UR; (R)-2-Amino-3-methylbutyric acid; NCGC00159470-02; D-2-Amino-3-methylbutanoic acid; D-Valine, 98+%; D-2-amino-3-methylbutyric acid; EINECS 211-368-9; 2-Amino-3-methyl-butyric acid; D valine; R-Valine; zlchem 296; PubChem11138; D-Valine, >=98%; DSSTox_CID_26064; DSSTox_RID_81315; DSSTox_GSID_46064; SCHEMBL43678; KSC352S5F; DTXSID0046064; CTK2F2952; HY-N0717A; ZLC0115; ZINC896156; ACT04818; BCP10545; (2R)-2-amino-3-methylbutanoicacid; Tox21_111694; ANW-34802; BDBM50357216; KM0815; SBB006709; AKOS006240045; AKOS015841471; AB02568; AM82362; KS-00000A95; AC-24061; AS-14130; D-Valine, Vetec(TM) reagent grade, 98%; AB0007136; CS-0010218; EN300-54608; 40V686; C06417; (R)-(-)-2-AMINO-3-METHYLBUTYRIC ACID; D-Valine, suitable for cell culture, BioReagent; J-300291; Q27103152; 9040E22A-FFB5-4A57-A5DC-9F7B09E64F07; F1905-7038; UNII-4CA13A832H component KZSNJWFQEVHDMF-SCSAIBSYSA-N

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IC50 > 50000000 nM

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References

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REF 1

Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018 Aug 23;61(16):7358-7373.

REF 2

Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2856-2860.

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